Hpn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hpn
Entrez Gene ID	29135
Full Name	hepsin
General protein information	Preferred Names hepsin Names serine protease hepsin hepsin (transmembrane protease, serine 1)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21
Summary	cell surface serine proteinase [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017112.1	NP_058808.1	serine protease hepsin precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HPN	XP_001157575.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004552	XP_313850.5
Canis lupus familiaris (dog)	HPN	XP_541697.2
Bos taurus (cattle)	HPN	NP_001073710.1
Danio rerio (zebrafish)	si:dkey-33i11.3	NP_001091657.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008649	XP_314746.4
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004568	XP_313873.5
Homo sapiens (human)	HPN	NP_892028.1
Rattus norvegicus (Norway rat)	Hpn	NP_058808.1
Danio rerio (zebrafish)	LOC100536154	XP_003200307.1
	HPN	XP_001093699.2
Mus musculus (house mouse)	Hpn	NP_032307.2

Gene Ontology
Bibliography

Related articles in PubMed

TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.
Heurich A, Hofmann-Winkler H, Gierer S, Liepold T, Jahn O, P?hlmann S
Journal of virology88(2)1293-307(2014 Jan)

Pla2g12b and Hpn are genes identified by mouse ENU mutagenesis that affect HDL cholesterol.
Aljakna A, Choi S, Savage H, Hageman Blair R, Gu T, Svenson KL, Churchill GA, Hibbs M, Korstanje R
PloS one7(8)e43139(2012)

Identification of hepsin and protein disulfide isomerase A3 as targets of gelatinolytic action in rat ovarian granulosa cells during the periovulatory period.
Rosewell K, Al-Alem L, Li F, Kelty B, Curry TE Jr
Biology of reproduction85(4)858-66(2011 Oct)

Thyroxine treatments do not correct inner ear defects in tmprss1 mutant mice.
Hanifa S, Scott HS, Crewther P, Guipponi M, Tan J
Neuroreport21(13)897-901(2010 Sep)

Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor.
Chen M, Chen LM, Lin CY, Chai KX
Molecular and cellular biochemistry337(1-2)259-66(2010 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggest that hepsin and PDIA3 undergo proteolysis by MMP2/9 in ovarian granulosa cells during ovulation and/or luteinization.
Title: Identification of hepsin and protein disulfide isomerase A3 as targets of gelatinolytic action in rat ovarian granulosa cells during the periovulatory period.

Ln-332 may be one mechanism by which hepsin promotes prostate tumor progression and metastasis, possibly by up-regulating prostate cancer cell motility.
Title: Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression.

The following Hpn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hpn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02895	NM_017112.1 Latest version!	Rattus norvegicus hepsin (Hpn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hpn ( NM_017112.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058808.1 Rattus norvegicus hepsin (Hpn), mRNA.

Price & Availability↑

CloneID	ORa02895
Clone ID Related Accession (Same CDS sequence)	NM_017112.1
Accession Version	NM_017112.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1251bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	serine protease hepsin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X70900.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X70900.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGAAGG AGGGTGGCCG GACTGCACCA TGCTGTTCCA GACCCAAGGT GGCAGCTCTC 
ACTGTGGGGA CCCTGCTGTT CCTGACAGGC ATTGGGGCTG CGTCCTGGGC CATTGTGACC 
ATCCTACTAC GGAGTGACCA GGAGCCACTG TACCAAGTGC AGCTCAGTCC CGGGGACTCT 
CGACTTTTGG TGTTGGACAA GACAGAGGGA ACGTGGAGGC TGCTGTGCTC CTCACGCTCC 
AACGCCAGGG TAGCAGGGCT CGGCTGTGAG GAGATGGGCT TTCTCAGGGC TCTGGCGCAC 
TCAGAGCTGG ATGTGCGAAC CGCGGGCGCC AACGGCACAT CGGGCTTCTT CTGCGTGGAC 
GAGGGCGGTC TGCCTCTGGC TCAGCGGTTG CTGGATGTCA TCTCTGTATG CGACTGTCCT 
AGAGGCCGAT TCCTGACTGC CACCTGCCAA GACTGTGGCC GCAGGAAGCT GCCGGTGGAT 
CGCATTGTGG GGGGCCAGGA CAGCAGCCTG GGAAGATGGC CATGGCAGGT CAGCCTGCGT 
TATGATGGGA CCCACCTCTG TGGGGGATCC CTGCTGTCCG GGGACTGGGT ACTGACCGCT 
GCACACTGCT TTCCAGAGAG GAACCGGGTC CTGTCTCGGT GGCGAGTATT TGCTGGTGCT 
GTAGCCCGGA CCTCACCTCA TGCCGTGCAG CTGGGGGTTC AGGCTGTGAT CTATCATGGG 
GGCTACCTTC CCTTTCGAGA CCCTACTATC GACGAAAACA GCAATGACAT TGCCCTGGTC 
CACCTCTCTA GCTCCCTGCC TCTCACAGAA TACATCCAGC CGGTTTGTCT CCCTGCTGCG 
GGACAGGCCC TGGTGGACGG CAAGGTCTGT ACAGTGACCG GCTGGGGTAA CACACAGTTC 
TATGGCCAGC AAGCTGTGGT GCTCCAAGAG GCCCGGGTCC CCATCATAAG CAACGAAGTT 
TGCAACAGCC CCGACTTCTA CGGGAATCAG ATCAAACCCA AGATGTTCTG TGCTGGCTAT 
CCTGAGGGTG GTATTGATGC ATGCCAGGGT GACAGCGGAG GCCACTTTGT ATGTGAGGAC 
AGAATCTCTG GAACATCAAG ATGGCGGCTC TGCGGCATTG TAAGCTGGGG TACGGGCTGT 
GCTTTGGCCC GGAAGCCGGG AGTGTACACC AAAGTCATTG ACTTCCGGGA GTGGATCTTC 
CAGGCCATAA AGACTCACTC CGAAGCTACC GGCATGGTAA CTCAGCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058808.1
CDS	185..1435
Translation	MAKEGGRTAPCCSRPKVAALTVGTLLFLTGIGAASWAIVTILLRSDQEPLYQVQLSPGDSRLLVLDKTEGTWRLLCSSRSNARVAGLGCEEMGFLRALAHSELDVRTAGANGTSGFFCVDEGGLPLAQRLLDVISVCDCPRGRFLTATCQDCGRRKLPVDRIVGGQDSSLGRWPWQVSLRYDGTHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVARTSPHAVQLGVQAVIYHGGYLPFRDPTIDENSNDIALVHLSSSLPLTEYIQPVCLPAAGQALVDGKVCTVTGWGNTQFYGQQAVVLQEARVPIISNEVCNSPDFYGNQIKPKMFCAGYPEGGIDACQGDSGGHFVCEDRISGTSRWRLCGIVSWGTGCALARKPGVYTKVIDFREWIFQAIKTHSEATGMVTQP

Target ORF information:

RefSeq Version	NM_017112.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus hepsin (Hpn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017112.1

ORF Insert Sequence:

ATGGCGAAGG AGGGTGGCCG GACTGCACCA TGCTGTTCCA GACCCAAGGT GGCAGCTCTC 
ACTGTGGGGA CCCTGCTGTT CCTGACAGGC ATTGGGGCTG CGTCCTGGGC CATTGTGACC 
ATCCTACTAC GGAGTGACCA GGAGCCACTG TACCAAGTGC AGCTCAGTCC CGGGGACTCT 
CGACTTTTGG TGTTGGACAA GACAGAGGGA ACGTGGAGGC TGCTGTGCTC CTCACGCTCC 
AACGCCAGGG TAGCAGGGCT CGGCTGTGAG GAGATGGGCT TTCTCAGGGC TCTGGCGCAC 
TCAGAGCTGG ATGTGCGAAC CGCGGGCGCC AACGGCACAT CGGGCTTCTT CTGCGTGGAC 
GAGGGCGGTC TGCCTCTGGC TCAGCGGTTG CTGGATGTCA TCTCTGTATG CGACTGTCCT 
AGAGGCCGAT TCCTGACTGC CACCTGCCAA GACTGTGGCC GCAGGAAGCT GCCGGTGGAT 
CGCATTGTGG GGGGCCAGGA CAGCAGCCTG GGAAGATGGC CATGGCAGGT CAGCCTGCGT 
TATGATGGGA CCCACCTCTG TGGGGGATCC CTGCTGTCCG GGGACTGGGT ACTGACCGCT 
GCACACTGCT TTCCAGAGAG GAACCGGGTC CTGTCTCGGT GGCGAGTATT TGCTGGTGCT 
GTAGCCCGGA CCTCACCTCA TGCCGTGCAG CTGGGGGTTC AGGCTGTGAT CTATCATGGG 
GGCTACCTTC CCTTTCGAGA CCCTACTATC GACGAAAACA GCAATGACAT TGCCCTGGTC 
CACCTCTCTA GCTCCCTGCC TCTCACAGAA TACATCCAGC CGGTTTGTCT CCCTGCTGCG 
GGACAGGCCC TGGTGGACGG CAAGGTCTGT ACAGTGACCG GCTGGGGTAA CACACAGTTC 
TATGGCCAGC AAGCTGTGGT GCTCCAAGAG GCCCGGGTCC CCATCATAAG CAACGAAGTT 
TGCAACAGCC CCGACTTCTA CGGGAATCAG ATCAAACCCA AGATGTTCTG TGCTGGCTAT 
CCTGAGGGTG GTATTGATGC ATGCCAGGGT GACAGCGGAG GCCACTTTGT ATGTGAGGAC 
AGAATCTCTG GAACATCAAG ATGGCGGCTC TGCGGCATTG TAAGCTGGGG TACGGGCTGT 
GCTTTGGCCC GGAAGCCGGG AGTGTACACC AAAGTCATTG ACTTCCGGGA GTGGATCTTC 
CAGGCCATAA AGACTCACTC CGAAGCTACC GGCATGGTAA CTCAGCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.
Journal of virology88(2)1293-307(2014 Jan)
Heurich A,Hofmann-Winkler H,Gierer S,Liepold T,Jahn O,P?hlmann S

Pla2g12b and Hpn are genes identified by mouse ENU mutagenesis that affect HDL cholesterol.
PloS one7(8)e43139(2012)
Aljakna A,Choi S,Savage H,Hageman Blair R,Gu T,Svenson KL,Churchill GA,Hibbs M,Korstanje R

Identification of hepsin and protein disulfide isomerase A3 as targets of gelatinolytic action in rat ovarian granulosa cells during the periovulatory period.
Biology of reproduction85(4)858-66(2011 Oct)
Rosewell K,Al-Alem L,Li F,Kelty B,Curry TE Jr

Thyroxine treatments do not correct inner ear defects in tmprss1 mutant mice.
Neuroreport21(13)897-901(2010 Sep)
Hanifa S,Scott HS,Crewther P,Guipponi M,Tan J

Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor.
Molecular and cellular biochemistry337(1-2)259-66(2010 Apr)
Chen M,Chen LM,Lin CY,Chai KX

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Hpn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報