Dcdc2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dcdc2
Entrez Gene ID	291130
Full Name	doublecortin domain containing 2
General protein information	Preferred Names doublecortin domain containing 2 Names doublecortin domain-containing protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17p11
Summary	This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Knockdown of this gene expression results in neuronal migration disorders similar to those seen in the brains of dyslexics. [provided by RefSeq, Sep 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001106110.2	NP_001099580.2	doublecortin domain-containing protein 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Dcdc2a	NP_808245.2
Danio rerio (zebrafish)	dcdc2b	NP_001032778.1
Homo sapiens (human)	DCDC2	NP_057440.2
Xenopus tropicalis (tropical clawed frog)	dcdc2	XP_004915336.1
	DCDC2	XP_001100219.1
Canis lupus familiaris (dog)	DCDC2	XP_853515.2
Rattus norvegicus (Norway rat)	Dcdc2	NP_001099580.2
Gallus gallus (chicken)	DCDC2	XP_003640800.2
Bos taurus (cattle)	DCDC2	XP_002697586.1

Gene Ontology
Bibliography

Related articles in PubMed

Complex effects of dyslexia risk factors account for ADHD traits: evidence from two independent samples.
Mascheretti S, Trezzi V, Giorda R, Boivin M, Plourde V, Vitaro F, Brendgen M, Dionne G, Marino C
Journal of child psychology and psychiatry, and allied disciplines58(1)75-82(2017 Jan)

DCDC2 Mutations Cause Neonatal Sclerosing Cholangitis.
Girard M, Bizet AA, Lachaux A, Gonzales E, Filhol E, Collardeau-Frachon S, Jeanpierre C, Henry C, Fabre M, Viremouneix L, Galmiche L, Debray D, Bole-Feysot C, Nitschke P, Pariente D, Guettier C, Lyonnet S, Heidet L, Bertholet A, Jacquemin E, Henrion-Caude A, Saunier S
Human mutation37(10)1025-9(2016 10)

Association of DCDC2 Polymorphisms with Normal Variations in Reading Abilities in a Chinese Population.
Zhang Y, Li J, Song S, Tardif T, Burmeister M, Villafuerte SM, Su M, McBride C, Shu H
PloS one11(4)e0153603(2016)

A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation.
Grati M, Chakchouk I, Ma Q, Bensaid M, Desmidt A, Turki N, Yan D, Baanannou A, Mittal R, Driss N, Blanton S, Farooq A, Lu Z, Liu XZ, Masmoudi S
Human molecular genetics24(9)2482-91(2015 May)

DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.
Schueler M, Braun DA, Chandrasekar G, Gee HY, Klasson TD, Halbritter J, Bieder A, Porath JD, Airik R, Zhou W, LoTurco JJ, Che A, Otto EA, B?ckenhauer D, Sebire NJ, Honzik T, Harris PC, Koon SJ, Gunay-Aygun M, Saunier S, Zerres K, Bruechle NO, Drenth JP, Pelletier L, Tapia-P?ez I, Lifton RP, Giles RH, Kere J, Hildebrandt F
American journal of human genetics96(1)81-92(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DCDC2 overexpression in C. elegans causes an abnormal neuronal phenotype that can only be seen in ciliated neurons. Together our results suggest a potential role for DCDC2 in the structure and function of primary cilia
Title: Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons.

These results support the claim that knockdown of Dcdc2 expression results in neuronal migration disorders similar to those seen in the brains of dyslexics.
Title: Postnatal analysis of the effect of embryonic knockdown and overexpression of candidate dyslexia susceptibility gene homolog Dcdc2 in the rat.

The following Dcdc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dcdc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11941	NM_001106110.2 Latest version!	Rattus norvegicus doublecortin domain containing 2 (Dcdc2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dcdc2 ( NM_001106110.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099580.2 Rattus norvegicus doublecortin domain containing 2 (Dcdc2), mRNA.

Price & Availability↑

CloneID	ORa11941
Clone ID Related Accession (Same CDS sequence)	NM_001106110.2
Accession Version	NM_001106110.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1428bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	doublecortin domain-containing protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AABR07027717.1, AABR07027716.1, AABR07027715.1, AABR07027713.1 and AABR07027712.1. On Feb 14, 2008 this sequence version replaced NM_001106110.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAACGGTC CCAGCCCCAG GTCCAGCCAC CTGTCGCAGC CGGTGGTGAA GAGTGTGCTG 
GTGTACCGCA ATGGGGACCC GTTCTTCGCC GGGCGCCGCG TCGTCATTCA CGAGAAGAAG 
GTGTCCAGCT TCGACATCTT CCTCAAGGAA GTGACCGGCG GTGTGCAGGC TCCCTTTGGG 
GCAGTTAGGA ACATCTACAC CCCGAGGACG GGCCACCGCA TCCGGAAGCT GGACCAGATA 
GAGAGCGGGG GCAACTACGT GGCTGGGGGC CAGGAAGCTT TCAAGAAACT CAACTACTTG 
GACATAGGAG AAATCAAGAA AAGACCAATG GAAGCTGTTA ATACTGAGGT GAAGCCTGTC 
ATCCACAGCA AAATCAACGT GTCTGCCCGA TTCAGGAAGG CGCTGCATGA GCCCTGTACC 
ATTTTCTTGA TTGCAAATGG AGACCTCATA AGCCCAGCTT CTCGCCTCCT CATCCCAAGA 
AAAGCTTTAA ATCAGTGGGA TCACGTACTA CAAATGGTCA CAGAAAAAAT AACTCTTCGG 
AGTGGGGCTG TCCACAGGCT GTATACATTA GAAGGAAAAC TGGTTGAGAG TGGAGCAGAG 
CTGGAGAACG GGCAGTTTTA TGTGGCCGTC GGCAGAGATA AGTTTAAGAG ACTACCGTAC 
AGTGAGTTAC TTTTTGACAA GTCAGCAATG AGAAGGCCTT ATGGTCAGAA AGCTTCTTCA 
CTACCTCCCA TGGTTGGATC CAGGAAGTCT AAAGGGAGCG GGAATTACCG ACAATCTAAG 
TCAACCATTG GCTCCAGTGA TAACTCATCT CCTCAGCCTC TGAAGAGGAA AGGGAAGAAA 
GACTCAAATT CAGAAAAACC CACGAAAGTG AAACAAAGTG TGAAGTCGAA GAATTCCCAC 
CAAGCAATTC CAGACAACGA TGAAGGCATT TTCAAAGCTG GAGCAGAGAG ATCTGAAACG 
AGGGGGGCAG CAGAAGTTCA GGAAGATGAA GACACTCAGG TTGAGGTACC AGTGGACCAG 
AGGCCAGCAG AAATAGTTGA TGAGGAAGAA GATGGAGAGA AAACAAGCAA AGATGCCAAC 
CAGAAGGATG ACTTTTCAGC AATGAACGGT GAGGCTGAAG ACAGAGCGGG GAGTAAAGTA 
GCCGATGCCC CTGAGGAGGA GGAGGGAATC CCAGACCAAG GGGAGAAGAA GGCAAGTCCC 
TCTCGGGTAA ATGGTGGCAC TGACGAAGAG AATGGTGAGG AATTGGACCA GGTTACCGAG 
GAGCTTCAGC CAACAGTGGA TGAGAAAGGA AAGGCTGAAG GAGACAACAG TGCACAAGAT 
GAGGCTGGTT TAGATGCTCA AAGACCACCA AGACCAGAAG TGACAGTCAC CAGCCCTCAA 
GAGAACGAAG GGAATGAATC AAACAAAGCC TCTTCTGCTG TGGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099580.2
CDS	41..1468
Translation	MNGPSPRSSHLSQPVVKSVLVYRNGDPFFAGRRVVIHEKKVSSFDIFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIESGGNYVAGGQEAFKKLNYLDIGEIKKRPMEAVNTEVKPVIHSKINVSARFRKALHEPCTIFLIANGDLISPASRLLIPRKALNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKRLPYSELLFDKSAMRRPYGQKASSLPPMVGSRKSKGSGNYRQSKSTIGSSDNSSPQPLKRKGKKDSNSEKPTKVKQSVKSKNSHQAIPDNDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKTSKDANQKDDFSAMNGEAEDRAGSKVADAPEEEEGIPDQGEKKASPSRVNGGTDEENGEELDQVTEELQPTVDEKGKAEGDNSAQDEAGLDAQRPPRPEVTVTSPQENEGNESNKASSAVA

Target ORF information:

RefSeq Version	NM_001106110.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus doublecortin domain containing 2 (Dcdc2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106110.2

ORF Insert Sequence:

ATGAACGGTC CCAGCCCCAG GTCCAGCCAC CTGTCGCAGC CGGTGGTGAA GAGTGTGCTG 
GTGTACCGCA ATGGGGACCC GTTCTTCGCC GGGCGCCGCG TCGTCATTCA CGAGAAGAAG 
GTGTCCAGCT TCGACATCTT CCTCAAGGAA GTGACCGGCG GTGTGCAGGC TCCCTTTGGG 
GCAGTTAGGA ACATCTACAC CCCGAGGACG GGCCACCGCA TCCGGAAGCT GGACCAGATA 
GAGAGCGGGG GCAACTACGT GGCTGGGGGC CAGGAAGCTT TCAAGAAACT CAACTACTTG 
GACATAGGAG AAATCAAGAA AAGACCAATG GAAGCTGTTA ATACTGAGGT GAAGCCTGTC 
ATCCACAGCA AAATCAACGT GTCTGCCCGA TTCAGGAAGG CGCTGCATGA GCCCTGTACC 
ATTTTCTTGA TTGCAAATGG AGACCTCATA AGCCCAGCTT CTCGCCTCCT CATCCCAAGA 
AAAGCTTTAA ATCAGTGGGA TCACGTACTA CAAATGGTCA CAGAAAAAAT AACTCTTCGG 
AGTGGGGCTG TCCACAGGCT GTATACATTA GAAGGAAAAC TGGTTGAGAG TGGAGCAGAG 
CTGGAGAACG GGCAGTTTTA TGTGGCCGTC GGCAGAGATA AGTTTAAGAG ACTACCGTAC 
AGTGAGTTAC TTTTTGACAA GTCAGCAATG AGAAGGCCTT ATGGTCAGAA AGCTTCTTCA 
CTACCTCCCA TGGTTGGATC CAGGAAGTCT AAAGGGAGCG GGAATTACCG ACAATCTAAG 
TCAACCATTG GCTCCAGTGA TAACTCATCT CCTCAGCCTC TGAAGAGGAA AGGGAAGAAA 
GACTCAAATT CAGAAAAACC CACGAAAGTG AAACAAAGTG TGAAGTCGAA GAATTCCCAC 
CAAGCAATTC CAGACAACGA TGAAGGCATT TTCAAAGCTG GAGCAGAGAG ATCTGAAACG 
AGGGGGGCAG CAGAAGTTCA GGAAGATGAA GACACTCAGG TTGAGGTACC AGTGGACCAG 
AGGCCAGCAG AAATAGTTGA TGAGGAAGAA GATGGAGAGA AAACAAGCAA AGATGCCAAC 
CAGAAGGATG ACTTTTCAGC AATGAACGGT GAGGCTGAAG ACAGAGCGGG GAGTAAAGTA 
GCCGATGCCC CTGAGGAGGA GGAGGGAATC CCAGACCAAG GGGAGAAGAA GGCAAGTCCC 
TCTCGGGTAA ATGGTGGCAC TGACGAAGAG AATGGTGAGG AATTGGACCA GGTTACCGAG 
GAGCTTCAGC CAACAGTGGA TGAGAAAGGA AAGGCTGAAG GAGACAACAG TGCACAAGAT 
GAGGCTGGTT TAGATGCTCA AAGACCACCA AGACCAGAAG TGACAGTCAC CAGCCCTCAA 
GAGAACGAAG GGAATGAATC AAACAAAGCC TCTTCTGCTG TGGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Complex effects of dyslexia risk factors account for ADHD traits: evidence from two independent samples.
Journal of child psychology and psychiatry, and allied disciplines58(1)75-82(2017 Jan)
Mascheretti S,Trezzi V,Giorda R,Boivin M,Plourde V,Vitaro F,Brendgen M,Dionne G,Marino C

DCDC2 Mutations Cause Neonatal Sclerosing Cholangitis.
Human mutation37(10)1025-9(2016 10)
Girard M,Bizet AA,Lachaux A,Gonzales E,Filhol E,Collardeau-Frachon S,Jeanpierre C,Henry C,Fabre M,Viremouneix L,Galmiche L,Debray D,Bole-Feysot C,Nitschke P,Pariente D,Guettier C,Lyonnet S,Heidet L,Bertholet A,Jacquemin E,Henrion-Caude A,Saunier S

Association of DCDC2 Polymorphisms with Normal Variations in Reading Abilities in a Chinese Population.
PloS one11(4)e0153603(2016)
Zhang Y,Li J,Song S,Tardif T,Burmeister M,Villafuerte SM,Su M,McBride C,Shu H

A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation.
Human molecular genetics24(9)2482-91(2015 May)
Grati M,Chakchouk I,Ma Q,Bensaid M,Desmidt A,Turki N,Yan D,Baanannou A,Mittal R,Driss N,Blanton S,Farooq A,Lu Z,Liu XZ,Masmoudi S

DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.
American journal of human genetics96(1)81-92(2015 Jan)
Schueler M,Braun DA,Chandrasekar G,Gee HY,Klasson TD,Halbritter J,Bieder A,Porath JD,Airik R,Zhou W,LoTurco JJ,Che A,Otto EA,B?ckenhauer D,Sebire NJ,Honzik T,Harris PC,Koon SJ,Gunay-Aygun M,Saunier S,Zerres K,Bruechle NO,Drenth JP,Pelletier L,Tapia-P?ez I,Lifton RP,Giles RH,Kere J,Hildebrandt F

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Dcdc2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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