Erlin2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Erlin2
Entrez Gene ID	290823
Full Name	ER lipid raft associated 2
Synonyms	RGD1309010,Spfh2
General protein information	Preferred Names ER lipid raft associated 2 Names erlin-2 SPFH domain family, member 2 SPFH domain-containing protein 2 endoplasmic reticulum lipid raft-associated protein 2 stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q12.3

mRNA and Protein(s)

mRNA	Protein	Name
XM_008771324.2	XP_008769546.1	erlin-2 isoform X1
NM_001106088.2	NP_001099558.1	erlin-2
XM_008771323.2	XP_008769545.1	erlin-2 isoform X1

Pathways from BioSystems

Homologies

Arabidopsis thaliana (thale cress)	AT2G03510	NP_027545.1
Oryza sativa (rice)	Os03g0421400	NP_001050383.1
Pan troglodytes (chimpanzee)	ERLIN2	XP_001169738.1
Canis lupus familiaris (dog)	ERLIN2	XP_005629927.1
Xenopus tropicalis (tropical clawed frog)	erlin2	NP_001016719.1
Bos taurus (cattle)	ERLIN2	NP_001040041.1
Rattus norvegicus (Norway rat)	Erlin2	NP_001099558.1
Danio rerio (zebrafish)	erlin2	NP_001121887.1
Caenorhabditis elegans (roundworm)	erl-1	NP_502339.1
Homo sapiens (human)	ERLIN2	NP_009106.1
	ERLIN2	XP_001088868.1
Mus musculus (house mouse)	Erlin2	NP_705820.1
Gallus gallus (chicken)	ERLIN2	XP_424380.1

Gene Ontology
Bibliography

Related articles in PubMed

Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells.
Fork C, Hitzel J, Nichols BJ, Tikkanen R, Brandes RP
Basic research in cardiology109(6)439(2014)

Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis.
Huber MD, Vesely PW, Datta K, Gerace L
The Journal of cell biology203(3)427-36(2013 Nov)

RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR).
El Khouri E, Le Pavec G, Toledano MB, Delaunay-Moisan A
The Journal of biological chemistry288(43)31177-91(2013 Oct)

Erlin-2 is associated with active ?-secretase in brain and affects amyloid ?-peptide production.
Teranishi Y, Hur JY, Gu GJ, Kihara T, Ishikawa T, Nishimura T, Winblad B, Behbahani H, Kamali-Moghaddam M, Frykman S, Tjernberg LO
Biochemical and biophysical research communications424(3)476-81(2012 Aug)

An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors.
Pearce MM, Wormer DB, Wilkens S, Wojcikiewicz RJ
The Journal of biological chemistry284(16)10433-45(2009 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a novel brain gamma-secretase associated protein , erlin-2, that resides in detergent resistant membranes and affects amyloid beta-peptide production.
Title: Erlin-2 is associated with active ?-secretase in brain and affects amyloid ?-peptide production.

Results suggest that this novel SPFH1/2 complex is a recognition factor that targets IP(3)Rs and perhaps other substrates for ERAD.
Title: An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors.

The following Erlin2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Erlin2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa00161	NM_001106088.2 Latest version!	Rattus norvegicus ER lipid raft associated 2 (Erlin2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa00161	XM_008771323.2 Latest version!	Rattus norvegicus ER lipid raft associated 2 (Erlin2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa00161	XM_008771324.2 Latest version!	Rattus norvegicus ER lipid raft associated 2 (Erlin2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Erlin2 ( NM_001106088.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099558.1 Rattus norvegicus ER lipid raft associated 2 (Erlin2), mRNA.

Price & Availability↑

CloneID	ORa00161
Clone ID Related Accession (Same CDS sequence)	XM_008771324.2 , NM_001106088.2 , XM_008771323.2
Accession Version	NM_001106088.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Rattus norvegicus(Norway rat)
Product	erlin-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC168668.1. On Sep 4, 2008 this sequence version replaced NM_001106088.1. ##Evidence-Data-START## Transcript exon combination :: BC168668.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCTCAAT TGGGAGCAGT TGTGGCTGTG GCTTCCAGTT TCTTTTGCGC ATCTCTCTTC 
TCAGCTGTGC ACAAGATAGA AGAGGGACAT ATCGGAGTAT ATTACAGAGG TGGTGCCCTG 
CTGACCTCCA CCAGTGGCCC AGGTTTCCAT CTCATGCTCC CGTTCATCAC ATCCTACAAG 
TCTGTACAGA CCACTCTCCA AACGGATGAA GTGAAGAACG TACCATGCGG AACCAGTGGT 
GGTGTGATGA TCTACTTTGA CAGAATTGAA GTGGTGAACT TCCTGGTCCC ACATGCAGTG 
TATGATATAG TGAAGAACTA TACTGCAGAC TATGACAAGG CCCTCATCTT CAACAAGATT 
CATCATGAGC TTAACCAGTT CTGCAGCGTC CATACACTTC AGGAAGTCTA TATCGAGCTG 
TTTGATCAAA TCGATGAAAA CCTCAAATTG GCTTTGCAGC AGGACCTGAC CTCCATGGCC 
CCTGGGCTTG TTATCCAAGC TGTACGAGTG ACAAAGCCCA ACATCCCTGA GGCAATCCGC 
AGGAACTATG AGTTGATGGA AAGCGAGAAG ACGAAGCTTC TCATTGCGGC CCAGAAACAG 
AAGGTGGTGG AGAAGGAGGC GGAAACGGAG AGGAAGAAGG CCCTCATTGA GGCAGAAAAA 
GTGGCACAGG TTGCAGAAAT CACCTATGGG CAGAAGGTGA TGGAGAAGGA GACTGAGAAG 
AAGATTTCAG AAATTGAGGA TGCTGCATTT CTGGCCCGGG AGAAGGCAAA GGCCGATGCT 
GAGTGCTACA CTGCTCTGAA GATCGCGGAA GCCAATAAGC TCAAGCTGAC CCCAGAATAC 
CTGCAGCTGA TGAAGTACAA GGCTATTGCT TCCAACAGCA AGATTTACTT TGGCAAAGAC 
ATCCCCAACA TGTTCATGGA CTCCGCAGGC GGCCTGGGCA AGCAGTCTGA GGGGCTGAGT 
GACAAGCTGG GCTTTGGCCT AGAAGACGAG CCCCTAGAGA CAGCCACAAA GGATAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099558.1
CDS	50..1069
Translation	MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPHAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTALKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGGLGKQSEGLSDKLGFGLEDEPLETATKDN

Target ORF information:

RefSeq Version	NM_001106088.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ER lipid raft associated 2 (Erlin2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106088.2

ORF Insert Sequence:

ATGGCTCAAT TGGGAGCAGT TGTGGCTGTG GCTTCCAGTT TCTTTTGCGC ATCTCTCTTC 
TCAGCTGTGC ACAAGATAGA AGAGGGACAT ATCGGAGTAT ATTACAGAGG TGGTGCCCTG 
CTGACCTCCA CCAGTGGCCC AGGTTTCCAT CTCATGCTCC CGTTCATCAC ATCCTACAAG 
TCTGTACAGA CCACTCTCCA AACGGATGAA GTGAAGAACG TACCATGCGG AACCAGTGGT 
GGTGTGATGA TCTACTTTGA CAGAATTGAA GTGGTGAACT TCCTGGTCCC ACATGCAGTG 
TATGATATAG TGAAGAACTA TACTGCAGAC TATGACAAGG CCCTCATCTT CAACAAGATT 
CATCATGAGC TTAACCAGTT CTGCAGCGTC CATACACTTC AGGAAGTCTA TATCGAGCTG 
TTTGATCAAA TCGATGAAAA CCTCAAATTG GCTTTGCAGC AGGACCTGAC CTCCATGGCC 
CCTGGGCTTG TTATCCAAGC TGTACGAGTG ACAAAGCCCA ACATCCCTGA GGCAATCCGC 
AGGAACTATG AGTTGATGGA AAGCGAGAAG ACGAAGCTTC TCATTGCGGC CCAGAAACAG 
AAGGTGGTGG AGAAGGAGGC GGAAACGGAG AGGAAGAAGG CCCTCATTGA GGCAGAAAAA 
GTGGCACAGG TTGCAGAAAT CACCTATGGG CAGAAGGTGA TGGAGAAGGA GACTGAGAAG 
AAGATTTCAG AAATTGAGGA TGCTGCATTT CTGGCCCGGG AGAAGGCAAA GGCCGATGCT 
GAGTGCTACA CTGCTCTGAA GATCGCGGAA GCCAATAAGC TCAAGCTGAC CCCAGAATAC 
CTGCAGCTGA TGAAGTACAA GGCTATTGCT TCCAACAGCA AGATTTACTT TGGCAAAGAC 
ATCCCCAACA TGTTCATGGA CTCCGCAGGC GGCCTGGGCA AGCAGTCTGA GGGGCTGAGT 
GACAAGCTGG GCTTTGGCCT AGAAGACGAG CCCCTAGAGA CAGCCACAAA GGATAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Erlin2 ( XM_008771324.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008769546.1 Rattus norvegicus ER lipid raft associated 2 (Erlin2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa00161
Clone ID Related Accession (Same CDS sequence)	XM_008771324.2 , NM_001106088.2 , XM_008771323.2
Accession Version	XM_008771324.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	erlin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005115.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008771324.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCAAT TGGGAGCAGT TGTGGCTGTG GCTTCCAGTT TCTTTTGCGC ATCTCTCTTC 
TCAGCTGTGC ACAAGATAGA AGAGGGACAT ATCGGAGTAT ATTACAGAGG TGGTGCCCTG 
CTGACCTCCA CCAGTGGCCC AGGTTTCCAT CTCATGCTCC CGTTCATCAC ATCCTACAAG 
TCTGTACAGA CCACTCTCCA AACGGATGAA GTGAAGAACG TACCATGCGG AACCAGTGGT 
GGTGTGATGA TCTACTTTGA CAGAATTGAA GTGGTGAACT TCCTGGTCCC ACATGCAGTG 
TATGATATAG TGAAGAACTA TACTGCAGAC TATGACAAGG CCCTCATCTT CAACAAGATT 
CATCATGAGC TTAACCAGTT CTGCAGCGTC CATACACTTC AGGAAGTCTA TATCGAGCTG 
TTTGATCAAA TCGATGAAAA CCTCAAATTG GCTTTGCAGC AGGACCTGAC CTCCATGGCC 
CCTGGGCTTG TTATCCAAGC TGTACGAGTG ACAAAGCCCA ACATCCCTGA GGCAATCCGC 
AGGAACTATG AGTTGATGGA AAGCGAGAAG ACGAAGCTTC TCATTGCGGC CCAGAAACAG 
AAGGTGGTGG AGAAGGAGGC GGAAACGGAG AGGAAGAAGG CCCTCATTGA GGCAGAAAAA 
GTGGCACAGG TTGCAGAAAT CACCTATGGG CAGAAGGTGA TGGAGAAGGA GACTGAGAAG 
AAGATTTCAG AAATTGAGGA TGCTGCATTT CTGGCCCGGG AGAAGGCAAA GGCCGATGCT 
GAGTGCTACA CTGCTCTGAA GATCGCGGAA GCCAATAAGC TCAAGCTGAC CCCAGAATAC 
CTGCAGCTGA TGAAGTACAA GGCTATTGCT TCCAACAGCA AGATTTACTT TGGCAAAGAC 
ATCCCCAACA TGTTCATGGA CTCCGCAGGC GGCCTGGGCA AGCAGTCTGA GGGGCTGAGT 
GACAAGCTGG GCTTTGGCCT AGAAGACGAG CCCCTAGAGA CAGCCACAAA GGATAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008769546.1
CDS	239..1258
Translation	MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPHAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTALKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGGLGKQSEGLSDKLGFGLEDEPLETATKDN

Target ORF information:

RefSeq Version	XM_008771324.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ER lipid raft associated 2 (Erlin2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008771324.2

ORF Insert Sequence:

ATGGCTCAAT TGGGAGCAGT TGTGGCTGTG GCTTCCAGTT TCTTTTGCGC ATCTCTCTTC 
TCAGCTGTGC ACAAGATAGA AGAGGGACAT ATCGGAGTAT ATTACAGAGG TGGTGCCCTG 
CTGACCTCCA CCAGTGGCCC AGGTTTCCAT CTCATGCTCC CGTTCATCAC ATCCTACAAG 
TCTGTACAGA CCACTCTCCA AACGGATGAA GTGAAGAACG TACCATGCGG AACCAGTGGT 
GGTGTGATGA TCTACTTTGA CAGAATTGAA GTGGTGAACT TCCTGGTCCC ACATGCAGTG 
TATGATATAG TGAAGAACTA TACTGCAGAC TATGACAAGG CCCTCATCTT CAACAAGATT 
CATCATGAGC TTAACCAGTT CTGCAGCGTC CATACACTTC AGGAAGTCTA TATCGAGCTG 
TTTGATCAAA TCGATGAAAA CCTCAAATTG GCTTTGCAGC AGGACCTGAC CTCCATGGCC 
CCTGGGCTTG TTATCCAAGC TGTACGAGTG ACAAAGCCCA ACATCCCTGA GGCAATCCGC 
AGGAACTATG AGTTGATGGA AAGCGAGAAG ACGAAGCTTC TCATTGCGGC CCAGAAACAG 
AAGGTGGTGG AGAAGGAGGC GGAAACGGAG AGGAAGAAGG CCCTCATTGA GGCAGAAAAA 
GTGGCACAGG TTGCAGAAAT CACCTATGGG CAGAAGGTGA TGGAGAAGGA GACTGAGAAG 
AAGATTTCAG AAATTGAGGA TGCTGCATTT CTGGCCCGGG AGAAGGCAAA GGCCGATGCT 
GAGTGCTACA CTGCTCTGAA GATCGCGGAA GCCAATAAGC TCAAGCTGAC CCCAGAATAC 
CTGCAGCTGA TGAAGTACAA GGCTATTGCT TCCAACAGCA AGATTTACTT TGGCAAAGAC 
ATCCCCAACA TGTTCATGGA CTCCGCAGGC GGCCTGGGCA AGCAGTCTGA GGGGCTGAGT 
GACAAGCTGG GCTTTGGCCT AGAAGACGAG CCCCTAGAGA CAGCCACAAA GGATAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Erlin2 ( XM_008771323.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008769545.1 Rattus norvegicus ER lipid raft associated 2 (Erlin2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa00161
Clone ID Related Accession (Same CDS sequence)	XM_008771324.2 , NM_001106088.2 , XM_008771323.2
Accession Version	XM_008771323.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	erlin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005115.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008771323.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCAAT TGGGAGCAGT TGTGGCTGTG GCTTCCAGTT TCTTTTGCGC ATCTCTCTTC 
TCAGCTGTGC ACAAGATAGA AGAGGGACAT ATCGGAGTAT ATTACAGAGG TGGTGCCCTG 
CTGACCTCCA CCAGTGGCCC AGGTTTCCAT CTCATGCTCC CGTTCATCAC ATCCTACAAG 
TCTGTACAGA CCACTCTCCA AACGGATGAA GTGAAGAACG TACCATGCGG AACCAGTGGT 
GGTGTGATGA TCTACTTTGA CAGAATTGAA GTGGTGAACT TCCTGGTCCC ACATGCAGTG 
TATGATATAG TGAAGAACTA TACTGCAGAC TATGACAAGG CCCTCATCTT CAACAAGATT 
CATCATGAGC TTAACCAGTT CTGCAGCGTC CATACACTTC AGGAAGTCTA TATCGAGCTG 
TTTGATCAAA TCGATGAAAA CCTCAAATTG GCTTTGCAGC AGGACCTGAC CTCCATGGCC 
CCTGGGCTTG TTATCCAAGC TGTACGAGTG ACAAAGCCCA ACATCCCTGA GGCAATCCGC 
AGGAACTATG AGTTGATGGA AAGCGAGAAG ACGAAGCTTC TCATTGCGGC CCAGAAACAG 
AAGGTGGTGG AGAAGGAGGC GGAAACGGAG AGGAAGAAGG CCCTCATTGA GGCAGAAAAA 
GTGGCACAGG TTGCAGAAAT CACCTATGGG CAGAAGGTGA TGGAGAAGGA GACTGAGAAG 
AAGATTTCAG AAATTGAGGA TGCTGCATTT CTGGCCCGGG AGAAGGCAAA GGCCGATGCT 
GAGTGCTACA CTGCTCTGAA GATCGCGGAA GCCAATAAGC TCAAGCTGAC CCCAGAATAC 
CTGCAGCTGA TGAAGTACAA GGCTATTGCT TCCAACAGCA AGATTTACTT TGGCAAAGAC 
ATCCCCAACA TGTTCATGGA CTCCGCAGGC GGCCTGGGCA AGCAGTCTGA GGGGCTGAGT 
GACAAGCTGG GCTTTGGCCT AGAAGACGAG CCCCTAGAGA CAGCCACAAA GGATAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008769545.1
CDS	302..1321
Translation	MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPHAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTALKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGGLGKQSEGLSDKLGFGLEDEPLETATKDN

Target ORF information:

RefSeq Version	XM_008771323.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ER lipid raft associated 2 (Erlin2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008771323.2

ORF Insert Sequence:

ATGGCTCAAT TGGGAGCAGT TGTGGCTGTG GCTTCCAGTT TCTTTTGCGC ATCTCTCTTC 
TCAGCTGTGC ACAAGATAGA AGAGGGACAT ATCGGAGTAT ATTACAGAGG TGGTGCCCTG 
CTGACCTCCA CCAGTGGCCC AGGTTTCCAT CTCATGCTCC CGTTCATCAC ATCCTACAAG 
TCTGTACAGA CCACTCTCCA AACGGATGAA GTGAAGAACG TACCATGCGG AACCAGTGGT 
GGTGTGATGA TCTACTTTGA CAGAATTGAA GTGGTGAACT TCCTGGTCCC ACATGCAGTG 
TATGATATAG TGAAGAACTA TACTGCAGAC TATGACAAGG CCCTCATCTT CAACAAGATT 
CATCATGAGC TTAACCAGTT CTGCAGCGTC CATACACTTC AGGAAGTCTA TATCGAGCTG 
TTTGATCAAA TCGATGAAAA CCTCAAATTG GCTTTGCAGC AGGACCTGAC CTCCATGGCC 
CCTGGGCTTG TTATCCAAGC TGTACGAGTG ACAAAGCCCA ACATCCCTGA GGCAATCCGC 
AGGAACTATG AGTTGATGGA AAGCGAGAAG ACGAAGCTTC TCATTGCGGC CCAGAAACAG 
AAGGTGGTGG AGAAGGAGGC GGAAACGGAG AGGAAGAAGG CCCTCATTGA GGCAGAAAAA 
GTGGCACAGG TTGCAGAAAT CACCTATGGG CAGAAGGTGA TGGAGAAGGA GACTGAGAAG 
AAGATTTCAG AAATTGAGGA TGCTGCATTT CTGGCCCGGG AGAAGGCAAA GGCCGATGCT 
GAGTGCTACA CTGCTCTGAA GATCGCGGAA GCCAATAAGC TCAAGCTGAC CCCAGAATAC 
CTGCAGCTGA TGAAGTACAA GGCTATTGCT TCCAACAGCA AGATTTACTT TGGCAAAGAC 
ATCCCCAACA TGTTCATGGA CTCCGCAGGC GGCCTGGGCA AGCAGTCTGA GGGGCTGAGT 
GACAAGCTGG GCTTTGGCCT AGAAGACGAG CCCCTAGAGA CAGCCACAAA GGATAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells.
Basic research in cardiology109(6)439(2014)
Fork C,Hitzel J,Nichols BJ,Tikkanen R,Brandes RP

Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis.
The Journal of cell biology203(3)427-36(2013 Nov)
Huber MD,Vesely PW,Datta K,Gerace L

RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR).
The Journal of biological chemistry288(43)31177-91(2013 Oct)
El Khouri E,Le Pavec G,Toledano MB,Delaunay-Moisan A

Erlin-2 is associated with active ?-secretase in brain and affects amyloid ?-peptide production.
Biochemical and biophysical research communications424(3)476-81(2012 Aug)
Teranishi Y,Hur JY,Gu GJ,Kihara T,Ishikawa T,Nishimura T,Winblad B,Behbahani H,Kamali-Moghaddam M,Frykman S,Tjernberg LO

An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors.
The Journal of biological chemistry284(16)10433-45(2009 Apr)
Pearce MM,Wormer DB,Wilkens S,Wojcikiewicz RJ

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Erlin2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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