Neil3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Neil3
Entrez Gene ID	290729
Full Name	nei-like DNA glycosylase 3
Synonyms	RGD1310562
General protein information	Preferred Names nei-like DNA glycosylase 3 Names endonuclease 8-like 3 endonuclease VIII-like 3 nei endonuclease VIII-like 3 nei like 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001170346.1	NP_001163817.1	endonuclease 8-like 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NEIL3	XP_526741.2
Mus musculus (house mouse)	Neil3	NP_666320.1
Canis lupus familiaris (dog)	NEIL3	XP_532852.3
Danio rerio (zebrafish)	neil3	NP_001007336.1
Gallus gallus (chicken)	NEIL3	XP_426306.3
Homo sapiens (human)	NEIL3	NP_060718.2
	NEIL3	XP_001090459.1
Bos taurus (cattle)	NEIL3	NP_001029662.1
Rattus norvegicus (Norway rat)	Neil3	NP_001163817.1
Xenopus tropicalis (tropical clawed frog)	neil3	NP_001017201.1

Gene Ontology
Bibliography

Related articles in PubMed

Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin.
Krokeide SZ, Laerdahl JK, Salah M, Luna L, Cederkvist FH, Fleming AM, Burrows CJ, Dalhus B, Bj?r?s M
DNA repair12(12)1159-64(2013 Dec)

The DNA glycosylases OGG1 and NEIL3 influence differentiation potential, proliferation, and senescence-associated signs in neural stem cells.
Reis A, Hermanson O
Biochemical and biophysical research communications423(4)621-6(2012 Jul)

The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo.
Liu M, Bandaru V, Bond JP, Jaruga P, Zhao X, Christov PP, Burrows CJ, Rizzo CJ, Dizdaroglu M, Wallace SS
Proceedings of the National Academy of Sciences of the United States of America107(11)4925-30(2010 Mar)

Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant.
Takao M, Oohata Y, Kitadokoro K, Kobayashi K, Iwai S, Yasui A, Yonei S, Zhang QM
Genes to cells : devoted to molecular & cellular mechanisms14(2)261-70(2009 Feb)

Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein.
Torisu K, Tsuchimoto D, Ohnishi Y, Nakabeppu Y
Journal of biochemistry138(6)763-72(2005 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results suggest that DNA glycosylases OGG1 and NEIL3 play multiple roles in governing essential neural stem cell characteristics.
Title: The DNA glycosylases OGG1 and NEIL3 influence differentiation potential, proliferation, and senescence-associated signs in neural stem cells.

The following Neil3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Neil3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06167	NM_001170346.1 Latest version!	Rattus norvegicus nei-like DNA glycosylase 3 (Neil3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Neil3 ( NM_001170346.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001163817.1 Rattus norvegicus nei-like DNA glycosylase 3 (Neil3), mRNA.

Price & Availability↑

CloneID	ORa06167
Clone ID Related Accession (Same CDS sequence)	NM_001170346.1
Accession Version	NM_001170346.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1821bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-31
Organism	Rattus norvegicus(Norway rat)
Product	endonuclease 8-like 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07025594.1. On Dec 17, 2009 this sequence version replaced XM_224835.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2689604, SAMN01906347 [ECO:0000350] ##Evidence-Data-END##

ATGGTGGAAG GGCCAGGATG TACACTGAAT GGAGAGAAGA TTCGGGCACG AGTGCTACCG 
GGACAGGCGA TGACTGGTGT GCGGGGAACA GCTCTGCAGG GCCTCTTGGG CTCTGCCTTG 
TCCCCCGCAG CCTCCCTGGC TGAGGTCACT AGCTCGGCTG CTCCAATGAA CGCTAAAGAT 
TCTGGCTGGA AAGTCTTGAG ACTGTTTAAT GGATGTGTTT ACAGTGGTGT GGAAACCTTG 
GGGAAGGAGC TGTTTATGTA CTTTGGCCCA AGAGCTTTAC GGATTCATTT CGGAATGAAA 
GGCTCCATCT TGATTAACCC GCCTAAGTGT GAAAATAGAG GTGGAGTTTC TCCAGCTTTT 
GAAGTGCAGC TCACCAATGA CTTGATCTGT TTCTTTGACT CTTCAGTAAA ACTCAGAAAT 
TCAGTGGAAA GCCAACAAAG AGTCAGAATG ATGGAAGGAT TGGATGTATG CTCACCAAAG 
TTCAGTCTCT CAAGAGCAGA AAGTGAAGTT AAGAAGCAGA GAGATCGGAT GCTGTGTGAT 
GTGTTACTGG ATCAGAGGGT GTTGCCTGGT GTAGGGAACA TCATCAAAAA TGAAGCTCTC 
TTTGACAGTG GACTCCATCC AACTGTTAAG GTGTGTCAAC TATCAGACAA ACAGGCCCAT 
CACCTTGTGA AGATGACCCG GGATTTCAGC ATTCTCTTCT ACAGGTGCCG TAAAGCAGGA 
TCTGCCATTT CTAAACACTA TAAGGTTTAT AAGCGTCCTA ACTGTGCACA GTGCCACTGC 
AAAATTAGAG TGTGTCGCTT AGGGGAGAAC AGCAGGATGA CGTATTTCTG TCCTCACTGT 
CAGAAAGAAA ACCCTCAACA TGTTCAAATA TGCTCACTGC CTTTCAGAAA TGCTGAAATC 
AGCTGGACTC CTAAAGGACA GGATTGCTTT ACCGACTCAG TAGCTCGGAA GTCTGAAGAG 
CAGTGGTCCT GCATGGTTTG CACCCTCATA AACAAACCCT CGGCTACGGC CTGCGATGCT 
TGCCTGACGA CAAGGCCTGT GGATTCAGTG CTCAAAAATG AAGAGAATTC CATTGCCTTT 
AGCAACTTAG TGAAGTACCC TTTTAATAAC TTTGAGAACA CACACACTGA AATAAAGATC 
AACAGGAAAA CTGTGTTTGG AAATACAACC CTTGTTTTGA CTGATTTGAG CAACAAATCT 
AGTGCTTTGG CCAGAAAAAG CAGCCCAAGC CAGACAATAG ATGGGGAATC TCAAATTTTT 
CTTCCTACAG ACATATGTTT CAGTGATCCA CAGCACATCT CCAAAGAAGG AGTAAACTAT 
ATAACTCAAC CATCCAACAA GGTAAACATG TCGTCCACAG TTGGTGCCCA GTCTAAATTA 
TTTACTTCAG CACATAAAAA ATTGAAAACA GCTCACTCTT TGGCAACAGA ACTTAAAAGT 
TACAACTCTG GACTTTCTAA CAGTGAACTC CAAACCAATA TAAGAAGTGA TCCTTGTTCT 
CTACATGCCA GCAGGCCTCA GTGCAAGACG CACAGCCGGC CCTGTGTTCT CCGAGTTGTG 
AGGAAGGATG GAGAAAACAA AGGAAGGCAG TTTTATGCAT GTTCTCTGCC CAGAGGAGCA 
CAGTGCGGAT TTTTTGAATG GGCAGACCTG TCCTTCCCGT TCTGCGGACA TGGCAAGCGC 
TCCATTATGA AAACTGTGTT GAAGATTGGA CCTAATAATG GGAAGAATTT TTTTGTATGT 
CCTTTGGAGA AAGAAAAGCA GTGTAATTTT TTCCAGTGGG CAGAAAGTGG ACCAGAAATG 
GAAATTATTC CAGGATGCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001163817.1
CDS	111..1931
Translation	MVEGPGCTLNGEKIRARVLPGQAMTGVRGTALQGLLGSALSPAASLAEVTSSAAPMNAKDSGWKVLRLFNGCVYSGVETLGKELFMYFGPRALRIHFGMKGSILINPPKCENRGGVSPAFEVQLTNDLICFFDSSVKLRNSVESQQRVRMMEGLDVCSPKFSLSRAESEVKKQRDRMLCDVLLDQRVLPGVGNIIKNEALFDSGLHPTVKVCQLSDKQAHHLVKMTRDFSILFYRCRKAGSAISKHYKVYKRPNCAQCHCKIRVCRLGENSRMTYFCPHCQKENPQHVQICSLPFRNAEISWTPKGQDCFTDSVARKSEEQWSCMVCTLINKPSATACDACLTTRPVDSVLKNEENSIAFSNLVKYPFNNFENTHTEIKINRKTVFGNTTLVLTDLSNKSSALARKSSPSQTIDGESQIFLPTDICFSDPQHISKEGVNYITQPSNKVNMSSTVGAQSKLFTSAHKKLKTAHSLATELKSYNSGLSNSELQTNIRSDPCSLHASRPQCKTHSRPCVLRVVRKDGENKGRQFYACSLPRGAQCGFFEWADLSFPFCGHGKRSIMKTVLKIGPNNGKNFFVCPLEKEKQCNFFQWAESGPEMEIIPGC

Target ORF information:

RefSeq Version	NM_001170346.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nei-like DNA glycosylase 3 (Neil3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001170346.1

ORF Insert Sequence:

ATGGTGGAAG GGCCAGGATG TACACTGAAT GGAGAGAAGA TTCGGGCACG AGTGCTACCG 
GGACAGGCGA TGACTGGTGT GCGGGGAACA GCTCTGCAGG GCCTCTTGGG CTCTGCCTTG 
TCCCCCGCAG CCTCCCTGGC TGAGGTCACT AGCTCGGCTG CTCCAATGAA CGCTAAAGAT 
TCTGGCTGGA AAGTCTTGAG ACTGTTTAAT GGATGTGTTT ACAGTGGTGT GGAAACCTTG 
GGGAAGGAGC TGTTTATGTA CTTTGGCCCA AGAGCTTTAC GGATTCATTT CGGAATGAAA 
GGCTCCATCT TGATTAACCC GCCTAAGTGT GAAAATAGAG GTGGAGTTTC TCCAGCTTTT 
GAAGTGCAGC TCACCAATGA CTTGATCTGT TTCTTTGACT CTTCAGTAAA ACTCAGAAAT 
TCAGTGGAAA GCCAACAAAG AGTCAGAATG ATGGAAGGAT TGGATGTATG CTCACCAAAG 
TTCAGTCTCT CAAGAGCAGA AAGTGAAGTT AAGAAGCAGA GAGATCGGAT GCTGTGTGAT 
GTGTTACTGG ATCAGAGGGT GTTGCCTGGT GTAGGGAACA TCATCAAAAA TGAAGCTCTC 
TTTGACAGTG GACTCCATCC AACTGTTAAG GTGTGTCAAC TATCAGACAA ACAGGCCCAT 
CACCTTGTGA AGATGACCCG GGATTTCAGC ATTCTCTTCT ACAGGTGCCG TAAAGCAGGA 
TCTGCCATTT CTAAACACTA TAAGGTTTAT AAGCGTCCTA ACTGTGCACA GTGCCACTGC 
AAAATTAGAG TGTGTCGCTT AGGGGAGAAC AGCAGGATGA CGTATTTCTG TCCTCACTGT 
CAGAAAGAAA ACCCTCAACA TGTTCAAATA TGCTCACTGC CTTTCAGAAA TGCTGAAATC 
AGCTGGACTC CTAAAGGACA GGATTGCTTT ACCGACTCAG TAGCTCGGAA GTCTGAAGAG 
CAGTGGTCCT GCATGGTTTG CACCCTCATA AACAAACCCT CGGCTACGGC CTGCGATGCT 
TGCCTGACGA CAAGGCCTGT GGATTCAGTG CTCAAAAATG AAGAGAATTC CATTGCCTTT 
AGCAACTTAG TGAAGTACCC TTTTAATAAC TTTGAGAACA CACACACTGA AATAAAGATC 
AACAGGAAAA CTGTGTTTGG AAATACAACC CTTGTTTTGA CTGATTTGAG CAACAAATCT 
AGTGCTTTGG CCAGAAAAAG CAGCCCAAGC CAGACAATAG ATGGGGAATC TCAAATTTTT 
CTTCCTACAG ACATATGTTT CAGTGATCCA CAGCACATCT CCAAAGAAGG AGTAAACTAT 
ATAACTCAAC CATCCAACAA GGTAAACATG TCGTCCACAG TTGGTGCCCA GTCTAAATTA 
TTTACTTCAG CACATAAAAA ATTGAAAACA GCTCACTCTT TGGCAACAGA ACTTAAAAGT 
TACAACTCTG GACTTTCTAA CAGTGAACTC CAAACCAATA TAAGAAGTGA TCCTTGTTCT 
CTACATGCCA GCAGGCCTCA GTGCAAGACG CACAGCCGGC CCTGTGTTCT CCGAGTTGTG 
AGGAAGGATG GAGAAAACAA AGGAAGGCAG TTTTATGCAT GTTCTCTGCC CAGAGGAGCA 
CAGTGCGGAT TTTTTGAATG GGCAGACCTG TCCTTCCCGT TCTGCGGACA TGGCAAGCGC 
TCCATTATGA AAACTGTGTT GAAGATTGGA CCTAATAATG GGAAGAATTT TTTTGTATGT 
CCTTTGGAGA AAGAAAAGCA GTGTAATTTT TTCCAGTGGG CAGAAAGTGG ACCAGAAATG 
GAAATTATTC CAGGATGCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin.
DNA repair12(12)1159-64(2013 Dec)
Krokeide SZ,Laerdahl JK,Salah M,Luna L,Cederkvist FH,Fleming AM,Burrows CJ,Dalhus B,Bj?r?s M

The DNA glycosylases OGG1 and NEIL3 influence differentiation potential, proliferation, and senescence-associated signs in neural stem cells.
Biochemical and biophysical research communications423(4)621-6(2012 Jul)
Reis A,Hermanson O

The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America107(11)4925-30(2010 Mar)
Liu M,Bandaru V,Bond JP,Jaruga P,Zhao X,Christov PP,Burrows CJ,Rizzo CJ,Dizdaroglu M,Wallace SS

Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant.
Genes to cells : devoted to molecular & cellular mechanisms14(2)261-70(2009 Feb)
Takao M,Oohata Y,Kitadokoro K,Kobayashi K,Iwai S,Yasui A,Yonei S,Zhang QM

Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein.
Journal of biochemistry138(6)763-72(2005 Dec)
Torisu K,Tsuchimoto D,Ohnishi Y,Nakabeppu Y

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Neil3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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