Nrl cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nrl
Entrez Gene ID	290221
Full Name	neural retina leucine zipper
General protein information	Preferred Names neural retina leucine zipper Names neural retina-specific leucine zipper protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p13

mRNA and Protein(s)

mRNA	Protein	Name
XM_006251937.3	XP_006251999.1	neural retina-specific leucine zipper protein isoform X1
XM_017599621.1	XP_017455110.1	neural retina-specific leucine zipper protein isoform X1
XM_006251935.3	XP_006251997.1	neural retina-specific leucine zipper protein isoform X1
XM_008770672.2	XP_008768894.1	neural retina-specific leucine zipper protein isoform X1
XM_017599620.1	XP_017455109.1	neural retina-specific leucine zipper protein isoform X1
NM_001106036.2	NP_001099506.1	neural retina-specific leucine zipper protein

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	nrl	NP_001035421.1
Pan troglodytes (chimpanzee)	NRL	XP_001166004.1
Mus musculus (house mouse)	Nrl	NP_032762.1
Rattus norvegicus (Norway rat)	Nrl	NP_001099506.1
Homo sapiens (human)	NRL	NP_006168.1
	NRL	XP_001111563.1
Canis lupus familiaris (dog)	NRL	XP_547742.2
Bos taurus (cattle)	NRL	XP_002690584.1
Xenopus tropicalis (tropical clawed frog)	nrl	NP_001027477.2

Gene Ontology
Bibliography

Related articles in PubMed

Novel p.M96T variant of NRL and shRNA-based suppression and replacement of NRL mutants associated with autosomal dominant retinitis pigmentosa.
Hernan I, Gamundi MJ, Borr?s E, Maseras M, Garc?a-Sandoval B, Blanco-Kelly F, Ayuso C, Carballo M
Clinical genetics82(5)446-52(2012 Nov)

Retinopathy mutations in the bZIP protein NRL alter phosphorylation and transcriptional activity.
Kanda A, Friedman JS, Nishiguchi KM, Swaroop A
Human mutation28(6)589-98(2007 Jun)

Retinoic acid regulates the expression of photoreceptor transcription factor NRL.
Khanna H, Akimoto M, Siffroi-Fernandez S, Friedman JS, Hicks D, Swaroop A
The Journal of biological chemistry281(37)27327-34(2006 Sep)

The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes.
Peng GH, Ahmad O, Ahmad F, Liu J, Chen S
Human molecular genetics14(6)747-64(2005 Mar)

Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl.
Yoshida S, Mears AJ, Friedman JS, Carter T, He S, Oh E, Jing Y, Farjo R, Fleury G, Barlow C, Hero AO, Swaroop A
Human molecular genetics13(14)1487-503(2004 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

signaling by RA via RA receptors regulates the expression of NRL, providing a framework for delineating early steps in photoreceptor cell fate determination
Title: Retinoic acid regulates the expression of photoreceptor transcription factor NRL.

The following Nrl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nrl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa00065	NM_001106036.2 Latest version!	Rattus norvegicus neural retina leucine zipper (Nrl), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa00065	XM_017599621.1 Latest version!	Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa00065	XM_008770672.2 Latest version!	Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa00065	XM_017599620.1 Latest version!	Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa00065	XM_006251937.3 Latest version!	Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa00065	XM_006251935.3 Latest version!	Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nrl ( NM_001106036.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099506.1 Rattus norvegicus neural retina leucine zipper (Nrl), mRNA.

Price & Availability↑

CloneID	ORa00065
Clone ID Related Accession (Same CDS sequence)	XM_006251937.3 , XM_017599621.1 , XM_006251935.3 , XM_008770672.2 , XM_017599620.1 , NM_001106036.2
Accession Version	NM_001106036.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	neural retina-specific leucine zipper protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474049.1. On Mar 3, 2011 this sequence version replaced NM_001106036.1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTCTTC CCCCCAGTCC CTTGGCTATG GAATATGTTA ATGACTTTGA CTTGATGAAG 
TTTGAAATAA AGCGGGAGCC TTCTGAGGGC CGGTCCGGAG TCCCCACAGC CTCACTGGGC 
TCTACACCGT ACAGTTCAGT GCCTCCCTCA CCCACCTTCA GTGAGCCAGG CATGGTGGGC 
AACAGCGAGG CCCCTAGGCC CGCAGGCCTG GAGGAGCTAT ACTGGCTGGC CACCCTGCAG 
CAGCAGTTGG GGGCCGATGA GGTTCTGGGG CTGAGTCCTG ATGAGGCTGT GGAACTACTG 
CAGAGCCAGG GCCCGGTCTC TGTAGAAGGG CCTCATGGCT ACTATTCAGG GAGCCCAGGA 
GAGACAGGAG CCCCGAATGT GCAGTTGCCC GAGAGATTTT CAGACGCCGC GCTGGTCTCG 
ATGTCGGTGC GCGAGTTGAA CCGGCAGCTG CGGGGCTGCG GGCGCGACGA GGCTCTGCGG 
CTGAAGCAGA GGCGCCGCAC GCTCAAGAAC CGCGGCTACG CGCAGGCCTG TCGCTCCAAG 
CGGCTGCAGC AGCGGCGCGG GCTGGAGGCC GAGCGCGCCC GCCTAGCCGC ACAGCTGGAT 
GCCCTACGGG CGGAGGTGGC CCGCCTGGCT CGAGAGCGCG ACCTCTACAA GGCCCGCTGT 
GACCGGCTGA CTTCCGGTGG CCCTGGGTCC GACGACCACA CACACCTCTT CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099506.1
CDS	1..717
Translation	MALPPSPLAMEYVNDFDLMKFEIKREPSEGRSGVPTASLGSTPYSSVPPSPTFSEPGMVGNSEAPRPAGLEELYWLATLQQQLGADEVLGLSPDEAVELLQSQGPVSVEGPHGYYSGSPGETGAPNVQLPERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKARCDRLTSGGPGSDDHTHLFL

Target ORF information:

RefSeq Version	NM_001106036.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neural retina leucine zipper (Nrl), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106036.2

ORF Insert Sequence:

ATGGCTCTTC CCCCCAGTCC CTTGGCTATG GAATATGTTA ATGACTTTGA CTTGATGAAG 
TTTGAAATAA AGCGGGAGCC TTCTGAGGGC CGGTCCGGAG TCCCCACAGC CTCACTGGGC 
TCTACACCGT ACAGTTCAGT GCCTCCCTCA CCCACCTTCA GTGAGCCAGG CATGGTGGGC 
AACAGCGAGG CCCCTAGGCC CGCAGGCCTG GAGGAGCTAT ACTGGCTGGC CACCCTGCAG 
CAGCAGTTGG GGGCCGATGA GGTTCTGGGG CTGAGTCCTG ATGAGGCTGT GGAACTACTG 
CAGAGCCAGG GCCCGGTCTC TGTAGAAGGG CCTCATGGCT ACTATTCAGG GAGCCCAGGA 
GAGACAGGAG CCCCGAATGT GCAGTTGCCC GAGAGATTTT CAGACGCCGC GCTGGTCTCG 
ATGTCGGTGC GCGAGTTGAA CCGGCAGCTG CGGGGCTGCG GGCGCGACGA GGCTCTGCGG 
CTGAAGCAGA GGCGCCGCAC GCTCAAGAAC CGCGGCTACG CGCAGGCCTG TCGCTCCAAG 
CGGCTGCAGC AGCGGCGCGG GCTGGAGGCC GAGCGCGCCC GCCTAGCCGC ACAGCTGGAT 
GCCCTACGGG CGGAGGTGGC CCGCCTGGCT CGAGAGCGCG ACCTCTACAA GGCCCGCTGT 
GACCGGCTGA CTTCCGGTGG CCCTGGGTCC GACGACCACA CACACCTCTT CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nrl ( XM_006251937.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006251999.1 Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa00065
Clone ID Related Accession (Same CDS sequence)	XM_006251937.3 , XM_017599621.1 , XM_006251935.3 , XM_008770672.2 , XM_017599620.1 , NM_001106036.2
Accession Version	XM_006251937.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	neural retina-specific leucine zipper protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006251937.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCTTC CCCCCAGTCC CTTGGCTATG GAATATGTTA ATGACTTTGA CTTGATGAAG 
TTTGAAATAA AGCGGGAGCC TTCTGAGGGC CGGTCCGGAG TCCCCACAGC CTCACTGGGC 
TCTACACCGT ACAGTTCAGT GCCTCCCTCA CCCACCTTCA GTGAGCCAGG CATGGTGGGC 
AACAGCGAGG CCCCTAGGCC CGCAGGCCTG GAGGAGCTAT ACTGGCTGGC CACCCTGCAG 
CAGCAGTTGG GGGCCGATGA GGTTCTGGGG CTGAGTCCTG ATGAGGCTGT GGAACTACTG 
CAGAGCCAGG GCCCGGTCTC TGTAGAAGGG CCTCATGGCT ACTATTCAGG GAGCCCAGGA 
GAGACAGGAG CCCCGAATGT GCAGTTGCCC GAGAGATTTT CAGACGCCGC GCTGGTCTCG 
ATGTCGGTGC GCGAGTTGAA CCGGCAGCTG CGGGGCTGCG GGCGCGACGA GGCTCTGCGG 
CTGAAGCAGA GGCGCCGCAC GCTCAAGAAC CGCGGCTACG CGCAGGCCTG TCGCTCCAAG 
CGGCTGCAGC AGCGGCGCGG GCTGGAGGCC GAGCGCGCCC GCCTAGCCGC ACAGCTGGAT 
GCCCTACGGG CGGAGGTGGC CCGCCTGGCT CGAGAGCGCG ACCTCTACAA GGCCCGCTGT 
GACCGGCTGA CTTCCGGTGG CCCTGGGTCC GACGACCACA CACACCTCTT CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006251999.1
CDS	199..915
Translation	MALPPSPLAMEYVNDFDLMKFEIKREPSEGRSGVPTASLGSTPYSSVPPSPTFSEPGMVGNSEAPRPAGLEELYWLATLQQQLGADEVLGLSPDEAVELLQSQGPVSVEGPHGYYSGSPGETGAPNVQLPERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKARCDRLTSGGPGSDDHTHLFL

Target ORF information:

RefSeq Version	XM_006251937.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006251937.3

ORF Insert Sequence:

ATGGCTCTTC CCCCCAGTCC CTTGGCTATG GAATATGTTA ATGACTTTGA CTTGATGAAG 
TTTGAAATAA AGCGGGAGCC TTCTGAGGGC CGGTCCGGAG TCCCCACAGC CTCACTGGGC 
TCTACACCGT ACAGTTCAGT GCCTCCCTCA CCCACCTTCA GTGAGCCAGG CATGGTGGGC 
AACAGCGAGG CCCCTAGGCC CGCAGGCCTG GAGGAGCTAT ACTGGCTGGC CACCCTGCAG 
CAGCAGTTGG GGGCCGATGA GGTTCTGGGG CTGAGTCCTG ATGAGGCTGT GGAACTACTG 
CAGAGCCAGG GCCCGGTCTC TGTAGAAGGG CCTCATGGCT ACTATTCAGG GAGCCCAGGA 
GAGACAGGAG CCCCGAATGT GCAGTTGCCC GAGAGATTTT CAGACGCCGC GCTGGTCTCG 
ATGTCGGTGC GCGAGTTGAA CCGGCAGCTG CGGGGCTGCG GGCGCGACGA GGCTCTGCGG 
CTGAAGCAGA GGCGCCGCAC GCTCAAGAAC CGCGGCTACG CGCAGGCCTG TCGCTCCAAG 
CGGCTGCAGC AGCGGCGCGG GCTGGAGGCC GAGCGCGCCC GCCTAGCCGC ACAGCTGGAT 
GCCCTACGGG CGGAGGTGGC CCGCCTGGCT CGAGAGCGCG ACCTCTACAA GGCCCGCTGT 
GACCGGCTGA CTTCCGGTGG CCCTGGGTCC GACGACCACA CACACCTCTT CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nrl ( XM_017599621.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017455110.1 Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X5, mRNA.

Price & Availability↑

CloneID	ORa00065
Clone ID Related Accession (Same CDS sequence)	XM_006251937.3 , XM_017599621.1 , XM_006251935.3 , XM_008770672.2 , XM_017599620.1 , NM_001106036.2
Accession Version	XM_017599621.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	neural retina-specific leucine zipper protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCTTC CCCCCAGTCC CTTGGCTATG GAATATGTTA ATGACTTTGA CTTGATGAAG 
TTTGAAATAA AGCGGGAGCC TTCTGAGGGC CGGTCCGGAG TCCCCACAGC CTCACTGGGC 
TCTACACCGT ACAGTTCAGT GCCTCCCTCA CCCACCTTCA GTGAGCCAGG CATGGTGGGC 
AACAGCGAGG CCCCTAGGCC CGCAGGCCTG GAGGAGCTAT ACTGGCTGGC CACCCTGCAG 
CAGCAGTTGG GGGCCGATGA GGTTCTGGGG CTGAGTCCTG ATGAGGCTGT GGAACTACTG 
CAGAGCCAGG GCCCGGTCTC TGTAGAAGGG CCTCATGGCT ACTATTCAGG GAGCCCAGGA 
GAGACAGGAG CCCCGAATGT GCAGTTGCCC GAGAGATTTT CAGACGCCGC GCTGGTCTCG 
ATGTCGGTGC GCGAGTTGAA CCGGCAGCTG CGGGGCTGCG GGCGCGACGA GGCTCTGCGG 
CTGAAGCAGA GGCGCCGCAC GCTCAAGAAC CGCGGCTACG CGCAGGCCTG TCGCTCCAAG 
CGGCTGCAGC AGCGGCGCGG GCTGGAGGCC GAGCGCGCCC GCCTAGCCGC ACAGCTGGAT 
GCCCTACGGG CGGAGGTGGC CCGCCTGGCT CGAGAGCGCG ACCTCTACAA GGCCCGCTGT 
GACCGGCTGA CTTCCGGTGG CCCTGGGTCC GACGACCACA CACACCTCTT CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017455110.1
CDS	269..985
Translation	MALPPSPLAMEYVNDFDLMKFEIKREPSEGRSGVPTASLGSTPYSSVPPSPTFSEPGMVGNSEAPRPAGLEELYWLATLQQQLGADEVLGLSPDEAVELLQSQGPVSVEGPHGYYSGSPGETGAPNVQLPERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKARCDRLTSGGPGSDDHTHLFL

Target ORF information:

RefSeq Version	XM_017599621.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017599621.1

ORF Insert Sequence:

ATGGCTCTTC CCCCCAGTCC CTTGGCTATG GAATATGTTA ATGACTTTGA CTTGATGAAG 
TTTGAAATAA AGCGGGAGCC TTCTGAGGGC CGGTCCGGAG TCCCCACAGC CTCACTGGGC 
TCTACACCGT ACAGTTCAGT GCCTCCCTCA CCCACCTTCA GTGAGCCAGG CATGGTGGGC 
AACAGCGAGG CCCCTAGGCC CGCAGGCCTG GAGGAGCTAT ACTGGCTGGC CACCCTGCAG 
CAGCAGTTGG GGGCCGATGA GGTTCTGGGG CTGAGTCCTG ATGAGGCTGT GGAACTACTG 
CAGAGCCAGG GCCCGGTCTC TGTAGAAGGG CCTCATGGCT ACTATTCAGG GAGCCCAGGA 
GAGACAGGAG CCCCGAATGT GCAGTTGCCC GAGAGATTTT CAGACGCCGC GCTGGTCTCG 
ATGTCGGTGC GCGAGTTGAA CCGGCAGCTG CGGGGCTGCG GGCGCGACGA GGCTCTGCGG 
CTGAAGCAGA GGCGCCGCAC GCTCAAGAAC CGCGGCTACG CGCAGGCCTG TCGCTCCAAG 
CGGCTGCAGC AGCGGCGCGG GCTGGAGGCC GAGCGCGCCC GCCTAGCCGC ACAGCTGGAT 
GCCCTACGGG CGGAGGTGGC CCGCCTGGCT CGAGAGCGCG ACCTCTACAA GGCCCGCTGT 
GACCGGCTGA CTTCCGGTGG CCCTGGGTCC GACGACCACA CACACCTCTT CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nrl ( XM_006251935.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006251997.1 Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa00065
Clone ID Related Accession (Same CDS sequence)	XM_006251937.3 , XM_017599621.1 , XM_006251935.3 , XM_008770672.2 , XM_017599620.1 , NM_001106036.2
Accession Version	XM_006251935.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	neural retina-specific leucine zipper protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006251935.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCTTC CCCCCAGTCC CTTGGCTATG GAATATGTTA ATGACTTTGA CTTGATGAAG 
TTTGAAATAA AGCGGGAGCC TTCTGAGGGC CGGTCCGGAG TCCCCACAGC CTCACTGGGC 
TCTACACCGT ACAGTTCAGT GCCTCCCTCA CCCACCTTCA GTGAGCCAGG CATGGTGGGC 
AACAGCGAGG CCCCTAGGCC CGCAGGCCTG GAGGAGCTAT ACTGGCTGGC CACCCTGCAG 
CAGCAGTTGG GGGCCGATGA GGTTCTGGGG CTGAGTCCTG ATGAGGCTGT GGAACTACTG 
CAGAGCCAGG GCCCGGTCTC TGTAGAAGGG CCTCATGGCT ACTATTCAGG GAGCCCAGGA 
GAGACAGGAG CCCCGAATGT GCAGTTGCCC GAGAGATTTT CAGACGCCGC GCTGGTCTCG 
ATGTCGGTGC GCGAGTTGAA CCGGCAGCTG CGGGGCTGCG GGCGCGACGA GGCTCTGCGG 
CTGAAGCAGA GGCGCCGCAC GCTCAAGAAC CGCGGCTACG CGCAGGCCTG TCGCTCCAAG 
CGGCTGCAGC AGCGGCGCGG GCTGGAGGCC GAGCGCGCCC GCCTAGCCGC ACAGCTGGAT 
GCCCTACGGG CGGAGGTGGC CCGCCTGGCT CGAGAGCGCG ACCTCTACAA GGCCCGCTGT 
GACCGGCTGA CTTCCGGTGG CCCTGGGTCC GACGACCACA CACACCTCTT CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006251997.1
CDS	211..927
Translation	MALPPSPLAMEYVNDFDLMKFEIKREPSEGRSGVPTASLGSTPYSSVPPSPTFSEPGMVGNSEAPRPAGLEELYWLATLQQQLGADEVLGLSPDEAVELLQSQGPVSVEGPHGYYSGSPGETGAPNVQLPERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKARCDRLTSGGPGSDDHTHLFL

Target ORF information:

RefSeq Version	XM_006251935.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006251935.3

ORF Insert Sequence:

ATGGCTCTTC CCCCCAGTCC CTTGGCTATG GAATATGTTA ATGACTTTGA CTTGATGAAG 
TTTGAAATAA AGCGGGAGCC TTCTGAGGGC CGGTCCGGAG TCCCCACAGC CTCACTGGGC 
TCTACACCGT ACAGTTCAGT GCCTCCCTCA CCCACCTTCA GTGAGCCAGG CATGGTGGGC 
AACAGCGAGG CCCCTAGGCC CGCAGGCCTG GAGGAGCTAT ACTGGCTGGC CACCCTGCAG 
CAGCAGTTGG GGGCCGATGA GGTTCTGGGG CTGAGTCCTG ATGAGGCTGT GGAACTACTG 
CAGAGCCAGG GCCCGGTCTC TGTAGAAGGG CCTCATGGCT ACTATTCAGG GAGCCCAGGA 
GAGACAGGAG CCCCGAATGT GCAGTTGCCC GAGAGATTTT CAGACGCCGC GCTGGTCTCG 
ATGTCGGTGC GCGAGTTGAA CCGGCAGCTG CGGGGCTGCG GGCGCGACGA GGCTCTGCGG 
CTGAAGCAGA GGCGCCGCAC GCTCAAGAAC CGCGGCTACG CGCAGGCCTG TCGCTCCAAG 
CGGCTGCAGC AGCGGCGCGG GCTGGAGGCC GAGCGCGCCC GCCTAGCCGC ACAGCTGGAT 
GCCCTACGGG CGGAGGTGGC CCGCCTGGCT CGAGAGCGCG ACCTCTACAA GGCCCGCTGT 
GACCGGCTGA CTTCCGGTGG CCCTGGGTCC GACGACCACA CACACCTCTT CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nrl ( XM_008770672.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008768894.1 Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X1, mRNA.

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CloneID	ORa00065
Clone ID Related Accession (Same CDS sequence)	XM_006251937.3 , XM_017599621.1 , XM_006251935.3 , XM_008770672.2 , XM_017599620.1 , NM_001106036.2
Accession Version	XM_008770672.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	neural retina-specific leucine zipper protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008770672.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCTTC CCCCCAGTCC CTTGGCTATG GAATATGTTA ATGACTTTGA CTTGATGAAG 
TTTGAAATAA AGCGGGAGCC TTCTGAGGGC CGGTCCGGAG TCCCCACAGC CTCACTGGGC 
TCTACACCGT ACAGTTCAGT GCCTCCCTCA CCCACCTTCA GTGAGCCAGG CATGGTGGGC 
AACAGCGAGG CCCCTAGGCC CGCAGGCCTG GAGGAGCTAT ACTGGCTGGC CACCCTGCAG 
CAGCAGTTGG GGGCCGATGA GGTTCTGGGG CTGAGTCCTG ATGAGGCTGT GGAACTACTG 
CAGAGCCAGG GCCCGGTCTC TGTAGAAGGG CCTCATGGCT ACTATTCAGG GAGCCCAGGA 
GAGACAGGAG CCCCGAATGT GCAGTTGCCC GAGAGATTTT CAGACGCCGC GCTGGTCTCG 
ATGTCGGTGC GCGAGTTGAA CCGGCAGCTG CGGGGCTGCG GGCGCGACGA GGCTCTGCGG 
CTGAAGCAGA GGCGCCGCAC GCTCAAGAAC CGCGGCTACG CGCAGGCCTG TCGCTCCAAG 
CGGCTGCAGC AGCGGCGCGG GCTGGAGGCC GAGCGCGCCC GCCTAGCCGC ACAGCTGGAT 
GCCCTACGGG CGGAGGTGGC CCGCCTGGCT CGAGAGCGCG ACCTCTACAA GGCCCGCTGT 
GACCGGCTGA CTTCCGGTGG CCCTGGGTCC GACGACCACA CACACCTCTT CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008768894.1
CDS	204..920
Translation	MALPPSPLAMEYVNDFDLMKFEIKREPSEGRSGVPTASLGSTPYSSVPPSPTFSEPGMVGNSEAPRPAGLEELYWLATLQQQLGADEVLGLSPDEAVELLQSQGPVSVEGPHGYYSGSPGETGAPNVQLPERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKARCDRLTSGGPGSDDHTHLFL

Target ORF information:

RefSeq Version	XM_008770672.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008770672.2

ORF Insert Sequence:

ATGGCTCTTC CCCCCAGTCC CTTGGCTATG GAATATGTTA ATGACTTTGA CTTGATGAAG 
TTTGAAATAA AGCGGGAGCC TTCTGAGGGC CGGTCCGGAG TCCCCACAGC CTCACTGGGC 
TCTACACCGT ACAGTTCAGT GCCTCCCTCA CCCACCTTCA GTGAGCCAGG CATGGTGGGC 
AACAGCGAGG CCCCTAGGCC CGCAGGCCTG GAGGAGCTAT ACTGGCTGGC CACCCTGCAG 
CAGCAGTTGG GGGCCGATGA GGTTCTGGGG CTGAGTCCTG ATGAGGCTGT GGAACTACTG 
CAGAGCCAGG GCCCGGTCTC TGTAGAAGGG CCTCATGGCT ACTATTCAGG GAGCCCAGGA 
GAGACAGGAG CCCCGAATGT GCAGTTGCCC GAGAGATTTT CAGACGCCGC GCTGGTCTCG 
ATGTCGGTGC GCGAGTTGAA CCGGCAGCTG CGGGGCTGCG GGCGCGACGA GGCTCTGCGG 
CTGAAGCAGA GGCGCCGCAC GCTCAAGAAC CGCGGCTACG CGCAGGCCTG TCGCTCCAAG 
CGGCTGCAGC AGCGGCGCGG GCTGGAGGCC GAGCGCGCCC GCCTAGCCGC ACAGCTGGAT 
GCCCTACGGG CGGAGGTGGC CCGCCTGGCT CGAGAGCGCG ACCTCTACAA GGCCCGCTGT 
GACCGGCTGA CTTCCGGTGG CCCTGGGTCC GACGACCACA CACACCTCTT CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nrl ( XM_017599620.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017455109.1 Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X4, mRNA.

Price & Availability↑

CloneID	ORa00065
Clone ID Related Accession (Same CDS sequence)	XM_006251937.3 , XM_017599621.1 , XM_006251935.3 , XM_008770672.2 , XM_017599620.1 , NM_001106036.2
Accession Version	XM_017599620.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	neural retina-specific leucine zipper protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCTTC CCCCCAGTCC CTTGGCTATG GAATATGTTA ATGACTTTGA CTTGATGAAG 
TTTGAAATAA AGCGGGAGCC TTCTGAGGGC CGGTCCGGAG TCCCCACAGC CTCACTGGGC 
TCTACACCGT ACAGTTCAGT GCCTCCCTCA CCCACCTTCA GTGAGCCAGG CATGGTGGGC 
AACAGCGAGG CCCCTAGGCC CGCAGGCCTG GAGGAGCTAT ACTGGCTGGC CACCCTGCAG 
CAGCAGTTGG GGGCCGATGA GGTTCTGGGG CTGAGTCCTG ATGAGGCTGT GGAACTACTG 
CAGAGCCAGG GCCCGGTCTC TGTAGAAGGG CCTCATGGCT ACTATTCAGG GAGCCCAGGA 
GAGACAGGAG CCCCGAATGT GCAGTTGCCC GAGAGATTTT CAGACGCCGC GCTGGTCTCG 
ATGTCGGTGC GCGAGTTGAA CCGGCAGCTG CGGGGCTGCG GGCGCGACGA GGCTCTGCGG 
CTGAAGCAGA GGCGCCGCAC GCTCAAGAAC CGCGGCTACG CGCAGGCCTG TCGCTCCAAG 
CGGCTGCAGC AGCGGCGCGG GCTGGAGGCC GAGCGCGCCC GCCTAGCCGC ACAGCTGGAT 
GCCCTACGGG CGGAGGTGGC CCGCCTGGCT CGAGAGCGCG ACCTCTACAA GGCCCGCTGT 
GACCGGCTGA CTTCCGGTGG CCCTGGGTCC GACGACCACA CACACCTCTT CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017455109.1
CDS	257..973
Translation	MALPPSPLAMEYVNDFDLMKFEIKREPSEGRSGVPTASLGSTPYSSVPPSPTFSEPGMVGNSEAPRPAGLEELYWLATLQQQLGADEVLGLSPDEAVELLQSQGPVSVEGPHGYYSGSPGETGAPNVQLPERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKARCDRLTSGGPGSDDHTHLFL

Target ORF information:

RefSeq Version	XM_017599620.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017599620.1

ORF Insert Sequence:

ATGGCTCTTC CCCCCAGTCC CTTGGCTATG GAATATGTTA ATGACTTTGA CTTGATGAAG 
TTTGAAATAA AGCGGGAGCC TTCTGAGGGC CGGTCCGGAG TCCCCACAGC CTCACTGGGC 
TCTACACCGT ACAGTTCAGT GCCTCCCTCA CCCACCTTCA GTGAGCCAGG CATGGTGGGC 
AACAGCGAGG CCCCTAGGCC CGCAGGCCTG GAGGAGCTAT ACTGGCTGGC CACCCTGCAG 
CAGCAGTTGG GGGCCGATGA GGTTCTGGGG CTGAGTCCTG ATGAGGCTGT GGAACTACTG 
CAGAGCCAGG GCCCGGTCTC TGTAGAAGGG CCTCATGGCT ACTATTCAGG GAGCCCAGGA 
GAGACAGGAG CCCCGAATGT GCAGTTGCCC GAGAGATTTT CAGACGCCGC GCTGGTCTCG 
ATGTCGGTGC GCGAGTTGAA CCGGCAGCTG CGGGGCTGCG GGCGCGACGA GGCTCTGCGG 
CTGAAGCAGA GGCGCCGCAC GCTCAAGAAC CGCGGCTACG CGCAGGCCTG TCGCTCCAAG 
CGGCTGCAGC AGCGGCGCGG GCTGGAGGCC GAGCGCGCCC GCCTAGCCGC ACAGCTGGAT 
GCCCTACGGG CGGAGGTGGC CCGCCTGGCT CGAGAGCGCG ACCTCTACAA GGCCCGCTGT 
GACCGGCTGA CTTCCGGTGG CCCTGGGTCC GACGACCACA CACACCTCTT CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel p.M96T variant of NRL and shRNA-based suppression and replacement of NRL mutants associated with autosomal dominant retinitis pigmentosa.
Clinical genetics82(5)446-52(2012 Nov)
Hernan I,Gamundi MJ,Borr?s E,Maseras M,Garc?a-Sandoval B,Blanco-Kelly F,Ayuso C,Carballo M

Retinopathy mutations in the bZIP protein NRL alter phosphorylation and transcriptional activity.
Human mutation28(6)589-98(2007 Jun)
Kanda A,Friedman JS,Nishiguchi KM,Swaroop A

Retinoic acid regulates the expression of photoreceptor transcription factor NRL.
The Journal of biological chemistry281(37)27327-34(2006 Sep)
Khanna H,Akimoto M,Siffroi-Fernandez S,Friedman JS,Hicks D,Swaroop A

The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes.
Human molecular genetics14(6)747-64(2005 Mar)
Peng GH,Ahmad O,Ahmad F,Liu J,Chen S

Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl.
Human molecular genetics13(14)1487-503(2004 Jul)
Yoshida S,Mears AJ,Friedman JS,Carter T,He S,Oh E,Jing Y,Farjo R,Fleury G,Barlow C,Hero AO,Swaroop A

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Nrl cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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