Ervfrd-1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ervfrd-1
Entrez Gene ID	288602
Full Name	endogenous retrovirus group FRD member 1, envelope
Synonyms	Gm52,Syna
General protein information	Preferred Names endogenous retrovirus group FRD member 1, envelope Names envelope glycoprotein syncytin-A endogenous retrovirus group FRD member 1 syncytin a
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q12
Summary	Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of a endogenous retrovirus provirus on rat chromosome 12 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001014771.2	NP_001014771.1	envelope glycoprotein syncytin-A precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Syna	NP_001013773.1
Rattus norvegicus (Norway rat)	Syna	NP_001014771.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel human endogenous retroviral protein inhibits cell-cell fusion.
Sugimoto J, Sugimoto M, Bernstein H, Jinno Y, Schust D
Scientific reports31462(2013)

Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene.
Dupressoir A, Vernochet C, Bawa O, Harper F, Pierron G, Opolon P, Heidmann T
Proceedings of the National Academy of Sciences of the United States of America106(29)12127-32(2009 Jul)

Syncytin-A and syncytin-B, two fusogenic placenta-specific murine envelope genes of retroviral origin conserved in Muridae.
Dupressoir A, Marceau G, Vernochet C, B?nit L, Kanellopoulos C, Sapin V, Heidmann T
Proceedings of the National Academy of Sciences of the United States of America102(3)725-30(2005 Jan)

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.
Blaise S, de Parseval N, B?nit L, Heidmann T
Proceedings of the National Academy of Sciences of the United States of America100(22)13013-8(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ervfrd-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ervfrd-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12007	NM_001014771.2 Latest version!	Rattus norvegicus endogenous retrovirus group FRD member 1, envelope (Ervfrd-1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$363.30 $519.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ervfrd-1 ( NM_001014771.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001014771.1 Rattus norvegicus endogenous retrovirus group FRD member 1, envelope (Ervfrd-1), mRNA.

Price & Availability↑

CloneID	ORa12007
Clone ID Related Accession (Same CDS sequence)	NM_001014771.2
Accession Version	NM_001014771.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1857bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	envelope glycoprotein syncytin-A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC135741.3. On May 14, 2011 this sequence version replaced NM_001014771.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB774879.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## endogenous retrovirus :: PMID: 15644441 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTTCGTC CTTGGGTTTT CTGTGTCCTC CTGTTCCCTT GTTCCTCTGC CCACTCGGAC 
AGCTGGATGC CCCTTGTAAA CCTCACCCAA CGCCTCCTCC GGGATGCTAA CTCTTCCTTT 
TCTTCCAACT GCTGGGTCTG CCTGTCCATC CAAACGCAGC GCTCTCTAGC CGTGCCAGCC 
CCACTCAGGA GTTGGACAGA GACACCCATG AAACTGCGTA TCATGTACTC GGCTCGGACC 
CTCTCAGGCT CTTACCCCAT TACCGACCTT GAGAGACGCC TCCAGAATTT CCAGCCATTG 
ACGCCTCACT ACTCTTTCGT CAATCCTGAC CGGCGGGCCA TTGCTTTCCT CCAGGTCACC 
AGTATAACAG GCATACTTCC GATACTTTCC CGGCTCACCC CGGTGAAATA CCCCAATGAC 
CGCTTCTACG AATCTGCCCA GCGCCCCATA TGGGGGTCAC TGTCTACCCA GACGATCCTC 
ACCGCCCAGG CCCCTCTCTG CATATCCCGT TTCTTCAAGA ATTCAAAATA TGCCACCTTC 
GTGGGTAATC TCTCTGCCTC TCTTTGCAAC CACACCTTTC AGCTTTCCCC CTCTGCCAAC 
CACCAGTCCA TTGATCTGTC CACCAGCTAT GCATTTGCCC CACTGATGGC CATGCCAGGC 
CTTAAATGGA GAAACCCCTT ACACTTTTCA GGACCCCCTT CCCTAAACTC AGGGAAACCT 
CACCACTCTT GCCCGGTAGA TGACATCCAT TGTCACACCT ACCCCACCAC CCCCTGGAGG 
TACTGCCCTT CCTTCCTGTC GTCTAGCACC TGCTACAATC TCACCTTATT CGAACCCAAC 
AATGTGAGTC ACCCTATTAC CCTGTCTGTA GACACCACCT ACTTCAAGAT TAAACTCCAG 
GGACACAAAG ACCCCTATCC ACTCTTTCAG TACCAGCCCC TCATGGGGGC AGCCCTCTCG 
GGACAATATT CAATCTGGGA GAATGAACCC AATGTCCAAG AAAATGGCGG GCTCACTCCA 
AATATCTTCT CCCATCTTGT CTCTTTAACA TACTCCTTCT GTCTCAACTC CTCCGGCGTT 
TTCTTCCTCT GTGGAAACTC AACTTATGTC TGTCTCCCGG CCAATTGGTC GGGCGTCTGT 
ACTCTTGTCT TTCAATACCC GGATATTGAA CTCCTTCCTA ACAACCAAAG CATAATGGTT 
CCCCTTTTTG CTACAGTTCC CTCTTCTGTC CCCGCTTCTC GCCGGAAGCG AGCCCTTCAT 
CTCCTTCCTC TTGCAGCCGG TCTGGGCATT GCTTCAGCCC TCGGGTTAGG CGCGGCTGGG 
ATCGCCACCT CAACCATGTA TTTCCAAAAG CTTTCCAAGG CTCTCTCGAA CAGCCTAGAC 
GAAGTGGCCA CATCCATCCT CAGCCTCCAA GACCAAATAG ACTCACTGGC GGGTGTCGTC 
CTCCAAAACC GCAGAGCTCT GGACCTCCTT GTGGCTGAGA AAGGGGGCAC CTGCCTCTTC 
CTCCAGGAAG AATGCTGCTT CTACATAAAC CAGTCTGGAG TAGTCCGGTA TGCGGCAAGG 
AAACTTCGAG AAAGGGCATC GGAACTCGGC CCAAGCTCGA GATCGTGGAT CCAGCAGCTG 
GGACTGGGAC CCTGGCTGCC CTCTTGGTTG ACTTCCTTCA TGGGACCCAT TCTCTTTATC 
CTGGTAGTGC TTGTTTTGGG GCCTTGTCTT CTCAATTGCC TGACGCATTC TGTATCCCGG 
CGAATGAGTT CTTTCATTCA CACCACCACC AAAGGGCACG TGGACAAGAT CCTTCTGCAT 
CGAGAGACCC AGTACAAGAG ACTTCCCCAA GAACCCCAGG AGGAGGATTC CGTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014771.1
CDS	217..2073
Translation	MVRPWVFCVLLFPCSSAHSDSWMPLVNLTQRLLRDANSSFSSNCWVCLSIQTQRSLAVPAPLRSWTETPMKLRIMYSARTLSGSYPITDLERRLQNFQPLTPHYSFVNPDRRAIAFLQVTSITGILPILSRLTPVKYPNDRFYESAQRPIWGSLSTQTILTAQAPLCISRFFKNSKYATFVGNLSASLCNHTFQLSPSANHQSIDLSTSYAFAPLMAMPGLKWRNPLHFSGPPSLNSGKPHHSCPVDDIHCHTYPTTPWRYCPSFLSSSTCYNLTLFEPNNVSHPITLSVDTTYFKIKLQGHKDPYPLFQYQPLMGAALSGQYSIWENEPNVQENGGLTPNIFSHLVSLTYSFCLNSSGVFFLCGNSTYVCLPANWSGVCTLVFQYPDIELLPNNQSIMVPLFATVPSSVPASRRKRALHLLPLAAGLGIASALGLGAAGIATSTMYFQKLSKALSNSLDEVATSILSLQDQIDSLAGVVLQNRRALDLLVAEKGGTCLFLQEECCFYINQSGVVRYAARKLRERASELGPSSRSWIQQLGLGPWLPSWLTSFMGPILFILVVLVLGPCLLNCLTHSVSRRMSSFIHTTTKGHVDKILLHRETQYKRLPQEPQEEDSV

Target ORF information:

RefSeq Version	NM_001014771.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus endogenous retrovirus group FRD member 1, envelope (Ervfrd-1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014771.2

ORF Insert Sequence:

ATGGTTCGTC CTTGGGTTTT CTGTGTCCTC CTGTTCCCTT GTTCCTCTGC CCACTCGGAC 
AGCTGGATGC CCCTTGTAAA CCTCACCCAA CGCCTCCTCC GGGATGCTAA CTCTTCCTTT 
TCTTCCAACT GCTGGGTCTG CCTGTCCATC CAAACGCAGC GCTCTCTAGC CGTGCCAGCC 
CCACTCAGGA GTTGGACAGA GACACCCATG AAACTGCGTA TCATGTACTC GGCTCGGACC 
CTCTCAGGCT CTTACCCCAT TACCGACCTT GAGAGACGCC TCCAGAATTT CCAGCCATTG 
ACGCCTCACT ACTCTTTCGT CAATCCTGAC CGGCGGGCCA TTGCTTTCCT CCAGGTCACC 
AGTATAACAG GCATACTTCC GATACTTTCC CGGCTCACCC CGGTGAAATA CCCCAATGAC 
CGCTTCTACG AATCTGCCCA GCGCCCCATA TGGGGGTCAC TGTCTACCCA GACGATCCTC 
ACCGCCCAGG CCCCTCTCTG CATATCCCGT TTCTTCAAGA ATTCAAAATA TGCCACCTTC 
GTGGGTAATC TCTCTGCCTC TCTTTGCAAC CACACCTTTC AGCTTTCCCC CTCTGCCAAC 
CACCAGTCCA TTGATCTGTC CACCAGCTAT GCATTTGCCC CACTGATGGC CATGCCAGGC 
CTTAAATGGA GAAACCCCTT ACACTTTTCA GGACCCCCTT CCCTAAACTC AGGGAAACCT 
CACCACTCTT GCCCGGTAGA TGACATCCAT TGTCACACCT ACCCCACCAC CCCCTGGAGG 
TACTGCCCTT CCTTCCTGTC GTCTAGCACC TGCTACAATC TCACCTTATT CGAACCCAAC 
AATGTGAGTC ACCCTATTAC CCTGTCTGTA GACACCACCT ACTTCAAGAT TAAACTCCAG 
GGACACAAAG ACCCCTATCC ACTCTTTCAG TACCAGCCCC TCATGGGGGC AGCCCTCTCG 
GGACAATATT CAATCTGGGA GAATGAACCC AATGTCCAAG AAAATGGCGG GCTCACTCCA 
AATATCTTCT CCCATCTTGT CTCTTTAACA TACTCCTTCT GTCTCAACTC CTCCGGCGTT 
TTCTTCCTCT GTGGAAACTC AACTTATGTC TGTCTCCCGG CCAATTGGTC GGGCGTCTGT 
ACTCTTGTCT TTCAATACCC GGATATTGAA CTCCTTCCTA ACAACCAAAG CATAATGGTT 
CCCCTTTTTG CTACAGTTCC CTCTTCTGTC CCCGCTTCTC GCCGGAAGCG AGCCCTTCAT 
CTCCTTCCTC TTGCAGCCGG TCTGGGCATT GCTTCAGCCC TCGGGTTAGG CGCGGCTGGG 
ATCGCCACCT CAACCATGTA TTTCCAAAAG CTTTCCAAGG CTCTCTCGAA CAGCCTAGAC 
GAAGTGGCCA CATCCATCCT CAGCCTCCAA GACCAAATAG ACTCACTGGC GGGTGTCGTC 
CTCCAAAACC GCAGAGCTCT GGACCTCCTT GTGGCTGAGA AAGGGGGCAC CTGCCTCTTC 
CTCCAGGAAG AATGCTGCTT CTACATAAAC CAGTCTGGAG TAGTCCGGTA TGCGGCAAGG 
AAACTTCGAG AAAGGGCATC GGAACTCGGC CCAAGCTCGA GATCGTGGAT CCAGCAGCTG 
GGACTGGGAC CCTGGCTGCC CTCTTGGTTG ACTTCCTTCA TGGGACCCAT TCTCTTTATC 
CTGGTAGTGC TTGTTTTGGG GCCTTGTCTT CTCAATTGCC TGACGCATTC TGTATCCCGG 
CGAATGAGTT CTTTCATTCA CACCACCACC AAAGGGCACG TGGACAAGAT CCTTCTGCAT 
CGAGAGACCC AGTACAAGAG ACTTCCCCAA GAACCCCAGG AGGAGGATTC CGTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel human endogenous retroviral protein inhibits cell-cell fusion.
Scientific reports31462(2013)
Sugimoto J,Sugimoto M,Bernstein H,Jinno Y,Schust D

Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene.
Proceedings of the National Academy of Sciences of the United States of America106(29)12127-32(2009 Jul)
Dupressoir A,Vernochet C,Bawa O,Harper F,Pierron G,Opolon P,Heidmann T

Syncytin-A and syncytin-B, two fusogenic placenta-specific murine envelope genes of retroviral origin conserved in Muridae.
Proceedings of the National Academy of Sciences of the United States of America102(3)725-30(2005 Jan)
Dupressoir A,Marceau G,Vernochet C,B?nit L,Kanellopoulos C,Sapin V,Heidmann T

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.
Proceedings of the National Academy of Sciences of the United States of America100(22)13013-8(2003 Oct)
Blaise S,de Parseval N,B?nit L,Heidmann T

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Ervfrd-1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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