Fis1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fis1
Entrez Gene ID	288584
Full Name	fission, mitochondrial 1
Synonyms	Ttc11
General protein information	Preferred Names fission, mitochondrial 1 Names mitochondrial fission 1 protein TPR repeat protein 11 fis1 homolog fission 1 (mitochondrial outer membrane) homolog rFis1 tetratricopeptide repeat domain 11 tetratricopeptide repeat protein 11
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q12

mRNA and Protein(s)

mRNA	Protein	Name
XM_006249123.3	XP_006249185.1	mitochondrial fission 1 protein isoform X3
XM_006249122.3	XP_006249184.1	mitochondrial fission 1 protein isoform X2
XM_006249121.3	XP_006249183.1	mitochondrial fission 1 protein isoform X1
NM_001105919.1	NP_001099389.1	mitochondrial fission 1 protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FIS1	XP_001143081.2
Bos taurus (cattle)	FIS1	NP_001029956.1
Danio rerio (zebrafish)	im:6905231	XP_005172294.1
Caenorhabditis elegans (roundworm)	fis-2	NP_001024560.1
Xenopus tropicalis (tropical clawed frog)	fis1	NP_001123678.1
Canis lupus familiaris (dog)	FIS1	XP_536854.1
Homo sapiens (human)	FIS1	NP_057152.2
	FIS1	XP_001108062.1
Mus musculus (house mouse)	Fis1	NP_079838.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009852	XP_318964.4
Drosophila melanogaster (fruit fly)	Fis1	NP_001137607.1
Rattus norvegicus (Norway rat)	Fis1	NP_001099389.1

Gene Ontology
Bibliography

Related articles in PubMed

High glucose concentration abrogates sevoflurane post-conditioning cardioprotection by advancing mitochondrial fission but dynamin-related protein 1 inhibitor restores these effects.
Yu J, Maimaitili Y, Xie P, Wu JJ, Wang J, Yang YN, Ma HP, Zheng H
Acta physiologica (Oxford, England)220(1)83-98(2017 May)

Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension.
Tian L, Neuber-Hess M, Mewburn J, Dasgupta A, Dunham-Snary K, Wu D, Chen KH, Hong Z, Sharp WW, Kutty S, Archer SL
Journal of molecular medicine (Berlin, Germany)95(4)381-393(2017 Apr)

Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics.
Aparicio-Trejo OE, Tapia E, Molina-Jij?n E, Medina-Campos ON, Mac?as-Ruvalcaba NA, Le?n-Contreras JC, Hern?ndez-Pando R, Garc?a-Arroyo FE, Crist?bal M, S?nchez-Lozada LG, Pedraza-Chaverri J
BioFactors (Oxford, England)43(2)293-310(2017 Mar)

PM
Guo Z, Hong Z, Dong W, Deng C, Zhao R, Xu J, Zhuang G, Zhang R
International journal of environmental research and public health14(2)(2017 01)

Status epilepticus triggers early mitochondrial fusion in the rat hippocampus in a lithium-pilocarpine model.
C?rdova-D?valos L, Carrera-Calvo D, Sol?s-Navarrete J, Mercado-G?mez OF, Arriaga-?vila V, Agredano-Moreno LT, Jim?nez-Garc?a LF, Guevara-Guzm?n R
Epilepsy research12311-9(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In the renal tissues of rats with chronic fluorosis, expression of both Mfn1 protein and mRNA was clearly reduced, whereas that of Fis1 was elevated.
Title: The decreased expression of mitofusin-1 and increased fission-1 together with alterations in mitochondrial morphology in the kidney of rats with chronic fluorosis may involve elevated oxidative stress.

Excessive intake of fluoride results in an altered mitochondrial distribution in axon and soma in cortical neurons, increased expression of Fis1 gene and enhanced mitochondrial fission.
Title: [Alteration of mitochondrial distribution and gene expression of fission 1 protein in cortical neurons of rats with chronic fluorosis].

Fis1 and Mfn1 activities influence mitochondrial signal generation thereby insulin exocytosis.
Title: Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells.

These experiments revealed that the N-terminal and C-terminal segments are both essential for oligomeric rFis1 interaction, and the middle TPR-like domains regulate proper oligomer assembly.
Title: Analysis of functional domains of rat mitochondrial Fis1, the mitochondrial fission-stimulating protein.

The following Fis1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fis1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa11673	NM_001105919.1 Latest version!	Rattus norvegicus fission, mitochondrial 1 (Fis1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa34748	XM_006249121.3 Latest version!	Rattus norvegicus fission, mitochondrial 1 (Fis1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa34749	XM_006249122.3 Latest version!	Rattus norvegicus fission, mitochondrial 1 (Fis1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa34750	XM_006249123.3 Latest version!	Rattus norvegicus fission, mitochondrial 1 (Fis1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fis1 ( NM_001105919.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099389.1 Rattus norvegicus fission, mitochondrial 1 (Fis1), mRNA.

Price & Availability↑

CloneID	ORa11673
Clone ID Related Accession (Same CDS sequence)	NM_001105919.1
Accession Version	NM_001105919.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	mitochondrial fission 1 protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473973.1. On or before Oct 3, 2007 this sequence version replaced XM_001076962.1, XM_213746.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906351 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGCCCAGAG ATGAAGCTGC AAGGAATTTT GAAAGGAAAT TTCAGTCTGA GCAGGCAGCT 
GGCTCTGTGT CCAAGAGCAC GCAGTTTGAA TACGCCTGGT GCCTGGTTCG AAGCAAATAC 
AATGACGACA TCCGTAGAGG CATCGTGCTG CTGGAGGAGC TGTTGCCCAA AGGTAGCAAA 
GAGGAGCAGC GGGATTATGT CTTCTACCTG GCCGTGGGCA ACTACCGGCT CAAGGAATAT 
GAAAAGGCTC TGAAGTATGT GCGGGGACTG TTACAGACTG AGCCCCAGAA CAACCAGGCC 
AAGGAGCTGG AACGCCTGAT TGACAAGGCC ATGAAGAAAG ATGGACTGGT AGGCATGGCC 
ATTGTTGGTG GCATGGCCCT GGGTGTGGCG GGCCTGGCTG GACTCATTGG ACTGGCTGTG 
TCCAAGTCCA AATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099389.1
CDS	288..725
Translation	MPRDEAARNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNDDIRRGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS

Target ORF information:

RefSeq Version	NM_001105919.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fission, mitochondrial 1 (Fis1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105919.1

ORF Insert Sequence:

ATGCCCAGAG ATGAAGCTGC AAGGAATTTT GAAAGGAAAT TTCAGTCTGA GCAGGCAGCT 
GGCTCTGTGT CCAAGAGCAC GCAGTTTGAA TACGCCTGGT GCCTGGTTCG AAGCAAATAC 
AATGACGACA TCCGTAGAGG CATCGTGCTG CTGGAGGAGC TGTTGCCCAA AGGTAGCAAA 
GAGGAGCAGC GGGATTATGT CTTCTACCTG GCCGTGGGCA ACTACCGGCT CAAGGAATAT 
GAAAAGGCTC TGAAGTATGT GCGGGGACTG TTACAGACTG AGCCCCAGAA CAACCAGGCC 
AAGGAGCTGG AACGCCTGAT TGACAAGGCC ATGAAGAAAG ATGGACTGGT AGGCATGGCC 
ATTGTTGGTG GCATGGCCCT GGGTGTGGCG GGCCTGGCTG GACTCATTGG ACTGGCTGTG 
TCCAAGTCCA AATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fis1 ( XM_006249121.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006249183.1 Rattus norvegicus fission, mitochondrial 1 (Fis1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa34748
Clone ID Related Accession (Same CDS sequence)	XM_006249121.3
Accession Version	XM_006249121.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mitochondrial fission 1 protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006249121.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGCTG TGCTGAACGA GCTGGTGTCT GTGGAGGATC TGAAGAATTT TGAAAGGAAA 
TTTCAGTCTG AGCAGGCAGC TGGCTCTGTG TCCAAGAGCA CGCAGTTTGA ATACGCCTGG 
TGCCTGGTTC GAAGCAAATA CAATGACGAC ATCCGTAGAG GCATCGTGCT GCTGGAGGAG 
CTGTTGCCCA AAGGTAGCAA AGAGGAGCAG CGGGATTATG TCTTCTACCT GGCCGTGGGC 
AACTACCGGC TCAAGGAATA TGAAAAGGCT CTGAAGTATG TGCGGGGACT GTTACAGACT 
GAGCCCCAGA ACAACCAGGC CAAGGAGCTG GAACGCCTGA TTGACAAGGC CATGAAGAAA 
GGTGACAGGC CTCATGCTGT CTGCTCTTCC TCCTCCCTCA GGCCCGGGCC TTGGGAACAC 
TGCCCACACC CCCTACACAC ACACAGTCCT TTATCAAACC TACCTTCCAA GGGTCTTGGT 
AGCCCTGGAG CCCCAACCCT CAGACTCTAC ATACAGGTCC CCCTCTTCTG TGGAGGGGAG 
TGTGGTCAGG GTAGGGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006249183.1
CDS	323..883
Translation	MEAVLNELVSVEDLKNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNDDIRRGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKGDRPHAVCSSSSLRPGPWEHCPHPLHTHSPLSNLPSKGLGSPGAPTLRLYIQVPLFCGGECGQGRG

Target ORF information:

RefSeq Version	XM_006249121.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fission, mitochondrial 1 (Fis1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006249121.3

ORF Insert Sequence:

ATGGAGGCTG TGCTGAACGA GCTGGTGTCT GTGGAGGATC TGAAGAATTT TGAAAGGAAA 
TTTCAGTCTG AGCAGGCAGC TGGCTCTGTG TCCAAGAGCA CGCAGTTTGA ATACGCCTGG 
TGCCTGGTTC GAAGCAAATA CAATGACGAC ATCCGTAGAG GCATCGTGCT GCTGGAGGAG 
CTGTTGCCCA AAGGTAGCAA AGAGGAGCAG CGGGATTATG TCTTCTACCT GGCCGTGGGC 
AACTACCGGC TCAAGGAATA TGAAAAGGCT CTGAAGTATG TGCGGGGACT GTTACAGACT 
GAGCCCCAGA ACAACCAGGC CAAGGAGCTG GAACGCCTGA TTGACAAGGC CATGAAGAAA 
GGTGACAGGC CTCATGCTGT CTGCTCTTCC TCCTCCCTCA GGCCCGGGCC TTGGGAACAC 
TGCCCACACC CCCTACACAC ACACAGTCCT TTATCAAACC TACCTTCCAA GGGTCTTGGT 
AGCCCTGGAG CCCCAACCCT CAGACTCTAC ATACAGGTCC CCCTCTTCTG TGGAGGGGAG 
TGTGGTCAGG GTAGGGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fis1 ( XM_006249122.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006249184.1 Rattus norvegicus fission, mitochondrial 1 (Fis1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa34749
Clone ID Related Accession (Same CDS sequence)	XM_006249122.3
Accession Version	XM_006249122.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mitochondrial fission 1 protein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006249122.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCAGAG ATGAAGCTGC AAGGAATTTT GAAAGGAAAT TTCAGTCTGA GCAGGCAGCT 
GGCTCTGTGT CCAAGAGCAC GCAGTTTGAA TACGCCTGGT GCCTGGTTCG AAGCAAATAC 
AATGACGACA TCCGTAGAGG CATCGTGCTG CTGGAGGAGC TGTTGCCCAA AGGTAGCAAA 
GAGGAGCAGC GGGATTATGT CTTCTACCTG GCCGTGGGCA ACTACCGGCT CAAGGAATAT 
GAAAAGGCTC TGAAGTATGT GCGGGGACTG TTACAGACTG AGCCCCAGAA CAACCAGGCC 
AAGGAGCTGG AACGCCTGAT TGACAAGGCC ATGAAGAAAG GTGACAGGCC TCATGCTGTC 
TGCTCTTCCT CCTCCCTCAG GCCCGGGCCT TGGGAACACT GCCCACACCC CCTACACACA 
CACAGTCCTT TATCAAACCT ACCTTCCAAG GGTCTTGGTA GCCCTGGAGC CCCAACCCTC 
AGACTCTACA TACAGGTCCC CCTCTTCTGT GGAGGGGAGT GTGGTCAGGG TAGGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006249184.1
CDS	317..856
Translation	MPRDEAARNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNDDIRRGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKGDRPHAVCSSSSLRPGPWEHCPHPLHTHSPLSNLPSKGLGSPGAPTLRLYIQVPLFCGGECGQGRG

Target ORF information:

RefSeq Version	XM_006249122.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fission, mitochondrial 1 (Fis1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006249122.3

ORF Insert Sequence:

ATGCCCAGAG ATGAAGCTGC AAGGAATTTT GAAAGGAAAT TTCAGTCTGA GCAGGCAGCT 
GGCTCTGTGT CCAAGAGCAC GCAGTTTGAA TACGCCTGGT GCCTGGTTCG AAGCAAATAC 
AATGACGACA TCCGTAGAGG CATCGTGCTG CTGGAGGAGC TGTTGCCCAA AGGTAGCAAA 
GAGGAGCAGC GGGATTATGT CTTCTACCTG GCCGTGGGCA ACTACCGGCT CAAGGAATAT 
GAAAAGGCTC TGAAGTATGT GCGGGGACTG TTACAGACTG AGCCCCAGAA CAACCAGGCC 
AAGGAGCTGG AACGCCTGAT TGACAAGGCC ATGAAGAAAG GTGACAGGCC TCATGCTGTC 
TGCTCTTCCT CCTCCCTCAG GCCCGGGCCT TGGGAACACT GCCCACACCC CCTACACACA 
CACAGTCCTT TATCAAACCT ACCTTCCAAG GGTCTTGGTA GCCCTGGAGC CCCAACCCTC 
AGACTCTACA TACAGGTCCC CCTCTTCTGT GGAGGGGAGT GTGGTCAGGG TAGGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fis1 ( XM_006249123.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006249185.1 Rattus norvegicus fission, mitochondrial 1 (Fis1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa34750
Clone ID Related Accession (Same CDS sequence)	XM_006249123.3
Accession Version	XM_006249123.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mitochondrial fission 1 protein isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006249123.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGCTG TGCTGAACGA GCTGGTGTCT GTGGAGGATC TGAAGAATTT TGAAAGGAAA 
TTTCAGTCTG AGCAGGCAGC TGGCTCTGTG TCCAAGAGCA CGCAGTTTGA ATACGCCTGG 
TGCCTGGTTC GAAGCAAATA CAATGACGAC ATCCGTAGAG GCATCGTGCT GCTGGAGGAG 
CTGTTGCCCA AAGGTAGCAA AGAGGAGCAG CGGGATTATG TCTTCTACCT GGCCGTGGGC 
AACTACCGGC TCAAGGAATA TGAAAAGGCT CTGAAGTATG TGCGGGGACT GTTACAGACT 
GAGCCCCAGA ACAACCAGGC CAAGGAGCTG GAACGCCTGA TTGACAAGGC CATGAAGAAA 
GATGGACTGG TAGGCATGGC CATTGTTGGT GGCATGGCCC TGGGTGTGGC GGGCCTGGCT 
GGACTCATTG GACTGGCTGT GTCCAAGTCC AAATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006249185.1
CDS	297..755
Translation	MEAVLNELVSVEDLKNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNDDIRRGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS

Target ORF information:

RefSeq Version	XM_006249123.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fission, mitochondrial 1 (Fis1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006249123.3

ORF Insert Sequence:

ATGGAGGCTG TGCTGAACGA GCTGGTGTCT GTGGAGGATC TGAAGAATTT TGAAAGGAAA 
TTTCAGTCTG AGCAGGCAGC TGGCTCTGTG TCCAAGAGCA CGCAGTTTGA ATACGCCTGG 
TGCCTGGTTC GAAGCAAATA CAATGACGAC ATCCGTAGAG GCATCGTGCT GCTGGAGGAG 
CTGTTGCCCA AAGGTAGCAA AGAGGAGCAG CGGGATTATG TCTTCTACCT GGCCGTGGGC 
AACTACCGGC TCAAGGAATA TGAAAAGGCT CTGAAGTATG TGCGGGGACT GTTACAGACT 
GAGCCCCAGA ACAACCAGGC CAAGGAGCTG GAACGCCTGA TTGACAAGGC CATGAAGAAA 
GATGGACTGG TAGGCATGGC CATTGTTGGT GGCATGGCCC TGGGTGTGGC GGGCCTGGCT 
GGACTCATTG GACTGGCTGT GTCCAAGTCC AAATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High glucose concentration abrogates sevoflurane post-conditioning cardioprotection by advancing mitochondrial fission but dynamin-related protein 1 inhibitor restores these effects.
Acta physiologica (Oxford, England)220(1)83-98(2017 May)
Yu J,Maimaitili Y,Xie P,Wu JJ,Wang J,Yang YN,Ma HP,Zheng H

Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension.
Journal of molecular medicine (Berlin, Germany)95(4)381-393(2017 Apr)
Tian L,Neuber-Hess M,Mewburn J,Dasgupta A,Dunham-Snary K,Wu D,Chen KH,Hong Z,Sharp WW,Kutty S,Archer SL

Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics.
BioFactors (Oxford, England)43(2)293-310(2017 Mar)
Aparicio-Trejo OE,Tapia E,Molina-Jij?n E,Medina-Campos ON,Mac?as-Ruvalcaba NA,Le?n-Contreras JC,Hern?ndez-Pando R,Garc?a-Arroyo FE,Crist?bal M,S?nchez-Lozada LG,Pedraza-Chaverri J

PM
International journal of environmental research and public health14(2)(2017 01)
Guo Z,Hong Z,Dong W,Deng C,Zhao R,Xu J,Zhuang G,Zhang R

Status epilepticus triggers early mitochondrial fusion in the rat hippocampus in a lithium-pilocarpine model.
Epilepsy research12311-9(2016 Jul)
C?rdova-D?valos L,Carrera-Calvo D,Sol?s-Navarrete J,Mercado-G?mez OF,Arriaga-?vila V,Agredano-Moreno LT,Jim?nez-Garc?a LF,Guevara-Guzm?n R

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Fis1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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