Pex5l cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pex5l
Entrez Gene ID	286937
Full Name	peroxisomal biogenesis factor 5-like
Synonyms	Pex2,TRIP8b,Trjip8b
General protein information	Preferred Names peroxisomal biogenesis factor 5-like Names PEX5-related protein PEX5-like protein TPR-containing Rab8b-interacting protein peroxin 2 peroxin-5-related protein pex5Rp tetratricopeptide repeat-containing Rab8b-interacting protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q24
Summary	plays a role in cAMP-induced ACTH secretion [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_173152.1	NP_775175.1	PEX5-related protein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PEX5L	NP_001069411.1
Xenopus tropicalis (tropical clawed frog)	pex5l	XP_002931623.2
Homo sapiens (human)	PEX5L	NP_001243679.1
	PEX5L	XP_001107401.1
Mus musculus (house mouse)	Pex5l	NP_067458.2
Rattus norvegicus (Norway rat)	Pex5l	NP_775175.1
Gallus gallus (chicken)	PEX5L	XP_004943508.1
Pan troglodytes (chimpanzee)	PEX5L	XP_001168616.1
Canis lupus familiaris (dog)	PEX5L	XP_005639796.1
Danio rerio (zebrafish)	pex5la	XP_685057.5

Gene Ontology
Bibliography

Related articles in PubMed

Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels.
Wilkars W, Wollberg J, Mohr E, Han M, Chetkovich DM, B?hring R, Bender RA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology28(5)2177-90(2014 May)

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Ghai R, Bugarcic A, Liu H, Norwood SJ, Skeldal S, Coulson EJ, Li SS, Teasdale RD, Collins BM
Proceedings of the National Academy of Sciences of the United States of America110(8)E643-52(2013 Feb)

Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms.
Wilkars W, Liu Z, Lewis AS, Stoub TR, Ramos EM, Brandt N, Nicholson DA, Chetkovich DM, Bender RA
PloS one7(2)e32181(2012)

Corticospinal-specific HCN expression in mouse motor cortex: I(h)-dependent synaptic integration as a candidate microcircuit mechanism involved in motor control.
Sheets PL, Suter BA, Kiritani T, Chan CS, Surmeier DJ, Shepherd GM
Journal of neurophysiology106(5)2216-31(2011 Nov)

Analysis of proteins interacting with TRIP8b adapter.
Popova NV, Plotnikov AN, Ziganshin RKh, Deyev IE, Petrenko AG
Biochemistry. Biokhimiia73(6)644-51(2008 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nedd4-2 plays an important role in the regulation of HCN1 trafficking and may compete with TRIP8b(1a-4) in this process
Title: Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels.

TRIP8b isoforms are important regulators of HCN1 trafficking in entorhinal neurons.
Title: Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms.

Hyperpolarization current expression was high in corticospinal neurons and low in corticostriatal and corticocortical neurons, a pattern mirrored by mRNA levels for HCN1 and Trip8b subunits.
Title: Corticospinal-specific HCN expression in mouse motor cortex: I(h)-dependent synaptic integration as a candidate microcircuit mechanism involved in motor control.

Our data suggest complex regulatory functions of TRIP8b in neuronal endocytosis through independent interaction with membrane proteins and components of the clathrin coat
Title: Association of adaptor protein TRIP8b with clathrin.

increasing cAMP levels in cells antagonized the up-regulation of HCN1 channels mediated by a TRIP8b construct binding the CNBD exclusively.
Title: Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites.

The following Pex5l gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pex5l cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03579	NM_173152.1 Latest version!	Rattus norvegicus peroxisomal biogenesis factor 5-like (Pex5l), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$356.30 $509.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pex5l ( NM_173152.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_775175.1 Rattus norvegicus peroxisomal biogenesis factor 5-like (Pex5l), mRNA.

Price & Availability↑

CloneID	ORa03579
Clone ID Related Accession (Same CDS sequence)	NM_173152.1
Accession Version	NM_173152.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1809bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	PEX5-related protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF324454.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF324454.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTACCAGG GACACATGCA GGGAAAAGGC TCTAGGGCTG CAGATAAGGC TGTTGCCATG 
GTGATGAAGG AGATACCGAG GGAGGAGTCT GCAGAAGAAA AGCCCCTCCT TACTATGACA 
TCACAGCTGG TGAATGAGCA ACAAGAAAGC AGACCTCTCC TGAGCCCCTC CATCGACGAC 
TTCCTCTGTG AAACCAAATC CGAGGCCATT GCAAAGCCAG TGACGTCCAA CACAGCTGTG 
TTGACCACTG GCTTGGATCT CCTTGACCTG AGTGAACCCG TCTCTCAAAC CCAAACCAAA 
GCCAAGAAAT CAGAGTCCTC ATCGAAGAGT TCATCCCTCA AGAAGAAAGC TGATGGCTCT 
GACCTCATCA GTGCAGATGC TGAGCAGAGA GCACAGGCTC TCCGAGGGCC AGAGACATCA 
TCCTTAGATT TAGATATTCA AACACAACTG GAAAAATGGG ATGATGTCAA GTTTCATGGT 
GACCGAACAA GCAAGGGGCA CCTCATGGCA GAGAGGAAGT CATGCTCTTC CAGAGCCGGA 
TCCAAAGAGC TTCTGTGGTC CTCAGAACAT AGATCTCAGC CAGAGCTGAG TACCGGGAAA 
AGTGCCCTCA ACTCCGAGTC GGCTTCTGAG TTGGAACTTG TGGCTCCAGC ACAGGCTCGG 
CTGACCAAAG AGCATCGCTG GGGAAGCGCC CTGCTCTCCA GGAACCATTC CTTAGAAGAG 
GAGTTTGAGA GGGCAAAAGC AGCAGTAGAG TCAGATACGG AGTTCTGGGA TAAGATGCAG 
GCAGAATGGG AAGAAATGGC CCGGAGGAAC TGGATATCAG AGAACCAGGA AGCTCAGAAC 
CAAGTCACCG TCTCAGCCAG TGAGAAGGGT TATTACTTTC ACACTGAAAA TCCCTTCAAG 
GACTGGCCTG GAGCATTTGA AGAAGGCTTA AAAAGACTGA AGGAAGGGGA CCTGCCCGTC 
ACCATCCTGT TCATGGAAGC AGCGATCCTT CAGGACCCTG GAAACGCTGA GGCATGGCAG 
TTTCTTGGTA TAACCCAGGC CGAGAATGAA AACGAACAGG CAGCCATTGT CGCCCTCCAG 
AGGTGCCTGG AGTTGCAGCC CAACAACTTG AAGGCTCTGA TGGCCTTGGC TGTGAGTTAC 
ACCAATACCA GCCACCAGCA GGATGCTTGT GAGGCGCTGA AGAACTGGAT TAAGCAAAAC 
CCAAAGTACA AGTACCTTGT GAAGAACAAG AAAGGCTCTC CAGGCCTCAC GCGGCGAATG 
TCTAAATCCC CAGTTGACAG CTCTGTCCTG GAAGGGGTGA AGGACCTGTA CCTGGAGGCT 
GCCCACCAAA ATGGTGACAT GATCGACCCA GACCTGCAGA CGGGTCTTGG AGTTCTGTTC 
CACCTGAGTG GAGAGTTCAA CCGAGCGATC GATGCATTTA ATGCTGCCTT AACTGTTCGG 
CCAGAGGATT ACTCGTTGTG GAACCGACTT GGGGCAACCT TGGCAAATGG AGACCGCAGT 
GAGGAAGCTG TAGAGGCCTA CACGAGAGCA CTGGAGATCC AGCCAGGTTT CATCCGGTCC 
AGGTACAACC TGGGAATCAG CTGCATCAAC CTGGGTGCCT ACAGAGAAGC GGTCAGCAAC 
TTTCTCACTG CCCTCAGCTT GCAGAGGAAG AGCAGGAACC AGCAGCAGGT CCCTCACCCT 
GCCATCTCCG GGAACATCTG GGCCGCCCTC AGGATTGCGC TGTCGCTGAT GGACCAGCCA 
GAGCTCTTCC AGGCAGCCAA CCTCGGCGAC CTGGATGTCC TCCTGAGAGC TTTCAACTTG 
GATCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775175.1
CDS	1..1809
Translation	MYQGHMQGKGSRAADKAVAMVMKEIPREESAEEKPLLTMTSQLVNEQQESRPLLSPSIDDFLCETKSEAIAKPVTSNTAVLTTGLDLLDLSEPVSQTQTKAKKSESSSKSSSLKKKADGSDLISADAEQRAQALRGPETSSLDLDIQTQLEKWDDVKFHGDRTSKGHLMAERKSCSSRAGSKELLWSSEHRSQPELSTGKSALNSESASELELVAPAQARLTKEHRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTVSASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGNAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTSHQQDACEALKNWIKQNPKYKYLVKNKKGSPGLTRRMSKSPVDSSVLEGVKDLYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP

Target ORF information:

RefSeq Version	NM_173152.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus peroxisomal biogenesis factor 5-like (Pex5l), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173152.1

ORF Insert Sequence:

ATGTACCAGG GACACATGCA GGGAAAAGGC TCTAGGGCTG CAGATAAGGC TGTTGCCATG 
GTGATGAAGG AGATACCGAG GGAGGAGTCT GCAGAAGAAA AGCCCCTCCT TACTATGACA 
TCACAGCTGG TGAATGAGCA ACAAGAAAGC AGACCTCTCC TGAGCCCCTC CATCGACGAC 
TTCCTCTGTG AAACCAAATC CGAGGCCATT GCAAAGCCAG TGACGTCCAA CACAGCTGTG 
TTGACCACTG GCTTGGATCT CCTTGACCTG AGTGAACCCG TCTCTCAAAC CCAAACCAAA 
GCCAAGAAAT CAGAGTCCTC ATCGAAGAGT TCATCCCTCA AGAAGAAAGC TGATGGCTCT 
GACCTCATCA GTGCAGATGC TGAGCAGAGA GCACAGGCTC TCCGAGGGCC AGAGACATCA 
TCCTTAGATT TAGATATTCA AACACAACTG GAAAAATGGG ATGATGTCAA GTTTCATGGT 
GACCGAACAA GCAAGGGGCA CCTCATGGCA GAGAGGAAGT CATGCTCTTC CAGAGCCGGA 
TCCAAAGAGC TTCTGTGGTC CTCAGAACAT AGATCTCAGC CAGAGCTGAG TACCGGGAAA 
AGTGCCCTCA ACTCCGAGTC GGCTTCTGAG TTGGAACTTG TGGCTCCAGC ACAGGCTCGG 
CTGACCAAAG AGCATCGCTG GGGAAGCGCC CTGCTCTCCA GGAACCATTC CTTAGAAGAG 
GAGTTTGAGA GGGCAAAAGC AGCAGTAGAG TCAGATACGG AGTTCTGGGA TAAGATGCAG 
GCAGAATGGG AAGAAATGGC CCGGAGGAAC TGGATATCAG AGAACCAGGA AGCTCAGAAC 
CAAGTCACCG TCTCAGCCAG TGAGAAGGGT TATTACTTTC ACACTGAAAA TCCCTTCAAG 
GACTGGCCTG GAGCATTTGA AGAAGGCTTA AAAAGACTGA AGGAAGGGGA CCTGCCCGTC 
ACCATCCTGT TCATGGAAGC AGCGATCCTT CAGGACCCTG GAAACGCTGA GGCATGGCAG 
TTTCTTGGTA TAACCCAGGC CGAGAATGAA AACGAACAGG CAGCCATTGT CGCCCTCCAG 
AGGTGCCTGG AGTTGCAGCC CAACAACTTG AAGGCTCTGA TGGCCTTGGC TGTGAGTTAC 
ACCAATACCA GCCACCAGCA GGATGCTTGT GAGGCGCTGA AGAACTGGAT TAAGCAAAAC 
CCAAAGTACA AGTACCTTGT GAAGAACAAG AAAGGCTCTC CAGGCCTCAC GCGGCGAATG 
TCTAAATCCC CAGTTGACAG CTCTGTCCTG GAAGGGGTGA AGGACCTGTA CCTGGAGGCT 
GCCCACCAAA ATGGTGACAT GATCGACCCA GACCTGCAGA CGGGTCTTGG AGTTCTGTTC 
CACCTGAGTG GAGAGTTCAA CCGAGCGATC GATGCATTTA ATGCTGCCTT AACTGTTCGG 
CCAGAGGATT ACTCGTTGTG GAACCGACTT GGGGCAACCT TGGCAAATGG AGACCGCAGT 
GAGGAAGCTG TAGAGGCCTA CACGAGAGCA CTGGAGATCC AGCCAGGTTT CATCCGGTCC 
AGGTACAACC TGGGAATCAG CTGCATCAAC CTGGGTGCCT ACAGAGAAGC GGTCAGCAAC 
TTTCTCACTG CCCTCAGCTT GCAGAGGAAG AGCAGGAACC AGCAGCAGGT CCCTCACCCT 
GCCATCTCCG GGAACATCTG GGCCGCCCTC AGGATTGCGC TGTCGCTGAT GGACCAGCCA 
GAGCTCTTCC AGGCAGCCAA CCTCGGCGAC CTGGATGTCC TCCTGAGAGC TTTCAACTTG 
GATCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology28(5)2177-90(2014 May)
Wilkars W,Wollberg J,Mohr E,Han M,Chetkovich DM,B?hring R,Bender RA

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Proceedings of the National Academy of Sciences of the United States of America110(8)E643-52(2013 Feb)
Ghai R,Bugarcic A,Liu H,Norwood SJ,Skeldal S,Coulson EJ,Li SS,Teasdale RD,Collins BM

Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms.
PloS one7(2)e32181(2012)
Wilkars W,Liu Z,Lewis AS,Stoub TR,Ramos EM,Brandt N,Nicholson DA,Chetkovich DM,Bender RA

Corticospinal-specific HCN expression in mouse motor cortex: I(h)-dependent synaptic integration as a candidate microcircuit mechanism involved in motor control.
Journal of neurophysiology106(5)2216-31(2011 Nov)
Sheets PL,Suter BA,Kiritani T,Chan CS,Surmeier DJ,Shepherd GM

Analysis of proteins interacting with TRIP8b adapter.
Biochemistry. Biokhimiia73(6)644-51(2008 Jun)
Popova NV,Plotnikov AN,Ziganshin RKh,Deyev IE,Petrenko AG

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Pex5l cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報