Gm2a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gm2a
Entrez Gene ID	282838
Full Name	GM2 ganglioside activator
General protein information	Preferred Names GM2 ganglioside activator Names ganglioside GM2 activator GM2 ganglioside activator protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q22
Summary	mouse homolog is involved in sphingolipid metabolism [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_172335.2	NP_758838.2	ganglioside GM2 activator precursor

Pathways from BioSystems

Homologies

	LOC713375	XP_001109570.1
Canis lupus familiaris (dog)	GM2A	XP_003639059.1
Homo sapiens (human)	GM2A	NP_000396.2
Pan troglodytes (chimpanzee)	GM2A	XP_003950707.1
Bos taurus (cattle)	GM2A	NP_001192476.1
Gallus gallus (chicken)	GM2A	XP_003642107.2
Xenopus tropicalis (tropical clawed frog)	gm2a	NP_001017081.1
Xenopus tropicalis (tropical clawed frog)	LOC100495195	XP_002932357.2
Mus musculus (house mouse)	Gm2a	NP_034429.1
Rattus norvegicus (Norway rat)	Gm2a	NP_758838.2
Danio rerio (zebrafish)	gm2a	NP_001017831.1

Gene Ontology
Bibliography

Related articles in PubMed

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell115(5)629-40(2003 Nov)

Regulation of mammalian phospholipase D2: interaction with and stimulation by G(M2) activator.
Sarkar S, Miwa N, Kominami H, Igarashi N, Hayashi S, Okada T, Jahangeer S, Nakamura S
The Biochemical journal359(Pt 3)599-604(2001 Nov)

Structure of the GM2A gene: identification of an exon 2 nonsense mutation and a naturally occurring transcript with an in-frame deletion of exon 2.
Chen B, Rigat B, Curry C, Mahuran DJ
American journal of human genetics65(1)77-87(1999 Jul)

Ganglioside GM2-activator protein and vesicular transport in collecting duct intercalated cells.
Mundel TM, Heid HW, Mahuran DJ, Kriz W, Mundel P
Journal of the American Society of Nephrology : JASN10(3)435-43(1999 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Gm2a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gm2a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03332	NM_172335.2 Latest version!	Rattus norvegicus GM2 ganglioside activator (Gm2a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gm2a ( NM_172335.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_758838.2 Rattus norvegicus GM2 ganglioside activator (Gm2a), mRNA.

Price & Availability↑

CloneID	ORa03332
Clone ID Related Accession (Same CDS sequence)	NM_172335.2
Accession Version	NM_172335.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Rattus norvegicus(Norway rat)
Product	ganglioside GM2 activator precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC072474.1. On Jun 20, 2004 this sequence version replaced NM_172335.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC072474.1, EV772107.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCGTCGTG TACCGCTGCT GCTCGTGCTG GGCTTGCTGT TCGTGCTGGG CTTGCTGTTC 
GCTGGCCCTG TCGCCCCTTC GCGCCTCATC TCGAAGCGCC CTTCCCAACT TGGTGGCTTC 
TCCTGGGATA ACTGTGATGA AGGAAAGGAC CCTGCAGTGA TCAAAAGCCT CACGCTCCAA 
CCTGACCCCA TTGTCGTTCC TGGAGATGTG ATCGTCAGTG CTGAGGGCAA GACCAGCATT 
CCCCTCACTT CTCCTCAGAA GGTGGAGCTC ACCGTGGAGA AGGAAGTGGC TGGCTTCTGG 
GTCAAGATCC CTTGCGTAGA ACAGCTAGGA AGCTGTACCT ATGAGAATGT CTGTGACCTG 
ATAGACCAAT ACATCCCCCC TGGAGAGACC TGCCCAGAGC CGCTGCACAC CTACGGGCTG 
CCCTGCCATT GTCCCTTCAA GGAAGGCACC TACTCACTGC CTTCGAGCAA CTTCACAGTG 
CCTGATCTGG AGCTTCCAAG CTGGCTAAGC ACGGGCAACT ACCGCATCCA GAGCATCTTG 
AGCAGCGGTG GAAAGCGCCT GGCCTGCATC AAGATTGCCG CCTCTCTCAA GGGCAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_758838.2
CDS	42..641
Translation	MRRVPLLLVLGLLFVLGLLFAGPVAPSRLISKRPSQLGGFSWDNCDEGKDPAVIKSLTLQPDPIVVPGDVIVSAEGKTSIPLTSPQKVELTVEKEVAGFWVKIPCVEQLGSCTYENVCDLIDQYIPPGETCPEPLHTYGLPCHCPFKEGTYSLPSSNFTVPDLELPSWLSTGNYRIQSILSSGGKRLACIKIAASLKGK

Target ORF information:

RefSeq Version	NM_172335.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GM2 ganglioside activator (Gm2a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172335.2

ORF Insert Sequence:

ATGCGTCGTG TACCGCTGCT GCTCGTGCTG GGCTTGCTGT TCGTGCTGGG CTTGCTGTTC 
GCTGGCCCTG TCGCCCCTTC GCGCCTCATC TCGAAGCGCC CTTCCCAACT TGGTGGCTTC 
TCCTGGGATA ACTGTGATGA AGGAAAGGAC CCTGCAGTGA TCAAAAGCCT CACGCTCCAA 
CCTGACCCCA TTGTCGTTCC TGGAGATGTG ATCGTCAGTG CTGAGGGCAA GACCAGCATT 
CCCCTCACTT CTCCTCAGAA GGTGGAGCTC ACCGTGGAGA AGGAAGTGGC TGGCTTCTGG 
GTCAAGATCC CTTGCGTAGA ACAGCTAGGA AGCTGTACCT ATGAGAATGT CTGTGACCTG 
ATAGACCAAT ACATCCCCCC TGGAGAGACC TGCCCAGAGC CGCTGCACAC CTACGGGCTG 
CCCTGCCATT GTCCCTTCAA GGAAGGCACC TACTCACTGC CTTCGAGCAA CTTCACAGTG 
CCTGATCTGG AGCTTCCAAG CTGGCTAAGC ACGGGCAACT ACCGCATCCA GAGCATCTTG 
AGCAGCGGTG GAAAGCGCCT GGCCTGCATC AAGATTGCCG CCTCTCTCAA GGGCAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Cell115(5)629-40(2003 Nov)
Mootha VK,Bunkenborg J,Olsen JV,Hjerrild M,Wisniewski JR,Stahl E,Bolouri MS,Ray HN,Sihag S,Kamal M,Patterson N,Lander ES,Mann M

Regulation of mammalian phospholipase D2: interaction with and stimulation by G(M2) activator.
The Biochemical journal359(Pt 3)599-604(2001 Nov)
Sarkar S,Miwa N,Kominami H,Igarashi N,Hayashi S,Okada T,Jahangeer S,Nakamura S

Structure of the GM2A gene: identification of an exon 2 nonsense mutation and a naturally occurring transcript with an in-frame deletion of exon 2.
American journal of human genetics65(1)77-87(1999 Jul)
Chen B,Rigat B,Curry C,Mahuran DJ

Ganglioside GM2-activator protein and vesicular transport in collecting duct intercalated cells.
Journal of the American Society of Nephrology : JASN10(3)435-43(1999 Mar)
Mundel TM,Heid HW,Mahuran DJ,Kriz W,Mundel P