Aip cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Aip
Entrez Gene ID	282827
Full Name	aryl-hydrocarbon receptor-interacting protein
Synonyms	XAP2
General protein information	Preferred Names aryl-hydrocarbon receptor-interacting protein Names AH receptor-interacting protein HBV-X associated protein immunophilin XAP2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q43

mRNA and Protein(s)

mRNA	Protein	Name
XM_006230699.3	XP_006230761.1	AH receptor-interacting protein isoform X1
XM_006230700.3	XP_006230762.1	AH receptor-interacting protein isoform X1
NM_172327.2	NP_758830.2	AH receptor-interacting protein

Pathways from BioSystems

Homologies

	AIP	XP_001105624.1
Danio rerio (zebrafish)	aip	NP_999877.1
Danio rerio (zebrafish)	LOC100149392	XP_001922877.1
Drosophila melanogaster (fruit fly)	CG1847	NP_727574.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000725	XP_311262.5
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011684	XP_320825.3
Bos taurus (cattle)	AIP	NP_898905.1
Rattus norvegicus (Norway rat)	Aip	NP_758830.2
Gallus gallus (chicken)	AIP	NP_989800.1
Homo sapiens (human)	AIP	NP_003968.2
Pan troglodytes (chimpanzee)	AIP	XP_508597.1
Canis lupus familiaris (dog)	AIP	XP_851841.1
Mus musculus (house mouse)	Aip	NP_057875.1
Caenorhabditis elegans (roundworm)	C56C10.10	NP_495339.1
Xenopus tropicalis (tropical clawed frog)	aip	NP_001096219.1

Gene Ontology
Bibliography

Related articles in PubMed

Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line.
Fukuda T, Tanaka T, Hamaguchi Y, Kawanami T, Nomiyama T, Yanase T
PloS one11(10)e0164131(2016)

Aip regulates cAMP signalling and GH secretion in GH3 cells.
Formosa R, Xuereb-Anastasi A, Vassallo J
Endocrine-related cancer20(4)495-505(2013 Aug)

Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor.
de Oliveira SK, Hoffmeister M, Gambaryan S, M?ller-Esterl W, Guimaraes JA, Smolenski AP
The Journal of biological chemistry282(18)13656-63(2007 May)

Redefining the role of the endogenous XAP2 and C-terminal hsp70-interacting protein on the endogenous Ah receptors expressed in mouse and rat cell lines.
Pollenz RS, Dougherty EJ
The Journal of biological chemistry280(39)33346-56(2005 Sep)

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.
Marschang P, Brich J, Weeber EJ, Sweatt JD, Shelton JM, Richardson JA, Hammer RE, Herz J
Molecular and cellular biology24(9)3782-93(2004 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results demonstrated that Aip inactivation promoted somatotroph tumorigenesis and overproduction of growth hormone probably through increased Stat3 activation.
Title: Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line.

Aip regulates cAMP signalling and growth hormone secretion in GH3 cells.
Title: Aip regulates cAMP signalling and GH secretion in GH3 cells.

The role of Xap2 and C-terminal hsp-70 interacting protein on the endogenous Ah receptors expressed in rat cell lines was determined.
Title: Redefining the role of the endogenous XAP2 and C-terminal hsp70-interacting protein on the endogenous Ah receptors expressed in mouse and rat cell lines.

results suggest that XAP2 functionally interacts with PDE4A5 in cells
Title: Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.

The following Aip gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aip cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa03302	NM_172327.2 Latest version!	Rattus norvegicus aryl-hydrocarbon receptor-interacting protein (Aip), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa03302	XM_006230699.3 Latest version!	Rattus norvegicus aryl-hydrocarbon receptor-interacting protein (Aip), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa03302	XM_006230700.3 Latest version!	Rattus norvegicus aryl-hydrocarbon receptor-interacting protein (Aip), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Aip ( NM_172327.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_758830.2 Rattus norvegicus aryl-hydrocarbon receptor-interacting protein (Aip), mRNA.

Price & Availability↑

CloneID	ORa03302
Clone ID Related Accession (Same CDS sequence)	XM_006230699.3 , XM_006230700.3 , NM_172327.2
Accession Version	NM_172327.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-04
Organism	Rattus norvegicus(Norway rat)
Product	AH receptor-interacting protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC089110.1. On Jan 30, 2005 this sequence version replaced NM_172327.1. ##Evidence-Data-START## Transcript exon combination :: BC089110.1, FQ214270.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGATC TCATCGCAAG ACTTCGAGAG GACGGGATCC AAAAGCGTGT GATACAGGAG 
GGCCGAGGAG AGTTGCCGGA ATTTCAGGAT GGCACTAAGG CCACCTTCCA CTTCCGGACG 
CTGCATAGTG ACCCGGAGGG CTCCGTCATA GATGACAGCC GAGCACGCGG CAAGCCCATG 
GAGCTCATCA TCGGCAAGAA GTTCAAGCTG CCTGTGTGGG AGACCATCGT GCGTACCATG 
CGTGAGGGGG AGACGGCCCA GTTCCTCTGC GATGTCAAGC ACACAGTCCT GTATCCTCTG 
GTGGCCAAGA GCCTCCGCAA CATCGCTGAG GGCAAGGACC CCTTGGAGGG CCAGCGGCAT 
TGCTGTGGAA TTGCTCAAAT GCATGAGCAT AGCTCCCTGG GTCATGCGGA CCTGGACGCC 
CTGCAGCAGA ACCCTCAACC CCTCATCTTC CACATCGAGA TGCTGAAGGT GGAGAGCCCT 
GGCACCTACC AGCAGGACCC ATGGGCAATG ACAGATGAGG AGAAAGCAAA GGCAGTACCA 
CTCATCCACC AAGAGGGCAA CCGCTTATAC CGTGAGGGGC AGGTGAAGGA GGCTGCTGCC 
AAGTACTACG ATGCCATTGC CTGCCTCAAG AACCTGCAGA TGAAGGAGCA GCCTGGATCA 
CCCGACTGGA TCCAGTTGGA CTTGCAGATC ACACCACTGC TACTCAACTA TTGCCAGTGC 
AAGCTGGTGG CTCAGGAGTA CTATGAGGTG CTGGATCACT GCTCCTCCAT CCTCAACAAG 
TATGATGACA ATGTCAAGGC TTACTTCAAG CGGGGTAAGG CCCATGCTGC TGTGTGGAAT 
GCCCAGGAGG CCCAGGCTGA CTTTGCCAAG GTGTTGGAGC TCGACCCTGC CCTGGCGCCT 
GTGGTAAGCA GAGAGCTGCG GGCCCTGGAG GCACGGATCC GGCAGAAGGA TGAGGAGGAC 
AAAGCCCGCT TCCGGGGCAT CTTTTCCCAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_758830.2
CDS	6..998
Translation	MADLIARLREDGIQKRVIQEGRGELPEFQDGTKATFHFRTLHSDPEGSVIDDSRARGKPMELIIGKKFKLPVWETIVRTMREGETAQFLCDVKHTVLYPLVAKSLRNIAEGKDPLEGQRHCCGIAQMHEHSSLGHADLDALQQNPQPLIFHIEMLKVESPGTYQQDPWAMTDEEKAKAVPLIHQEGNRLYREGQVKEAAAKYYDAIACLKNLQMKEQPGSPDWIQLDLQITPLLLNYCQCKLVAQEYYEVLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRALEARIRQKDEEDKARFRGIFSH

Target ORF information:

RefSeq Version	NM_172327.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aryl-hydrocarbon receptor-interacting protein (Aip), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172327.2

ORF Insert Sequence:

ATGGCGGATC TCATCGCAAG ACTTCGAGAG GACGGGATCC AAAAGCGTGT GATACAGGAG 
GGCCGAGGAG AGTTGCCGGA ATTTCAGGAT GGCACTAAGG CCACCTTCCA CTTCCGGACG 
CTGCATAGTG ACCCGGAGGG CTCCGTCATA GATGACAGCC GAGCACGCGG CAAGCCCATG 
GAGCTCATCA TCGGCAAGAA GTTCAAGCTG CCTGTGTGGG AGACCATCGT GCGTACCATG 
CGTGAGGGGG AGACGGCCCA GTTCCTCTGC GATGTCAAGC ACACAGTCCT GTATCCTCTG 
GTGGCCAAGA GCCTCCGCAA CATCGCTGAG GGCAAGGACC CCTTGGAGGG CCAGCGGCAT 
TGCTGTGGAA TTGCTCAAAT GCATGAGCAT AGCTCCCTGG GTCATGCGGA CCTGGACGCC 
CTGCAGCAGA ACCCTCAACC CCTCATCTTC CACATCGAGA TGCTGAAGGT GGAGAGCCCT 
GGCACCTACC AGCAGGACCC ATGGGCAATG ACAGATGAGG AGAAAGCAAA GGCAGTACCA 
CTCATCCACC AAGAGGGCAA CCGCTTATAC CGTGAGGGGC AGGTGAAGGA GGCTGCTGCC 
AAGTACTACG ATGCCATTGC CTGCCTCAAG AACCTGCAGA TGAAGGAGCA GCCTGGATCA 
CCCGACTGGA TCCAGTTGGA CTTGCAGATC ACACCACTGC TACTCAACTA TTGCCAGTGC 
AAGCTGGTGG CTCAGGAGTA CTATGAGGTG CTGGATCACT GCTCCTCCAT CCTCAACAAG 
TATGATGACA ATGTCAAGGC TTACTTCAAG CGGGGTAAGG CCCATGCTGC TGTGTGGAAT 
GCCCAGGAGG CCCAGGCTGA CTTTGCCAAG GTGTTGGAGC TCGACCCTGC CCTGGCGCCT 
GTGGTAAGCA GAGAGCTGCG GGCCCTGGAG GCACGGATCC GGCAGAAGGA TGAGGAGGAC 
AAAGCCCGCT TCCGGGGCAT CTTTTCCCAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Aip ( XM_006230699.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006230761.1 Rattus norvegicus aryl-hydrocarbon receptor-interacting protein (Aip), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa03302
Clone ID Related Accession (Same CDS sequence)	XM_006230699.3 , XM_006230700.3 , NM_172327.2
Accession Version	XM_006230699.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	AH receptor-interacting protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006230699.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGATC TCATCGCAAG ACTTCGAGAG GACGGGATCC AAAAGCGTGT GATACAGGAG 
GGCCGAGGAG AGTTGCCGGA ATTTCAGGAT GGCACTAAGG CCACCTTCCA CTTCCGGACG 
CTGCATAGTG ACCCGGAGGG CTCCGTCATA GATGACAGCC GAGCACGCGG CAAGCCCATG 
GAGCTCATCA TCGGCAAGAA GTTCAAGCTG CCTGTGTGGG AGACCATCGT GCGTACCATG 
CGTGAGGGGG AGACGGCCCA GTTCCTCTGC GATGTCAAGC ACACAGTCCT GTATCCTCTG 
GTGGCCAAGA GCCTCCGCAA CATCGCTGAG GGCAAGGACC CCTTGGAGGG CCAGCGGCAT 
TGCTGTGGAA TTGCTCAAAT GCATGAGCAT AGCTCCCTGG GTCATGCGGA CCTGGACGCC 
CTGCAGCAGA ACCCTCAACC CCTCATCTTC CACATCGAGA TGCTGAAGGT GGAGAGCCCT 
GGCACCTACC AGCAGGACCC ATGGGCAATG ACAGATGAGG AGAAAGCAAA GGCAGTACCA 
CTCATCCACC AAGAGGGCAA CCGCTTATAC CGTGAGGGGC AGGTGAAGGA GGCTGCTGCC 
AAGTACTACG ATGCCATTGC CTGCCTCAAG AACCTGCAGA TGAAGGAGCA GCCTGGATCA 
CCCGACTGGA TCCAGTTGGA CTTGCAGATC ACACCACTGC TACTCAACTA TTGCCAGTGC 
AAGCTGGTGG CTCAGGAGTA CTATGAGGTG CTGGATCACT GCTCCTCCAT CCTCAACAAG 
TATGATGACA ATGTCAAGGC TTACTTCAAG CGGGGTAAGG CCCATGCTGC TGTGTGGAAT 
GCCCAGGAGG CCCAGGCTGA CTTTGCCAAG GTGTTGGAGC TCGACCCTGC CCTGGCGCCT 
GTGGTAAGCA GAGAGCTGCG GGCCCTGGAG GCACGGATCC GGCAGAAGGA TGAGGAGGAC 
AAAGCCCGCT TCCGGGGCAT CTTTTCCCAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006230761.1
CDS	202..1194
Translation	MADLIARLREDGIQKRVIQEGRGELPEFQDGTKATFHFRTLHSDPEGSVIDDSRARGKPMELIIGKKFKLPVWETIVRTMREGETAQFLCDVKHTVLYPLVAKSLRNIAEGKDPLEGQRHCCGIAQMHEHSSLGHADLDALQQNPQPLIFHIEMLKVESPGTYQQDPWAMTDEEKAKAVPLIHQEGNRLYREGQVKEAAAKYYDAIACLKNLQMKEQPGSPDWIQLDLQITPLLLNYCQCKLVAQEYYEVLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRALEARIRQKDEEDKARFRGIFSH

Target ORF information:

RefSeq Version	XM_006230699.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aryl-hydrocarbon receptor-interacting protein (Aip), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006230699.3

ORF Insert Sequence:

ATGGCGGATC TCATCGCAAG ACTTCGAGAG GACGGGATCC AAAAGCGTGT GATACAGGAG 
GGCCGAGGAG AGTTGCCGGA ATTTCAGGAT GGCACTAAGG CCACCTTCCA CTTCCGGACG 
CTGCATAGTG ACCCGGAGGG CTCCGTCATA GATGACAGCC GAGCACGCGG CAAGCCCATG 
GAGCTCATCA TCGGCAAGAA GTTCAAGCTG CCTGTGTGGG AGACCATCGT GCGTACCATG 
CGTGAGGGGG AGACGGCCCA GTTCCTCTGC GATGTCAAGC ACACAGTCCT GTATCCTCTG 
GTGGCCAAGA GCCTCCGCAA CATCGCTGAG GGCAAGGACC CCTTGGAGGG CCAGCGGCAT 
TGCTGTGGAA TTGCTCAAAT GCATGAGCAT AGCTCCCTGG GTCATGCGGA CCTGGACGCC 
CTGCAGCAGA ACCCTCAACC CCTCATCTTC CACATCGAGA TGCTGAAGGT GGAGAGCCCT 
GGCACCTACC AGCAGGACCC ATGGGCAATG ACAGATGAGG AGAAAGCAAA GGCAGTACCA 
CTCATCCACC AAGAGGGCAA CCGCTTATAC CGTGAGGGGC AGGTGAAGGA GGCTGCTGCC 
AAGTACTACG ATGCCATTGC CTGCCTCAAG AACCTGCAGA TGAAGGAGCA GCCTGGATCA 
CCCGACTGGA TCCAGTTGGA CTTGCAGATC ACACCACTGC TACTCAACTA TTGCCAGTGC 
AAGCTGGTGG CTCAGGAGTA CTATGAGGTG CTGGATCACT GCTCCTCCAT CCTCAACAAG 
TATGATGACA ATGTCAAGGC TTACTTCAAG CGGGGTAAGG CCCATGCTGC TGTGTGGAAT 
GCCCAGGAGG CCCAGGCTGA CTTTGCCAAG GTGTTGGAGC TCGACCCTGC CCTGGCGCCT 
GTGGTAAGCA GAGAGCTGCG GGCCCTGGAG GCACGGATCC GGCAGAAGGA TGAGGAGGAC 
AAAGCCCGCT TCCGGGGCAT CTTTTCCCAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Aip ( XM_006230700.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006230762.1 Rattus norvegicus aryl-hydrocarbon receptor-interacting protein (Aip), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa03302
Clone ID Related Accession (Same CDS sequence)	XM_006230699.3 , XM_006230700.3 , NM_172327.2
Accession Version	XM_006230700.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	AH receptor-interacting protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006230700.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGATC TCATCGCAAG ACTTCGAGAG GACGGGATCC AAAAGCGTGT GATACAGGAG 
GGCCGAGGAG AGTTGCCGGA ATTTCAGGAT GGCACTAAGG CCACCTTCCA CTTCCGGACG 
CTGCATAGTG ACCCGGAGGG CTCCGTCATA GATGACAGCC GAGCACGCGG CAAGCCCATG 
GAGCTCATCA TCGGCAAGAA GTTCAAGCTG CCTGTGTGGG AGACCATCGT GCGTACCATG 
CGTGAGGGGG AGACGGCCCA GTTCCTCTGC GATGTCAAGC ACACAGTCCT GTATCCTCTG 
GTGGCCAAGA GCCTCCGCAA CATCGCTGAG GGCAAGGACC CCTTGGAGGG CCAGCGGCAT 
TGCTGTGGAA TTGCTCAAAT GCATGAGCAT AGCTCCCTGG GTCATGCGGA CCTGGACGCC 
CTGCAGCAGA ACCCTCAACC CCTCATCTTC CACATCGAGA TGCTGAAGGT GGAGAGCCCT 
GGCACCTACC AGCAGGACCC ATGGGCAATG ACAGATGAGG AGAAAGCAAA GGCAGTACCA 
CTCATCCACC AAGAGGGCAA CCGCTTATAC CGTGAGGGGC AGGTGAAGGA GGCTGCTGCC 
AAGTACTACG ATGCCATTGC CTGCCTCAAG AACCTGCAGA TGAAGGAGCA GCCTGGATCA 
CCCGACTGGA TCCAGTTGGA CTTGCAGATC ACACCACTGC TACTCAACTA TTGCCAGTGC 
AAGCTGGTGG CTCAGGAGTA CTATGAGGTG CTGGATCACT GCTCCTCCAT CCTCAACAAG 
TATGATGACA ATGTCAAGGC TTACTTCAAG CGGGGTAAGG CCCATGCTGC TGTGTGGAAT 
GCCCAGGAGG CCCAGGCTGA CTTTGCCAAG GTGTTGGAGC TCGACCCTGC CCTGGCGCCT 
GTGGTAAGCA GAGAGCTGCG GGCCCTGGAG GCACGGATCC GGCAGAAGGA TGAGGAGGAC 
AAAGCCCGCT TCCGGGGCAT CTTTTCCCAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006230762.1
CDS	185..1177
Translation	MADLIARLREDGIQKRVIQEGRGELPEFQDGTKATFHFRTLHSDPEGSVIDDSRARGKPMELIIGKKFKLPVWETIVRTMREGETAQFLCDVKHTVLYPLVAKSLRNIAEGKDPLEGQRHCCGIAQMHEHSSLGHADLDALQQNPQPLIFHIEMLKVESPGTYQQDPWAMTDEEKAKAVPLIHQEGNRLYREGQVKEAAAKYYDAIACLKNLQMKEQPGSPDWIQLDLQITPLLLNYCQCKLVAQEYYEVLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRALEARIRQKDEEDKARFRGIFSH

Target ORF information:

RefSeq Version	XM_006230700.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aryl-hydrocarbon receptor-interacting protein (Aip), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006230700.3

ORF Insert Sequence:

ATGGCGGATC TCATCGCAAG ACTTCGAGAG GACGGGATCC AAAAGCGTGT GATACAGGAG 
GGCCGAGGAG AGTTGCCGGA ATTTCAGGAT GGCACTAAGG CCACCTTCCA CTTCCGGACG 
CTGCATAGTG ACCCGGAGGG CTCCGTCATA GATGACAGCC GAGCACGCGG CAAGCCCATG 
GAGCTCATCA TCGGCAAGAA GTTCAAGCTG CCTGTGTGGG AGACCATCGT GCGTACCATG 
CGTGAGGGGG AGACGGCCCA GTTCCTCTGC GATGTCAAGC ACACAGTCCT GTATCCTCTG 
GTGGCCAAGA GCCTCCGCAA CATCGCTGAG GGCAAGGACC CCTTGGAGGG CCAGCGGCAT 
TGCTGTGGAA TTGCTCAAAT GCATGAGCAT AGCTCCCTGG GTCATGCGGA CCTGGACGCC 
CTGCAGCAGA ACCCTCAACC CCTCATCTTC CACATCGAGA TGCTGAAGGT GGAGAGCCCT 
GGCACCTACC AGCAGGACCC ATGGGCAATG ACAGATGAGG AGAAAGCAAA GGCAGTACCA 
CTCATCCACC AAGAGGGCAA CCGCTTATAC CGTGAGGGGC AGGTGAAGGA GGCTGCTGCC 
AAGTACTACG ATGCCATTGC CTGCCTCAAG AACCTGCAGA TGAAGGAGCA GCCTGGATCA 
CCCGACTGGA TCCAGTTGGA CTTGCAGATC ACACCACTGC TACTCAACTA TTGCCAGTGC 
AAGCTGGTGG CTCAGGAGTA CTATGAGGTG CTGGATCACT GCTCCTCCAT CCTCAACAAG 
TATGATGACA ATGTCAAGGC TTACTTCAAG CGGGGTAAGG CCCATGCTGC TGTGTGGAAT 
GCCCAGGAGG CCCAGGCTGA CTTTGCCAAG GTGTTGGAGC TCGACCCTGC CCTGGCGCCT 
GTGGTAAGCA GAGAGCTGCG GGCCCTGGAG GCACGGATCC GGCAGAAGGA TGAGGAGGAC 
AAAGCCCGCT TCCGGGGCAT CTTTTCCCAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line.
PloS one11(10)e0164131(2016)
Fukuda T,Tanaka T,Hamaguchi Y,Kawanami T,Nomiyama T,Yanase T

Aip regulates cAMP signalling and GH secretion in GH3 cells.
Endocrine-related cancer20(4)495-505(2013 Aug)
Formosa R,Xuereb-Anastasi A,Vassallo J

Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor.
The Journal of biological chemistry282(18)13656-63(2007 May)
de Oliveira SK,Hoffmeister M,Gambaryan S,M?ller-Esterl W,Guimaraes JA,Smolenski AP

Redefining the role of the endogenous XAP2 and C-terminal hsp70-interacting protein on the endogenous Ah receptors expressed in mouse and rat cell lines.
The Journal of biological chemistry280(39)33346-56(2005 Sep)
Pollenz RS,Dougherty EJ

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.
Molecular and cellular biology24(9)3782-93(2004 May)
Marschang P,Brich J,Weeber EJ,Sweatt JD,Shelton JM,Richardson JA,Hammer RE,Herz J

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Aip cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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