Cadps cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cadps
Entrez Gene ID	26989
Full Name	calcium dependent secretion activator
Synonyms	Caps,Caps1,Caps2
General protein information	Preferred Names calcium dependent secretion activator Names calcium-dependent secretion activator 1 CAPS-1 Ca++-dependent secretion activator Ca2+ dependent secretion activator Ca2+-dependent activator protein Ca<2+-dependent activator protein for secretion calcium-dependent activator protein for secretion 1 rCAPS
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p15
Summary	plays a role in calcium ion-dependent regulated exocytosis in neuroendocrine cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013219.1	NP_037351.1	calcium-dependent secretion activator 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CADPS	XP_001174527.1
Danio rerio (zebrafish)	cadpsa	XP_005155902.1
Mus musculus (house mouse)	Cadps	NP_001036082.1
Rattus norvegicus (Norway rat)	Cadps	NP_037351.1
Gallus gallus (chicken)	CADPS	XP_001233835.1
Drosophila melanogaster (fruit fly)	Caps	NP_001245439.1
Xenopus tropicalis (tropical clawed frog)	cadps	NP_001096182.1
Homo sapiens (human)	CADPS	NP_003707.2
Canis lupus familiaris (dog)	CADPS	XP_848403.2
Caenorhabditis elegans (roundworm)	unc-31	NP_001255664.1
Bos taurus (cattle)	CADPS	NP_001069488.1
Danio rerio (zebrafish)	cadpsb	XP_005166165.1
	LOC703270	XP_001091569.2

Gene Ontology
Bibliography

Related articles in PubMed

The Vesicle Priming Factor CAPS Functions as a Homodimer via C2 Domain Interactions to Promote Regulated Vesicle Exocytosis.
Petrie M, Esquibel J, Kabachinski G, Maciuba S, Takahashi H, Edwardson JM, Martin TF
The Journal of biological chemistry291(40)21257-21270(2016 Sep)

Resident CAPS on dense-core vesicles docks and primes vesicles for fusion.
Kabachinski G, Kielar-Grevstad DM, Zhang X, James DJ, Martin TF
Molecular biology of the cell27(4)654-68(2016 Feb)

CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons.
Farina M, van de Bospoort R, He E, Persoon CM, van Weering JR, Broeke JH, Verhage M, Toonen RF
eLife4(2015 Feb)

The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones.
Imig C, Min SW, Krinner S, Arancillo M, Rosenmund C, S?dhof TC, Rhee J, Brose N, Cooper BH
Neuron84(2)416-31(2014 Oct)

CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis.
Kabachinski G, Yamaga M, Kielar-Grevstad DM, Bruinsma S, Martin TF
Molecular biology of the cell25(4)508-21(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The unique tandem C2-PH domain of CAPS may serve as a PI(4,5)P2-triggered switch for dimerization. CAPS dimerization may be coupled to oligomeric SNARE complex assembly for vesicle docking and priming.
Title: The Vesicle Priming Factor CAPS Functions as a Homodimer via C2 Domain Interactions to Promote Regulated Vesicle Exocytosis.

results indicate that dense-core vesicles carry CAPS to sites of exocytosis, where CAPS promotes vesicle docking and fusion competence, probably by initiating SNARE complex assembly.
Title: Resident CAPS on dense-core vesicles docks and primes vesicles for fusion.

Transport vesicle fusion into PIP2-rich membrane domains is facilitated by sequential PIP2-dependent activation of CAPS and PIP2-dependent recruitment of Munc13.
Title: CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis.

CAPS1 binds to the full-length of cytoplasmic syntaxin-1 with preference to its "open" conformation, whereas Munc13-1 binds to the first 80 N-terminal residues of syntaxin-1.
Title: Calcium-dependent activator protein for secretion 1 (CAPS1) binds to syntaxin-1 in a distinct mode from Munc13-1.

The results show that Munc13 homology domain-1 is a SNARE-binding domain and that SNARE protein binding is essential for CAPS function in dense-core vesicle exocytosis.
Title: Munc13 homology domain-1 in CAPS/UNC31 mediates SNARE binding required for priming vesicle exocytosis.

The following Cadps gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cadps cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42440	NM_013219.1 Latest version!	Rattus norvegicus calcium dependent secretion activator (Cadps), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$643.30 $919.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cadps ( NM_013219.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037351.1 Rattus norvegicus calcium dependent secretion activator (Cadps), mRNA.

Price & Availability↑

CloneID	ORa42440
Clone ID Related Accession (Same CDS sequence)	NM_013219.1
Accession Version	NM_013219.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3870bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	calcium-dependent secretion activator 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U16802.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U16802.1 [ECO:0000332] ##Evidence-Data-END##

ATGCTGGACC CTTCGTCCAG CGAAGAGGAA TCGGATGAGA TCCTGGAAGA GGAGAGCGGC 
AAGGAGGTGC TGGGCTCGGC CGCGTCCGGA GCGCGCCTGT CTCCAAGCCG CACCAACGAG 
GGCTCGGCGG GCAGCGCCGG CATGGGGGGC AGTGGCGCCG GGGCCGGGGT GGGCGCCGGC 
GGCGGTGGGG GTAGCGGCGC GAGCAGCGGC GGCGGGGCCG GGGGGCTGCA GCCCAGCAGC 
CGCGCCGGCG GCGGCCGGCC CTCCAGCCCC AGCCCGTCGG TGGTGAGCGA GAAGGAGAAG 
GAAGAGTTGG AGCGGCTGCA GAAGGAAGAG GAGGAGAGGA AGAAGAGGCT GCAGCTGTAC 
GTGTTCGTGA TGCGCTGCAT TGCCTACCCC TTCAACGCCA AGCAGCCCAC CGACATGGCT 
CGGCGGCCAA GGAAGATCAG CAAACAGCAG CTGCAGACTG TCAAGGACCG ATTCCAGGCT 
TTCCTCAATG GGGAGACCCA AATCGTGGCA GATGAAGCCT TTATGAATGC TGTCCAGAGC 
TACTATGAGG TGTTTCTCAA GAGTGACCGT GTGGCCCGCA TGGTACAGAG TGGGGGCTGC 
TCAGCCAACG ACTCTCGGGA GGTCTTCAAG AAACACATCG AGAAGAGGGT ACGCAGCCTA 
CCTGAGATTG ATGGCCTCAG CAAGGAGACT GTGCTAAGCT CCTGGATGGC TAAGTTTGAC 
GCCATCTACC GTGGTGAGGA GGACCCCAGG AAGCAGCAAG CCCGGATGAC AGCCAGTGCA 
GCTTCTGAGT TGATTCTGAG CAAGGAACAG CTCTATGAGA TGTTCCAGAA CATTCTTGGG 
ATCAAGAAAT TTGAACATCA ACTCCTATAT AATGCGTGTC AGCTGGACAA TCCAGATGAG 
CAGGCAGCCC AGATCAGACG AGAGCTGGAC GGACGTCTCC AAATGGCAGA CCAAATAGCC 
AGGGAACGCA AATTTCCTAA GTTCGTATCC AAAGAAATGG AAAATATGTA CATCGAGGAG 
CTGAAGTCCT CCGTCAACCT ACTCATGGCC AACTTGGAGA GCATGCCGGT GTCCAAGGGT 
GGAGAGTTCA AGCTGCAGAA ACTGAAACGC AGTCACAACG CGTCCATCAT TGACATGGGT 
GAGGAGAGCG AGAACCAGCT GTCCAAGTCG GATGTCCTGC TGTCCTTCTC CTTGGAGGTT 
GTCATCATGG AAGTCCAAGG CCTTAAGTCC TTGGCTCCAA ACCGAATCGT GTACTGCACA 
ATGGAGGTGG AGGGTGGAGA GAAACTTCAG ACTGATCAAG CAGAGGCTTC TAAACCAACC 
TGGGGCACTC AAGGCGACTT CTCTACAACC CACGCGCTGC CAGCTGTTAA AGTAAAGCTA 
TTCACAGAGA GCACTGGTGT CCTGGCCTTG GAAGACAAGG AACTCGGGCG GGTTATCCTC 
CATCCCACCC CAAACAGCCC CAAACAATCC GAGTGGCACA AAATGACAGT CTCCAAAAAC 
TGCCCCGATC AAGACCTCAA AATCAAACTC GCTGTCCGAA TGGATAAGCC TCAAAACATG 
AAGCACTCTG GGTACTTATG GACCATTGGT AAGAATGTGT GGAAGAGGTG GAAGAAAAGG 
TTCTTTGTGT TGGTGCAGGT CAGCCAGTAC ACTTTTGCCA TGTGCAGCTA TCGAGAAAAG 
AAAGCAGAAC CTCAGGAACT CCTACAGCTG GATGGCTACA CCGTGGATTA CACCGACCCT 
CAGCCAGGTT TGGAGGGTGG CCGAGCCTTC TTCAATGCAG TCAAAGAAGG AGACACGGTG 
ATATTTGCCA GTGACGATGA GCAAGATCGA ATCCTGTGGG TCCAAGCTAT GTACAGGGCC 
ACCGGGCAGT CGCACAAACC TGTGCCCCCT ACCCAGGTGC AGAAGCTCAA GCCAAGGGCG 
GAAACGTGCC TCAGCATGGA TGCCCCCATC TCCCAGTTTT ACGCAGATAG AGCTCAAAAG 
CATGGCATGG ATGAATTTAT CTCGTCCAAC CCCTGTAACT TTGACCACGC TTCCCTCTTT 
GAGATGGTAC AGCGGCTGAC TTTGGATCAC AGACTAAACG ATTCCTATTC TTGCCTGGGC 
TGGTTCAGTC CTGGCCAGGT GTTTGTGTTA GACGAGTACT GCGCTCGGAA TGGAGTCCGA 
GGATGTCATC GGCATCTCTG TTACCTTAGA GACTTGCTGG AACGGGCAGA AAATGGCGCC 
ATGATCGACC CCACGCTTCT TCATTACAGC TTTGCCTTCT GCGCATCCCA TGTCCACGGG 
AACAGGCCTG ATGGAATCGG AACTGTGACT GTTGAAGAAA AAGAGCGCTT TGAAGAAATC 
AAAGAGAGAC TCCGAGTTCT GCTGGAAAAT CAAATTACAC ATTTCAGGTA CTGCTTTCCG 
TTTGGTCGAC CTGAAGGTGC TTTGAAAGCG ACTCTCTCAC TTTTGGAACG GGTTTTGATG 
AAAGATATTG TCACTCCAGT ACCCCAAGAG GAGGTCAAAA CTGTCATCCG TAAATGCCTA 
GAGCAGGCTG CTCTAGTCAA CTACTCTCGC CTATCTGAGT ATGCCAAAAT CGAAGAAAAT 
GTAGGCCGCT TAATCACTCC CGCCAAAAAG CTCGAAGACA CAATCCGTCT TGCTGAACTA 
GTCATTGAAG TGCTGCAACA AAACGAAGAG CACCACGCCG AGGCCTTTGC GTGGTGGTCA 
GACTTAATGG TGGAGCACGC GGAGACGTTC CTGTCACTCT TTGCAGTGGA CATGGATGCA 
GCATTAGAGG TGCAACCCCC AGACACGTGG GACAGTTTCC CACTCTTCCA GCTGCTGAAT 
GACTTTCTCC GTACAGACTA TAACTTGTGC AATGGAAAGT TTCACAAACA CCTGCAGGAT 
CTGTTCGCCC CACTCGTTGT TAGATACGTG GATCTGATGG AGTCCTCAAT TGCACAATCT 
ATCCACAGGG GCTTTGAGCG GGAGTCATGG GAACCAGTCA ATAACGGATC GGGTACATCA 
GAAGATTTGT TCTGGAAACT TGATGCCCTT CAGACTTTCA TCCGTGACCT ACACTGGCCT 
GAGGAAGAGT TTGGAAAGCA CTTAGAGCAG CGGCTAAAAC TAATGGCAAG CGACATGATT 
GAGTCCTGCG TCAAGAGAAC CAGGATTGCA TTTGAAGTTA AGCTGCAAAA AACCAGTCGA 
TCAACAGATT TTCGAGTCCC ACAGTCAATA TGCACCATGT TTAATGTTAT GGTTGATGCC 
AAAGCTCAAT CAACAAAACT TTGCAGCATG GAAATGGGCC AGGAGCATCA ATACCATTCA 
AAAATAGACG AACTAATTGA AGAAACCGTT AAGGAAATGA TCACACTCTT GGTGGCAAAG 
TTTGTAACTA TATTGGAAGG CGTACTGGCA AAGTTATCCA GATACGACGA GGGGACTTTG 
TTTTCTTCGT TTCTGTCATT TACGGTGAAG GCGGCATCTA AGTATGTGGA CGTACCTAAA 
CCCGGGATGG ATGTGGCCGA CGCCTACGTG ACTTTCGTCC GCCACTCTCA GGATGTCCTT 
CGTGATAAGG TCAATGAGGA GATGTATATA GAAAGGTTAT TTGATCAATG GTACAACAGC 
TCCATGAACG TCATCTGCAC CTGGCTGACC GACCGGATGG ACCTCCAGCT TCACATTTAT 
CAGCTGAAAA CACTAATTAG GATGGTAAAG AAAACCTACA GAGATTTCCG ATTGCAAGGG 
GTCCTGGATT CCACCTTAAA CAGCAAGACC TATGAGACCA TTCGAAATCG GCTCACTGTA 
GAGGAACGTA CCGCGTCCGT GAGTGAGGGA GGGGGCTTGC AAGGCATCAG CATGAAGGAC 
AGTGACGAGG AAGATGAAGA AGACGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037351.1
CDS	62..3931
Translation	MLDPSSSEEESDEILEEESGKEVLGSAASGARLSPSRTNEGSAGSAGMGGSGAGAGVGAGGGGGSGASSGGGAGGLQPSSRAGGGRPSSPSPSVVSEKEKEELERLQKEEEERKKRLQLYVFVMRCIAYPFNAKQPTDMARRPRKISKQQLQTVKDRFQAFLNGETQIVADEAFMNAVQSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVRSLPEIDGLSKETVLSSWMAKFDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGRLQMADQIARERKFPKFVSKEMENMYIEELKSSVNLLMANLESMPVSKGGEFKLQKLKRSHNASIIDMGEESENQLSKSDVLLSFSLEVVIMEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEASKPTWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQSEWHKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWTIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTDPQPGLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLKPRAETCLSMDAPISQFYADRAQKHGMDEFISSNPCNFDHASLFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVHGNRPDGIGTVTVEEKERFEEIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYSRLSEYAKIEENVGRLITPAKKLEDTIRLAELVIEVLQQNEEHHAEAFAWWSDLMVEHAETFLSLFAVDMDAALEVQPPDTWDSFPLFQLLNDFLRTDYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVNNGSGTSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSRSTDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYDEGTLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQWYNSSMNVICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQGVLDSTLNSKTYETIRNRLTVEERTASVSEGGGLQGISMKDSDEEDEEDD

Target ORF information:

RefSeq Version	NM_013219.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus calcium dependent secretion activator (Cadps), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013219.1

ORF Insert Sequence:

ATGCTGGACC CTTCGTCCAG CGAAGAGGAA TCGGATGAGA TCCTGGAAGA GGAGAGCGGC 
AAGGAGGTGC TGGGCTCGGC CGCGTCCGGA GCGCGCCTGT CTCCAAGCCG CACCAACGAG 
GGCTCGGCGG GCAGCGCCGG CATGGGGGGC AGTGGCGCCG GGGCCGGGGT GGGCGCCGGC 
GGCGGTGGGG GTAGCGGCGC GAGCAGCGGC GGCGGGGCCG GGGGGCTGCA GCCCAGCAGC 
CGCGCCGGCG GCGGCCGGCC CTCCAGCCCC AGCCCGTCGG TGGTGAGCGA GAAGGAGAAG 
GAAGAGTTGG AGCGGCTGCA GAAGGAAGAG GAGGAGAGGA AGAAGAGGCT GCAGCTGTAC 
GTGTTCGTGA TGCGCTGCAT TGCCTACCCC TTCAACGCCA AGCAGCCCAC CGACATGGCT 
CGGCGGCCAA GGAAGATCAG CAAACAGCAG CTGCAGACTG TCAAGGACCG ATTCCAGGCT 
TTCCTCAATG GGGAGACCCA AATCGTGGCA GATGAAGCCT TTATGAATGC TGTCCAGAGC 
TACTATGAGG TGTTTCTCAA GAGTGACCGT GTGGCCCGCA TGGTACAGAG TGGGGGCTGC 
TCAGCCAACG ACTCTCGGGA GGTCTTCAAG AAACACATCG AGAAGAGGGT ACGCAGCCTA 
CCTGAGATTG ATGGCCTCAG CAAGGAGACT GTGCTAAGCT CCTGGATGGC TAAGTTTGAC 
GCCATCTACC GTGGTGAGGA GGACCCCAGG AAGCAGCAAG CCCGGATGAC AGCCAGTGCA 
GCTTCTGAGT TGATTCTGAG CAAGGAACAG CTCTATGAGA TGTTCCAGAA CATTCTTGGG 
ATCAAGAAAT TTGAACATCA ACTCCTATAT AATGCGTGTC AGCTGGACAA TCCAGATGAG 
CAGGCAGCCC AGATCAGACG AGAGCTGGAC GGACGTCTCC AAATGGCAGA CCAAATAGCC 
AGGGAACGCA AATTTCCTAA GTTCGTATCC AAAGAAATGG AAAATATGTA CATCGAGGAG 
CTGAAGTCCT CCGTCAACCT ACTCATGGCC AACTTGGAGA GCATGCCGGT GTCCAAGGGT 
GGAGAGTTCA AGCTGCAGAA ACTGAAACGC AGTCACAACG CGTCCATCAT TGACATGGGT 
GAGGAGAGCG AGAACCAGCT GTCCAAGTCG GATGTCCTGC TGTCCTTCTC CTTGGAGGTT 
GTCATCATGG AAGTCCAAGG CCTTAAGTCC TTGGCTCCAA ACCGAATCGT GTACTGCACA 
ATGGAGGTGG AGGGTGGAGA GAAACTTCAG ACTGATCAAG CAGAGGCTTC TAAACCAACC 
TGGGGCACTC AAGGCGACTT CTCTACAACC CACGCGCTGC CAGCTGTTAA AGTAAAGCTA 
TTCACAGAGA GCACTGGTGT CCTGGCCTTG GAAGACAAGG AACTCGGGCG GGTTATCCTC 
CATCCCACCC CAAACAGCCC CAAACAATCC GAGTGGCACA AAATGACAGT CTCCAAAAAC 
TGCCCCGATC AAGACCTCAA AATCAAACTC GCTGTCCGAA TGGATAAGCC TCAAAACATG 
AAGCACTCTG GGTACTTATG GACCATTGGT AAGAATGTGT GGAAGAGGTG GAAGAAAAGG 
TTCTTTGTGT TGGTGCAGGT CAGCCAGTAC ACTTTTGCCA TGTGCAGCTA TCGAGAAAAG 
AAAGCAGAAC CTCAGGAACT CCTACAGCTG GATGGCTACA CCGTGGATTA CACCGACCCT 
CAGCCAGGTT TGGAGGGTGG CCGAGCCTTC TTCAATGCAG TCAAAGAAGG AGACACGGTG 
ATATTTGCCA GTGACGATGA GCAAGATCGA ATCCTGTGGG TCCAAGCTAT GTACAGGGCC 
ACCGGGCAGT CGCACAAACC TGTGCCCCCT ACCCAGGTGC AGAAGCTCAA GCCAAGGGCG 
GAAACGTGCC TCAGCATGGA TGCCCCCATC TCCCAGTTTT ACGCAGATAG AGCTCAAAAG 
CATGGCATGG ATGAATTTAT CTCGTCCAAC CCCTGTAACT TTGACCACGC TTCCCTCTTT 
GAGATGGTAC AGCGGCTGAC TTTGGATCAC AGACTAAACG ATTCCTATTC TTGCCTGGGC 
TGGTTCAGTC CTGGCCAGGT GTTTGTGTTA GACGAGTACT GCGCTCGGAA TGGAGTCCGA 
GGATGTCATC GGCATCTCTG TTACCTTAGA GACTTGCTGG AACGGGCAGA AAATGGCGCC 
ATGATCGACC CCACGCTTCT TCATTACAGC TTTGCCTTCT GCGCATCCCA TGTCCACGGG 
AACAGGCCTG ATGGAATCGG AACTGTGACT GTTGAAGAAA AAGAGCGCTT TGAAGAAATC 
AAAGAGAGAC TCCGAGTTCT GCTGGAAAAT CAAATTACAC ATTTCAGGTA CTGCTTTCCG 
TTTGGTCGAC CTGAAGGTGC TTTGAAAGCG ACTCTCTCAC TTTTGGAACG GGTTTTGATG 
AAAGATATTG TCACTCCAGT ACCCCAAGAG GAGGTCAAAA CTGTCATCCG TAAATGCCTA 
GAGCAGGCTG CTCTAGTCAA CTACTCTCGC CTATCTGAGT ATGCCAAAAT CGAAGAAAAT 
GTAGGCCGCT TAATCACTCC CGCCAAAAAG CTCGAAGACA CAATCCGTCT TGCTGAACTA 
GTCATTGAAG TGCTGCAACA AAACGAAGAG CACCACGCCG AGGCCTTTGC GTGGTGGTCA 
GACTTAATGG TGGAGCACGC GGAGACGTTC CTGTCACTCT TTGCAGTGGA CATGGATGCA 
GCATTAGAGG TGCAACCCCC AGACACGTGG GACAGTTTCC CACTCTTCCA GCTGCTGAAT 
GACTTTCTCC GTACAGACTA TAACTTGTGC AATGGAAAGT TTCACAAACA CCTGCAGGAT 
CTGTTCGCCC CACTCGTTGT TAGATACGTG GATCTGATGG AGTCCTCAAT TGCACAATCT 
ATCCACAGGG GCTTTGAGCG GGAGTCATGG GAACCAGTCA ATAACGGATC GGGTACATCA 
GAAGATTTGT TCTGGAAACT TGATGCCCTT CAGACTTTCA TCCGTGACCT ACACTGGCCT 
GAGGAAGAGT TTGGAAAGCA CTTAGAGCAG CGGCTAAAAC TAATGGCAAG CGACATGATT 
GAGTCCTGCG TCAAGAGAAC CAGGATTGCA TTTGAAGTTA AGCTGCAAAA AACCAGTCGA 
TCAACAGATT TTCGAGTCCC ACAGTCAATA TGCACCATGT TTAATGTTAT GGTTGATGCC 
AAAGCTCAAT CAACAAAACT TTGCAGCATG GAAATGGGCC AGGAGCATCA ATACCATTCA 
AAAATAGACG AACTAATTGA AGAAACCGTT AAGGAAATGA TCACACTCTT GGTGGCAAAG 
TTTGTAACTA TATTGGAAGG CGTACTGGCA AAGTTATCCA GATACGACGA GGGGACTTTG 
TTTTCTTCGT TTCTGTCATT TACGGTGAAG GCGGCATCTA AGTATGTGGA CGTACCTAAA 
CCCGGGATGG ATGTGGCCGA CGCCTACGTG ACTTTCGTCC GCCACTCTCA GGATGTCCTT 
CGTGATAAGG TCAATGAGGA GATGTATATA GAAAGGTTAT TTGATCAATG GTACAACAGC 
TCCATGAACG TCATCTGCAC CTGGCTGACC GACCGGATGG ACCTCCAGCT TCACATTTAT 
CAGCTGAAAA CACTAATTAG GATGGTAAAG AAAACCTACA GAGATTTCCG ATTGCAAGGG 
GTCCTGGATT CCACCTTAAA CAGCAAGACC TATGAGACCA TTCGAAATCG GCTCACTGTA 
GAGGAACGTA CCGCGTCCGT GAGTGAGGGA GGGGGCTTGC AAGGCATCAG CATGAAGGAC 
AGTGACGAGG AAGATGAAGA AGACGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Vesicle Priming Factor CAPS Functions as a Homodimer via C2 Domain Interactions to Promote Regulated Vesicle Exocytosis.
The Journal of biological chemistry291(40)21257-21270(2016 Sep)
Petrie M,Esquibel J,Kabachinski G,Maciuba S,Takahashi H,Edwardson JM,Martin TF

Resident CAPS on dense-core vesicles docks and primes vesicles for fusion.
Molecular biology of the cell27(4)654-68(2016 Feb)
Kabachinski G,Kielar-Grevstad DM,Zhang X,James DJ,Martin TF

CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons.
eLife4(2015 Feb)
Farina M,van de Bospoort R,He E,Persoon CM,van Weering JR,Broeke JH,Verhage M,Toonen RF

The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones.
Neuron84(2)416-31(2014 Oct)
Imig C,Min SW,Krinner S,Arancillo M,Rosenmund C,S?dhof TC,Rhee J,Brose N,Cooper BH

CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis.
Molecular biology of the cell25(4)508-21(2014 Feb)
Kabachinski G,Yamaga M,Kielar-Grevstad DM,Bruinsma S,Martin TF

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Cadps cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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