Rheb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rheb
Entrez Gene ID	26954
Full Name	Ras homolog, mTORC1 binding
General protein information	Preferred Names Ras homolog, mTORC1 binding Names GTP-binding protein Rheb Ras homolog enriched in brain
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q11
Summary	may play a role in synaptic plasticity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013216.1	NP_037348.1	GTP-binding protein Rheb

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RHEB	XP_519513.1
	RHEB	XP_001104682.1
Canis lupus familiaris (dog)	RHEB	XP_532768.1
Schizosaccharomyces pombe (fission yeast)	rhb1	NP_595194.1
Homo sapiens (human)	RHEB	NP_005605.1
Bos taurus (cattle)	RHEB	NP_001026934.1
Mus musculus (house mouse)	Rheb	NP_444305.2
Caenorhabditis elegans (roundworm)	rheb-1	NP_499079.1
Saccharomyces cerevisiae (baker's yeast)	RHB1	NP_009956.2
Magnaporthe oryzae (rice blast fungus)	MGG_06914	XP_003709648.1
Neurospora crassa	NCU01444	XP_955966.1
Danio rerio (zebrafish)	zgc:73144	NP_957023.1
Kluyveromyces lactis	KLLA0A11330g	XP_451492.1
Xenopus tropicalis (tropical clawed frog)	rheb	NP_001015922.1
Rattus norvegicus (Norway rat)	Rheb	NP_037348.1
Gallus gallus (chicken)	RHEB	XP_001232988.3

Gene Ontology
Bibliography

Related articles in PubMed

Trillium tschonoskii maxim saponin mitigates D-galactose-induced brain aging of rats through rescuing dysfunctional autophagy mediated by Rheb-mTOR signal pathway.
Wang L, Du J, Zhao F, Chen Z, Chang J, Qin F, Wang Z, Wang F, Chen X, Chen N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie98516-522(2017 Dec)

Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway.
Meng W, Liang X, Chen H, Luo H, Bai J, Li G, Zhang Q, Xiao T, He S, Zhang Y, Xu Z, Xiao B, Liu M, Hu F, Liu F
Diabetes66(5)1198-1213(2017 05)

Influence of miR-155 on Cell Apoptosis in Rats with Ischemic Stroke: Role of the Ras Homolog Enriched in Brain (Rheb)/mTOR Pathway.
Xing G, Luo Z, Zhong C, Pan X, Xu X
Medical science monitor : international medical journal of experimental and clinical research225141-5153(2016 Dec)

Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder.
F?cking M, Dicker P, Lopez LM, Hryniewiecka M, Wynne K, English JA, Cagney G, Cotter DR
Translational psychiatry6(11)e959(2016 11)

Panaxatriol derived from ginseng augments resistance exercised-induced protein synthesis via mTORC1 signaling in rat skeletal muscle.
Takamura Y, Makanae Y, Ato S, Yoshii N, Kido K, Nomura M, Uchiyama A, Shiozawa N, Fujita S
Nutrition research (New York, N.Y.)36(11)1193-1201(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Inhibition of miR-155 may play protective roles in ischemic stroke by phosphorylating S6K through the Rheb/mTOR pathway.
Title: Influence of miR-155 on Cell Apoptosis in Rats with Ischemic Stroke: Role of the Ras Homolog Enriched in Brain (Rheb)/mTOR Pathway.

After spinal cord injury, expressing constitutively active Rheb increased the number of axons, but not the number of neurons, that projected into the peripheral nerve graft, indicative of augmented sprouting.
Title: Expressing Constitutively Active Rheb in Adult Neurons after a Complete Spinal Cord Injury Enhances Axonal Regeneration beyond a Chondroitinase-Treated Glial Scar.

Rheb activation disrupts neuronal spine synapse formation via syntenin accumulation in tuberous sclerosis complex.
Title: Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex.

Suggest alteration of protein prenylation in cardiac hypertrophy induces cardiomyocyte hypertrophy through Rheb-mTORC1 signalling and leads to chronic heart failure.
Title: The alteration of protein prenylation induces cardiomyocyte hypertrophy through Rheb-mTORC1 signalling and leads to chronic heart failure.

In conclusion, dendritic spine abnormalities in TSC neurons may be caused through activation of Rheb, but not through of mTORC1.
Title: Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex.

The following Rheb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rheb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02335	NM_013216.1 Latest version!	Rattus norvegicus Ras homolog, mTORC1 binding (Rheb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rheb ( NM_013216.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037348.1 Rattus norvegicus Ras homolog, mTORC1 binding (Rheb), mRNA.

Price & Availability↑

CloneID	ORa02335
Clone ID Related Accession (Same CDS sequence)	NM_013216.1
Accession Version	NM_013216.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	GTP-binding protein Rheb
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U08227.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U08227.1, BC088857.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCTCAGT CCAAGTCCCG GAAGATCGCC ATCCTGGGCT ATCGGTCTGT GGGAAAGTCC 
TCATTGACAA TTCAGTTTGT TGAAGGTCAA TTTGTTGATT CCTACGATCC AACCATAGAA 
AACACATTCA CCAAGCTGAT CACAGTAAAT GGGCAAGAGT ATCATCTTCA GCTTGTAGAC 
ACAGCAGGGC AGGATGAATA TTCCATTTTT CCTCAGACAT ACTCCATAGA TATTAATGGT 
TATATTCTTG TGTATTCTGT TACATCAATC AAAAGCTTTG AAGTAATTAA AGTTATCCAC 
GGCAAGCTGT TGGACATGGT GGGGAAAGTG CAGATACCGA TTATGTTAGT CGGAAATAAG 
AAGGACCTGC ATATGGAAAG GGTGATCAGT TATGAAGAAG GAAAGGCTTT GGCAGAATCT 
TGGAATGCAG CTTTTTTGGA ATCTTCTGCA AAAGAAAATC AGACTGCTGT GGATGTTTTT 
AGAAGGATAA TTTTGGAAGC AGAAAAGATT GACGGAGCGG CTTCACAAGG GAAGTCTTCG 
TGCTCGGTGA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037348.1
CDS	124..678
Translation	MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKIDGAASQGKSSCSVM

Target ORF information:

RefSeq Version	NM_013216.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Ras homolog, mTORC1 binding (Rheb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013216.1

ORF Insert Sequence:

ATGCCTCAGT CCAAGTCCCG GAAGATCGCC ATCCTGGGCT ATCGGTCTGT GGGAAAGTCC 
TCATTGACAA TTCAGTTTGT TGAAGGTCAA TTTGTTGATT CCTACGATCC AACCATAGAA 
AACACATTCA CCAAGCTGAT CACAGTAAAT GGGCAAGAGT ATCATCTTCA GCTTGTAGAC 
ACAGCAGGGC AGGATGAATA TTCCATTTTT CCTCAGACAT ACTCCATAGA TATTAATGGT 
TATATTCTTG TGTATTCTGT TACATCAATC AAAAGCTTTG AAGTAATTAA AGTTATCCAC 
GGCAAGCTGT TGGACATGGT GGGGAAAGTG CAGATACCGA TTATGTTAGT CGGAAATAAG 
AAGGACCTGC ATATGGAAAG GGTGATCAGT TATGAAGAAG GAAAGGCTTT GGCAGAATCT 
TGGAATGCAG CTTTTTTGGA ATCTTCTGCA AAAGAAAATC AGACTGCTGT GGATGTTTTT 
AGAAGGATAA TTTTGGAAGC AGAAAAGATT GACGGAGCGG CTTCACAAGG GAAGTCTTCG 
TGCTCGGTGA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Trillium tschonoskii maxim saponin mitigates D-galactose-induced brain aging of rats through rescuing dysfunctional autophagy mediated by Rheb-mTOR signal pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie98516-522(2017 Dec)
Wang L,Du J,Zhao F,Chen Z,Chang J,Qin F,Wang Z,Wang F,Chen X,Chen N

Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway.
Diabetes66(5)1198-1213(2017 05)
Meng W,Liang X,Chen H,Luo H,Bai J,Li G,Zhang Q,Xiao T,He S,Zhang Y,Xu Z,Xiao B,Liu M,Hu F,Liu F

Influence of miR-155 on Cell Apoptosis in Rats with Ischemic Stroke: Role of the Ras Homolog Enriched in Brain (Rheb)/mTOR Pathway.
Medical science monitor : international medical journal of experimental and clinical research225141-5153(2016 Dec)
Xing G,Luo Z,Zhong C,Pan X,Xu X

Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder.
Translational psychiatry6(11)e959(2016 11)
F?cking M,Dicker P,Lopez LM,Hryniewiecka M,Wynne K,English JA,Cagney G,Cotter DR

Panaxatriol derived from ginseng augments resistance exercised-induced protein synthesis via mTORC1 signaling in rat skeletal muscle.
Nutrition research (New York, N.Y.)36(11)1193-1201(2016 Nov)
Takamura Y,Makanae Y,Ato S,Yoshii N,Kido K,Nomura M,Uchiyama A,Shiozawa N,Fujita S

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Rheb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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