Has3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Has3
Entrez Gene ID	266805
Full Name	hyaluronan synthase 3
General protein information	Preferred Names hyaluronan synthase 3 Names hyaluronan synthase 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19q12
Summary	involved in the synthesis of hyaluronan, a major extracellular matrix molecule [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006255561.3	XP_006255623.1	hyaluronan synthase 3 isoform X1
NM_172319.1	NP_758822.1	hyaluronan synthase 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	HAS3	NP_001186209.1
Bos taurus (cattle)	HAS3	NP_001179796.1
Mus musculus (house mouse)	Has3	NP_032243.2
Xenopus tropicalis (tropical clawed frog)	has3	XP_002936057.2
Pan troglodytes (chimpanzee)	HAS3	XP_511060.2
	HAS3	NP_001104247.1
Canis lupus familiaris (dog)	HAS3	XP_546859.2
Danio rerio (zebrafish)	has3	NP_775327.1
Gallus gallus (chicken)	HAS3	XP_425137.4
Rattus norvegicus (Norway rat)	Has3	NP_758822.1

Gene Ontology
Bibliography

Related articles in PubMed

Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3.
Bart G, Vico NO, Hassinen A, Pujol FM, Deen AJ, Ruusala A, Tammi RH, Squire A, Heldin P, Kellokumpu S, Tammi MI
The Journal of biological chemistry290(18)11479-90(2015 May)

Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes.
T?rr?nen K, Nikunen K, K?rn? R, Tammi M, Tammi R, Rilla K
Histochemistry and cell biology141(1)17-31(2014 Jan)

Low dose ultraviolet B irradiation increases hyaluronan synthesis in epidermal keratinocytes via sequential induction of hyaluronan synthases Has1-3 mediated by p38 and Ca2+/calmodulin-dependent protein kinase II (CaMKII) signaling.
Rauhala L, H?m?l?inen L, Salonen P, Bart G, Tammi M, Pasonen-Sepp?nen S, Tammi R
The Journal of biological chemistry288(25)17999-8012(2013 Jun)

The enzymatic degradation of hyaluronan is associated with disease progression in experimental pulmonary hypertension.
Ormiston ML, Slaughter GR, Deng Y, Stewart DJ, Courtman DW
American journal of physiology. Lung cellular and molecular physiology298(2)L148-57(2010 Feb)

Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model.
Mrabat H, Beagle J, Hang Z, Garg HG, Hales CA, Quinn DA
Lung187(4)233-9(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that p38 and Ca(2+)/calmodulin-dependent protein kinase II pathways were found to be involved in the UVB-induced up-regulation of Has2 and Has3 expression.
Title: Low dose ultraviolet B irradiation increases hyaluronan synthesis in epidermal keratinocytes via sequential induction of hyaluronan synthases Has1-3 mediated by p38 and Ca2+/calmodulin-dependent protein kinase II (CaMKII) signaling.

Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model.
Title: Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model.

belongs to the targets of keratinocyte growth factor in keratinocytes, and support the idea that enhanced hyaluronan synthesis acts an effector for the migratory response of keratinocytes in wound healing
Title: Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3.

Epidermal hyaluronan synthesis, controlled by epidermal growth factor and transforming growth factor beta through changes in expression of Has2 and Has3, correlates with epidermal proliferation, thickness, and differentiation.
Title: EGF upregulates, whereas TGF-beta downregulates, the hyaluronan synthases Has2 and Has3 in organotypic keratinocyte cultures: correlations with epidermal proliferation and differentiation.

protein malnutrition has a primary impact on the gene expression of Has2 and Has3, which leads to the reduction of hyaluronan content and to disfunction of the skin
Title: Dietary protein as a potent regulator of the hyaluronan synthase gene in rat skin.

The following Has3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Has3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa38903	NM_172319.1 Latest version!	Rattus norvegicus hyaluronan synthase 3 (Has3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa38903	XM_006255561.3 Latest version!	Rattus norvegicus hyaluronan synthase 3 (Has3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Has3 ( NM_172319.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_758822.1 Rattus norvegicus hyaluronan synthase 3 (Has3), mRNA.

Price & Availability↑

CloneID	ORa38903
Clone ID Related Accession (Same CDS sequence)	XM_006255561.3 , NM_172319.1
Accession Version	NM_172319.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1665bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	hyaluronan synthase 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB097569.1. On Jun 25, 2006 this sequence version replaced XM_001076370.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB097569.1 [ECO:0000332] ##Evidence-Data-END##

ATGCCGGTGC AGCTGACTAC AGCCCTTCGT GTGGTGGGCA CCAGTCTGTT TGCCCTGGTA 
GTGCTGGGGG GCATCCTGGC AGCCTATGTC ACAGGCTACC AGTTTATCCA CACGGAAAAG 
CACTATCTGT CCTTCGGCCT CTACGGTGCC ATCCTGGGTC TGCATCTGCT CATCCAGAGC 
CTGTTTGCCT TCCTGGAGCA CCGTCGCATG CGCAGGGCAG GGCGCCCACT GAAGCTGCAC 
TGCTCTCAGA GACGGCGTTC GGTGGCACTC TGCATCGCTG CCTACCAAGA GGACCCTGAG 
TACTTGCGCA AGTGCCTTCG CTCAGCTCAG CGCATTGCCT TCCCAAACCT CAAGGTGGTC 
ATGGTAGTGG ATGGCAATCG CCAGGAAGAT GCCTACATGC TGGACATCTT CCATGAGGTC 
CTGGGTGGCA CTGAGCAAGC TGGCTTCTTT GTGTGGCGTA GCAATTTCCA TGAGGCGGGT 
GAAGGAGAGA CAGAGGCCAG CTTGCAGGAA GGCATGGAGC GTGTTCGAGC TGTGGTGTGG 
GCCAGCACCT TCTCATGCAT CATGCAGAAG TGGGGGGGCA AGCGTGAAGT CATGTACACA 
GCTTTCAAGG CCCTTGGCAA CTCAGTGGAC TACATCCAGG TGTGTGACTC TGACACTGTG 
CTGGACCCAG CCTGCACCAT TGAGATGCTT CGGGTCTTGG AGGAAGATCC CCAAGTAGGA 
GGTGTTGGAG GAGATGTCCA AATCCTCAAC AAATACGATT CATGGATCTC CTTCCTGAGC 
AGCGTGAGGT ACTGGATGGC CTTCAACGTG GAGCGGGCCT GCCAGTCCTA CTTTGGCTGT 
GTGCAGTGTA TTAGTGGGCC TCTGGGCATG TACCGCAACA GCCTCCTTCA GCAGTTCCTG 
GAGGACTGGT ACCATCAGAA GTTCCTAGGC AGCAAGTGCA GCTTTGGGGA TGATCGGCAC 
CTTACCAACC GAGTCCTGAG TCTTGGCTAC CGGACTAAGT ATACAGCACG CTCCAAGTGC 
CTCACAGAGA CCCCCACTAA GTATCTCCGA TGGCTCAACC AGCAGACCCG CTGGAGCAAG 
TCTTACTTTC GGGAGTGGCT CTACAACTCT CTGTGGTTCC ATAAGCACCA CCTGTGGATG 
ACCTATGAGT CAGTGGTCAC AGGCTTCTTC CCCTTCTTCC TCATCGCCAC AGTCATACAA 
CTTTTCTACC GTGGCCGCAT CTGGAACATT CTCCTCTTCC TACTAACGGT GCAGCTGGTG 
GGCATTATCA AGGCTACCTA TGCCTGCTTC CTCCGAGGCA ATGCAGAGAT GATCTTCATG 
TCCCTCTACT CCCTTCTCTA TATGTCCAGC CTGCTGCCAG CCAAGATCTT TGCTATTGCT 
ACCATCAACA AGTCTGGCTG GGGCACTTCT GGCAGGAAAA CCATTGTAGT GAACTTCATT 
GGCCTAATCC CTGTGTCCAT CTGGGTGGCA GTTCTTCTAG GGGGGTTAGC CTACACAGCT 
TATTGTCAGG ACCTGTTCAG TGAGACTGAG CTAGCCTTCC TGGTCTCTGG GGCCATCTTG 
TATGGCTGCT ACTGGGTGGC CCTCCTCATG CTGTATTTGG CCATTATTGC CCGGAGGTGT 
GGGAAAAAGC CAGAACAGTA TAGCCTGGCT TTTGCTGAGG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_758822.1
CDS	172..1836
Translation	MPVQLTTALRVVGTSLFALVVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHRRMRRAGRPLKLHCSQRRRSVALCIAAYQEDPEYLRKCLRSAQRIAFPNLKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMERVRAVVWASTFSCIMQKWGGKREVMYTAFKALGNSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV

Target ORF information:

RefSeq Version	NM_172319.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus hyaluronan synthase 3 (Has3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172319.1

ORF Insert Sequence:

ATGCCGGTGC AGCTGACTAC AGCCCTTCGT GTGGTGGGCA CCAGTCTGTT TGCCCTGGTA 
GTGCTGGGGG GCATCCTGGC AGCCTATGTC ACAGGCTACC AGTTTATCCA CACGGAAAAG 
CACTATCTGT CCTTCGGCCT CTACGGTGCC ATCCTGGGTC TGCATCTGCT CATCCAGAGC 
CTGTTTGCCT TCCTGGAGCA CCGTCGCATG CGCAGGGCAG GGCGCCCACT GAAGCTGCAC 
TGCTCTCAGA GACGGCGTTC GGTGGCACTC TGCATCGCTG CCTACCAAGA GGACCCTGAG 
TACTTGCGCA AGTGCCTTCG CTCAGCTCAG CGCATTGCCT TCCCAAACCT CAAGGTGGTC 
ATGGTAGTGG ATGGCAATCG CCAGGAAGAT GCCTACATGC TGGACATCTT CCATGAGGTC 
CTGGGTGGCA CTGAGCAAGC TGGCTTCTTT GTGTGGCGTA GCAATTTCCA TGAGGCGGGT 
GAAGGAGAGA CAGAGGCCAG CTTGCAGGAA GGCATGGAGC GTGTTCGAGC TGTGGTGTGG 
GCCAGCACCT TCTCATGCAT CATGCAGAAG TGGGGGGGCA AGCGTGAAGT CATGTACACA 
GCTTTCAAGG CCCTTGGCAA CTCAGTGGAC TACATCCAGG TGTGTGACTC TGACACTGTG 
CTGGACCCAG CCTGCACCAT TGAGATGCTT CGGGTCTTGG AGGAAGATCC CCAAGTAGGA 
GGTGTTGGAG GAGATGTCCA AATCCTCAAC AAATACGATT CATGGATCTC CTTCCTGAGC 
AGCGTGAGGT ACTGGATGGC CTTCAACGTG GAGCGGGCCT GCCAGTCCTA CTTTGGCTGT 
GTGCAGTGTA TTAGTGGGCC TCTGGGCATG TACCGCAACA GCCTCCTTCA GCAGTTCCTG 
GAGGACTGGT ACCATCAGAA GTTCCTAGGC AGCAAGTGCA GCTTTGGGGA TGATCGGCAC 
CTTACCAACC GAGTCCTGAG TCTTGGCTAC CGGACTAAGT ATACAGCACG CTCCAAGTGC 
CTCACAGAGA CCCCCACTAA GTATCTCCGA TGGCTCAACC AGCAGACCCG CTGGAGCAAG 
TCTTACTTTC GGGAGTGGCT CTACAACTCT CTGTGGTTCC ATAAGCACCA CCTGTGGATG 
ACCTATGAGT CAGTGGTCAC AGGCTTCTTC CCCTTCTTCC TCATCGCCAC AGTCATACAA 
CTTTTCTACC GTGGCCGCAT CTGGAACATT CTCCTCTTCC TACTAACGGT GCAGCTGGTG 
GGCATTATCA AGGCTACCTA TGCCTGCTTC CTCCGAGGCA ATGCAGAGAT GATCTTCATG 
TCCCTCTACT CCCTTCTCTA TATGTCCAGC CTGCTGCCAG CCAAGATCTT TGCTATTGCT 
ACCATCAACA AGTCTGGCTG GGGCACTTCT GGCAGGAAAA CCATTGTAGT GAACTTCATT 
GGCCTAATCC CTGTGTCCAT CTGGGTGGCA GTTCTTCTAG GGGGGTTAGC CTACACAGCT 
TATTGTCAGG ACCTGTTCAG TGAGACTGAG CTAGCCTTCC TGGTCTCTGG GGCCATCTTG 
TATGGCTGCT ACTGGGTGGC CCTCCTCATG CTGTATTTGG CCATTATTGC CCGGAGGTGT 
GGGAAAAAGC CAGAACAGTA TAGCCTGGCT TTTGCTGAGG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Has3 ( XM_006255561.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006255623.1 Rattus norvegicus hyaluronan synthase 3 (Has3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa38903
Clone ID Related Accession (Same CDS sequence)	XM_006255561.3 , NM_172319.1
Accession Version	XM_006255561.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1665bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	hyaluronan synthase 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006255561.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGGTGC AGCTGACTAC AGCCCTTCGT GTGGTGGGCA CCAGTCTGTT TGCCCTGGTA 
GTGCTGGGGG GCATCCTGGC AGCCTATGTC ACAGGCTACC AGTTTATCCA CACGGAAAAG 
CACTATCTGT CCTTCGGCCT CTACGGTGCC ATCCTGGGTC TGCATCTGCT CATCCAGAGC 
CTGTTTGCCT TCCTGGAGCA CCGTCGCATG CGCAGGGCAG GGCGCCCACT GAAGCTGCAC 
TGCTCTCAGA GACGGCGTTC GGTGGCACTC TGCATCGCTG CCTACCAAGA GGACCCTGAG 
TACTTGCGCA AGTGCCTTCG CTCAGCTCAG CGCATTGCCT TCCCAAACCT CAAGGTGGTC 
ATGGTAGTGG ATGGCAATCG CCAGGAAGAT GCCTACATGC TGGACATCTT CCATGAGGTC 
CTGGGTGGCA CTGAGCAAGC TGGCTTCTTT GTGTGGCGTA GCAATTTCCA TGAGGCGGGT 
GAAGGAGAGA CAGAGGCCAG CTTGCAGGAA GGCATGGAGC GTGTTCGAGC TGTGGTGTGG 
GCCAGCACCT TCTCATGCAT CATGCAGAAG TGGGGGGGCA AGCGTGAAGT CATGTACACA 
GCTTTCAAGG CCCTTGGCAA CTCAGTGGAC TACATCCAGG TGTGTGACTC TGACACTGTG 
CTGGACCCAG CCTGCACCAT TGAGATGCTT CGGGTCTTGG AGGAAGATCC CCAAGTAGGA 
GGTGTTGGAG GAGATGTCCA AATCCTCAAC AAATACGATT CATGGATCTC CTTCCTGAGC 
AGCGTGAGGT ACTGGATGGC CTTCAACGTG GAGCGGGCCT GCCAGTCCTA CTTTGGCTGT 
GTGCAGTGTA TTAGTGGGCC TCTGGGCATG TACCGCAACA GCCTCCTTCA GCAGTTCCTG 
GAGGACTGGT ACCATCAGAA GTTCCTAGGC AGCAAGTGCA GCTTTGGGGA TGATCGGCAC 
CTTACCAACC GAGTCCTGAG TCTTGGCTAC CGGACTAAGT ATACAGCACG CTCCAAGTGC 
CTCACAGAGA CCCCCACTAA GTATCTCCGA TGGCTCAACC AGCAGACCCG CTGGAGCAAG 
TCTTACTTTC GGGAGTGGCT CTACAACTCT CTGTGGTTCC ATAAGCACCA CCTGTGGATG 
ACCTATGAGT CAGTGGTCAC AGGCTTCTTC CCCTTCTTCC TCATCGCCAC AGTCATACAA 
CTTTTCTACC GTGGCCGCAT CTGGAACATT CTCCTCTTCC TACTAACGGT GCAGCTGGTG 
GGCATTATCA AGGCTACCTA TGCCTGCTTC CTCCGAGGCA ATGCAGAGAT GATCTTCATG 
TCCCTCTACT CCCTTCTCTA TATGTCCAGC CTGCTGCCAG CCAAGATCTT TGCTATTGCT 
ACCATCAACA AGTCTGGCTG GGGCACTTCT GGCAGGAAAA CCATTGTAGT GAACTTCATT 
GGCCTAATCC CTGTGTCCAT CTGGGTGGCA GTTCTTCTAG GGGGGTTAGC CTACACAGCT 
TATTGTCAGG ACCTGTTCAG TGAGACTGAG CTAGCCTTCC TGGTCTCTGG GGCCATCTTG 
TATGGCTGCT ACTGGGTGGC CCTCCTCATG CTGTATTTGG CCATTATTGC CCGGAGGTGT 
GGGAAAAAGC CAGAACAGTA TAGCCTGGCT TTTGCTGAGG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006255623.1
CDS	1413..3077
Translation	MPVQLTTALRVVGTSLFALVVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHRRMRRAGRPLKLHCSQRRRSVALCIAAYQEDPEYLRKCLRSAQRIAFPNLKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMERVRAVVWASTFSCIMQKWGGKREVMYTAFKALGNSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV

Target ORF information:

RefSeq Version	XM_006255561.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus hyaluronan synthase 3 (Has3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006255561.3

ORF Insert Sequence:

ATGCCGGTGC AGCTGACTAC AGCCCTTCGT GTGGTGGGCA CCAGTCTGTT TGCCCTGGTA 
GTGCTGGGGG GCATCCTGGC AGCCTATGTC ACAGGCTACC AGTTTATCCA CACGGAAAAG 
CACTATCTGT CCTTCGGCCT CTACGGTGCC ATCCTGGGTC TGCATCTGCT CATCCAGAGC 
CTGTTTGCCT TCCTGGAGCA CCGTCGCATG CGCAGGGCAG GGCGCCCACT GAAGCTGCAC 
TGCTCTCAGA GACGGCGTTC GGTGGCACTC TGCATCGCTG CCTACCAAGA GGACCCTGAG 
TACTTGCGCA AGTGCCTTCG CTCAGCTCAG CGCATTGCCT TCCCAAACCT CAAGGTGGTC 
ATGGTAGTGG ATGGCAATCG CCAGGAAGAT GCCTACATGC TGGACATCTT CCATGAGGTC 
CTGGGTGGCA CTGAGCAAGC TGGCTTCTTT GTGTGGCGTA GCAATTTCCA TGAGGCGGGT 
GAAGGAGAGA CAGAGGCCAG CTTGCAGGAA GGCATGGAGC GTGTTCGAGC TGTGGTGTGG 
GCCAGCACCT TCTCATGCAT CATGCAGAAG TGGGGGGGCA AGCGTGAAGT CATGTACACA 
GCTTTCAAGG CCCTTGGCAA CTCAGTGGAC TACATCCAGG TGTGTGACTC TGACACTGTG 
CTGGACCCAG CCTGCACCAT TGAGATGCTT CGGGTCTTGG AGGAAGATCC CCAAGTAGGA 
GGTGTTGGAG GAGATGTCCA AATCCTCAAC AAATACGATT CATGGATCTC CTTCCTGAGC 
AGCGTGAGGT ACTGGATGGC CTTCAACGTG GAGCGGGCCT GCCAGTCCTA CTTTGGCTGT 
GTGCAGTGTA TTAGTGGGCC TCTGGGCATG TACCGCAACA GCCTCCTTCA GCAGTTCCTG 
GAGGACTGGT ACCATCAGAA GTTCCTAGGC AGCAAGTGCA GCTTTGGGGA TGATCGGCAC 
CTTACCAACC GAGTCCTGAG TCTTGGCTAC CGGACTAAGT ATACAGCACG CTCCAAGTGC 
CTCACAGAGA CCCCCACTAA GTATCTCCGA TGGCTCAACC AGCAGACCCG CTGGAGCAAG 
TCTTACTTTC GGGAGTGGCT CTACAACTCT CTGTGGTTCC ATAAGCACCA CCTGTGGATG 
ACCTATGAGT CAGTGGTCAC AGGCTTCTTC CCCTTCTTCC TCATCGCCAC AGTCATACAA 
CTTTTCTACC GTGGCCGCAT CTGGAACATT CTCCTCTTCC TACTAACGGT GCAGCTGGTG 
GGCATTATCA AGGCTACCTA TGCCTGCTTC CTCCGAGGCA ATGCAGAGAT GATCTTCATG 
TCCCTCTACT CCCTTCTCTA TATGTCCAGC CTGCTGCCAG CCAAGATCTT TGCTATTGCT 
ACCATCAACA AGTCTGGCTG GGGCACTTCT GGCAGGAAAA CCATTGTAGT GAACTTCATT 
GGCCTAATCC CTGTGTCCAT CTGGGTGGCA GTTCTTCTAG GGGGGTTAGC CTACACAGCT 
TATTGTCAGG ACCTGTTCAG TGAGACTGAG CTAGCCTTCC TGGTCTCTGG GGCCATCTTG 
TATGGCTGCT ACTGGGTGGC CCTCCTCATG CTGTATTTGG CCATTATTGC CCGGAGGTGT 
GGGAAAAAGC CAGAACAGTA TAGCCTGGCT TTTGCTGAGG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3.
The Journal of biological chemistry290(18)11479-90(2015 May)
Bart G,Vico NO,Hassinen A,Pujol FM,Deen AJ,Ruusala A,Tammi RH,Squire A,Heldin P,Kellokumpu S,Tammi MI

Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes.
Histochemistry and cell biology141(1)17-31(2014 Jan)
T?rr?nen K,Nikunen K,K?rn? R,Tammi M,Tammi R,Rilla K

Low dose ultraviolet B irradiation increases hyaluronan synthesis in epidermal keratinocytes via sequential induction of hyaluronan synthases Has1-3 mediated by p38 and Ca2+/calmodulin-dependent protein kinase II (CaMKII) signaling.
The Journal of biological chemistry288(25)17999-8012(2013 Jun)
Rauhala L,H?m?l?inen L,Salonen P,Bart G,Tammi M,Pasonen-Sepp?nen S,Tammi R

The enzymatic degradation of hyaluronan is associated with disease progression in experimental pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology298(2)L148-57(2010 Feb)
Ormiston ML,Slaughter GR,Deng Y,Stewart DJ,Courtman DW

Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model.
Lung187(4)233-9(2009 Aug)
Mrabat H,Beagle J,Hang Z,Garg HG,Hales CA,Quinn DA

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Has3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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