Nalcn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nalcn
Entrez Gene ID	266760
Full Name	sodium leak channel, non-selective
Synonyms	Vgcnl1
General protein information	Preferred Names sodium leak channel, non-selective Names sodium leak channel non-selective protein brain voltage-gated cation channel four domain-type voltage-gated ion channel alpha-1 subunit rb21-channel voltage gated channel like 1 voltage gated channel-like protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15q25
Summary	may act as a voltage activated cation channel [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_153630.1	NP_705894.1	sodium leak channel non-selective protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NALCN	XP_001149573.1
Canis lupus familiaris (dog)	NALCN	XP_542654.4
Bos taurus (cattle)	NALCN	XP_002692026.1
Rattus norvegicus (Norway rat)	Nalcn	NP_705894.1
Drosophila melanogaster (fruit fly)	na	NP_001096981.1
Homo sapiens (human)	NALCN	NP_443099.1
Caenorhabditis elegans (roundworm)	nca-2	NP_498054.2
Mus musculus (house mouse)	Nalcn	NP_796367.3
Caenorhabditis elegans (roundworm)	unc-77	NP_741413.2
Gallus gallus (chicken)	NALCN	XP_416967.2
Danio rerio (zebrafish)	nalcn	NP_001017549.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003921	XP_318373.5
Xenopus tropicalis (tropical clawed frog)	nalcn	XP_002937125.2

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in NALCN cause an autosomal-recessive syndrome with severe hypotonia, speech impairment, and cognitive delay.
Al-Sayed MD, Al-Zaidan H, Albakheet A, Hakami H, Kenana R, Al-Yafee Y, Al-Dosary M, Qari A, Al-Sheddi T, Al-Muheiza M, Al-Qubbaj W, Lakmache Y, Al-Hindi H, Ghaziuddin M, Colak D, Kaya N
American journal of human genetics93(4)721-6(2013 Oct)

Recessive truncating NALCN mutation in infantile neuroaxonal dystrophy with facial dysmorphism.
K?ro?lu ?, Seven M, Tolun A
Journal of medical genetics50(8)515-20(2013 Aug)

The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm.
Lu B, Su Y, Das S, Liu J, Xia J, Ren D
Cell129(2)371-83(2007 Apr)

An unusual cation channel mediates photic control of locomotion in Drosophila.
Nash HA, Scott RL, Lear BC, Allada R
Current biology : CB12(24)2152-8(2002 Dec)

Cloning of a novel four repeat protein related to voltage-gated sodium and calcium channels.
Lee JH, Cribbs LL, Perez-Reyes E
FEBS letters445(2-3)231-6(1999 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Nalcn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nalcn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03119	NM_153630.1 Latest version!	Rattus norvegicus sodium leak channel, non-selective (Nalcn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$951.30 $1359.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nalcn ( NM_153630.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_705894.1 Rattus norvegicus sodium leak channel, non-selective (Nalcn), mRNA.

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CloneID	ORa03119
Clone ID Related Accession (Same CDS sequence)	NM_153630.1
Accession Version	NM_153630.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5214bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	sodium leak channel non-selective protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF078779.1. On Dec 17, 2003 this sequence version replaced XM_346479.1. ##Evidence-Data-START## Transcript exon combination :: AF078779.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296 [ECO:0000350] ##Evidence-Data-END##

ATGCTCAAAA GAAAGCAGAG TTCCAGGGTG GAAGCCCAGC CAGTAACTGA CTTTGGTCCT 
GACGAATCTC TGTCAGACAA TGCTGACATA CTCTGGATTA ATAAGCCATG GGTGCACTCT 
CTGCTGCGCA TCTGTGCCAT CATCAGCGTC ATCTCAGTGT GCATGAACAC ACCTATGACC 
TTCGAGCACT ATCCTCCCCT TCAGTATGTG ACCTTCACCC TGGACACTTT ACTGATGTTT 
CTCTACACTG CAGAGATGAT AGCAAAGATG CACATACGGG GAATTGTCAA GGGCGATAGC 
TCCTATGTGA AGGACCGCTG GTGTGTTTTT GATGGATTCA TGGTCTTTTG CCTTTGGGTT 
TCTCTCGTGT TACAGGTGTT TGAAATAGCT GACATAGTTG ATCAGATGTC ACCTTGGGGC 
ATGCTGCGGA TCCCACGGCC ACTCATTATG ATCCGGGCTT TCAGGATTTA TTTCCGATTC 
GAACTGCCAA GGACCCGAAT TACAAACATT TTAAAGCGGT CAGGAGAACA AATATGGAGT 
GTCTCAATCT TCCTCCTCTT CTTCCTTCTT CTGTATGGGA TTTTAGGAGT TCAGATGTTT 
GGAACATTTA CCTACCACTG CGTAGTCAAT GACACAAAGC CAGGGAATGT AACCTGGAAT 
AGCTTAGCTA TCCCAGATAC GCACTGCTCG CCAGAGCTAG AAGAAGGCTA TCAGTGCCCC 
CCAGGATTTA AATGCATGGA CCTGGAAGAC CTGGGACTTA GCAGGCAAGA GCTGGGCTAC 
AGTGGCTTTA ATGAGATAGG CACGAGTATA TTCACAGTCT ATGAGGCTTC ATCTCAGGAA 
GGCTGGGTAT TCCTCATGTA CAGAGCAATC GACAGTTTCC CCCGTTGGCG TTCCTACTTC 
TACTTCATCA CGCTGATTTT CTTCCTTGCC TGGCTTGTCA AGAATGTGTT CATTGCTGTC 
ATCATTGAGA CATTTGCAGA AATCAGAGTA CAATTTCAAC AAATGTGGGG AACTCGGAGC 
AGCACAACTT CCACTGCCAC CACGCAGATG TTCCATGAAG ATGCTGCCGG TGGCTGGCAG 
CTGGTAGCTG TGGATGTCAA CAAGCCCCAG GGACGTGCCC CAGCCTGCCT ACAGAAAATG 
ATGCGGTCAT CAGTTTTCCA CATGTTTATC CTGAGCATGG TGACTGTGGA TGTAATAGTT 
GCTGCCAGCA ACTACTACAA GGGAGAGAAC TTCAGAAGGC AGTATGACGA GTTCTACCTT 
GCAGAGGTGG CTTTTACAGT TCTTTTTGAT CTGGAAGCAC TTCTGAAGAT ATGGTGTTTG 
GGGTTTACTG GCTACATCAG CTCATCTCTC CACAAGTTTG AACTACTTCT GGTTATTGGG 
ACAACTCTCC ATGTATACCC TGATCTTTAT CATTCTCAAT TTACCTACTT CCAGGTTCTT 
CGGGTAGTCC GGCTTATTAA GATTTCCCCA GCATTGGAAG ATTTTGTGTA CAAGATATTT 
GGTCCCGGGA AAAAACTTGG AAGCTTGGTG GTGTTCACTG CCAGTCTCCT GATAGTTATG 
TCCGCCATCA GTTTGCAGAT GTTCTGCTTC GTCGAAGAAC TGGACAGATT CACCACATTT 
CCAAGGGCAT TTATGTCCAT GTTCCAGATC CTCACCCAGG AAGGATGGGT GGATGTGATG 
GATCAGACTC TGAATGCTGT GGGGCATATG TGGGCTCCAC TGGTTGCCAT CTATTTCATC 
CTCTACCATC TCTTTGCAAC GCTGATCCTC CTGAGTTTGT TTGTTGCTGT TATTTTGGAC 
AACTTAGAAC TTGATGAAGA TCTAAAGAAG CTCAAACAAT TAAAACAAAG TGAAGCGAAC 
GCAGATACCA AAGAAAAACT TCCTTTGCGC TTGAGAATCT TCGAAAAATT CCCAAACAGA 
CCGCAAATGG TGAAAATCTC AAAACTTCCT TCAGATTTTA CAGTTCCTAA GATCAGGGAA 
AGCTTCATGA AGCAGTTCAT TGACCGCCAG CAACAGGACA CCTGCTGTCT CTTCAGAATT 
CTCCCCTCTA CCTCTTCCTC ATCCTGTGAC AACCCCAAGC GGCCCACAGT TGAAGACAAC 
AAATACATTG ATCAAAAACT CCGCAAGTCT GTTTTCAGCA TAAGGGCAAG GAACCTTCTG 
GAAAAGGAGA CCGCAGTCAC AAAAATCTTA AGAGCTTGCA CTCGACAGCG CATGCTGAGC 
GGATCATTCG AGGGGCAGCC AGCAAAGGAG AGGTCGATCC TCAGCGTGCA GCATCACATC 
CGCCAGGAGC GCAGGTCACT CAGACATGGA TCCAACAGCC AGAGGATCAG CAGGGGCAAA 
TCTCTTGAAA CGTTAACTCA AGATCATTCC AATACGGTGC GCTACAGAAA TGCACAAAGA 
GAAGACAGTG AAATAAAGAT GATCCAGGAG AAGAAGGAGC AAGCAGAGAT GAAAAGGAAG 
GTGCAAGAAG AGGAGCTGCG AGAGAACCAC CCATACTTTG ACAAGCCTCT CTTCATCGTG 
GGTCGAGAAC ACAGGTTCAG AAACTTCTGC CGCGTGGTGG TTCGAGCACG CTTCAATGCA 
TCCAAAACAG ACCCTGTCAC GGGAGCTGTG AAAAATACAA AGTACCACCA ACTTTATGAT 
TTGCTGGGAC TTGTCACCTA CCTGGACTGG GTCATGATCA CTGTAACCAT CTGCTCTTGC 
ATTTCTATGA TGTTCGAATC CCCCTTCCGG AGAGTCATGC ATGCACCCAC TTTACAGATC 
GCTGAATATG TGTTTGTGAT ATTCATGAGC ATTGAGCTTA ATCTGAAGAT TATGGCAGAT 
GGCTTGTTTT TCACTCCAAC TGCTGTCATC AGGGACTTTG GTGGCGTCAT GGACATATTT 
ATCTATCTTG TGAGCTTGAT ATTTCTTTGT TGGATGCCTC AAAATGTGCC TGCTGAGTCA 
GGAGCCCAGC TCCTGATGGT TCTTCGGTGC CTAAGACCTC TTCGGATATT CAAACTGGTG 
CCACAAATGA GGAAAGTTGT TCGAGAACTT TTCAGTGGTT TCAAGGAAAT ATTTTTGGTC 
TCCATTCTGT TGCTGACACT AATGCTTGTT TTTGCAAGCT TTGGTGTTCA GCTCTTTGCC 
GGAAAGCTAG CCAAGTGCAA TGACCCCAAC ATTATCAGAA GGGAAGACTG TAACGGCATC 
TTCAGAATTA ATGTAAGTGT GTCCAAGAAC TTAAATTTAA AACTAAGACC TGGAGAGAAA 
AAACCTGGAT TTTGGGTGCC CCGTGTTTGG GCAAATCCTC GTAACTTTAA CTTTGACAAT 
GTGGGAAATG CTATGCTGGC ATTGTTTGAA GTTCTGTCCT TGAAAGGCTG GGTAGAAGTG 
AGAGATGTCA TTATTCATCG TGTGGGGCCG ATCCATGGAA TCTATATTCA TGTTTTCGTA 
TTCCTGGGTT GCATGATTGG ACTGACTCTT TTTGTCGGTG TAGTTATTGC TAACTTCAAT 
GAAAACAAGG GGACAGCCCT GCTGACGGTA GATCAGAGAA GATGGGAAGA TCTCAAGAGC 
AGATTGAAGA TCGCACAGCC TCTTCATCTC CCACCTCGGC CGGATAATGA TGGATTTAGA 
GCTAAAATGT ATGACATAAC CCAGCATCCG TTTTTTAAAA GGACAATTGC GTTGCTGGTT 
CTGGCCCAGT CTGTGTTGCT ATCTGTCAAG TGGGATGTTG AGGATCCTGT GACAGTTCCT 
TTGGCAACCA TGTCGGTCGT GTTCACCTTC ATCTTTGTCT TAGAGGTTAC AATGAAGATC 
ATAGCAATGT CACCAGCTGG TTTCTGGCAA AGCAGAAGAA ACCGATATGA TCTCTTGGTG 
ACGTCTCTTG GTGTTGTGTG GGTGGTGCTC CATTTTGCTC TGCTGAATGC ATACACCTAC 
ATGATGGGAG CCTGTGTGAT TGTCTTTAGA TTTTTCTCCA TCTGTGGAAA GCATGTGACA 
TTAAAGATGC TCCTTTTGAC TGTGGTTGTC AGCATGTACA AGAGCTTCTT TATCATCGTA 
GGAATGTTTC TCTTGCTGCT GTGCTATGCC TTTGCTGGGG TGGTTCTGTT TGGCACTGTA 
AAGTATGGAG AGAACATTAA CAGGCATGCC AATTTTTCTT CAGCTGGCAA AGCCATTACT 
GTATTGTTCC GAATTGTCAC AGGGGAAGAC TGGAATAAGA TTATGCATGA TTGTATGGTT 
CAGCCTCCAT TTTGTACTCC TGATGAATTT ACATATTGGG CAACAGACTG TGGCAATTAT 
GCAGGGGCAC TTATGTACTT CTGCTCATTC TATGTCATCA TCGCCTACAT CATGCTGAAT 
CTACTTGTAG CCATAATTGT GGAGAATTTC TCTTTGTTTT ATTCCACTGA AGAGGACCAG 
CTTTTGAGTT ACAATGATCT TCGCCATTTT CAAATCATAT GGAATATGGT AGATGATAAC 
GAGAGGTGTG ATCCCACCTT CCGAGTGAAG TTCCTGCTAC GGCTACTGCG TGGGAGGCTA 
GAAGTGGACC TTGATAAAGA CAAGCTCCTG TTTAAGCACA TGTGCTATGA GATGGAGAGG 
CTGCACAATG GTGGTGATGT CACCTTCCAT GATGTCTTGA GCATGCTGTC CTACCGCTCT 
GTAGACATCA GGAAGAGCCT GCAGCTAGAG GAACTGCTGG CAAGGGAGCA GCTGGAGTAC 
ACCATAGAGG AGGAGGTGGC TAAGCAGACT ATTCGCATGT GGCTGAAGAA GTGCTTAAAA 
CGCATCCGGG CTAAACAGCA GCAGTCATGC AGCATCATCC ACAGCCTGAG AGAGAGCCAG 
CAGCAAGAGT TGAGCCGATT CCTGAATCCT CCCAGCATTG AGACCACCCA ACCAAGCGAA 
GATACCAACG CCAACAGCCA GGACCACAAT ACGCAACCTG AGTCAAGCAG TCAGCAGCAG 
CTCTTGAGCC CTACTCTGTC AGACAGAGGA GGAAGTCGAC AGGATGCAGC AGATACTGGG 
AAACCCCAAA GAAAGATTGG GCAATGGCGT CTGCCCTCAG CTCCCAAACC AATAAGCCAT 
TCTGTGTCTT CGGTTAACCT ACGGTTTGGA GGAAGGACAA CAATGAAGTC TGTGGTGTGC 
AAGATGAACC CCATGCCAGA CACAGCTTCC TGTGGCTCCG AAGTTAAAAA GTGGTGGACC 
AGACAGCTGA CTGTGGAGAG TGACGAGAGT GGAGATGACC TCCTAGATAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_705894.1
CDS	60..5273
Translation	MLKRKQSSRVEAQPVTDFGPDESLSDNADILWINKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEASSQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGTRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPLVAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPKIRESFMKQFIDRQQQDTCCLFRILPSTSSSSCDNPKRPTVEDNKYIDQKLRKSVFSIRARNLLEKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGSNSQRISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMITVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDNERCDPTFRVKFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIHSLRESQQQELSRFLNPPSIETTQPSEDTNANSQDHNTQPESSSQQQLLSPTLSDRGGSRQDAADTGKPQRKIGQWRLPSAPKPISHSVSSVNLRFGGRTTMKSVVCKMNPMPDTASCGSEVKKWWTRQLTVESDESGDDLLDI

Target ORF information:

RefSeq Version	NM_153630.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sodium leak channel, non-selective (Nalcn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153630.1

ORF Insert Sequence:

ATGCTCAAAA GAAAGCAGAG TTCCAGGGTG GAAGCCCAGC CAGTAACTGA CTTTGGTCCT 
GACGAATCTC TGTCAGACAA TGCTGACATA CTCTGGATTA ATAAGCCATG GGTGCACTCT 
CTGCTGCGCA TCTGTGCCAT CATCAGCGTC ATCTCAGTGT GCATGAACAC ACCTATGACC 
TTCGAGCACT ATCCTCCCCT TCAGTATGTG ACCTTCACCC TGGACACTTT ACTGATGTTT 
CTCTACACTG CAGAGATGAT AGCAAAGATG CACATACGGG GAATTGTCAA GGGCGATAGC 
TCCTATGTGA AGGACCGCTG GTGTGTTTTT GATGGATTCA TGGTCTTTTG CCTTTGGGTT 
TCTCTCGTGT TACAGGTGTT TGAAATAGCT GACATAGTTG ATCAGATGTC ACCTTGGGGC 
ATGCTGCGGA TCCCACGGCC ACTCATTATG ATCCGGGCTT TCAGGATTTA TTTCCGATTC 
GAACTGCCAA GGACCCGAAT TACAAACATT TTAAAGCGGT CAGGAGAACA AATATGGAGT 
GTCTCAATCT TCCTCCTCTT CTTCCTTCTT CTGTATGGGA TTTTAGGAGT TCAGATGTTT 
GGAACATTTA CCTACCACTG CGTAGTCAAT GACACAAAGC CAGGGAATGT AACCTGGAAT 
AGCTTAGCTA TCCCAGATAC GCACTGCTCG CCAGAGCTAG AAGAAGGCTA TCAGTGCCCC 
CCAGGATTTA AATGCATGGA CCTGGAAGAC CTGGGACTTA GCAGGCAAGA GCTGGGCTAC 
AGTGGCTTTA ATGAGATAGG CACGAGTATA TTCACAGTCT ATGAGGCTTC ATCTCAGGAA 
GGCTGGGTAT TCCTCATGTA CAGAGCAATC GACAGTTTCC CCCGTTGGCG TTCCTACTTC 
TACTTCATCA CGCTGATTTT CTTCCTTGCC TGGCTTGTCA AGAATGTGTT CATTGCTGTC 
ATCATTGAGA CATTTGCAGA AATCAGAGTA CAATTTCAAC AAATGTGGGG AACTCGGAGC 
AGCACAACTT CCACTGCCAC CACGCAGATG TTCCATGAAG ATGCTGCCGG TGGCTGGCAG 
CTGGTAGCTG TGGATGTCAA CAAGCCCCAG GGACGTGCCC CAGCCTGCCT ACAGAAAATG 
ATGCGGTCAT CAGTTTTCCA CATGTTTATC CTGAGCATGG TGACTGTGGA TGTAATAGTT 
GCTGCCAGCA ACTACTACAA GGGAGAGAAC TTCAGAAGGC AGTATGACGA GTTCTACCTT 
GCAGAGGTGG CTTTTACAGT TCTTTTTGAT CTGGAAGCAC TTCTGAAGAT ATGGTGTTTG 
GGGTTTACTG GCTACATCAG CTCATCTCTC CACAAGTTTG AACTACTTCT GGTTATTGGG 
ACAACTCTCC ATGTATACCC TGATCTTTAT CATTCTCAAT TTACCTACTT CCAGGTTCTT 
CGGGTAGTCC GGCTTATTAA GATTTCCCCA GCATTGGAAG ATTTTGTGTA CAAGATATTT 
GGTCCCGGGA AAAAACTTGG AAGCTTGGTG GTGTTCACTG CCAGTCTCCT GATAGTTATG 
TCCGCCATCA GTTTGCAGAT GTTCTGCTTC GTCGAAGAAC TGGACAGATT CACCACATTT 
CCAAGGGCAT TTATGTCCAT GTTCCAGATC CTCACCCAGG AAGGATGGGT GGATGTGATG 
GATCAGACTC TGAATGCTGT GGGGCATATG TGGGCTCCAC TGGTTGCCAT CTATTTCATC 
CTCTACCATC TCTTTGCAAC GCTGATCCTC CTGAGTTTGT TTGTTGCTGT TATTTTGGAC 
AACTTAGAAC TTGATGAAGA TCTAAAGAAG CTCAAACAAT TAAAACAAAG TGAAGCGAAC 
GCAGATACCA AAGAAAAACT TCCTTTGCGC TTGAGAATCT TCGAAAAATT CCCAAACAGA 
CCGCAAATGG TGAAAATCTC AAAACTTCCT TCAGATTTTA CAGTTCCTAA GATCAGGGAA 
AGCTTCATGA AGCAGTTCAT TGACCGCCAG CAACAGGACA CCTGCTGTCT CTTCAGAATT 
CTCCCCTCTA CCTCTTCCTC ATCCTGTGAC AACCCCAAGC GGCCCACAGT TGAAGACAAC 
AAATACATTG ATCAAAAACT CCGCAAGTCT GTTTTCAGCA TAAGGGCAAG GAACCTTCTG 
GAAAAGGAGA CCGCAGTCAC AAAAATCTTA AGAGCTTGCA CTCGACAGCG CATGCTGAGC 
GGATCATTCG AGGGGCAGCC AGCAAAGGAG AGGTCGATCC TCAGCGTGCA GCATCACATC 
CGCCAGGAGC GCAGGTCACT CAGACATGGA TCCAACAGCC AGAGGATCAG CAGGGGCAAA 
TCTCTTGAAA CGTTAACTCA AGATCATTCC AATACGGTGC GCTACAGAAA TGCACAAAGA 
GAAGACAGTG AAATAAAGAT GATCCAGGAG AAGAAGGAGC AAGCAGAGAT GAAAAGGAAG 
GTGCAAGAAG AGGAGCTGCG AGAGAACCAC CCATACTTTG ACAAGCCTCT CTTCATCGTG 
GGTCGAGAAC ACAGGTTCAG AAACTTCTGC CGCGTGGTGG TTCGAGCACG CTTCAATGCA 
TCCAAAACAG ACCCTGTCAC GGGAGCTGTG AAAAATACAA AGTACCACCA ACTTTATGAT 
TTGCTGGGAC TTGTCACCTA CCTGGACTGG GTCATGATCA CTGTAACCAT CTGCTCTTGC 
ATTTCTATGA TGTTCGAATC CCCCTTCCGG AGAGTCATGC ATGCACCCAC TTTACAGATC 
GCTGAATATG TGTTTGTGAT ATTCATGAGC ATTGAGCTTA ATCTGAAGAT TATGGCAGAT 
GGCTTGTTTT TCACTCCAAC TGCTGTCATC AGGGACTTTG GTGGCGTCAT GGACATATTT 
ATCTATCTTG TGAGCTTGAT ATTTCTTTGT TGGATGCCTC AAAATGTGCC TGCTGAGTCA 
GGAGCCCAGC TCCTGATGGT TCTTCGGTGC CTAAGACCTC TTCGGATATT CAAACTGGTG 
CCACAAATGA GGAAAGTTGT TCGAGAACTT TTCAGTGGTT TCAAGGAAAT ATTTTTGGTC 
TCCATTCTGT TGCTGACACT AATGCTTGTT TTTGCAAGCT TTGGTGTTCA GCTCTTTGCC 
GGAAAGCTAG CCAAGTGCAA TGACCCCAAC ATTATCAGAA GGGAAGACTG TAACGGCATC 
TTCAGAATTA ATGTAAGTGT GTCCAAGAAC TTAAATTTAA AACTAAGACC TGGAGAGAAA 
AAACCTGGAT TTTGGGTGCC CCGTGTTTGG GCAAATCCTC GTAACTTTAA CTTTGACAAT 
GTGGGAAATG CTATGCTGGC ATTGTTTGAA GTTCTGTCCT TGAAAGGCTG GGTAGAAGTG 
AGAGATGTCA TTATTCATCG TGTGGGGCCG ATCCATGGAA TCTATATTCA TGTTTTCGTA 
TTCCTGGGTT GCATGATTGG ACTGACTCTT TTTGTCGGTG TAGTTATTGC TAACTTCAAT 
GAAAACAAGG GGACAGCCCT GCTGACGGTA GATCAGAGAA GATGGGAAGA TCTCAAGAGC 
AGATTGAAGA TCGCACAGCC TCTTCATCTC CCACCTCGGC CGGATAATGA TGGATTTAGA 
GCTAAAATGT ATGACATAAC CCAGCATCCG TTTTTTAAAA GGACAATTGC GTTGCTGGTT 
CTGGCCCAGT CTGTGTTGCT ATCTGTCAAG TGGGATGTTG AGGATCCTGT GACAGTTCCT 
TTGGCAACCA TGTCGGTCGT GTTCACCTTC ATCTTTGTCT TAGAGGTTAC AATGAAGATC 
ATAGCAATGT CACCAGCTGG TTTCTGGCAA AGCAGAAGAA ACCGATATGA TCTCTTGGTG 
ACGTCTCTTG GTGTTGTGTG GGTGGTGCTC CATTTTGCTC TGCTGAATGC ATACACCTAC 
ATGATGGGAG CCTGTGTGAT TGTCTTTAGA TTTTTCTCCA TCTGTGGAAA GCATGTGACA 
TTAAAGATGC TCCTTTTGAC TGTGGTTGTC AGCATGTACA AGAGCTTCTT TATCATCGTA 
GGAATGTTTC TCTTGCTGCT GTGCTATGCC TTTGCTGGGG TGGTTCTGTT TGGCACTGTA 
AAGTATGGAG AGAACATTAA CAGGCATGCC AATTTTTCTT CAGCTGGCAA AGCCATTACT 
GTATTGTTCC GAATTGTCAC AGGGGAAGAC TGGAATAAGA TTATGCATGA TTGTATGGTT 
CAGCCTCCAT TTTGTACTCC TGATGAATTT ACATATTGGG CAACAGACTG TGGCAATTAT 
GCAGGGGCAC TTATGTACTT CTGCTCATTC TATGTCATCA TCGCCTACAT CATGCTGAAT 
CTACTTGTAG CCATAATTGT GGAGAATTTC TCTTTGTTTT ATTCCACTGA AGAGGACCAG 
CTTTTGAGTT ACAATGATCT TCGCCATTTT CAAATCATAT GGAATATGGT AGATGATAAC 
GAGAGGTGTG ATCCCACCTT CCGAGTGAAG TTCCTGCTAC GGCTACTGCG TGGGAGGCTA 
GAAGTGGACC TTGATAAAGA CAAGCTCCTG TTTAAGCACA TGTGCTATGA GATGGAGAGG 
CTGCACAATG GTGGTGATGT CACCTTCCAT GATGTCTTGA GCATGCTGTC CTACCGCTCT 
GTAGACATCA GGAAGAGCCT GCAGCTAGAG GAACTGCTGG CAAGGGAGCA GCTGGAGTAC 
ACCATAGAGG AGGAGGTGGC TAAGCAGACT ATTCGCATGT GGCTGAAGAA GTGCTTAAAA 
CGCATCCGGG CTAAACAGCA GCAGTCATGC AGCATCATCC ACAGCCTGAG AGAGAGCCAG 
CAGCAAGAGT TGAGCCGATT CCTGAATCCT CCCAGCATTG AGACCACCCA ACCAAGCGAA 
GATACCAACG CCAACAGCCA GGACCACAAT ACGCAACCTG AGTCAAGCAG TCAGCAGCAG 
CTCTTGAGCC CTACTCTGTC AGACAGAGGA GGAAGTCGAC AGGATGCAGC AGATACTGGG 
AAACCCCAAA GAAAGATTGG GCAATGGCGT CTGCCCTCAG CTCCCAAACC AATAAGCCAT 
TCTGTGTCTT CGGTTAACCT ACGGTTTGGA GGAAGGACAA CAATGAAGTC TGTGGTGTGC 
AAGATGAACC CCATGCCAGA CACAGCTTCC TGTGGCTCCG AAGTTAAAAA GTGGTGGACC 
AGACAGCTGA CTGTGGAGAG TGACGAGAGT GGAGATGACC TCCTAGATAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in NALCN cause an autosomal-recessive syndrome with severe hypotonia, speech impairment, and cognitive delay.
American journal of human genetics93(4)721-6(2013 Oct)
Al-Sayed MD,Al-Zaidan H,Albakheet A,Hakami H,Kenana R,Al-Yafee Y,Al-Dosary M,Qari A,Al-Sheddi T,Al-Muheiza M,Al-Qubbaj W,Lakmache Y,Al-Hindi H,Ghaziuddin M,Colak D,Kaya N

Recessive truncating NALCN mutation in infantile neuroaxonal dystrophy with facial dysmorphism.
Journal of medical genetics50(8)515-20(2013 Aug)
K?ro?lu ?,Seven M,Tolun A

The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm.
Cell129(2)371-83(2007 Apr)
Lu B,Su Y,Das S,Liu J,Xia J,Ren D

An unusual cation channel mediates photic control of locomotion in Drosophila.
Current biology : CB12(24)2152-8(2002 Dec)
Nash HA,Scott RL,Lear BC,Allada R

Cloning of a novel four repeat protein related to voltage-gated sodium and calcium channels.
FEBS letters445(2-3)231-6(1999 Feb)
Lee JH,Cribbs LL,Perez-Reyes E

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Nalcn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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