Tor1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tor1a
Entrez Gene ID	266606
Full Name	torsin family 1, member A
Synonyms	Dyt1
General protein information	Preferred Names torsin family 1, member A Names torsin-1A dystonia 1 protein dystonia 1, torsion (autosomal dominant dystonia 1, torsion (autosomal dominant; torsin A) torsin A torsin ATPase 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_153303.2	NP_695215.2	torsin-1A precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tor1a	NP_659133.1
Drosophila melanogaster (fruit fly)	Torsin	NP_572178.1
Xenopus tropicalis (tropical clawed frog)	tor1b	NP_001016237.1
Homo sapiens (human)	TOR1A	NP_000104.1
Pan troglodytes (chimpanzee)	TOR1A	XP_001164380.2
Canis lupus familiaris (dog)	TOR1A	XP_548417.3
Bos taurus (cattle)	TOR1A	NP_001092528.1
Rattus norvegicus (Norway rat)	Tor1a	NP_695215.2
Gallus gallus (chicken)	TOR1A	NP_001025858.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009547	XP_310142.4

Gene Ontology
Bibliography

Related articles in PubMed

Exploring the Interaction Between eIF2? Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain.
Beauvais G, Rodriguez-Losada N, Ying L, Zakirova Z, Watson JL, Readhead B, Gadue P, French DL, Ehrlich ME, Gonzalez-Alegre P
Neuroscience371455-468(2017 Dec)

Regulation of Torsin ATPases by LAP1 and LULL1.
Zhao C, Brown RS, Chase AR, Eisele MR, Schlieker C
Proceedings of the National Academy of Sciences of the United States of America110(17)E1545-54(2013 Apr)

Generation of a novel rodent model for DYT1 dystonia.
Grundmann K, Gl?ckle N, Martella G, Sciamanna G, Hauser TK, Yu L, Castaneda S, Pichler B, Fehrenbacher B, Schaller M, Nuscher B, Haass C, Hettich J, Yue Z, Nguyen HP, Pisani A, Riess O, Ott T
Neurobiology of disease47(1)61-74(2012 Jul)

CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.
Granata A, Koo SJ, Haucke V, Schiavo G, Warner TT
The EMBO journal30(1)181-93(2011 Jan)

A molecular mechanism underlying the neural-specific defect in torsinA mutant mice.
Kim CE, Perez A, Perkins G, Ellisman MH, Dauer WT
Proceedings of the National Academy of Sciences of the United States of America107(21)9861-6(2010 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

developed transgenic rat models for DYT1 dystonia harboring the full length human mutant and wildtype Tor1A gene.
Title: Generation of a novel rodent model for DYT1 dystonia.

These findings provide new insights into the pathogenic mechanism of torsinA DeltaE and torsinA Delta323-8 mutations in dystonia.
Title: TorsinA protein degradation and autophagy in DYT1 dystonia.

The striking induction of torsinA in astrocytes and satellite cells points to the potential involvement of glial elements in the pathobiology of DYT1 dystonia
Title: Glial elements contribute to stress-induced torsinA expression in the CNS and peripheral nervous system.

torsinA plays a role together with snapin in regulated exocytosis
Title: The dystonia-associated protein torsinA modulates synaptic vesicle recycling.

Ours are the first data to demonstrate the specific modulation of torsinA expression in the basal ganglia of the hyperkinesia model, suggesting that GPi neurons containing torsinA possess pathologic plasticity for LID.
Title: Modulation of torsinA expression in the globus pallidus internus is associated with levodopa-induced dyskinesia in hemiparkinsonian rats.

The following Tor1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tor1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13845	NM_153303.2 Latest version!	Rattus norvegicus torsin family 1, member A (Tor1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tor1a ( NM_153303.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_695215.2 Rattus norvegicus torsin family 1, member A (Tor1a), mRNA.

Price & Availability↑

CloneID	ORa13845
Clone ID Related Accession (Same CDS sequence)	NM_153303.2
Accession Version	NM_153303.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	torsin-1A precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078714.1. On Aug 23, 2004 this sequence version replaced NM_153303.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078714.1, AY054303.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMN01906347 [ECO:0000348] ##Evidence-Data-END##

ATGAAGCTGG GCCGGGCCAC TCTGGCCCTG CTGCTGCTGG TGCCGTGCGT GGTTCGTGCG 
GTGGAGCCCA TCAGCCTGGG TCTGGCCCTA GCCGGCGTAC TCACCGGCTA TATCTCCTAT 
CCTCGCCTCT ACTGCCTCTT CGCCGAGTGC TGCGGCCAGA AGCGGAGCCT CAGCCGTGAG 
GCGCTGCAGA AGGATCTGGA TAACAAGCTC TTTGGACAAC ACCTTGCCAA AAGAGTCATC 
TTAAACGCCG TGTCTGGTTT CCTAAGCAAC CCGAAGCCCA AGAAGCCCCT CACCCTCTCC 
CTGCACGGGT GGACAGGCAC CGGCAAAAAC TTCGCTAGCA AGATCATCGC AGAGAATATT 
TACGAGGGTG GACTGAACAG TGACTATGTA CACCTGTTTG TGGCCACGCT ACACTTCCCC 
CACGCCTCTA ACATCACCCT GTATAAGGAC CAATTACAGA TGTGGATTCG AGGCAACGTG 
AGCGCCTGTG CTCGGTCCAT CTTCATCTTT GACGAGATGG ACAAGATGCA CGCCGGCCTC 
ATCGACGCCA TCAAGCCTTT CCTAGACTAT TACGACGTGG TAGATGAGGT CTCCTATCAG 
AAGGCCATCT TCATCTTCCT CAGCAATGCA GGGGCAGAAA GGATCACAGA CGTGGCTCTG 
GATTTCTGGA GAAGTGGGAA GCAGAGAGAG GAGATCAAGC TCAGAGACAT GGAGCACGCC 
CTGGCCGTGT CGGTCTTCAA TAACAAGAAC AGTGGCTTCT GGCACAGCAG CCTCATTGAC 
CGGAACCTCA TAGACTATTT TGTCCCCTTC CTGCCCCTGG AGTACAAGCA CCTGAAAATG 
TGCATCAGAG TTGAGATGCA GTCCCGTGGC TATGAAGAAG ATGAGGACAT AATCAATAAG 
GTAGCTGAAG AGATGACGTT CTTCCCCAAG GAGGAGAAGG TCTTCTCTGA CAAGGGCTGC 
AAGACTGTGT TCACCAAGCT GGACTACTAC CTGGATGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_695215.2
CDS	39..1040
Translation	MKLGRATLALLLLVPCVVRAVEPISLGLALAGVLTGYISYPRLYCLFAECCGQKRSLSREALQKDLDNKLFGQHLAKRVILNAVSGFLSNPKPKKPLTLSLHGWTGTGKNFASKIIAENIYEGGLNSDYVHLFVATLHFPHASNITLYKDQLQMWIRGNVSACARSIFIFDEMDKMHAGLIDAIKPFLDYYDVVDEVSYQKAIFIFLSNAGAERITDVALDFWRSGKQREEIKLRDMEHALAVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEEDEDIINKVAEEMTFFPKEEKVFSDKGCKTVFTKLDYYLDD

Target ORF information:

RefSeq Version	NM_153303.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus torsin family 1, member A (Tor1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153303.2

ORF Insert Sequence:

ATGAAGCTGG GCCGGGCCAC TCTGGCCCTG CTGCTGCTGG TGCCGTGCGT GGTTCGTGCG 
GTGGAGCCCA TCAGCCTGGG TCTGGCCCTA GCCGGCGTAC TCACCGGCTA TATCTCCTAT 
CCTCGCCTCT ACTGCCTCTT CGCCGAGTGC TGCGGCCAGA AGCGGAGCCT CAGCCGTGAG 
GCGCTGCAGA AGGATCTGGA TAACAAGCTC TTTGGACAAC ACCTTGCCAA AAGAGTCATC 
TTAAACGCCG TGTCTGGTTT CCTAAGCAAC CCGAAGCCCA AGAAGCCCCT CACCCTCTCC 
CTGCACGGGT GGACAGGCAC CGGCAAAAAC TTCGCTAGCA AGATCATCGC AGAGAATATT 
TACGAGGGTG GACTGAACAG TGACTATGTA CACCTGTTTG TGGCCACGCT ACACTTCCCC 
CACGCCTCTA ACATCACCCT GTATAAGGAC CAATTACAGA TGTGGATTCG AGGCAACGTG 
AGCGCCTGTG CTCGGTCCAT CTTCATCTTT GACGAGATGG ACAAGATGCA CGCCGGCCTC 
ATCGACGCCA TCAAGCCTTT CCTAGACTAT TACGACGTGG TAGATGAGGT CTCCTATCAG 
AAGGCCATCT TCATCTTCCT CAGCAATGCA GGGGCAGAAA GGATCACAGA CGTGGCTCTG 
GATTTCTGGA GAAGTGGGAA GCAGAGAGAG GAGATCAAGC TCAGAGACAT GGAGCACGCC 
CTGGCCGTGT CGGTCTTCAA TAACAAGAAC AGTGGCTTCT GGCACAGCAG CCTCATTGAC 
CGGAACCTCA TAGACTATTT TGTCCCCTTC CTGCCCCTGG AGTACAAGCA CCTGAAAATG 
TGCATCAGAG TTGAGATGCA GTCCCGTGGC TATGAAGAAG ATGAGGACAT AATCAATAAG 
GTAGCTGAAG AGATGACGTT CTTCCCCAAG GAGGAGAAGG TCTTCTCTGA CAAGGGCTGC 
AAGACTGTGT TCACCAAGCT GGACTACTAC CTGGATGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Exploring the Interaction Between eIF2? Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain.
Neuroscience371455-468(2017 Dec)
Beauvais G,Rodriguez-Losada N,Ying L,Zakirova Z,Watson JL,Readhead B,Gadue P,French DL,Ehrlich ME,Gonzalez-Alegre P

Regulation of Torsin ATPases by LAP1 and LULL1.
Proceedings of the National Academy of Sciences of the United States of America110(17)E1545-54(2013 Apr)
Zhao C,Brown RS,Chase AR,Eisele MR,Schlieker C

Generation of a novel rodent model for DYT1 dystonia.
Neurobiology of disease47(1)61-74(2012 Jul)
Grundmann K,Gl?ckle N,Martella G,Sciamanna G,Hauser TK,Yu L,Castaneda S,Pichler B,Fehrenbacher B,Schaller M,Nuscher B,Haass C,Hettich J,Yue Z,Nguyen HP,Pisani A,Riess O,Ott T

CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.
The EMBO journal30(1)181-93(2011 Jan)
Granata A,Koo SJ,Haucke V,Schiavo G,Warner TT

A molecular mechanism underlying the neural-specific defect in torsinA mutant mice.
Proceedings of the National Academy of Sciences of the United States of America107(21)9861-6(2010 May)
Kim CE,Perez A,Perkins G,Ellisman MH,Dauer WT

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Tor1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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