Slc16a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc16a2
Entrez Gene ID	259248
Full Name	solute carrier family 16 member 2
General protein information	Preferred Names solute carrier family 16 member 2 Names monocarboxylate transporter 8 MCT 8 solute carrier family 16 (monocarboxylic acid transporters), member 2 solute carrier family 16, member 2 (monocarboxylic acid transporter 8) solute carrier family 16, member 2 (thyroid hormone transporter)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq22
Summary	human homolog is a monocarboxylate transporter [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_147216.1	NP_671749.1	monocarboxylate transporter 8

Pathways from BioSystems

Homologies

Homo sapiens (human)	SLC16A2	NP_006508.2
Canis lupus familiaris (dog)	SLC16A2	XP_005641562.1
Mus musculus (house mouse)	Slc16a2	NP_033223.2
	SLC16A2	XP_001096017.1
Danio rerio (zebrafish)	slc16a2	NP_001245159.1
Gallus gallus (chicken)	SLC16A2	XP_426274.2
Bos taurus (cattle)	SLC16A2	NP_001193868.1
Rattus norvegicus (Norway rat)	Slc16a2	NP_671749.1
Xenopus tropicalis (tropical clawed frog)	LOC100494635	XP_002931873.2

Gene Ontology
Bibliography

Related articles in PubMed

Mct8 and trh co-expression throughout the hypothalamic paraventricular nucleus is modified by dehydration-induced anorexia in rats.
Alvarez-Salas E, Mengod G, Garc?a-Luna C, Soberanes-Ch?vez P, Matamoros-Trejo G, de Gortari P
Neuropeptides5633-40(2016 Apr)

Parallel regulation of thyroid hormone transporters OATP1c1 and MCT8 during and after endotoxemia at the blood-brain barrier of male rodents.
Wittmann G, Szabon J, Moh?csik P, Nouriel SS, Gereben B, Fekete C, Lechan RM
Endocrinology156(4)1552-64(2015 Apr)

Further Insights into the Allan-Herndon-Dudley Syndrome: Clinical and Functional Characterization of a Novel MCT8 Mutation.
Armour CM, Kersseboom S, Yoon G, Visser TJ
PloS one10(10)e0139343(2015)

Tissue-specific alterations in thyroid hormone homeostasis in combined Mct10 and Mct8 deficiency.
M?ller J, Mayerl S, Visser TJ, Darras VM, Boelen A, Frappart L, Mariotta L, Verrey F, Heuer H
Endocrinology155(1)315-25(2014 Jan)

Expression of organic anion transporting polypeptide 1c1 and monocarboxylate transporter 8 in the rat placental barrier and the compensatory response to thyroid dysfunction.
Sun YN, Liu YJ, Zhang L, Ye Y, Lin LX, Li YM, Yan YQ, Chen ZP
PloS one9(4)e96047(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We found that dehydration induced anorexia rats showed increased number of thyrotropin-releasing hormone (TRH) cells in caudal paraventricular hypothalamic nucleus, as well as a decreased percentage of TRH-expressing neurons that co-expressed monocarboxylate transporter-8 mRNA signal.
Title: Mct8 and trh co-expression throughout the hypothalamic paraventricular nucleus is modified by dehydration-induced anorexia in rats.

The data demonstrate that OATP1c1 and MCT8 expression are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents.
Title: Parallel regulation of thyroid hormone transporters OATP1c1 and MCT8 during and after endotoxemia at the blood-brain barrier of male rodents.

the coordinated effects of Oatp1c1, Mct8, D2 and D3 in the placental barrier may regulate both transplacental TH passage and the development of trophoblast cells during thyroid dysfunction throughout the pregnancy.
Title: Expression of organic anion transporting polypeptide 1c1 and monocarboxylate transporter 8 in the rat placental barrier and the compensatory response to thyroid dysfunction.

Prolonged cerebral ischemia causes compensatory increase of MCT8 mRNA expression on the capillary endothelial cell membranes in the lateral ventricle of rats.
Title: [Expression of monocarboxylate transporter 8 mRNA in the brain tissue of rats with cerebral ischemia].

Data report here that in addition to neuronal expression, MCT8 mRNA and protein are expressed in cerebral microvessels in rats.
Title: Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.

The following Slc16a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc16a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02882	NM_147216.1 Latest version!	Rattus norvegicus solute carrier family 16 member 2 (Slc16a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc16a2 ( NM_147216.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_671749.1 Rattus norvegicus solute carrier family 16 member 2 (Slc16a2), mRNA.

Price & Availability↑

CloneID	ORa02882
Clone ID Related Accession (Same CDS sequence)	NM_147216.1
Accession Version	NM_147216.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1638bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	monocarboxylate transporter 8
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ496570.1. ##Evidence-Data-START## Transcript exon combination :: AJ496570.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGCTGC CAAGCCCGGC GAGCGAGGAA GCTGAGGGGC CCTGTCAGGA GGCAAACCAG 
GAATATCAGG AGCCGGTGTG TAGTCCTGTG CCCGAGCCGG AGCCAGAGCC GGAGCCCGAA 
CCGGAGCCTG AGCCAGAGCC GGTGCCAGTG CCCCCACCCG AGCCTCAGCC TGAGCCCGAG 
CCCCAGCCCC TACCCGACCC TGCACCCCTG CCGGTGCTGG GCTTTGAGGC TGAGCCAGTG 
CAAGAACCCG AGCCCACGCC CACAGTGGAG ACCCGAGGCA CCGCGCGTGG CTTTCAGCCT 
CCCGAAGGTG GCTTCGGCTG GATAGTGGTG TTTGCAGCCA CCTGGTGCAA CGGSTCCATC 
TTCGGCATCC ATAACTCTGT TGGTATCCTC TACTCCATGC TACTAGAGGA GGAAAAAGAG 
AAAAATCGCC AAGTGGAGTT CCAAGCAGCC TGGGTCGGAG CCCTCGCCAT GGGCATGATC 
TTCTTCTGTT CTCCCATTGT GAGTATATTC ACTGACCGTT TGGGCTGCCG GATCACAGCC 
ACCACCGGGG CGGCCGTTGC TTTCATTGGC CTCCACACCA GCTCCTTCAC CAGCCCCCTA 
AGCCTGCGCT ACTTCACCTA TGGGATTCTG TTTGGTTGTG GCTGCTCATT CGCCTTTCAA 
CCATCACTCG TCATCCTGGA CCACTACTTT CAACGTCGCC TGGGTCTGGC CAATGGTGTG 
GTGTCTGCTG GGAGTAGCAT CTTCTCCATG TCTTTTCCCT TCCTCATCAA AATGCTGGGA 
GACAGAATCA AGCTGGCCCA AACCTTCCAG GTGCTGAGTA CCTTCATGTT TGTTCTTACG 
CTGCTCTCAC TCACCTACCG GCCCCTCCTG CCCAGCTCCC AGGACACCCC AAGCAAGAGA 
GGCGCCCACA CCCTGCGACA GCGCTTTCTG GTTCAGTTCA GAAAGTACTT CAACATGCGT 
GTATTTCGCC AGCGCACCTA CCGTATCTGG GCCTTTGGGA TCGCTGCTGC TGCCCTTGGT 
TACTTCGTCC CCTACGTACA CCTGATGAAA TATGTGGAAG ATAAGTTCAA GGAGATCAAG 
GAAACCTGGG TGCTCTTGGT GTGTATTGGG GCTACTTCAG GCCTTGGACG TCTCGTCTCA 
GGCCACATCA GTGACTCCAT CCCTGGACTT AAGAAGATAT ACTTGCAGGT CCTCTCATTC 
CTGCTCCTGG GCTTGATGTC TATGATGATC CCCCTATGCC GGGACTTCGG GGGCCTTATC 
GTTGTCTGCC TCTTCCTGGG CCTATGTGAT GGCTTCTTCA TCACCATCAT GGCTCCCATT 
GCGTTTGAAC TGGTGGGACC CATGCAGGCC TCACAGGCCA TTGGCTACCT CCTAGGCATG 
ATGGCCCTGC CAATGATTGC TGGGCCCCCC ATTGCAGGCC TCCTCCGAAA CTGCTTTGGT 
AACTACCATG TGGCCTTCTA CTTTGCGGGT GTCCCCCCAA TTATTGGGGC TGTGATCCTT 
TTCTTCGTCC CTCTGATGCA TCAAAGGATG TTTAAGAAAG AGCAGAGAGA GTCCAGCAAG 
GATAAGATGC TGTCCCACGA TCCAGACCCC AACGGAGAAC TGCTGCCAGG CTCCCCAACA 
CCTGAAGAGC CCATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_671749.1
CDS	1..1638
Translation	MALPSPASEEAEGPCQEANQEYQEPVCSPVPEPEPEPEPEPEPEPEPVPVPPPEPQPEPEPQPLPDPAPLPVLGFEAEPVQEPEPTPTVETRGTARGFQPPEGGFGWIVVFAATWCNnullSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAAVAFIGLHTSSFTSPLSLRYFTYGILFGCGCSFAFQPSLVILDHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDRIKLAQTFQVLSTFMFVLTLLSLTYRPLLPSSQDTPSKRGAHTLRQRFLVQFRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGNYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRESSKDKMLSHDPDPNGELLPGSPTPEEPI

Target ORF information:

RefSeq Version	NM_147216.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 16 member 2 (Slc16a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_147216.1

ORF Insert Sequence:

ATGGCGCTGC CAAGCCCGGC GAGCGAGGAA GCTGAGGGGC CCTGTCAGGA GGCAAACCAG 
GAATATCAGG AGCCGGTGTG TAGTCCTGTG CCCGAGCCGG AGCCAGAGCC GGAGCCCGAA 
CCGGAGCCTG AGCCAGAGCC GGTGCCAGTG CCCCCACCCG AGCCTCAGCC TGAGCCCGAG 
CCCCAGCCCC TACCCGACCC TGCACCCCTG CCGGTGCTGG GCTTTGAGGC TGAGCCAGTG 
CAAGAACCCG AGCCCACGCC CACAGTGGAG ACCCGAGGCA CCGCGCGTGG CTTTCAGCCT 
CCCGAAGGTG GCTTCGGCTG GATAGTGGTG TTTGCAGCCA CCTGGTGCAA CGGSTCCATC 
TTCGGCATCC ATAACTCTGT TGGTATCCTC TACTCCATGC TACTAGAGGA GGAAAAAGAG 
AAAAATCGCC AAGTGGAGTT CCAAGCAGCC TGGGTCGGAG CCCTCGCCAT GGGCATGATC 
TTCTTCTGTT CTCCCATTGT GAGTATATTC ACTGACCGTT TGGGCTGCCG GATCACAGCC 
ACCACCGGGG CGGCCGTTGC TTTCATTGGC CTCCACACCA GCTCCTTCAC CAGCCCCCTA 
AGCCTGCGCT ACTTCACCTA TGGGATTCTG TTTGGTTGTG GCTGCTCATT CGCCTTTCAA 
CCATCACTCG TCATCCTGGA CCACTACTTT CAACGTCGCC TGGGTCTGGC CAATGGTGTG 
GTGTCTGCTG GGAGTAGCAT CTTCTCCATG TCTTTTCCCT TCCTCATCAA AATGCTGGGA 
GACAGAATCA AGCTGGCCCA AACCTTCCAG GTGCTGAGTA CCTTCATGTT TGTTCTTACG 
CTGCTCTCAC TCACCTACCG GCCCCTCCTG CCCAGCTCCC AGGACACCCC AAGCAAGAGA 
GGCGCCCACA CCCTGCGACA GCGCTTTCTG GTTCAGTTCA GAAAGTACTT CAACATGCGT 
GTATTTCGCC AGCGCACCTA CCGTATCTGG GCCTTTGGGA TCGCTGCTGC TGCCCTTGGT 
TACTTCGTCC CCTACGTACA CCTGATGAAA TATGTGGAAG ATAAGTTCAA GGAGATCAAG 
GAAACCTGGG TGCTCTTGGT GTGTATTGGG GCTACTTCAG GCCTTGGACG TCTCGTCTCA 
GGCCACATCA GTGACTCCAT CCCTGGACTT AAGAAGATAT ACTTGCAGGT CCTCTCATTC 
CTGCTCCTGG GCTTGATGTC TATGATGATC CCCCTATGCC GGGACTTCGG GGGCCTTATC 
GTTGTCTGCC TCTTCCTGGG CCTATGTGAT GGCTTCTTCA TCACCATCAT GGCTCCCATT 
GCGTTTGAAC TGGTGGGACC CATGCAGGCC TCACAGGCCA TTGGCTACCT CCTAGGCATG 
ATGGCCCTGC CAATGATTGC TGGGCCCCCC ATTGCAGGCC TCCTCCGAAA CTGCTTTGGT 
AACTACCATG TGGCCTTCTA CTTTGCGGGT GTCCCCCCAA TTATTGGGGC TGTGATCCTT 
TTCTTCGTCC CTCTGATGCA TCAAAGGATG TTTAAGAAAG AGCAGAGAGA GTCCAGCAAG 
GATAAGATGC TGTCCCACGA TCCAGACCCC AACGGAGAAC TGCTGCCAGG CTCCCCAACA 
CCTGAAGAGC CCATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mct8 and trh co-expression throughout the hypothalamic paraventricular nucleus is modified by dehydration-induced anorexia in rats.
Neuropeptides5633-40(2016 Apr)
Alvarez-Salas E,Mengod G,Garc?a-Luna C,Soberanes-Ch?vez P,Matamoros-Trejo G,de Gortari P

Parallel regulation of thyroid hormone transporters OATP1c1 and MCT8 during and after endotoxemia at the blood-brain barrier of male rodents.
Endocrinology156(4)1552-64(2015 Apr)
Wittmann G,Szabon J,Moh?csik P,Nouriel SS,Gereben B,Fekete C,Lechan RM

Further Insights into the Allan-Herndon-Dudley Syndrome: Clinical and Functional Characterization of a Novel MCT8 Mutation.
PloS one10(10)e0139343(2015)
Armour CM,Kersseboom S,Yoon G,Visser TJ

Tissue-specific alterations in thyroid hormone homeostasis in combined Mct10 and Mct8 deficiency.
Endocrinology155(1)315-25(2014 Jan)
M?ller J,Mayerl S,Visser TJ,Darras VM,Boelen A,Frappart L,Mariotta L,Verrey F,Heuer H

Expression of organic anion transporting polypeptide 1c1 and monocarboxylate transporter 8 in the rat placental barrier and the compensatory response to thyroid dysfunction.
PloS one9(4)e96047(2014)
Sun YN,Liu YJ,Zhang L,Ye Y,Lin LX,Li YM,Yan YQ,Chen ZP

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Slc16a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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