Maob cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Maob
Entrez Gene ID	25750
Full Name	monoamine oxidase B
General protein information	Preferred Names monoamine oxidase B Names amine oxidase [flavin-containing] B MAO-B monoamine oxidase type B
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq11
Summary	major neurotransmitter-degrading enzyme in the CNS; degrades biogenic monoamines in the brain [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013198.1	NP_037330.1	amine oxidase [flavin-containing] B

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	mao	NP_997992.2
Neurospora crassa	NCU05933	XP_958128.1
	MAOB	XP_002806250.1
Canis lupus familiaris (dog)	MAOB	NP_001002970.1
Gallus gallus (chicken)	MAOB	XP_416766.2
Magnaporthe oryzae (rice blast fungus)	MGG_16538	XP_003711032.1
Homo sapiens (human)	MAOB	NP_000889.3
Pan troglodytes (chimpanzee)	MAOB	XP_003317481.1
Bos taurus (cattle)	MAOB	NP_808813.2
Rattus norvegicus (Norway rat)	Maob	NP_037330.1
Mus musculus (house mouse)	Maob	NP_766366.2
Xenopus tropicalis (tropical clawed frog)	LOC100494267	XP_002932838.1

Gene Ontology
Bibliography

Related articles in PubMed

A spectrophotometric assay for monoamine oxidase activity with 2, 4-dinitrophenylhydrazine as a derivatized reagent.
Huang G, Zhu F, Chen Y, Chen S, Liu Z, Li X, Gan L, Zhang L, Yu Y
Analytical biochemistry51218-25(2016 Nov)

Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis.
Chen S, Lu FF, Seeman P, Liu F
Neurochemical research37(12)2805-13(2012 Dec)

Topological probes of monoamine oxidases A and B in rat liver mitochondria: inhibition by TEMPO-substituted pargyline analogues and inactivation by proteolysis.
Wang J, Edmondson DE
Biochemistry50(13)2499-505(2011 Apr)

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
Zhao X, Le?n IR, Bak S, Mogensen M, Wrzesinski K, H?jlund K, Jensen ON
Molecular & cellular proteomics : MCP10(1)M110.000299(2011 Jan)

Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase.
Vaarmann A, Gandhi S, Abramov AY
The Journal of biological chemistry285(32)25018-23(2010 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Benzylamine and serotonin oxidation were catalyzed by MAO-B and MAO-A, respectively, to aldehydes. These were derivatized with DNPH, and the corresponding quinones were further formed by adding NaOH. These DNPH derivatives with large conjugated structures were directly measured spectrophotometrically at 465 nm and 425 nm
Title: A spectrophotometric assay for monoamine oxidase activity with 2, 4-dinitrophenylhydrazine as a derivatized reagent.

Monoamine oxidase B is increased in prefrontal cortex following ethanol administration.
Title: Ethanol increases TIEG2-MAO B cell death cascade in the prefrontal cortex of ethanol-preferring rats.

investigation of topological orientation of MAO-B (and MAO-A) in liver mitochondrial membranes
Title: Topological probes of monoamine oxidases A and B in rat liver mitochondria: inhibition by TEMPO-substituted pargyline analogues and inactivation by proteolysis.

Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase
Title: Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase.

significant effects of hormone replacement and gonadectomy on catechol-O-methyltransferase and monoamine oxidase isoforms in both striatum and cortex
Title: Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats.

The following Maob gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Maob cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12447	NM_013198.1 Latest version!	Rattus norvegicus monoamine oxidase B (Maob), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Maob ( NM_013198.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037330.1 Rattus norvegicus monoamine oxidase B (Maob), mRNA.

Price & Availability↑

CloneID	ORa12447
Clone ID Related Accession (Same CDS sequence)	NM_013198.1
Accession Version	NM_013198.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	amine oxidase [flavin-containing] B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M23601.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M23601.1, FQ210326.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGAGCAACA AATGCGATGT GATCGTGGTG GGGGGCGGCA TCTCAGGTAT GGCAGCAGCC 
AAACTTTTGC ATGACTGTGG CCTCAGTGTG GTGGTTCTGG AAGCACGAGA CTGTGTGGGA 
GGCAGGACTT ACACAATTAG GAATAAAAAT GTTAAATATG TGGACCTTGG AGGATCTTAT 
GTTGGGCCGA CCCAGAATCG TATCTTACGA TTGGCCAAAG AGCTAGGATT GGAGACCTAT 
AAAGTGAATG AAGTTGAGCG GCTGATCCAC TTTGTAAAGG GAAAATCATA TGCCTTCAGG 
GGCCCATTCC CACCAGTGTG GAATCCAATC ACTTACCTAG ATTATAACAA CCTCTGGAGA 
ACAATGGATG AGATGGGCCA AGAGATTCCC AGTGATGCTC CATGGAAGGC ACCCCTTGCT 
GAAGAGTGGG ACTACATGAC AATGAAAGAG TTGCTAGATA AGATCTGCTG GACCAACTCT 
ACAAAGCAGA TTGCCACACT CTTTGTGAAC CTATGTGTAA CTGCGGAGAC CCATGAGGTT 
TCTGCACTGT GGTTCCTGTG GTATGTGAAG CAGTGTGGGG GTACAACCAG AATCATATCA 
ACAACCAATG GAGGACAGGA GAGGAAATTT ATTGGTGGAT CTGGTCAAGT GAGTGAGCGG 
ATAAAGGATA TCCTTGGGGA CAGAGTGAAG CTGGAGAGGC CGGTGATCCA CATTGACCAG 
ACAGGAGAAA ATGTTGTTGT GAAAACCCTA AACCATGAAA TATATGAGGC TAAATATGTG 
ATTAGTGCCA TCCCACCTGT TTTGGGCATG AAGATTCACC ATAGTCCTCC TCTGCCCATT 
CTAAGAAACC AGCTGATTAC TCGTGTGCCT TTGGGTTCAG TTATTAAGTG CATGGTTTAT 
TATAAAGAAC CCTTCTGGAG GAAAAAGGAT TTCTGTGGAA CCATGGTTAT TGAAGGAGAG 
GAAGCTCCAA TTGCGTACAC ATTGGATGAT ACCAAGCCAG ATGCAGGCTG TGCTGCTATA 
ATGGGATTTA TCCTTGCTCA CAAAGCTAGA AAACTGGTAC GCCTTACTAA AGAAGAAAGA 
CTGAGGAAGC TCTGTGAGCT ATACGCGAAA GTTCTGAACT CTCAAGAAGC TCTGCAGCCA 
GTCCATTATG AAGAGAAGAA CTGGTGTGAG GAGCAGTACT CCGGGGGCTG CTACACAGCC 
TACTTCCCTC CTGGCATCTT GACCCAGTAT GGAAGGGTTC TACGCCAGCC AGTGGGCAAG 
ATTTTCTTTG CAGGCACCGA GACAGCTTCA CATTGGAGTG GCTACATGGA GGGGGCTGTA 
GAGGCTGGAG AGAGAGCTGC CAGAGAGATT CTTCATGCCA TTGGGAAGAT TCCAGAGGAT 
GAAATTTGGC AGCCAGAACC AGAATCTGTG GATGTCCCAG CAAGACCCAT TACCAACACC 
TTCCTGGAGA GACACTTGCC TTCTGTACCA GGTCTACTAA AGCTGCTTGG ATTGACCACC 
ATCTTGTCAG CAACAGCTCT TGGTTTCCTG GCCCACAAAA AGGGTCTGTT TGTACGTTTC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037330.1
CDS	64..1626
Translation	MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDCVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDAGCAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNTFLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF

Target ORF information:

RefSeq Version	NM_013198.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus monoamine oxidase B (Maob), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013198.1

ORF Insert Sequence:

ATGAGCAACA AATGCGATGT GATCGTGGTG GGGGGCGGCA TCTCAGGTAT GGCAGCAGCC 
AAACTTTTGC ATGACTGTGG CCTCAGTGTG GTGGTTCTGG AAGCACGAGA CTGTGTGGGA 
GGCAGGACTT ACACAATTAG GAATAAAAAT GTTAAATATG TGGACCTTGG AGGATCTTAT 
GTTGGGCCGA CCCAGAATCG TATCTTACGA TTGGCCAAAG AGCTAGGATT GGAGACCTAT 
AAAGTGAATG AAGTTGAGCG GCTGATCCAC TTTGTAAAGG GAAAATCATA TGCCTTCAGG 
GGCCCATTCC CACCAGTGTG GAATCCAATC ACTTACCTAG ATTATAACAA CCTCTGGAGA 
ACAATGGATG AGATGGGCCA AGAGATTCCC AGTGATGCTC CATGGAAGGC ACCCCTTGCT 
GAAGAGTGGG ACTACATGAC AATGAAAGAG TTGCTAGATA AGATCTGCTG GACCAACTCT 
ACAAAGCAGA TTGCCACACT CTTTGTGAAC CTATGTGTAA CTGCGGAGAC CCATGAGGTT 
TCTGCACTGT GGTTCCTGTG GTATGTGAAG CAGTGTGGGG GTACAACCAG AATCATATCA 
ACAACCAATG GAGGACAGGA GAGGAAATTT ATTGGTGGAT CTGGTCAAGT GAGTGAGCGG 
ATAAAGGATA TCCTTGGGGA CAGAGTGAAG CTGGAGAGGC CGGTGATCCA CATTGACCAG 
ACAGGAGAAA ATGTTGTTGT GAAAACCCTA AACCATGAAA TATATGAGGC TAAATATGTG 
ATTAGTGCCA TCCCACCTGT TTTGGGCATG AAGATTCACC ATAGTCCTCC TCTGCCCATT 
CTAAGAAACC AGCTGATTAC TCGTGTGCCT TTGGGTTCAG TTATTAAGTG CATGGTTTAT 
TATAAAGAAC CCTTCTGGAG GAAAAAGGAT TTCTGTGGAA CCATGGTTAT TGAAGGAGAG 
GAAGCTCCAA TTGCGTACAC ATTGGATGAT ACCAAGCCAG ATGCAGGCTG TGCTGCTATA 
ATGGGATTTA TCCTTGCTCA CAAAGCTAGA AAACTGGTAC GCCTTACTAA AGAAGAAAGA 
CTGAGGAAGC TCTGTGAGCT ATACGCGAAA GTTCTGAACT CTCAAGAAGC TCTGCAGCCA 
GTCCATTATG AAGAGAAGAA CTGGTGTGAG GAGCAGTACT CCGGGGGCTG CTACACAGCC 
TACTTCCCTC CTGGCATCTT GACCCAGTAT GGAAGGGTTC TACGCCAGCC AGTGGGCAAG 
ATTTTCTTTG CAGGCACCGA GACAGCTTCA CATTGGAGTG GCTACATGGA GGGGGCTGTA 
GAGGCTGGAG AGAGAGCTGC CAGAGAGATT CTTCATGCCA TTGGGAAGAT TCCAGAGGAT 
GAAATTTGGC AGCCAGAACC AGAATCTGTG GATGTCCCAG CAAGACCCAT TACCAACACC 
TTCCTGGAGA GACACTTGCC TTCTGTACCA GGTCTACTAA AGCTGCTTGG ATTGACCACC 
ATCTTGTCAG CAACAGCTCT TGGTTTCCTG GCCCACAAAA AGGGTCTGTT TGTACGTTTC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A spectrophotometric assay for monoamine oxidase activity with 2, 4-dinitrophenylhydrazine as a derivatized reagent.
Analytical biochemistry51218-25(2016 Nov)
Huang G,Zhu F,Chen Y,Chen S,Liu Z,Li X,Gan L,Zhang L,Yu Y

Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis.
Neurochemical research37(12)2805-13(2012 Dec)
Chen S,Lu FF,Seeman P,Liu F

Topological probes of monoamine oxidases A and B in rat liver mitochondria: inhibition by TEMPO-substituted pargyline analogues and inactivation by proteolysis.
Biochemistry50(13)2499-505(2011 Apr)
Wang J,Edmondson DE

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
Molecular & cellular proteomics : MCP10(1)M110.000299(2011 Jan)
Zhao X,Le?n IR,Bak S,Mogensen M,Wrzesinski K,H?jlund K,Jensen ON

Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase.
The Journal of biological chemistry285(32)25018-23(2010 Aug)
Vaarmann A,Gandhi S,Abramov AY

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Maob cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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