Kcnj6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnj6
Entrez Gene ID	25743
Full Name	potassium voltage-gated channel subfamily J member 6
General protein information	Preferred Names potassium voltage-gated channel subfamily J member 6 Names G protein-activated inward rectifier potassium channel 2 BIR1 GIRK-2 GIRK2 KATP-2 inward rectifier K(+) channel Kir3.2 potassium channel, inwardly rectifying subfamily J member 6 potassium inwardly-rectifying channel, subfamily J, member 6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q11
Summary	inwardly-rectifying potassium channel [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008768567.2	XP_008766789.1	G protein-activated inward rectifier potassium channel 2 isoform X2
NM_013192.2	NP_037324.1	G protein-activated inward rectifier potassium channel 2
XM_017597888.1	XP_017453377.1	G protein-activated inward rectifier potassium channel 2 isoform X1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	KCNJ6	XP_004934603.1
Mus musculus (house mouse)	Kcnj6	NP_034736.2
Homo sapiens (human)	KCNJ6	NP_002231.1
Rattus norvegicus (Norway rat)	Kcnj6	NP_037324.1
Danio rerio (zebrafish)	kcnj6	XP_697984.5
	KCNJ6	XP_001083031.1
Pan troglodytes (chimpanzee)	KCNJ6	XP_001170389.1
Canis lupus familiaris (dog)	KCNJ6	XP_544881.3
Bos taurus (cattle)	KCNJ6	XP_002685215.2
Xenopus tropicalis (tropical clawed frog)	kcnj9	NP_001096554.1

Gene Ontology
Bibliography

Related articles in PubMed

Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels.
Baculis BC, Weiss AC, Pang W, Jeong HG, Lee JH, Liu DC, Tsai NP, Chung HJ
Scientific reports7(1)12313(2017 Sep)

The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway.
Liang W, Chen M, Zheng D, Li J, Song M, Zhang W, Feng J, Lan J
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology41(3)1020-1034(2017)

G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy.
Lyu C, Mulder J, Barde S, Sahlholm K, Zeberg H, Nilsson J, ?rhem P, H?kfelt T, Fried K, Shi TJ
Molecular pain1144(2015 Jul)

Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.
Montalbano A, Corradetti R, Mlinar B
PloS one10(10)e0140369(2015)

Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome.
Best TK, Cramer NP, Chakrabarti L, Haydar TF, Galdzicki Z
Experimental neurology233(2)749-57(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The opening of ATP-sensitive K+ channels protects cardiomyocytes against the high glucose-induced injury and inflammation by inhibiting the ROS-TLR4-necroptosis pathway.
Title: The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway.

Fourteen days after axotomy, GIRK1 and GIRK2 were down-regulated in DRG neurons at the mRNA and protein levels.
Title: G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy.

inwardly rectifying K+ channels coupled to 5-HT1A autoreceptors display pharmacological properties generally expected for neuronal GIRK channels, but different from GIRK1-GIRK2 heteromers
Title: Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.

Data describe the developmental regulation and subcellular diversity of neuronal GIRK/Kir3 channels, and support the contention that distinct subpopulations of GIRK channels exert separable influences on neuronal excitability.
Title: Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain.

Estradiol regulates dopamine-activataed GIRK channel activity in pituitary lactotrophs, regulating prolactin release during the estrous cycle.
Title: Estrogen regulation of the dopamine-activated GIRK channel in pituitary lactotrophs: implications for regulation of prolactin release during the estrous cycle.

The following Kcnj6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnj6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13047	NM_013192.2 Latest version!	Rattus norvegicus potassium inwardly-rectifying channel, subfamily J, member 6 (Kcnj6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa43213	XM_008768567.2 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily J member 6 (Kcnj6), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa57647	XM_017597888.1 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily J member 6 (Kcnj6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnj6 ( NM_013192.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037324.1 Rattus norvegicus potassium inwardly-rectifying channel, subfamily J, member 6 (Kcnj6), mRNA.

Price & Availability↑

CloneID	ORa13047
Clone ID Related Accession (Same CDS sequence)	NM_013192.2
Accession Version	NM_013192.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1278bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-22
Organism	Rattus norvegicus(Norway rat)
Product	G protein-activated inward rectifier potassium channel 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB073753.1. On or before Jan 12, 2005 this sequence version replaced XM_346416.1, NM_013192.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB073753.1 [ECO:0000332] ##Evidence-Data-END##

ATGACAATGG CCAAGTTAAC TGAATCCATG ACTAATGTCC TGGAGGGGGA TTCCATGGAC 
CAAGACGTGG AAAGCCCAGT GGCCATTCAC CAGCCAAAGT TGCCTAAGCA GGCCAGGGAT 
GACCTGCCAA GACACATCAG CCGAGACAGG ACCAAAAGGA AAATCCAGAG GTACGTGAGG 
AAGGATGGGA AGTGTAACGT CCACCACGGC AACGTGCGGG AGACGTACCG ATACCTGACG 
GACATCTTCA CCACCCTGGT GGACCTAAAG TGGAGATTCA ACCTATTGAT CTTTGTCATG 
GTCTACACAG TGACGTGGCT TTTCTTTGGG ATGATCTGGT GGCTAATTGC ATACATCCGG 
GGAGATATGG ACCACATAGA GGACCCCTCG TGGACTCCCT GTGTTACCAA CCTCAACGGG 
TTTGTCTCCG CTTTTTTATT CTCAATAGAG ACAGAAACCA CCATTGGTTA TGGCTACAGG 
GTCATCACGG ACAAGTGCCC AGAAGGAATT ATTCTCCTCT TAATCCAGTC CGTGTTGGGG 
TCCATTGTCA ACGCCTTCAT GGTAGGATGT ATGTTTGTGA AAATATCCCA ACCCAAGAAG 
AGGGCAGAGA CCCTGGTCTT TTCCACCCAT GCGGTAATCT CCATGCGGGA TGGGAAACTA 
TGCCTGATGT TCCGGGTAGG GGACTTGAGG AATTCCCACA TTGTGGAGGC CTCCATCAGA 
GCCAAGTTGA TCAAGTCCAA ACAGACTTCA GAGGGGGAGT TCATTCCCCT CAACCAGACG 
GATATCAACG TAGGGTACTA CACCGGGGAT GACCGACTCT TTCTCGTGTC ACCGCTGATT 
ATTAGCCATG AAATTAACCA ACAGAGTCCC TTCTGGGAGA TCTCCAAAGC CCAGCTGCCT 
AAAGAGGAAC TGGAGATTGT GGTCATCCTG GAGGGAATGG TGGAAGCCAC AGGAATGACG 
TGCCAAGCTC GAAGCTCCTA CATCACCAGT GAGATCCTGT GGGGTTACCG GTTCACACCA 
GTCCTGACAC TGGAGGACGG GTTCTATGAA GTTGACTACA ACAGCTTCCA TGAGACCTAT 
GAGACCAGCA CCCCGTCCCT TAGCGCCAAA GAGCTAGCCG AGCTGGCTAA CCGGGCAGAG 
CTGCCCCTGA GCTGGTCTGT GTCCAGCAAA CTGAACCAAC ATGCAGAACT GGAGACGGAA 
GAGGAAGAGA AGAACCCGGA AGAACTGACA GAGAGGAATG GTGATGTGGC AAACCTAGAG 
AATGAGTCCA AAGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037324.1
CDS	212..1489
Translation	MTMAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSLSAKELAELANRAELPLSWSVSSKLNQHAELETEEEEKNPEELTERNGDVANLENESKV

Target ORF information:

RefSeq Version	NM_013192.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium inwardly-rectifying channel, subfamily J, member 6 (Kcnj6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013192.2

ORF Insert Sequence:

ATGACAATGG CCAAGTTAAC TGAATCCATG ACTAATGTCC TGGAGGGGGA TTCCATGGAC 
CAAGACGTGG AAAGCCCAGT GGCCATTCAC CAGCCAAAGT TGCCTAAGCA GGCCAGGGAT 
GACCTGCCAA GACACATCAG CCGAGACAGG ACCAAAAGGA AAATCCAGAG GTACGTGAGG 
AAGGATGGGA AGTGTAACGT CCACCACGGC AACGTGCGGG AGACGTACCG ATACCTGACG 
GACATCTTCA CCACCCTGGT GGACCTAAAG TGGAGATTCA ACCTATTGAT CTTTGTCATG 
GTCTACACAG TGACGTGGCT TTTCTTTGGG ATGATCTGGT GGCTAATTGC ATACATCCGG 
GGAGATATGG ACCACATAGA GGACCCCTCG TGGACTCCCT GTGTTACCAA CCTCAACGGG 
TTTGTCTCCG CTTTTTTATT CTCAATAGAG ACAGAAACCA CCATTGGTTA TGGCTACAGG 
GTCATCACGG ACAAGTGCCC AGAAGGAATT ATTCTCCTCT TAATCCAGTC CGTGTTGGGG 
TCCATTGTCA ACGCCTTCAT GGTAGGATGT ATGTTTGTGA AAATATCCCA ACCCAAGAAG 
AGGGCAGAGA CCCTGGTCTT TTCCACCCAT GCGGTAATCT CCATGCGGGA TGGGAAACTA 
TGCCTGATGT TCCGGGTAGG GGACTTGAGG AATTCCCACA TTGTGGAGGC CTCCATCAGA 
GCCAAGTTGA TCAAGTCCAA ACAGACTTCA GAGGGGGAGT TCATTCCCCT CAACCAGACG 
GATATCAACG TAGGGTACTA CACCGGGGAT GACCGACTCT TTCTCGTGTC ACCGCTGATT 
ATTAGCCATG AAATTAACCA ACAGAGTCCC TTCTGGGAGA TCTCCAAAGC CCAGCTGCCT 
AAAGAGGAAC TGGAGATTGT GGTCATCCTG GAGGGAATGG TGGAAGCCAC AGGAATGACG 
TGCCAAGCTC GAAGCTCCTA CATCACCAGT GAGATCCTGT GGGGTTACCG GTTCACACCA 
GTCCTGACAC TGGAGGACGG GTTCTATGAA GTTGACTACA ACAGCTTCCA TGAGACCTAT 
GAGACCAGCA CCCCGTCCCT TAGCGCCAAA GAGCTAGCCG AGCTGGCTAA CCGGGCAGAG 
CTGCCCCTGA GCTGGTCTGT GTCCAGCAAA CTGAACCAAC ATGCAGAACT GGAGACGGAA 
GAGGAAGAGA AGAACCCGGA AGAACTGACA GAGAGGAATG GTGATGTGGC AAACCTAGAG 
AATGAGTCCA AAGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnj6 ( XM_008768567.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008766789.1 Rattus norvegicus potassium voltage-gated channel subfamily J member 6 (Kcnj6), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa43213
Clone ID Related Accession (Same CDS sequence)	XM_008768567.2
Accession Version	XM_008768567.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1224bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	G protein-activated inward rectifier potassium channel 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005110.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008768567.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACCAAG ACGTGGAAAG CCCAGTGGCC ATTCACCAGC CAAAGTTGCC TAAGCAGGCC 
AGGGATGACC TGCCAAGACA CATCAGCCGA GACAGGACCA AAAGGAAAAT CCAGAGGTAC 
GTGAGGAAGG ATGGGAAATG TAACGTCCAC CACGGCAACG TGCGGGAGAC GTACCGATAC 
CTGACGGACA TCTTCACCAC CCTGGTGGAC CTAAAGTGGA GATTCAACCT ATTGATCTTT 
GTCATGGTCT ACACAGTGAC GTGGCTTTTC TTTGGGATGA TCTGGTGGCT AATTGCATAC 
ATCCGGGGAG ATATGGACCA CATAGAGGAC CCCTCGTGGA CTCCCTGTGT TACCAACCTC 
AACGGGTTTG TCTCCGCTTT TTTATTCTCA ATAGAGACAG AAACCACCAT TGGTTATGGC 
TACAGGGTCA TCACGGACAA GTGCCCAGAA GGAATTATTC TCCTCTTAAT CCAGTCCGTG 
TTGGGGTCCA TTGTCAACGC CTTCATGGTA GGATGTATGT TTGTGAAAAT ATCCCAACCC 
AAGAAGAGGG CAGAGACCCT GGTCTTTTCC ACCCATGCGG TAATCTCCAT GCGGGATGGG 
AAACTATGCC TGATGTTCCG GGTAGGGGAC TTGAGGAATT CCCACATTGT GGAGGCCTCC 
ATCAGAGCCA AGTTGATCAA GTCCAAACAG ACTTCAGAGG GGGAGTTCAT TCCCCTCAAC 
CAGACGGATA TCAACGTAGG GTACTACACC GGGGATGACC GACTCTTTCT CGTGTCACCG 
CTGATTATTA GCCATGAAAT TAACCAACAG AGTCCCTTCT GGGAGATCTC CAAAGCCCAG 
CTGCCTAAAG AGGAACTGGA GATTGTGGTC ATCCTGGAGG GAATGGTGGA AGCCACAGGA 
ATGACGTGCC AAGCTCGAAG CTCCTACATC ACCAGTGAGA TCCTGTGGGG TTACCGGTTC 
ACACCAGTCC TGACACTGGA GGACGGGTTC TATGAAGTTG ACTACAACAG CTTCCATGAG 
ACCTATGAGA CCAGCACCCC GTCCCTTAGC GCCAAAGAGC TAGCCGAGCT GGCTAACCGG 
GCAGAGCTGC CCCTGAGCTG GTCTGTGTCC AGCAAACTGA ACCAACATGC AGAACTGGAG 
ACGGAAGAGG AAGAGAAGAA CCCGGAAGAA CTGACAGAGA GGAATGGTGA TGTGGCAAAC 
CTAGAGAATG AGTCCAAAGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008766789.1
CDS	53..1276
Translation	MDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSLSAKELAELANRAELPLSWSVSSKLNQHAELETEEEEKNPEELTERNGDVANLENESKV

Target ORF information:

RefSeq Version	XM_008768567.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily J member 6 (Kcnj6), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008768567.2

ORF Insert Sequence:

ATGGACCAAG ACGTGGAAAG CCCAGTGGCC ATTCACCAGC CAAAGTTGCC TAAGCAGGCC 
AGGGATGACC TGCCAAGACA CATCAGCCGA GACAGGACCA AAAGGAAAAT CCAGAGGTAC 
GTGAGGAAGG ATGGGAAATG TAACGTCCAC CACGGCAACG TGCGGGAGAC GTACCGATAC 
CTGACGGACA TCTTCACCAC CCTGGTGGAC CTAAAGTGGA GATTCAACCT ATTGATCTTT 
GTCATGGTCT ACACAGTGAC GTGGCTTTTC TTTGGGATGA TCTGGTGGCT AATTGCATAC 
ATCCGGGGAG ATATGGACCA CATAGAGGAC CCCTCGTGGA CTCCCTGTGT TACCAACCTC 
AACGGGTTTG TCTCCGCTTT TTTATTCTCA ATAGAGACAG AAACCACCAT TGGTTATGGC 
TACAGGGTCA TCACGGACAA GTGCCCAGAA GGAATTATTC TCCTCTTAAT CCAGTCCGTG 
TTGGGGTCCA TTGTCAACGC CTTCATGGTA GGATGTATGT TTGTGAAAAT ATCCCAACCC 
AAGAAGAGGG CAGAGACCCT GGTCTTTTCC ACCCATGCGG TAATCTCCAT GCGGGATGGG 
AAACTATGCC TGATGTTCCG GGTAGGGGAC TTGAGGAATT CCCACATTGT GGAGGCCTCC 
ATCAGAGCCA AGTTGATCAA GTCCAAACAG ACTTCAGAGG GGGAGTTCAT TCCCCTCAAC 
CAGACGGATA TCAACGTAGG GTACTACACC GGGGATGACC GACTCTTTCT CGTGTCACCG 
CTGATTATTA GCCATGAAAT TAACCAACAG AGTCCCTTCT GGGAGATCTC CAAAGCCCAG 
CTGCCTAAAG AGGAACTGGA GATTGTGGTC ATCCTGGAGG GAATGGTGGA AGCCACAGGA 
ATGACGTGCC AAGCTCGAAG CTCCTACATC ACCAGTGAGA TCCTGTGGGG TTACCGGTTC 
ACACCAGTCC TGACACTGGA GGACGGGTTC TATGAAGTTG ACTACAACAG CTTCCATGAG 
ACCTATGAGA CCAGCACCCC GTCCCTTAGC GCCAAAGAGC TAGCCGAGCT GGCTAACCGG 
GCAGAGCTGC CCCTGAGCTG GTCTGTGTCC AGCAAACTGA ACCAACATGC AGAACTGGAG 
ACGGAAGAGG AAGAGAAGAA CCCGGAAGAA CTGACAGAGA GGAATGGTGA TGTGGCAAAC 
CTAGAGAATG AGTCCAAAGT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnj6 ( XM_017597888.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017453377.1 Rattus norvegicus potassium voltage-gated channel subfamily J member 6 (Kcnj6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa57647
Clone ID Related Accession (Same CDS sequence)	XM_017597888.1
Accession Version	XM_017597888.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1191bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	G protein-activated inward rectifier potassium channel 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005110.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACCAAG ACGTGGAAAG CCCAGTGGCC ATTCACCAGC CAAAGTTGCC TAAGCAGGCC 
AGGGATGACC TGCCAAGACA CATCAGCCGA GACAGGACCA AAAGGAAAAT CCAGAGGTAC 
GTGAGGAAGG ATGGGAAATG TAACGTCCAC CACGGCAACG TGCGGGAGAC GTACCGATAC 
CTGACGGACA TCTTCACCAC CCTGGTGGAC CTAAAGTGGA GATTCAACCT ATTGATCTTT 
GTCATGGTCT ACACAGTGAC GTGGCTTTTC TTTGGGATGA TCTGGTGGCT AATTGCATAC 
ATCCGGGGAG ATATGGACCA CATAGAGGAC CCCTCGTGGA CTCCCTGTGT TACCAACCTC 
AACGGGTTTG TCTCCGCTTT TTTATTCTCA ATAGAGACAG AAACCACCAT TGGTTATGGC 
TACAGGGTCA TCACGGACAA GTGCCCAGAA GGAATTATTC TCCTCTTAAT CCAGTCCGTG 
TTGGGGTCCA TTGTCAACGC CTTCATGGTA GGATGTATGT TTGTGAAAAT ATCCCAACCC 
AAGAAGAGGG CAGAGACCCT GGTCTTTTCC ACCCATGCGG TAATCTCCAT GCGGGATGGG 
AAACTATGCC TGATGTTCCG GGTAGGGGAC TTGAGGAATT CCCACATTGT GGAGGCCTCC 
ATCAGAGCCA AGTTGATCAA GTCCAAACAG ACTTCAGAGG GGGAGTTCAT TCCCCTCAAC 
CAGACGGATA TCAACGTAGG GTACTACACC GGGGATGACC GACTCTTTCT CGTGTCACCG 
CTGATTATTA GCCATGAAAT TAACCAACAG AGTCCCTTCT GGGAGATCTC CAAAGCCCAG 
CTGCCTAAAG AGGAACTGGA GATTGTGGTC ATCCTGGAGG GAATGGTGGA AGCCACAGGA 
ATGACGTGCC AAGCTCGAAG CTCCTACATC ACCAGTGAGA TCCTGTGGGG TTACCGGTTC 
ACACCAGTCC TGACACTGGA GGACGGGTTC TATGAAGTTG ACTACAACAG CTTCCATGAG 
ACCTATGAGA CCAGCACCCC GTCCCTTAGC GCCAAAGAGC TAGCCGAGCT GGCTAACCGG 
GCAGAGCTGC CCCTGAGCTG GTCTGTGTCC AGCAAACTGA ACCAACATGC AGAACTGGAG 
ACGGAAGAGG AAGAGAAGAA CCCGGAAGAA CTGACAGAGA GGAATGGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017453377.1
CDS	34..1224
Translation	MDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSLSAKELAELANRAELPLSWSVSSKLNQHAELETEEEEKNPEELTERNG

Target ORF information:

RefSeq Version	XM_017597888.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily J member 6 (Kcnj6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597888.1

ORF Insert Sequence:

ATGGACCAAG ACGTGGAAAG CCCAGTGGCC ATTCACCAGC CAAAGTTGCC TAAGCAGGCC 
AGGGATGACC TGCCAAGACA CATCAGCCGA GACAGGACCA AAAGGAAAAT CCAGAGGTAC 
GTGAGGAAGG ATGGGAAATG TAACGTCCAC CACGGCAACG TGCGGGAGAC GTACCGATAC 
CTGACGGACA TCTTCACCAC CCTGGTGGAC CTAAAGTGGA GATTCAACCT ATTGATCTTT 
GTCATGGTCT ACACAGTGAC GTGGCTTTTC TTTGGGATGA TCTGGTGGCT AATTGCATAC 
ATCCGGGGAG ATATGGACCA CATAGAGGAC CCCTCGTGGA CTCCCTGTGT TACCAACCTC 
AACGGGTTTG TCTCCGCTTT TTTATTCTCA ATAGAGACAG AAACCACCAT TGGTTATGGC 
TACAGGGTCA TCACGGACAA GTGCCCAGAA GGAATTATTC TCCTCTTAAT CCAGTCCGTG 
TTGGGGTCCA TTGTCAACGC CTTCATGGTA GGATGTATGT TTGTGAAAAT ATCCCAACCC 
AAGAAGAGGG CAGAGACCCT GGTCTTTTCC ACCCATGCGG TAATCTCCAT GCGGGATGGG 
AAACTATGCC TGATGTTCCG GGTAGGGGAC TTGAGGAATT CCCACATTGT GGAGGCCTCC 
ATCAGAGCCA AGTTGATCAA GTCCAAACAG ACTTCAGAGG GGGAGTTCAT TCCCCTCAAC 
CAGACGGATA TCAACGTAGG GTACTACACC GGGGATGACC GACTCTTTCT CGTGTCACCG 
CTGATTATTA GCCATGAAAT TAACCAACAG AGTCCCTTCT GGGAGATCTC CAAAGCCCAG 
CTGCCTAAAG AGGAACTGGA GATTGTGGTC ATCCTGGAGG GAATGGTGGA AGCCACAGGA 
ATGACGTGCC AAGCTCGAAG CTCCTACATC ACCAGTGAGA TCCTGTGGGG TTACCGGTTC 
ACACCAGTCC TGACACTGGA GGACGGGTTC TATGAAGTTG ACTACAACAG CTTCCATGAG 
ACCTATGAGA CCAGCACCCC GTCCCTTAGC GCCAAAGAGC TAGCCGAGCT GGCTAACCGG 
GCAGAGCTGC CCCTGAGCTG GTCTGTGTCC AGCAAACTGA ACCAACATGC AGAACTGGAG 
ACGGAAGAGG AAGAGAAGAA CCCGGAAGAA CTGACAGAGA GGAATGGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels.
Scientific reports7(1)12313(2017 Sep)
Baculis BC,Weiss AC,Pang W,Jeong HG,Lee JH,Liu DC,Tsai NP,Chung HJ

The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology41(3)1020-1034(2017)
Liang W,Chen M,Zheng D,Li J,Song M,Zhang W,Feng J,Lan J

G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy.
Molecular pain1144(2015 Jul)
Lyu C,Mulder J,Barde S,Sahlholm K,Zeberg H,Nilsson J,?rhem P,H?kfelt T,Fried K,Shi TJ

Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.
PloS one10(10)e0140369(2015)
Montalbano A,Corradetti R,Mlinar B

Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome.
Experimental neurology233(2)749-57(2012 Feb)
Best TK,Cramer NP,Chakrabarti L,Haydar TF,Galdzicki Z

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Kcnj6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報