Itgb4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Itgb4
Entrez Gene ID	25724
Full Name	integrin subunit beta 4
General protein information	Preferred Names integrin subunit beta 4 Names integrin beta-4 GP150
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.1
Summary	beta subunit of integrin alpha6/beta4 which is a cell surface receptor for laminin; involved in hemidesmosome formation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013180.1	NP_037312.1	integrin beta-4 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ITGB4	NP_001180186.2
Danio rerio (zebrafish)	itgb4	NP_001019557.1
Pan troglodytes (chimpanzee)	ITGB4	XP_003315785.1
Rattus norvegicus (Norway rat)	Itgb4	NP_037312.1
Xenopus tropicalis (tropical clawed frog)	itgb4	XP_004918514.1
Canis lupus familiaris (dog)	ITGB4	XP_005624218.1
Gallus gallus (chicken)	ITGB4	XP_003642374.2
Homo sapiens (human)	ITGB4	NP_000204.3
	ITGB4	XP_002800666.1
Mus musculus (house mouse)	Itgb4	NP_001005608.2

Gene Ontology
Bibliography

Related articles in PubMed

A dual role for Integrin ?6?4 in modulating Hereditary Neuropathy with liability to Pressure Palsies.
Poitelon Y, Matafora V, Silvestri N, Zambroni D, McGarry C, Serghany N, Rush T, Vizzuso D, Court FA, Bachi A, Wrabetz L, Feltri ML
Journal of neurochemistry(2018 Jan)

Interaction of integrin ?4 with S1P receptors in S1P- and HGF-induced endothelial barrier enhancement.
Ni X, Epshtein Y, Chen W, Zhou T, Xie L, Garcia JG, Jacobson JR
Journal of cellular biochemistry115(6)1187-95(2014 Jun)

Relationship between annexin A7 and integrin ?4 in autophagy.
Li H, Huang S, Wang S, Wang L, Qi L, Zhang Y, Zhang S, Zhao B, Miao J
The international journal of biochemistry & cell biology45(11)2605-11(2013 Nov)

Phenotypic spectrum of epidermolysis bullosa associated with ?6?4 integrin mutations.
Schumann H, Kiritsi D, Pigors M, Hausser I, Kohlhase J, Peters J, Ott H, Hyla-Klekot L, Gacka E, Sieron AL, Valari M, Bruckner-Tuderman L, Has C
The British journal of dermatology169(1)115-24(2013 Jul)

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Ghai R, Bugarcic A, Liu H, Norwood SJ, Skeldal S, Coulson EJ, Li SS, Teasdale RD, Collins BM
Proceedings of the National Academy of Sciences of the United States of America110(8)E643-52(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study suggests that downregulation of integrin beta4 is important for the development ozone stress-induced airway hyperresponsiveness, presumably because it causes increased oxidative damage and epithelial apoptosis.
Title: Involvement of integrin beta4 in ozone stress-induced airway hyperresponsiveness.

changes in transcription factor, c-Jun and krox-20, and integrin beta4 expression are temporally correlated with the process of demyelination, suggesting roles in regulating the myelin response to CNC injury
Title: c-Jun, krox-20, and integrin beta4 expression following chronic nerve compression injury.

During early stages of myelination, PMP22 and beta4 integrin are coexpressed at the DRG cell surface and can be coimmunoprecipitated together with laminin and alpha6 integrin.
Title: Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.

the SDL segment of the beta4 integrin subunit is required for ligand binding and is involved in outside-in signaling
Title: Crucial role of the specificity-determining loop of the integrin beta4 subunit in the binding of cells to laminin-5 and outside-in signal transduction.

The following Itgb4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itgb4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02233	NM_013180.1 Latest version!	Rattus norvegicus integrin subunit beta 4 (Itgb4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$1595.30 $2279.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Itgb4 ( NM_013180.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037312.1 Rattus norvegicus integrin subunit beta 4 (Itgb4), mRNA.

Price & Availability↑

CloneID	ORa02233
Clone ID Related Accession (Same CDS sequence)	NM_013180.1
Accession Version	NM_013180.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5424bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	integrin beta-4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U60096.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U60096.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689599, SAMEA2689602 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGGGC TATGTTCCAG CCCGTGGGTG AAGCTGCTAC TGGCAGTAGT GCTGAGTGCC 
GGTCTCCCTG GAAACATGGC CAACCGCTGT AAGAAGGCTC AGGTGAAGAG CTGTACGGAG 
TGCATCCGAG TGGACAAGAG CTGTGCCTAC TGCACAGACG AGCTGTTCAA GGAGCGACGC 
TGCAACACCC AGGCGGACGT TCTGGCTGCA GGCTGCCGGG GAGAGAGCGT GTTGGTCATG 
GAGAGCAGCC TTGAGATCAC AGAGAACATC CAGATTGACA CCAGCCTGCA CCGCAGCCAG 
GTATCTCCCC AAGGCCTGCA AGTGCGGCTG CGGCCGGGTG AGGAGCGCAA CTTTGTGTTC 
AAGGTGTTTG AGCCCCTGGA GAGCCCCGTG GATCTGTATA TCCTCATGGA CTTTTCCAAC 
TCCATGTCTG ATGATCTGGA CAACCTCAAG CAGATGGGGC AGAACCTGGC CAAGATCCTG 
CGCCAGCTCA CCAGTGACTA CACTATTGGA TTCGGAAAGT TTGTGGACAA AGTCAGTGTC 
CCTCAGACGG ACATGAGGCC CGAGAAGCTG AAGGAGCCGT GGCCCAACAG CGACCCCCCA 
TTCTCCTTCA AGAATGTTAT CAGCTTAACA GAGAATGTGG AAGAATTCTG GGACAAACTG 
CAAGGAGAAC GCATCTCAGG CAACCTGGAC GCTCCTGAAG GAGGCTTCGA CGCCATCCTG 
CAGACAGCCG TGTGCACAAG GGACATTGGC TGGAGAGCGG ACAGCACCCA CCTGCTGGTG 
TTCTCCACCG AGTCTGCCTT CCACTATGAG GCTGATGGTG CCAACGTGCT GGCCGGCATC 
ATGAACCGCA ATGATGAGAA GTGCCACCTG GATGCCACAG GCGCCTACAC CCAGTATAAG 
ACCCAGGACT ACCCATCTGT GCCCACACTG GTTCGCCTGC TTGCCAAACA CAACATTATC 
CCCATCTTTG CCGTCACCAA CTACTCTTAC AGTTACTACG AGAAGCTCCA TAAATATTTC 
CCTGTCTCCT CTCTGGGAGT CCTGCAGGAA GATTCATCCA ACATCGTGGA GCTGCTGGAG 
GAGGCTTTCT ATCGAATTCG CTCCAACCTG GACATCCGGG CTCTGGACAG CCCGAGAGGC 
CTGAGGACAG AGGTCACCTC CGATACCCTC CAGAAGACAG AGACTGGGTC CTTTCACATC 
AAGCGGGGGG AAGTGGGCAC ATACAATGTG CATCTTCGGG CAGTGGAGGA CATAGATGGG 
ACACACGTGT GCCAGCTGGC CAAAGAAGAC CAAAGAGGTA ACATCCACCT GAAACCCTCC 
TTCTCCGATG GCCTCCGGAT GGACGCGAGC GTCATCTGTG ACATGTGCGC CTGCGAGCTG 
CAAAAGGAAG TTCAGTCAGC TCGCTGTCAC TACAGAGGAG ACTTCATGTG TGGACACTGT 
GTGTGCAACG AGGGCTGGAG TGGCAAAACC TGCAATTGCT CCACGGGTTC CCTGAGTGAC 
ACGCAGCCCT GCCTGCGTGA GGGTGAGGAC AAACCATGCT CGGGCCATGG CGAGTGCCAG 
TGCGGACGTT GTGTGTGCTA CGGTGAAGGC CGCTACGAGG GTCACTTCTG CGAGTATGAC 
AACTTCCAGT GTCCCCGCAC CTCTGGATTC CTTTGCAATG ACCGGGGACG CTGCTCCATG 
GGAGAGTGTG TGTGTGAGCC TGGTTGGACC GGCCGCAGCT GTGACTGTCC CCTCAGCAAT 
GCCACCTGTA TCGATAGCAA TGGGGGCATC TGCAATGGAC TAGGCTTCTG TGAGTGTGGC 
CGTTGTCACT GCAACCAGCG GTCTTCGCTC TACACGGACA CCACCTGTGA GATCAACTAC 
TCGGCGATAC GCCTGGGCCT CTGTGAGGAC CTCCGCTCCT GTGTACAGTG CCAGGCCTGG 
GGCACTGGGG AGAAGAAAGG GCGCACGTGT GAGGAATGCA ACTTTAAGGT CAAGATGGTA 
GACGAGCTTA AGAAAGCGGA AGAGGTGGTG GAGTACTGCT CCTTCCGGGA CGAGGATGAC 
GACTGCACTT ACAGCTACAC CGTGGAGGGC GACGGCAGCC CTGGGCCCAA CAGCACCGTC 
CTGGTCCACA AGAAGAAAGA CTGCCTCCCG GCTCCTTCTT GGTGGCTCAT TCCCCTGCTC 
ATCTTCCTCC TGTTGCTCCT GGTGTTGCTT CTGCTGCTCT GCTGGAAATA CTGTGCCTGC 
TGCAAAGCCT GCCTGGGACT TCTTCCTTGC TGCAACCAAG GTCACATGGT GGGCTTTAAG 
GAAGATCACT ATATGCTGCG GGAGAACCTG ATGGCCTCTG ACCACCTGGA CACGCCCATG 
CTGAGAAGTG GGAACCTCAA GGGACGAGAC ACAGTCCGCT GGAAGATCAC CAACAATGTG 
CAACGGCCTG GCTTTGCCAC CCATGCTGCC AGCATCAGCC CCACAGAGCT CGTACCCTAT 
GGGCTATCCC TGCGCCTTGG CCGCCTCTGC ACTGAGAACC TCATGAAGCC TGGCACCCGA 
GAGTGTGACC AGCTACGCCA GGAGGTGGAG GAAAATCTGA ATGAGGTATA CAGACAAGTC 
AACGGCGTAC ACAAGCTCCA GCAGACGAAG TTCCGACAGC AACCCAACGC TGGGAAAAAG 
CAAGACCACA CCATTGTGGA CACAGTGTTG CTGGCGCCCC GCTCTGCCAA GCAGTCGCTG 
CTGAAGCTGA CAGAGAAGCA GGTGGAGCAG GGGTCCTTCC ATGAACTCAA GGTGGCCCCT 
GGTTACTACA CCCTCACAGC AGAGCAGGAT GCCCGGGGCA TGGTGGAGTT CCAGGAGGGG 
GTAGAGCTGG TGGACGTGCG TGTGCCCCTC TTCATCCGGC CTGAGGATGA TGATGAGAAA 
CAGCTGCTGG TGGAGGCCAT TGATGTCCCC GTGGGCACTG CCACCCTTGG TCGACGCCTG 
GTAAACATCA CCATCATTAA GGAGCAAGCT AGCGGGATAG TGTCCTTTGA GCAGCCTGAA 
TACTCAGTGA GTCGTGGAGA CCAGGTGGCC CGCATCCCTG TCATCCGGCA CATCCTGGAC 
AACGGCAAGT CCCAGGTCTC CTATAGCACA CAGGATAATA CAGCACATGG ACACCGGGAT 
TATGTCCCTG TGGAAGGGGA GCTGTTGTTC TACCCCGGAG AGACCTGGAA GGAACTGCAG 
GTGAAGCTCC TGGAGCTGCA GGAAGTCGAC TCCCTCCTTC GTGGCCGCCA GGTCCGACGC 
TTCCAAGTTC AACTCAGCAA CCCCAAGTTT GGAGCCCGCC TGGGCCAGCC CAACACAGCC 
ACTGTTATCA TCGGGGAACA AGATGAAACG GACAGAAGTC TCATAAATGA GATATCCGCA 
TCGCCGCCAC TACCCCGTGG AGACCTGGGT GCCCCGCAGA ACCCCAATGC CAAGGCTGCC 
GGATCCAGGA AGATCCATTT CAACTGGCTG CCCCCTCCTG GCAAGCCAAT GGGGTATAGG 
GTGAAATACT GGGTCCAGGG CGACTCTGAG TCCGAAGCCC ACCTGCTGGA CAGCAAGGTG 
CCCTCAGTGG AGCTCACCAA CCTGTATCCC TATTGCGACT ACGAAATGAA GGTGTGCGCC 
TACGGGGCAC ACGGGGAGGG GCCCTATAGC TCACTGGTGT CCTGCCGCAC CCACCAGGAA 
GTGCCCAGTG AGCCAGGAAG GCTGGCTTTC AATGTAGTTT CTTCTACGGT GACCCAGCTG 
AGCTGGGCAG AACCAGCTGA AACCAACGGG GAGATCACAG CCTATGAGGT CTGCTATGGA 
CTGGTCAACG AGGACAACCG ACCCATTGGA CCTATGAAGA AGGTGCTTGT GGACAACCCC 
AAGAACCGGA TGCTGCTCAT TGAGAATCTT CGAGAGTCCC AGCCATACCG ATACACGGTG 
AAGGCGCGAA ACGGGGCAGG ATGGGGACCC GAGAGAGAGG CTATCATCAA CCTGGCCACA 
CAGCCCAAGC GGCCCATGTC CATTCCTATC ATCCCAGACA TCCCCATAGT GGACGCCCAG 
GGTGGAGAAG ACTACGAAAA CTTCCTCATG TACAGTGACG ACGTTCTGCG CTCCCCAGCC 
AGCAGCCAGA GGCCCAGCGT TTCAGATGAC ACTGAGCACC TGGTGAATGG CCGGATGGAC 
TTTGCCTATC CAGGCAGTGC CAACTCCCTG CATAGGATGA CTGCTGCCAA CGTGGCCTAT 
GGCACACATC TAAGCCCACA CCAGACCCAC CGAATGCTGA GCACGTCTTC TACCCTTACC 
CGGGACTACC ACTCTCTGAC GCGCACAGAC CACTCTCAGT CAGGCACACT TCCCCGGGAC 
TACTCCACTC TCACTTCCCT TTCCTCCCAA GGCCTCCCTC CTATCTGGGA AGATGGGAGG 
AGCAGGCTTC CGCTGTCCTG GACCCTTGGG TCCTGGAGCC GGGCTCAGAT GAAGGGTGTG 
CCCGCATCCA GGGGCTCACC AGACTCTATA ATCCTGGCCG GGCAGTCAGC AGCGCCCTCC 
TGGGGTACAG ATTCCCGTGG GGCTATGGGT GTGCCCGACA CACCCACTCG GCTGGTGTTC 
TCCGCCCTGG GGCCCACATC TCTGAAGGTG AGCTGGCAGG AGCCACAGTG TGATCGAGCA 
CTGCTGGGCT ACAGCGTGGA ATACCAGCTA CTCAACGGCG GCGAGATGCA TCGGCTCAAC 
ATCCCTAACC CTGGCCAAAC CTCTGTGGTG GTAGAGGATC TCCTGCCTAA CCACTCCTAT 
GTGTTCCGGG TACGGGCACA AAGCCAGGAG GGCTGGGGCC GGGAGCGAGA GGGTGTCATC 
ACCATCGAGT CCCAGGTGCA CCCGCAGAGC CCTCTCTGCC CCCTGCCAGG CTCCGCCTTC 
ACCTTGAGCA CCCCCAGCGC CCCAGGCCCC CTGGTGTTCA CTGCCCTAAG CCCAGACTCT 
CTGCAGCTGA GCTGGGAGCG CCCAAGAAGG CCCAACGGAG ATATCCTTGG CTACCTGGTG 
ACCTGTGAGA TGGCCCAAGG AGGAGGACCA GCCAGAACCT TCCGGGTGGA TGGGGACAAC 
CCTGAGAGCC GGCTGACGGT TCCTGGCCTC AGTGAGAACG TTCCTTACAA GTTCAAGGTG 
CAGGCCCGGA CAACAGAGGG CTTTGGGCCC GAGCGTGAGG GTATCATCAC CATCGAGTCT 
CAGGATGGAG GCCCCTTCCC ACAGCTGGGC AGCCATTCTG GGCTTTTCCA GAACCCACTG 
CAAAGTGAGT ACAGCACTGT CACCAGCACT CACAGCACTA CCACCACCGA GCCCTTCCTT 
ATAGATGGAC TAACCCTGGG GACCCAGCGC CTGGAAGCAG GGGGCTCCCT CACCCGGCAT 
GTGACCCAGG AATTTGTGAG CCGGACCCTG ACCACCAGTG GCTCTCTCAG CACTCATATG 
GACCAACAGT TCTTCCAAAC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037312.1
CDS	206..5629
Translation	MAGLCSSPWVKLLLAVVLSAGLPGNMANRCKKAQVKSCTECIRVDKSCAYCTDELFKERRCNTQADVLAAGCRGESVLVMESSLEITENIQIDTSLHRSQVSPQGLQVRLRPGEERNFVFKVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTENVEEFWDKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGANVLAGIMNRNDEKCHLDATGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSDTLQKTETGSFHIKRGEVGTYNVHLRAVEDIDGTHVCQLAKEDQRGNIHLKPSFSDGLRMDASVICDMCACELQKEVQSARCHYRGDFMCGHCVCNEGWSGKTCNCSTGSLSDTQPCLREGEDKPCSGHGECQCGRCVCYGEGRYEGHFCEYDNFQCPRTSGFLCNDRGRCSMGECVCEPGWTGRSCDCPLSNATCIDSNGGICNGLGFCECGRCHCNQRSSLYTDTTCEINYSAIRLGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDELKKAEEVVEYCSFRDEDDDCTYSYTVEGDGSPGPNSTVLVHKKKDCLPAPSWWLIPLLIFLLLLLVLLLLLCWKYCACCKACLGLLPCCNQGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDTVRWKITNNVQRPGFATHAASISPTELVPYGLSLRLGRLCTENLMKPGTRECDQLRQEVEENLNEVYRQVNGVHKLQQTKFRQQPNAGKKQDHTIVDTVLLAPRSAKQSLLKLTEKQVEQGSFHELKVAPGYYTLTAEQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPVGTATLGRRLVNITIIKEQASGIVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFYPGETWKELQVKLLELQEVDSLLRGRQVRRFQVQLSNPKFGARLGQPNTATVIIGEQDETDRSLINEISASPPLPRGDLGAPQNPNAKAAGSRKIHFNWLPPPGKPMGYRVKYWVQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAHGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQGGEDYENFLMYSDDVLRSPASSQRPSVSDDTEHLVNGRMDFAYPGSANSLHRMTAANVAYGTHLSPHQTHRMLSTSSTLTRDYHSLTRTDHSQSGTLPRDYSTLTSLSSQGLPPIWEDGRSRLPLSWTLGSWSRAQMKGVPASRGSPDSIILAGQSAAPSWGTDSRGAMGVPDTPTRLVFSALGPTSLKVSWQEPQCDRALLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGGPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLGSHSGLFQNPLQSEYSTVTSTHSTTTTEPFLIDGLTLGTQRLEAGGSLTRHVTQEFVSRTLTTSGSLSTHMDQQFFQT

Target ORF information:

RefSeq Version	NM_013180.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus integrin subunit beta 4 (Itgb4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013180.1

ORF Insert Sequence:

ATGGCAGGGC TATGTTCCAG CCCGTGGGTG AAGCTGCTAC TGGCAGTAGT GCTGAGTGCC 
GGTCTCCCTG GAAACATGGC CAACCGCTGT AAGAAGGCTC AGGTGAAGAG CTGTACGGAG 
TGCATCCGAG TGGACAAGAG CTGTGCCTAC TGCACAGACG AGCTGTTCAA GGAGCGACGC 
TGCAACACCC AGGCGGACGT TCTGGCTGCA GGCTGCCGGG GAGAGAGCGT GTTGGTCATG 
GAGAGCAGCC TTGAGATCAC AGAGAACATC CAGATTGACA CCAGCCTGCA CCGCAGCCAG 
GTATCTCCCC AAGGCCTGCA AGTGCGGCTG CGGCCGGGTG AGGAGCGCAA CTTTGTGTTC 
AAGGTGTTTG AGCCCCTGGA GAGCCCCGTG GATCTGTATA TCCTCATGGA CTTTTCCAAC 
TCCATGTCTG ATGATCTGGA CAACCTCAAG CAGATGGGGC AGAACCTGGC CAAGATCCTG 
CGCCAGCTCA CCAGTGACTA CACTATTGGA TTCGGAAAGT TTGTGGACAA AGTCAGTGTC 
CCTCAGACGG ACATGAGGCC CGAGAAGCTG AAGGAGCCGT GGCCCAACAG CGACCCCCCA 
TTCTCCTTCA AGAATGTTAT CAGCTTAACA GAGAATGTGG AAGAATTCTG GGACAAACTG 
CAAGGAGAAC GCATCTCAGG CAACCTGGAC GCTCCTGAAG GAGGCTTCGA CGCCATCCTG 
CAGACAGCCG TGTGCACAAG GGACATTGGC TGGAGAGCGG ACAGCACCCA CCTGCTGGTG 
TTCTCCACCG AGTCTGCCTT CCACTATGAG GCTGATGGTG CCAACGTGCT GGCCGGCATC 
ATGAACCGCA ATGATGAGAA GTGCCACCTG GATGCCACAG GCGCCTACAC CCAGTATAAG 
ACCCAGGACT ACCCATCTGT GCCCACACTG GTTCGCCTGC TTGCCAAACA CAACATTATC 
CCCATCTTTG CCGTCACCAA CTACTCTTAC AGTTACTACG AGAAGCTCCA TAAATATTTC 
CCTGTCTCCT CTCTGGGAGT CCTGCAGGAA GATTCATCCA ACATCGTGGA GCTGCTGGAG 
GAGGCTTTCT ATCGAATTCG CTCCAACCTG GACATCCGGG CTCTGGACAG CCCGAGAGGC 
CTGAGGACAG AGGTCACCTC CGATACCCTC CAGAAGACAG AGACTGGGTC CTTTCACATC 
AAGCGGGGGG AAGTGGGCAC ATACAATGTG CATCTTCGGG CAGTGGAGGA CATAGATGGG 
ACACACGTGT GCCAGCTGGC CAAAGAAGAC CAAAGAGGTA ACATCCACCT GAAACCCTCC 
TTCTCCGATG GCCTCCGGAT GGACGCGAGC GTCATCTGTG ACATGTGCGC CTGCGAGCTG 
CAAAAGGAAG TTCAGTCAGC TCGCTGTCAC TACAGAGGAG ACTTCATGTG TGGACACTGT 
GTGTGCAACG AGGGCTGGAG TGGCAAAACC TGCAATTGCT CCACGGGTTC CCTGAGTGAC 
ACGCAGCCCT GCCTGCGTGA GGGTGAGGAC AAACCATGCT CGGGCCATGG CGAGTGCCAG 
TGCGGACGTT GTGTGTGCTA CGGTGAAGGC CGCTACGAGG GTCACTTCTG CGAGTATGAC 
AACTTCCAGT GTCCCCGCAC CTCTGGATTC CTTTGCAATG ACCGGGGACG CTGCTCCATG 
GGAGAGTGTG TGTGTGAGCC TGGTTGGACC GGCCGCAGCT GTGACTGTCC CCTCAGCAAT 
GCCACCTGTA TCGATAGCAA TGGGGGCATC TGCAATGGAC TAGGCTTCTG TGAGTGTGGC 
CGTTGTCACT GCAACCAGCG GTCTTCGCTC TACACGGACA CCACCTGTGA GATCAACTAC 
TCGGCGATAC GCCTGGGCCT CTGTGAGGAC CTCCGCTCCT GTGTACAGTG CCAGGCCTGG 
GGCACTGGGG AGAAGAAAGG GCGCACGTGT GAGGAATGCA ACTTTAAGGT CAAGATGGTA 
GACGAGCTTA AGAAAGCGGA AGAGGTGGTG GAGTACTGCT CCTTCCGGGA CGAGGATGAC 
GACTGCACTT ACAGCTACAC CGTGGAGGGC GACGGCAGCC CTGGGCCCAA CAGCACCGTC 
CTGGTCCACA AGAAGAAAGA CTGCCTCCCG GCTCCTTCTT GGTGGCTCAT TCCCCTGCTC 
ATCTTCCTCC TGTTGCTCCT GGTGTTGCTT CTGCTGCTCT GCTGGAAATA CTGTGCCTGC 
TGCAAAGCCT GCCTGGGACT TCTTCCTTGC TGCAACCAAG GTCACATGGT GGGCTTTAAG 
GAAGATCACT ATATGCTGCG GGAGAACCTG ATGGCCTCTG ACCACCTGGA CACGCCCATG 
CTGAGAAGTG GGAACCTCAA GGGACGAGAC ACAGTCCGCT GGAAGATCAC CAACAATGTG 
CAACGGCCTG GCTTTGCCAC CCATGCTGCC AGCATCAGCC CCACAGAGCT CGTACCCTAT 
GGGCTATCCC TGCGCCTTGG CCGCCTCTGC ACTGAGAACC TCATGAAGCC TGGCACCCGA 
GAGTGTGACC AGCTACGCCA GGAGGTGGAG GAAAATCTGA ATGAGGTATA CAGACAAGTC 
AACGGCGTAC ACAAGCTCCA GCAGACGAAG TTCCGACAGC AACCCAACGC TGGGAAAAAG 
CAAGACCACA CCATTGTGGA CACAGTGTTG CTGGCGCCCC GCTCTGCCAA GCAGTCGCTG 
CTGAAGCTGA CAGAGAAGCA GGTGGAGCAG GGGTCCTTCC ATGAACTCAA GGTGGCCCCT 
GGTTACTACA CCCTCACAGC AGAGCAGGAT GCCCGGGGCA TGGTGGAGTT CCAGGAGGGG 
GTAGAGCTGG TGGACGTGCG TGTGCCCCTC TTCATCCGGC CTGAGGATGA TGATGAGAAA 
CAGCTGCTGG TGGAGGCCAT TGATGTCCCC GTGGGCACTG CCACCCTTGG TCGACGCCTG 
GTAAACATCA CCATCATTAA GGAGCAAGCT AGCGGGATAG TGTCCTTTGA GCAGCCTGAA 
TACTCAGTGA GTCGTGGAGA CCAGGTGGCC CGCATCCCTG TCATCCGGCA CATCCTGGAC 
AACGGCAAGT CCCAGGTCTC CTATAGCACA CAGGATAATA CAGCACATGG ACACCGGGAT 
TATGTCCCTG TGGAAGGGGA GCTGTTGTTC TACCCCGGAG AGACCTGGAA GGAACTGCAG 
GTGAAGCTCC TGGAGCTGCA GGAAGTCGAC TCCCTCCTTC GTGGCCGCCA GGTCCGACGC 
TTCCAAGTTC AACTCAGCAA CCCCAAGTTT GGAGCCCGCC TGGGCCAGCC CAACACAGCC 
ACTGTTATCA TCGGGGAACA AGATGAAACG GACAGAAGTC TCATAAATGA GATATCCGCA 
TCGCCGCCAC TACCCCGTGG AGACCTGGGT GCCCCGCAGA ACCCCAATGC CAAGGCTGCC 
GGATCCAGGA AGATCCATTT CAACTGGCTG CCCCCTCCTG GCAAGCCAAT GGGGTATAGG 
GTGAAATACT GGGTCCAGGG CGACTCTGAG TCCGAAGCCC ACCTGCTGGA CAGCAAGGTG 
CCCTCAGTGG AGCTCACCAA CCTGTATCCC TATTGCGACT ACGAAATGAA GGTGTGCGCC 
TACGGGGCAC ACGGGGAGGG GCCCTATAGC TCACTGGTGT CCTGCCGCAC CCACCAGGAA 
GTGCCCAGTG AGCCAGGAAG GCTGGCTTTC AATGTAGTTT CTTCTACGGT GACCCAGCTG 
AGCTGGGCAG AACCAGCTGA AACCAACGGG GAGATCACAG CCTATGAGGT CTGCTATGGA 
CTGGTCAACG AGGACAACCG ACCCATTGGA CCTATGAAGA AGGTGCTTGT GGACAACCCC 
AAGAACCGGA TGCTGCTCAT TGAGAATCTT CGAGAGTCCC AGCCATACCG ATACACGGTG 
AAGGCGCGAA ACGGGGCAGG ATGGGGACCC GAGAGAGAGG CTATCATCAA CCTGGCCACA 
CAGCCCAAGC GGCCCATGTC CATTCCTATC ATCCCAGACA TCCCCATAGT GGACGCCCAG 
GGTGGAGAAG ACTACGAAAA CTTCCTCATG TACAGTGACG ACGTTCTGCG CTCCCCAGCC 
AGCAGCCAGA GGCCCAGCGT TTCAGATGAC ACTGAGCACC TGGTGAATGG CCGGATGGAC 
TTTGCCTATC CAGGCAGTGC CAACTCCCTG CATAGGATGA CTGCTGCCAA CGTGGCCTAT 
GGCACACATC TAAGCCCACA CCAGACCCAC CGAATGCTGA GCACGTCTTC TACCCTTACC 
CGGGACTACC ACTCTCTGAC GCGCACAGAC CACTCTCAGT CAGGCACACT TCCCCGGGAC 
TACTCCACTC TCACTTCCCT TTCCTCCCAA GGCCTCCCTC CTATCTGGGA AGATGGGAGG 
AGCAGGCTTC CGCTGTCCTG GACCCTTGGG TCCTGGAGCC GGGCTCAGAT GAAGGGTGTG 
CCCGCATCCA GGGGCTCACC AGACTCTATA ATCCTGGCCG GGCAGTCAGC AGCGCCCTCC 
TGGGGTACAG ATTCCCGTGG GGCTATGGGT GTGCCCGACA CACCCACTCG GCTGGTGTTC 
TCCGCCCTGG GGCCCACATC TCTGAAGGTG AGCTGGCAGG AGCCACAGTG TGATCGAGCA 
CTGCTGGGCT ACAGCGTGGA ATACCAGCTA CTCAACGGCG GCGAGATGCA TCGGCTCAAC 
ATCCCTAACC CTGGCCAAAC CTCTGTGGTG GTAGAGGATC TCCTGCCTAA CCACTCCTAT 
GTGTTCCGGG TACGGGCACA AAGCCAGGAG GGCTGGGGCC GGGAGCGAGA GGGTGTCATC 
ACCATCGAGT CCCAGGTGCA CCCGCAGAGC CCTCTCTGCC CCCTGCCAGG CTCCGCCTTC 
ACCTTGAGCA CCCCCAGCGC CCCAGGCCCC CTGGTGTTCA CTGCCCTAAG CCCAGACTCT 
CTGCAGCTGA GCTGGGAGCG CCCAAGAAGG CCCAACGGAG ATATCCTTGG CTACCTGGTG 
ACCTGTGAGA TGGCCCAAGG AGGAGGACCA GCCAGAACCT TCCGGGTGGA TGGGGACAAC 
CCTGAGAGCC GGCTGACGGT TCCTGGCCTC AGTGAGAACG TTCCTTACAA GTTCAAGGTG 
CAGGCCCGGA CAACAGAGGG CTTTGGGCCC GAGCGTGAGG GTATCATCAC CATCGAGTCT 
CAGGATGGAG GCCCCTTCCC ACAGCTGGGC AGCCATTCTG GGCTTTTCCA GAACCCACTG 
CAAAGTGAGT ACAGCACTGT CACCAGCACT CACAGCACTA CCACCACCGA GCCCTTCCTT 
ATAGATGGAC TAACCCTGGG GACCCAGCGC CTGGAAGCAG GGGGCTCCCT CACCCGGCAT 
GTGACCCAGG AATTTGTGAG CCGGACCCTG ACCACCAGTG GCTCTCTCAG CACTCATATG 
GACCAACAGT TCTTCCAAAC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A dual role for Integrin ?6?4 in modulating Hereditary Neuropathy with liability to Pressure Palsies.
Journal of neurochemistry(2018 Jan)
Poitelon Y,Matafora V,Silvestri N,Zambroni D,McGarry C,Serghany N,Rush T,Vizzuso D,Court FA,Bachi A,Wrabetz L,Feltri ML

Interaction of integrin ?4 with S1P receptors in S1P- and HGF-induced endothelial barrier enhancement.
Journal of cellular biochemistry115(6)1187-95(2014 Jun)
Ni X,Epshtein Y,Chen W,Zhou T,Xie L,Garcia JG,Jacobson JR

Relationship between annexin A7 and integrin ?4 in autophagy.
The international journal of biochemistry & cell biology45(11)2605-11(2013 Nov)
Li H,Huang S,Wang S,Wang L,Qi L,Zhang Y,Zhang S,Zhao B,Miao J

Phenotypic spectrum of epidermolysis bullosa associated with ?6?4 integrin mutations.
The British journal of dermatology169(1)115-24(2013 Jul)
Schumann H,Kiritsi D,Pigors M,Hausser I,Kohlhase J,Peters J,Ott H,Hyla-Klekot L,Gacka E,Sieron AL,Valari M,Bruckner-Tuderman L,Has C

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Proceedings of the National Academy of Sciences of the United States of America110(8)E643-52(2013 Feb)
Ghai R,Bugarcic A,Liu H,Norwood SJ,Skeldal S,Coulson EJ,Li SS,Teasdale RD,Collins BM

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Itgb4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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