Gucy2c cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gucy2c
Entrez Gene ID	25711
Full Name	guanylate cyclase 2C
Synonyms	GCC
General protein information	Preferred Names guanylate cyclase 2C Names heat-stable enterotoxin receptor GC-C Guanylate cyclase 2C (heat stable enterotoxin receptor) STA receptor guanylyl cyclase C intestinal guanylate cyclase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q43
Summary	guanylyl cyclase; functions as receptor for heat-stable enterotoxin responsible for acute diarrhea [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013170.1	NP_037302.1	heat-stable enterotoxin receptor precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GUCY2C	XP_528746.2
	GUCY2C	XP_001089601.1
Danio rerio (zebrafish)	LOC568219	XP_696628.4
Homo sapiens (human)	GUCY2C	NP_004954.2
Bos taurus (cattle)	GUCY2C	NP_776972.1
Mus musculus (house mouse)	Gucy2c	NP_001120790.1
Rattus norvegicus (Norway rat)	Gucy2c	NP_037302.1
Xenopus tropicalis (tropical clawed frog)	gucy2c	XP_002934756.1
Canis lupus familiaris (dog)	GUCY2C	XP_543798.3
Danio rerio (zebrafish)	LOC572052	XP_700803.6
Gallus gallus (chicken)	GUCY2C	XP_416207.3

Gene Ontology
Bibliography

Related articles in PubMed

Interleukin-15 derived from Guanylin-GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes.
Akieda-Asai S, Ida T, Miyazato M, Kangawa K, Date Y
Peptides9914-19(2018 01)

Guanylin-Guanylyl cyclase-C signaling in macrophages regulates mesenteric fat inflammation induced by high-fat diet.
Hasegawa K, Akieda-Asai S, Fujii Y, Bae CR, Yasuda M, Date Y
Endocrine journal62(10)939-47(2015)

Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to a high-fat diet.
Akieda-Asai S, Sugiyama M, Miyazawa T, Koda S, Okano I, Senba K, Poleni PE, Hizukuri Y, Okamoto A, Yamahara K, Mutoh E, Aoyama F, Sawaguchi A, Furuya M, Miyazato M, Kangawa K, Date Y
Journal of lipid research54(1)85-96(2013 Jan)

The rat kidney contains high levels of prouroguanylin (the uroguanylin precursor) but does not express GC-C (the enteric uroguanylin receptor).
Qian X, Moss NG, Fellner RC, Taylor-Blake B, Goy MF
American journal of physiology. Renal physiology300(2)F561-73(2011 Feb)

The linker region in receptor guanylyl cyclases is a key regulatory module: mutational analysis of guanylyl cyclase C.
Saha S, Biswas KH, Kondapalli C, Isloor N, Visweswariah SS
The Journal of biological chemistry284(40)27135-45(2009 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data (including data from studies in transgenic rats) suggest guanylin--guanylyl cyclase-C signaling in macrophages in mesenteric fat regulates cGMP--PKG--VASP pathway and mesenteric panniculitis/obesity via down-regulation of proinflammatory factors.
Title: Guanylin-Guanylyl cyclase-C signaling in macrophages regulates mesenteric fat inflammation induced by high-fat diet.

the macrophagic guanylin-GC-C system contributes to the altered expression of genes involved in lipid metabolism, leading to resistance to obesity
Title: Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to a high-fat diet.

these studies provide a comprehensive description of Ugn and GC-C expression in the kidney of the Sprague-Dawley rat.
Title: The rat kidney contains high levels of prouroguanylin (the uroguanylin precursor) but does not express GC-C (the enteric uroguanylin receptor).

the role of the linker region in receptor guanylyl cyclases
Title: The linker region in receptor guanylyl cyclases is a key regulatory module: mutational analysis of guanylyl cyclase C.

The following Gucy2c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gucy2c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02205	NM_013170.1 Latest version!	Rattus norvegicus guanylate cyclase 2C (Gucy2c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gucy2c ( NM_013170.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037302.1 Rattus norvegicus guanylate cyclase 2C (Gucy2c), mRNA.

Price & Availability↑

CloneID	ORa02205
Clone ID Related Accession (Same CDS sequence)	NM_013170.1
Accession Version	NM_013170.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3219bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	heat-stable enterotoxin receptor precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M55636.1. On Dec 17, 2003 this sequence version replaced XM_346727.1. ##Evidence-Data-START## Transcript exon combination :: M55636.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052297, SAMEA2689594 [ECO:0000350] ##Evidence-Data-END##

ATGACGTCAC TCCTGGGCTT GGCTGTGCGG TTACTGCTCT TCCAACCCAC GCTGATGTTC 
TGGGCCTCCC AGGTGAGGCA GAAGTGCCAC AATGGCACCT ACGAGATCAG TGTCCTGATG 
ATGGATAACT CAGCCTACAA AGAACCTTTG CAAAACTTGA GGGATGCTGT GGAGGAAGGA 
CTGGACATCG TGCGAAAGCG CCTGCGCGAA GCCGAACTAA ATGTGACTGT GAACGCAACC 
TTCATCTACT CCGATGGTCT GATCCATAAG TCAGGTGACT GCCGGAGCAG TACCTGTGAA 
GGCCTTGACC TCCTCAGGGA AATTACAAGA GATCGTAAGA TGGGCTGTGT CCTCATGGGG 
CCCTCGTGCA CGTATTCCAC CTTCCAGATG TACCTTGACA CAGAGTTGAA CTATCCCATG 
ATTTCCGCTG GAAGTTTTGG ATTGTCCTGT GACTATAAGG AAACCCTAAC CAGGATCCTG 
CCTCCAGCCA GGAAGCTGAT GTACTTCTTG GTCGATTTCT GGAAAGTCAA CAATGCACCT 
TTCAAAACCT TTTCCTGGAA CTCTTCATAT GTTTACAAGA ACGGATCGGA GCCTGAAGAT 
TGTTTCTGGT ACCTCAACGC TCTAGAGGCT GGGGTGTCCT ATTTTTCTGA GGTGCTCAGC 
TTCAAGGATG TATTGAGACG CAGTGAACAG TTCCAGGAAA TCCTAATGGG CCGTAACAGG 
AAGAGCAATG TGATTGTTAT GTGTGGCACG CCAGAAACCT TCTACAATGT GAAAGGTGAC 
CTCAAAGTGG CTGACGACAC TGTTGTCATC CTGGTAGATC TGTTCAGTAA CCATTACTTT 
GAGGATGACA CCAGAGCTCC TGAGTATATG GACAATGTCC TCGTCCTGAC ACTGCCTCCT 
GAAAAGTTCA TCGCGAACGC CTCTGTCTCT GGGAGGTTTC CATCGGAAAG AAGCGACTTT 
TCTCTCGCTT ACTTGGAGGG GACCTTGCTG TTTGGACACA TGCTGCAGAC GTTTCTTGAA 
AATGGAGAAT CTGTCACCAC GCCCAAGTTC GCTCGTGCGT TCAGGAATCT CACTTTTCAA 
GGCTTAGAGG GGCCCGTGAC TCTGGATGAC AGTGGGGACA TTGACAACAT TATGTGTCTT 
CTGTATGTGT CTCTGGATAC CAGGAAATAC AAGGTTCTTA TGGCGTATGA CACCCATAAA 
AACCAAACGA TCCCTGTGGC TACGAGCCCC AACTTCATCT GGAAGAACCA CAGACTCCCT 
AATGACGTTC CTGGGCTGGG CCCTCAAATC CTGATGATTG CCGTCTTCAC GCTCACGGGG 
ATTGTGGTCG TTCTGCTGCT GATTGCCCTC CTTGTGCTCA GAAAATACAG AAGAGATCAT 
GAACTTCGAC AGAAGAAATG GTCCCACATC CCTTCTGAAA ATATCTTTCC TCTGGAGACC 
AACGAGACCA ACCATGTCAG CCTGAAGATT GACGATGACA GGAGGCGGGA TACAATCCAG 
AGAGTGCGAC AGTGCAAATA CGACAAGAAG AAAGTGATCC TGAAAGACCT CAAGCACTGT 
GATGGTAACT TCAGTGAGAA GCAGAAGATA GAACTGAACA AGCTACTGCA GTCAGACTAC 
TACAACCTGA CCAAGTTCTA CGGCACCGTG AAGCTAGACA CCAGGATCTT TGGGGTGGTC 
GAGTACTGCG AGAGGGGGTC CCTCCGGGAA GTGTTAAATG ACACGATTTC CTACCCTGAT 
GGCACGTTCA TGGATTGGGA GTTTAAGATC TCTGTCTTAA ATGACATTGC TAAGGGGATG 
TCCTATCTGC ACTCCAGTAA GATTGAAGTC CACGGGCGTC TGAAGTCCAC CAACTGCGTG 
GTGGACAGTC GCATGGTGGT GAAGATCACT GATTTTGGGT GCAATTCCAT CCTGCCTCCA 
AAGAAAGACC TGTGGACTGC CCCCGAGCAC CTGCGCCAAG CTACTATCTC TCAGAAAGGA 
GACGTGTACA GCTTCAGCAT CATTGCCCAG GAGATCATCC TCCGCAAGGA AACTTTCTAC 
ACGCTGAGCT GCCGGGATCA GAATGAGAAG ATTTTCAGAG TGGAAAATTC CTATGGGACG 
AAACCCTTCC GCCCAGATCT CTTCCTGGAA ACCGCAGATG AGAAGGAGCT GGAGGTCTAT 
CTATTGGTCA AAAGCTGTTG GGAGGAGGAT CCAGAAAAGA GACCAGATTT CAAGAAAATC 
GAGAGCACAC TAGCCAAGAT ATTTGGCCTT TTTCATGACC AAAAAAATGA ATCTTACATG 
GACACCTTGA TCCGACGTCT ACAGCTGTAT TCTCGGAACC TGGAGCACCT GGTGGAGGAA 
AGGACTCAGC TGTACAAGGC CGAGAGGGAC AGGGCTGACC ACCTTAACTT TATGCTGCTC 
CCACGGCTGG TGGTAAAGTC CCTGAAGGAG AAAGGCATCG TGGAGCCAGA GCTGTACGAA 
GAAGTCACAA TCTATTTCAG TGACATTGTC GGTTTCACGA CCATCTGCAA GTACAGCACG 
CCCATGGAGG TGGTGGACAT GCTGAATGAC ATCTACAAGA GTTTTGACCA GATTGTGGAT 
CACCACGACG TCTACAAGGT AGAAACCATC GGCGATGCCT ACGTGGTGGC CAGCGGCCTG 
CCTATGAGAA ACGGCAACCG GCATGCAGTG GACATTTCCA AGATGGCCTT GGACATCCTC 
AGCTTCATGG GGACCTTTGA GCTGGAGCAT CTCCCCGGCC TCCCCGTGTG GATTCGCATT 
GGGGTTCATT CTGGCCCCTG TGCTGCTGGT GTGGTGGGGA TCAAGATGCC TCGTTATTGC 
CTGTTTGGAG ACACTGTCAA CACTGCCTCC AGGATGGAGT CCACCGGCCT TCCCTTAAGG 
ATTCACATGA GCAGCTCCAC CATTGCCATC CTGAGGAGAA CGGATTGCCA GTTCCTGTAC 
GAAGTGAGGG GAGAAACGTA CTTAAAGGGA AGAGGGACCG AGACCACATA CTGGCTGACT 
GGGATGAAGG ACCAAGAGTA CAACCTGCCA ACCCCACCAA CAGTGGAGAA CCAACAGCGT 
CTGCAAACTG AGTTCTCAGA CATGATCGTT AGTGCCTTAC AGAAAAGACA GGCCTCGGGC 
GTGAAGAGCC GGAGGCCCAC TCGGGTGGCC AGCTACAAGA AAGGCTTTTT GGAATACATG 
CAGCTGAACA ACTCAGACCA CGATAGCACC TATTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037302.1
CDS	11..3229
Translation	MTSLLGLAVRLLLFQPTLMFWASQVRQKCHNGTYEISVLMMDNSAYKEPLQNLRDAVEEGLDIVRKRLREAELNVTVNATFIYSDGLIHKSGDCRSSTCEGLDLLREITRDRKMGCVLMGPSCTYSTFQMYLDTELNYPMISAGSFGLSCDYKETLTRILPPARKLMYFLVDFWKVNNAPFKTFSWNSSYVYKNGSEPEDCFWYLNALEAGVSYFSEVLSFKDVLRRSEQFQEILMGRNRKSNVIVMCGTPETFYNVKGDLKVADDTVVILVDLFSNHYFEDDTRAPEYMDNVLVLTLPPEKFIANASVSGRFPSERSDFSLAYLEGTLLFGHMLQTFLENGESVTTPKFARAFRNLTFQGLEGPVTLDDSGDIDNIMCLLYVSLDTRKYKVLMAYDTHKNQTIPVATSPNFIWKNHRLPNDVPGLGPQILMIAVFTLTGIVVVLLLIALLVLRKYRRDHELRQKKWSHIPSENIFPLETNETNHVSLKIDDDRRRDTIQRVRQCKYDKKKVILKDLKHCDGNFSEKQKIELNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQATISQKGDVYSFSIIAQEIILRKETFYTLSCRDQNEKIFRVENSYGTKPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFMGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTIAILRRTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNLPTPPTVENQQRLQTEFSDMIVSALQKRQASGVKSRRPTRVASYKKGFLEYMQLNNSDHDSTYF

Target ORF information:

RefSeq Version	NM_013170.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus guanylate cyclase 2C (Gucy2c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013170.1

ORF Insert Sequence:

ATGACGTCAC TCCTGGGCTT GGCTGTGCGG TTACTGCTCT TCCAACCCAC GCTGATGTTC 
TGGGCCTCCC AGGTGAGGCA GAAGTGCCAC AATGGCACCT ACGAGATCAG TGTCCTGATG 
ATGGATAACT CAGCCTACAA AGAACCTTTG CAAAACTTGA GGGATGCTGT GGAGGAAGGA 
CTGGACATCG TGCGAAAGCG CCTGCGCGAA GCCGAACTAA ATGTGACTGT GAACGCAACC 
TTCATCTACT CCGATGGTCT GATCCATAAG TCAGGTGACT GCCGGAGCAG TACCTGTGAA 
GGCCTTGACC TCCTCAGGGA AATTACAAGA GATCGTAAGA TGGGCTGTGT CCTCATGGGG 
CCCTCGTGCA CGTATTCCAC CTTCCAGATG TACCTTGACA CAGAGTTGAA CTATCCCATG 
ATTTCCGCTG GAAGTTTTGG ATTGTCCTGT GACTATAAGG AAACCCTAAC CAGGATCCTG 
CCTCCAGCCA GGAAGCTGAT GTACTTCTTG GTCGATTTCT GGAAAGTCAA CAATGCACCT 
TTCAAAACCT TTTCCTGGAA CTCTTCATAT GTTTACAAGA ACGGATCGGA GCCTGAAGAT 
TGTTTCTGGT ACCTCAACGC TCTAGAGGCT GGGGTGTCCT ATTTTTCTGA GGTGCTCAGC 
TTCAAGGATG TATTGAGACG CAGTGAACAG TTCCAGGAAA TCCTAATGGG CCGTAACAGG 
AAGAGCAATG TGATTGTTAT GTGTGGCACG CCAGAAACCT TCTACAATGT GAAAGGTGAC 
CTCAAAGTGG CTGACGACAC TGTTGTCATC CTGGTAGATC TGTTCAGTAA CCATTACTTT 
GAGGATGACA CCAGAGCTCC TGAGTATATG GACAATGTCC TCGTCCTGAC ACTGCCTCCT 
GAAAAGTTCA TCGCGAACGC CTCTGTCTCT GGGAGGTTTC CATCGGAAAG AAGCGACTTT 
TCTCTCGCTT ACTTGGAGGG GACCTTGCTG TTTGGACACA TGCTGCAGAC GTTTCTTGAA 
AATGGAGAAT CTGTCACCAC GCCCAAGTTC GCTCGTGCGT TCAGGAATCT CACTTTTCAA 
GGCTTAGAGG GGCCCGTGAC TCTGGATGAC AGTGGGGACA TTGACAACAT TATGTGTCTT 
CTGTATGTGT CTCTGGATAC CAGGAAATAC AAGGTTCTTA TGGCGTATGA CACCCATAAA 
AACCAAACGA TCCCTGTGGC TACGAGCCCC AACTTCATCT GGAAGAACCA CAGACTCCCT 
AATGACGTTC CTGGGCTGGG CCCTCAAATC CTGATGATTG CCGTCTTCAC GCTCACGGGG 
ATTGTGGTCG TTCTGCTGCT GATTGCCCTC CTTGTGCTCA GAAAATACAG AAGAGATCAT 
GAACTTCGAC AGAAGAAATG GTCCCACATC CCTTCTGAAA ATATCTTTCC TCTGGAGACC 
AACGAGACCA ACCATGTCAG CCTGAAGATT GACGATGACA GGAGGCGGGA TACAATCCAG 
AGAGTGCGAC AGTGCAAATA CGACAAGAAG AAAGTGATCC TGAAAGACCT CAAGCACTGT 
GATGGTAACT TCAGTGAGAA GCAGAAGATA GAACTGAACA AGCTACTGCA GTCAGACTAC 
TACAACCTGA CCAAGTTCTA CGGCACCGTG AAGCTAGACA CCAGGATCTT TGGGGTGGTC 
GAGTACTGCG AGAGGGGGTC CCTCCGGGAA GTGTTAAATG ACACGATTTC CTACCCTGAT 
GGCACGTTCA TGGATTGGGA GTTTAAGATC TCTGTCTTAA ATGACATTGC TAAGGGGATG 
TCCTATCTGC ACTCCAGTAA GATTGAAGTC CACGGGCGTC TGAAGTCCAC CAACTGCGTG 
GTGGACAGTC GCATGGTGGT GAAGATCACT GATTTTGGGT GCAATTCCAT CCTGCCTCCA 
AAGAAAGACC TGTGGACTGC CCCCGAGCAC CTGCGCCAAG CTACTATCTC TCAGAAAGGA 
GACGTGTACA GCTTCAGCAT CATTGCCCAG GAGATCATCC TCCGCAAGGA AACTTTCTAC 
ACGCTGAGCT GCCGGGATCA GAATGAGAAG ATTTTCAGAG TGGAAAATTC CTATGGGACG 
AAACCCTTCC GCCCAGATCT CTTCCTGGAA ACCGCAGATG AGAAGGAGCT GGAGGTCTAT 
CTATTGGTCA AAAGCTGTTG GGAGGAGGAT CCAGAAAAGA GACCAGATTT CAAGAAAATC 
GAGAGCACAC TAGCCAAGAT ATTTGGCCTT TTTCATGACC AAAAAAATGA ATCTTACATG 
GACACCTTGA TCCGACGTCT ACAGCTGTAT TCTCGGAACC TGGAGCACCT GGTGGAGGAA 
AGGACTCAGC TGTACAAGGC CGAGAGGGAC AGGGCTGACC ACCTTAACTT TATGCTGCTC 
CCACGGCTGG TGGTAAAGTC CCTGAAGGAG AAAGGCATCG TGGAGCCAGA GCTGTACGAA 
GAAGTCACAA TCTATTTCAG TGACATTGTC GGTTTCACGA CCATCTGCAA GTACAGCACG 
CCCATGGAGG TGGTGGACAT GCTGAATGAC ATCTACAAGA GTTTTGACCA GATTGTGGAT 
CACCACGACG TCTACAAGGT AGAAACCATC GGCGATGCCT ACGTGGTGGC CAGCGGCCTG 
CCTATGAGAA ACGGCAACCG GCATGCAGTG GACATTTCCA AGATGGCCTT GGACATCCTC 
AGCTTCATGG GGACCTTTGA GCTGGAGCAT CTCCCCGGCC TCCCCGTGTG GATTCGCATT 
GGGGTTCATT CTGGCCCCTG TGCTGCTGGT GTGGTGGGGA TCAAGATGCC TCGTTATTGC 
CTGTTTGGAG ACACTGTCAA CACTGCCTCC AGGATGGAGT CCACCGGCCT TCCCTTAAGG 
ATTCACATGA GCAGCTCCAC CATTGCCATC CTGAGGAGAA CGGATTGCCA GTTCCTGTAC 
GAAGTGAGGG GAGAAACGTA CTTAAAGGGA AGAGGGACCG AGACCACATA CTGGCTGACT 
GGGATGAAGG ACCAAGAGTA CAACCTGCCA ACCCCACCAA CAGTGGAGAA CCAACAGCGT 
CTGCAAACTG AGTTCTCAGA CATGATCGTT AGTGCCTTAC AGAAAAGACA GGCCTCGGGC 
GTGAAGAGCC GGAGGCCCAC TCGGGTGGCC AGCTACAAGA AAGGCTTTTT GGAATACATG 
CAGCTGAACA ACTCAGACCA CGATAGCACC TATTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Interleukin-15 derived from Guanylin-GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes.
Peptides9914-19(2018 01)
Akieda-Asai S,Ida T,Miyazato M,Kangawa K,Date Y

Guanylin-Guanylyl cyclase-C signaling in macrophages regulates mesenteric fat inflammation induced by high-fat diet.
Endocrine journal62(10)939-47(2015)
Hasegawa K,Akieda-Asai S,Fujii Y,Bae CR,Yasuda M,Date Y

Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to a high-fat diet.
Journal of lipid research54(1)85-96(2013 Jan)
Akieda-Asai S,Sugiyama M,Miyazawa T,Koda S,Okano I,Senba K,Poleni PE,Hizukuri Y,Okamoto A,Yamahara K,Mutoh E,Aoyama F,Sawaguchi A,Furuya M,Miyazato M,Kangawa K,Date Y

The rat kidney contains high levels of prouroguanylin (the uroguanylin precursor) but does not express GC-C (the enteric uroguanylin receptor).
American journal of physiology. Renal physiology300(2)F561-73(2011 Feb)
Qian X,Moss NG,Fellner RC,Taylor-Blake B,Goy MF

The linker region in receptor guanylyl cyclases is a key regulatory module: mutational analysis of guanylyl cyclase C.
The Journal of biological chemistry284(40)27135-45(2009 Oct)
Saha S,Biswas KH,Kondapalli C,Isloor N,Visweswariah SS

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Gucy2c cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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