Ucp3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Ursolic acid increases energy expenditure through enhancing free fatty acid uptake and ?-oxidation via an UCP3/AMPK-dependent pathway in skeletal muscle.
Chu X, He X, Shi Z, Li C, Guo F, Li S, Li Y, Na L, Sun C
Molecular nutrition & food research59(8)1491-503(2015 Aug)

Alterations in proton leak, oxidative status and uncoupling protein 3 content in skeletal muscle subsarcolemmal and intermyofibrillar mitochondria in old rats.
Crescenzo R, Bianco F, Mazzoli A, Giacco A, Liverini G, Iossa S
BMC geriatrics1479(2014 Jun)

Endurance training blocks uncoupling protein 1 up-regulation in brown adipose tissue while increasing uncoupling protein 3 in the muscle tissue of rats fed with a high-sugar diet.
de Queiroz KB, Rodovalho GV, Guimar?es JB, de Lima DC, Coimbra CC, Evangelista EA, Guerra-S? R
Nutrition research (New York, N.Y.)32(9)709-17(2012 Sep)

A long-term high-fat diet increases oxidative stress, mitochondrial damage and apoptosis in the inner ear of D-galactose-induced aging rats.
Du Z, Yang Y, Hu Y, Sun Y, Zhang S, Peng W, Zhong Y, Huang X, Kong W
Hearing research287(1-2)15-24(2012 May)

Data suggest that UCP3 expression, energy metabolism, and uptake/beta-oxidation of free fatty acids in skeletal muscle can be regulated by dietary components; here, ursolic acid, a dietary triterpenoid, has anti-obesity effects.
Title: Ursolic acid increases energy expenditure through enhancing free fatty acid uptake and ?-oxidation via an UCP3/AMPK-dependent pathway in skeletal muscle.

Based on Ucp3 content, a decrease in oxidative capacity and proton leak in intermyofibrillar and subsarcolemmal mitochondria could induce a decline in energy expenditure and thus contribute to the reduced resting metabolic rate found in old rats.
Title: Alterations in proton leak, oxidative status and uncoupling protein 3 content in skeletal muscle subsarcolemmal and intermyofibrillar mitochondria in old rats.

Endurance training blocked the high-sugar diet induced up-regulation of UCP1 expression in interscapular brown adipose tissue, whereas it up-regulated the expression of Ucp3 mRNA in muscle.
Title: Endurance training blocks uncoupling protein 1 up-regulation in brown adipose tissue while increasing uncoupling protein 3 in the muscle tissue of rats fed with a high-sugar diet.

Examined the effect of D-Asp uptake on the expression of the mitochondrial uncoupling protein-3 (UCP3), beta-actin, and alpha-tubulin in rat Harderian gland.
Title: Effect of D-aspartate uptake on uncoupling protein-3 and ?-tubulin expressions in rat Harderian gland.

High fat diets increase the expression of fatty acid oxidation enzymes such as UCP3,PDK4, and MCAD concomitant with elevated plasma fatty acid levels and the induction of PGC-1 beta, but independent of changes in AMPK, p38, and PKA signaling.
Title: Interactions between the consumption of a high-fat diet and fasting in the regulation of fatty acid oxidation enzyme gene expression: an evaluation of potential mechanisms.