Igfbp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Igfbp2
Entrez Gene ID	25662
Full Name	insulin-like growth factor binding protein 2
Synonyms	BRL-BP,IBP-2,IGFBP-2,ILGFBPA
General protein information	Preferred Names insulin-like growth factor binding protein 2 Names insulin-like growth factor-binding protein 2 IGF-binding protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q33
Summary	protein that binds to Igf-I and Igf-II [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013122.2	NP_037254.2	insulin-like growth factor-binding protein 2 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	IGFBP2	XP_005640799.1
Gallus gallus (chicken)	IGFBP2	NP_990690.1
Pan troglodytes (chimpanzee)	IGFBP2	XP_003950020.1
Mus musculus (house mouse)	Igfbp2	NP_032368.2
Danio rerio (zebrafish)	igfbp2a	NP_571533.1
	IGFBP2	XP_001087071.1
Bos taurus (cattle)	IGFBP2	NP_776980.1
Xenopus tropicalis (tropical clawed frog)	igfbp2	NP_001093707.1
Homo sapiens (human)	IGFBP2	NP_000588.2
Rattus norvegicus (Norway rat)	Igfbp2	NP_037254.2
Danio rerio (zebrafish)	igfbp2b	NP_001119936.1

Gene Ontology
Bibliography

Related articles in PubMed

Prenatal administration of retinoic acid increases the trophoblastic insulin-like growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia.
Kutasy B, Friedmacher F, Duess JW, Puri P
Pediatric surgery international30(2)137-42(2014 Feb)

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M
Circulation research113(10)1138-47(2013 Oct)

Comparative analysis of aqueous humor cytokine levels between patients with exudative age-related macular degeneration and normal controls.
Cha DM, Woo SJ, Kim HJ, Lee C, Park KH
Investigative ophthalmology & visual science54(10)7038-44(2013 Oct)

Identification of Igf2, Igfbp2 and Enpp2 as estrogen-responsive genes in rat hippocampus.
Takeo C, Ikeda K, Horie-Inoue K, Inoue S
Endocrine journal56(1)113-20(2009)

Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence.
Zhou J, Li W, Kamei H, Duan C
PloS one3(12)e3926(2008)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Insulin-like growth factor 2 (IGF2) is an important regulator of fetal growth.
Title: Prenatal administration of retinoic acid increases the trophoblastic insulin-like growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia.

A brain region- and cell type-specific responses to estrogen in rat brain, suggesting that Igf signaling may mediate the estrogen function in the hippocampus.
Title: Identification of Igf2, Igfbp2 and Enpp2 as estrogen-responsive genes in rat hippocampus.

In conclusion, MMP-9-induced IGFBP2 proteolysis may be regarded as an important post-translational event involved in astrocytoma aggressiveness. These new findings support drug targeting of MMP-9 as an interesting approach in the treatment of
Title: Matrix metalloproteinase-9 interplays with the IGFBP2-IGFII complex to promote cell growth and motility in astrocytomas.

Abnormal expression of IGFBP-2 correlates with hyperoxia-induced lung injury in neonatal rats.
Title: [Relation of insulin-like growth factor binding protein-2 with hyperoxia-induced lung injury in term and premature neonatal rats].

IGFBP-2 plays a role in the lamellar bone formation process.
Title: In vivo mechanical loading modulates insulin-like growth factor binding protein-2 gene expression in rat osteocytes.

The following Igfbp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Igfbp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02061	NM_013122.2 Latest version!	Rattus norvegicus insulin-like growth factor binding protein 2 (Igfbp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Igfbp2 ( NM_013122.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037254.2 Rattus norvegicus insulin-like growth factor binding protein 2 (Igfbp2), mRNA.

Price & Availability↑

CloneID	ORa02061
Clone ID Related Accession (Same CDS sequence)	NM_013122.2
Accession Version	NM_013122.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	insulin-like growth factor-binding protein 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC092570.1. On Jun 10, 2007 this sequence version replaced NM_013122.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC092570.1, FQ212531.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCTGCCGA GATTGGGCGG CCCCGCGCTG CCGCTGCTCC TGCCGTCGCT GCTCTTGCTG 
CTGCTGTTGG GCGCGGGCGG TTGCGGTCCT GGGGTGCGCG CCGAGGTGCT GTTCCGCTGC 
CCACCCTGCA CGCCCGAGCG TCTGGCCGCC TGCGGACCCC CACCCGACGC GCCCTGCGCC 
GAGCTGGTGC GAGAGCCCGG CTGCGGTTGC TGCTCCGTGT GCGCACGACA GGAGGGCGAA 
GCTTGCGGCG TCTACATCCC GCGCTGCGCC CAGACGTTAC GCTGTTACCC CAACCCGGGC 
TCCGAGCTGC CCCTGAAGGC ACTGGTCACC GGCGCGGGTA CCTGTGAAAA GAGACGCGTG 
GGCGCCACCC CACAGCAAGT TGCAGACAGT GAGGATGACC ACTCGGAGGG AGGCCTGGTG 
GAGAACCATG TGGACGGAAC CATGAACATG TTGGGAGGCA GCAGTGCTGG CCGGAAGCCC 
CCTAAGTCAG GCATGAAGGA ACTGGCTGTG TTCCGGGAGA AGGTCAACGA GCAGCACCGG 
CAGATGGGCA AAGGTGCCAA ACACCTCAGC CTGGAGGAGC CCAAGAAGCT GCGCCCACCT 
CCTGCCAGGA CCCCTTGCCA GCAGGAGCTG GACCAGGTCC TGGAGCGCAT CTCCACCATG 
CGCCTTCCGG ATGATCGGGG TCCTCTGGAA CATCTCTACT CCCTGCATAT CCCCAACTGT 
GACAAGCATG GCCTGTACAA CCTCAAACAG TGCAAGATGT CTCTGAATGG ACAGCGTGGG 
GAGTGCTGGT GTGTGAACCC CAATACTGGG AAGCCAATCC AGGGAGCTCC CACCATCCGG 
GGAGACCCCG AGTGCCATCT CTTCTACAAC GAGCAGCAGG AGAATGATGG GGCTCACGCC 
CAAAGGGTGC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037254.2
CDS	72..986
Translation	MLPRLGGPALPLLLPSLLLLLLLGAGGCGPGVRAEVLFRCPPCTPERLAACGPPPDAPCAELVREPGCGCCSVCARQEGEACGVYIPRCAQTLRCYPNPGSELPLKALVTGAGTCEKRRVGATPQQVADSEDDHSEGGLVENHVDGTMNMLGGSSAGRKPPKSGMKELAVFREKVNEQHRQMGKGAKHLSLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDDRGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKPIQGAPTIRGDPECHLFYNEQQENDGAHAQRVQ

Target ORF information:

RefSeq Version	NM_013122.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin-like growth factor binding protein 2 (Igfbp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013122.2

ORF Insert Sequence:

ATGCTGCCGA GATTGGGCGG CCCCGCGCTG CCGCTGCTCC TGCCGTCGCT GCTCTTGCTG 
CTGCTGTTGG GCGCGGGCGG TTGCGGTCCT GGGGTGCGCG CCGAGGTGCT GTTCCGCTGC 
CCACCCTGCA CGCCCGAGCG TCTGGCCGCC TGCGGACCCC CACCCGACGC GCCCTGCGCC 
GAGCTGGTGC GAGAGCCCGG CTGCGGTTGC TGCTCCGTGT GCGCACGACA GGAGGGCGAA 
GCTTGCGGCG TCTACATCCC GCGCTGCGCC CAGACGTTAC GCTGTTACCC CAACCCGGGC 
TCCGAGCTGC CCCTGAAGGC ACTGGTCACC GGCGCGGGTA CCTGTGAAAA GAGACGCGTG 
GGCGCCACCC CACAGCAAGT TGCAGACAGT GAGGATGACC ACTCGGAGGG AGGCCTGGTG 
GAGAACCATG TGGACGGAAC CATGAACATG TTGGGAGGCA GCAGTGCTGG CCGGAAGCCC 
CCTAAGTCAG GCATGAAGGA ACTGGCTGTG TTCCGGGAGA AGGTCAACGA GCAGCACCGG 
CAGATGGGCA AAGGTGCCAA ACACCTCAGC CTGGAGGAGC CCAAGAAGCT GCGCCCACCT 
CCTGCCAGGA CCCCTTGCCA GCAGGAGCTG GACCAGGTCC TGGAGCGCAT CTCCACCATG 
CGCCTTCCGG ATGATCGGGG TCCTCTGGAA CATCTCTACT CCCTGCATAT CCCCAACTGT 
GACAAGCATG GCCTGTACAA CCTCAAACAG TGCAAGATGT CTCTGAATGG ACAGCGTGGG 
GAGTGCTGGT GTGTGAACCC CAATACTGGG AAGCCAATCC AGGGAGCTCC CACCATCCGG 
GGAGACCCCG AGTGCCATCT CTTCTACAAC GAGCAGCAGG AGAATGATGG GGCTCACGCC 
CAAAGGGTGC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prenatal administration of retinoic acid increases the trophoblastic insulin-like growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia.
Pediatric surgery international30(2)137-42(2014 Feb)
Kutasy B,Friedmacher F,Duess JW,Puri P

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Circulation research113(10)1138-47(2013 Oct)
Abonnenc M,Nabeebaccus AA,Mayr U,Barallobre-Barreiro J,Dong X,Cuello F,Sur S,Drozdov I,Langley SR,Lu R,Stathopoulou K,Didangelos A,Yin X,Zimmermann WH,Shah AM,Zampetaki A,Mayr M

Comparative analysis of aqueous humor cytokine levels between patients with exudative age-related macular degeneration and normal controls.
Investigative ophthalmology & visual science54(10)7038-44(2013 Oct)
Cha DM,Woo SJ,Kim HJ,Lee C,Park KH

Identification of Igf2, Igfbp2 and Enpp2 as estrogen-responsive genes in rat hippocampus.
Endocrine journal56(1)113-20(2009)
Takeo C,Ikeda K,Horie-Inoue K,Inoue S

Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence.
PloS one3(12)e3926(2008)
Zhou J,Li W,Kamei H,Duan C

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Igfbp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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