Cd28 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cd28
Entrez Gene ID	25660
Full Name	Cd28 molecule
Synonyms	CD28RNA
General protein information	Preferred Names Cd28 molecule Names T-cell-specific surface glycoprotein CD28 CD28 antigen
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q32
Summary	costimulatory molecule involved in induction of T cell proliferation and initiation of the Th2 response; may be important in maintanence of basal IgE production; binds to B7-1 or B7-2 on antigen presenting cells (APCs) [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013121.1	NP_037253.1	T-cell-specific surface glycoprotein CD28 precursor
XM_008767078.2	XP_008765300.1	T-cell-specific surface glycoprotein CD28 isoform X1
XM_008767079.2	XP_008765301.1	T-cell-specific surface glycoprotein CD28 isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CD28	NP_851347.1
Canis lupus familiaris (dog)	CD28	NP_001003087.1
Rattus norvegicus (Norway rat)	Cd28	NP_037253.1
Homo sapiens (human)	CD28	NP_006130.1
Pan troglodytes (chimpanzee)	CD28	XP_003309460.1
Mus musculus (house mouse)	Cd28	NP_031668.3
Xenopus tropicalis (tropical clawed frog)	cd28	NP_001103519.1
	CD28	NP_001036106.2
Gallus gallus (chicken)	CD28	NP_990642.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of novel MicroRNA signatures linked to experimental autoimmune myasthenia gravis pathogenesis: down-regulated miR-145 promotes pathogenetic Th17 cell response.
Wang J, Zheng S, Xin N, Dou C, Fu L, Zhang X, Chen J, Zhang Y, Geng D, Xiao C, Cui G, Shen X, Lu Y, Wang J, Dong R, Qiao Y, Zhang Y
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology8(5)1287-302(2013 Dec)

Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation.
Gieseke F, Kruchen A, Tzaribachev N, Bentzien F, Dominici M, M?ller I
European journal of immunology43(10)2741-9(2013 Oct)

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Liang Y, Cucchetti M, Roncagalli R, Yokosuka T, Malzac A, Bertosio E, Imbert J, Nijman IJ, Suchanek M, Saito T, W?lfing C, Malissen B, Malissen M
Nature immunology14(8)858-66(2013 Aug)

Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes.
Ammann JU, Cooke A, Trowsdale J
Journal of immunology (Baltimore, Md. : 1950)190(10)5030-6(2013 May)

CD28 superagonist antibody treatment attenuated obliterative bronchiolitis in rat allo-orthotopic tracheal transplantation by preferentially expanding Foxp3-expressing regulatory T cells.
Shi Q, Niu Y, Cao H, Zhou X, Jiang S, Liu Z, Fan H
Transplantation proceedings44(4)1060-6(2012 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study identified two crucial immune-related molecules-CD28 and NFATc1, as putative targets of miR-145 in human and experimental myasthenia gravis
Title: Identification of novel MicroRNA signatures linked to experimental autoimmune myasthenia gravis pathogenesis: down-regulated miR-145 promotes pathogenetic Th17 cell response.

CD28 superagonist antibody treatment attenuated obliterative bronchiolitis in rat allo-orthotopic tracheal transplantation by preferentially expanding Foxp3-expressing regulatory T cells.
Title: CD28 superagonist antibody treatment attenuated obliterative bronchiolitis in rat allo-orthotopic tracheal transplantation by preferentially expanding Foxp3-expressing regulatory T cells.

Data demonstrate that the superagonistic monoclonal antibody for CD28, JJ316, preferentially expanded Treg cells.
Title: A superagonistic monoclonal antibody for CD28 ameliorates crescentic glomerulonephritis in wistar-kyoto rats.

Data show several homologies across human, rat and mouse in the kinetic of loss of several LAgs such as CD5, CD4 and CD28.
Title: Loss of surface antigens is a conserved feature of apoptotic lymphocytes from several mammalian species.

CD2/CD28 costimulation is the strongest T cell stimulus in vivo in rat lamina propria.
Title: In vivo proliferation of rat lamina propria T lymphocytes: general hyporesponsiveness but increased importance of the CD2 and CD28 pathways.

The following Cd28 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cd28 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa02058	NM_013121.1 Latest version!	Rattus norvegicus Cd28 molecule (Cd28), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa32263	XM_008767079.2 Latest version!	Rattus norvegicus Cd28 molecule (Cd28), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa32263	XM_008767078.2 Latest version!	Rattus norvegicus Cd28 molecule (Cd28), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cd28 ( NM_013121.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037253.1 Rattus norvegicus Cd28 molecule (Cd28), mRNA.

Price & Availability↑

CloneID	ORa02058
Clone ID Related Accession (Same CDS sequence)	NM_013121.1
Accession Version	NM_013121.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 657bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	T-cell-specific surface glycoprotein CD28 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X55288.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X55288.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGACACTCA GACTGCTATT CTTGGCTCTC AGCTTCTTCT CAGTTCAAGT AACAGAAAAC 
AAGATTTTGG TGAAGCAGTC CCCGCTGCTT GTGGTAGATA ACAATGAGGT CAGCCTCAGC 
TGCAGGTATT CCTACAACCT TCTTGCAAAG GAGTTCCGGG CATCCCTTTA CAAGGGCGTG 
AACAGTGACG TGGAAGTCTG TGTCGGGAAT GGGAATTTTA CCTATCAGCC CCAGTTCCGC 
CCAAACGTGG GGTTCAACTG TGATGGGAAT TTCGACAATG AAACAGTGAC GTTCCGTCTC 
TGGAATCTCG ATGTTAATCA CACAGATATT TACTTCTGCA AAATCGAGGT CATGTATCCT 
CCGCCATACC TGGACAACGA GAAGAGCAAC GGAACTATTA TTCACATAAA AGAGAAACAT 
CTTTGTCATG CTCAGACGTC TCCTAAGCTG TTTTGGCCAC TGGTCGTGGT TGCTGGAGTC 
CTGCTGTGTT ATGGCTTGCT AGTGACAGTG ACTCTTTGTA TTATCTGGAC AAATAGCAGA 
AGGAACAGGC TCCTTCAAAG TGACTACATG AACATGACAC CGCGGAGACT CGGGCCCACG 
CGAAAGCATT ACCAACCCTA TGCCCCAGCG AGAGACTTTG CAGCGTACCG CCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037253.1
CDS	33..689
Translation	MTLRLLFLALSFFSVQVTENKILVKQSPLLVVDNNEVSLSCRYSYNLLAKEFRASLYKGVNSDVEVCVGNGNFTYQPQFRPNVGFNCDGNFDNETVTFRLWNLDVNHTDIYFCKIEVMYPPPYLDNEKSNGTIIHIKEKHLCHAQTSPKLFWPLVVVAGVLLCYGLLVTVTLCIIWTNSRRNRLLQSDYMNMTPRRLGPTRKHYQPYAPARDFAAYRP

Target ORF information:

RefSeq Version	NM_013121.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Cd28 molecule (Cd28), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013121.1

ORF Insert Sequence:

ATGACACTCA GACTGCTATT CTTGGCTCTC AGCTTCTTCT CAGTTCAAGT AACAGAAAAC 
AAGATTTTGG TGAAGCAGTC CCCGCTGCTT GTGGTAGATA ACAATGAGGT CAGCCTCAGC 
TGCAGGTATT CCTACAACCT TCTTGCAAAG GAGTTCCGGG CATCCCTTTA CAAGGGCGTG 
AACAGTGACG TGGAAGTCTG TGTCGGGAAT GGGAATTTTA CCTATCAGCC CCAGTTCCGC 
CCAAACGTGG GGTTCAACTG TGATGGGAAT TTCGACAATG AAACAGTGAC GTTCCGTCTC 
TGGAATCTCG ATGTTAATCA CACAGATATT TACTTCTGCA AAATCGAGGT CATGTATCCT 
CCGCCATACC TGGACAACGA GAAGAGCAAC GGAACTATTA TTCACATAAA AGAGAAACAT 
CTTTGTCATG CTCAGACGTC TCCTAAGCTG TTTTGGCCAC TGGTCGTGGT TGCTGGAGTC 
CTGCTGTGTT ATGGCTTGCT AGTGACAGTG ACTCTTTGTA TTATCTGGAC AAATAGCAGA 
AGGAACAGGC TCCTTCAAAG TGACTACATG AACATGACAC CGCGGAGACT CGGGCCCACG 
CGAAAGCATT ACCAACCCTA TGCCCCAGCG AGAGACTTTG CAGCGTACCG CCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cd28 ( XM_008767078.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008765300.1 Rattus norvegicus Cd28 molecule (Cd28), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa32263
Clone ID Related Accession (Same CDS sequence)	XM_008767078.2 , XM_008767079.2
Accession Version	XM_008767078.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	T-cell-specific surface glycoprotein CD28 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008767078.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCTTCA TTCCAACAGT GACACTGGTT CTTTTACTGA GGAGCTTAGA AAACAAGATT 
TTGGTGAAGC AGTCCCCGCT GCTTGTGGTA GATAACAATG AGGTCAGCCT CAGCTGCAGG 
TATTCCTACA ACCTTCTTGC AAAGGAGTTC CGGGCATCCC TTTACAAGGG CGTGAACAGT 
GACGTGGAAG TCTGTGTCGG GAATGGGAAT TTTACCTATC AGCCCCAGTT CCGCCCAAAC 
GTGGGGTTCA ACTGTGATGG GAATTTCGAC AATGAAACAG TGACGTTCCG TCTCTGGAAT 
CTGCATGTTA ATCACACAGA TATTTACTTC TGCAAAATCG AGGTCATGTA TCCTCCGCCA 
TACCTGGACA ACGAGAAGAG CAACGGAACT ATTATTCACA TAAAAGAGAA ACATCTTTGT 
CATGCTCAGA CGTCTCCTAA GCTGTTTTGG GCACTGGTCG TGGTTGCTGG AGTCCTGCTG 
TGTTATGGCT TGCTAGTGAC AGTGACTCTT TGTATTATCT GGACAAATAG CAGAAGGAAC 
AGGCTCCTTC AAAGTGACTA CATGAACATG ACACCGCGGA GACTCGGGCC CACGCGCAAG 
CATTACCAAC CCTATGCCCC AGCGAGAGAC TTTGCAGCGT ACCGCCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008765300.1
CDS	729..1379
Translation	MSFIPTVTLVLLLRSLENKILVKQSPLLVVDNNEVSLSCRYSYNLLAKEFRASLYKGVNSDVEVCVGNGNFTYQPQFRPNVGFNCDGNFDNETVTFRLWNLHVNHTDIYFCKIEVMYPPPYLDNEKSNGTIIHIKEKHLCHAQTSPKLFWALVVVAGVLLCYGLLVTVTLCIIWTNSRRNRLLQSDYMNMTPRRLGPTRKHYQPYAPARDFAAYRP

Target ORF information:

RefSeq Version	XM_008767078.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Cd28 molecule (Cd28), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008767078.2

ORF Insert Sequence:

ATGTCCTTCA TTCCAACAGT GACACTGGTT CTTTTACTGA GGAGCTTAGA AAACAAGATT 
TTGGTGAAGC AGTCCCCGCT GCTTGTGGTA GATAACAATG AGGTCAGCCT CAGCTGCAGG 
TATTCCTACA ACCTTCTTGC AAAGGAGTTC CGGGCATCCC TTTACAAGGG CGTGAACAGT 
GACGTGGAAG TCTGTGTCGG GAATGGGAAT TTTACCTATC AGCCCCAGTT CCGCCCAAAC 
GTGGGGTTCA ACTGTGATGG GAATTTCGAC AATGAAACAG TGACGTTCCG TCTCTGGAAT 
CTGCATGTTA ATCACACAGA TATTTACTTC TGCAAAATCG AGGTCATGTA TCCTCCGCCA 
TACCTGGACA ACGAGAAGAG CAACGGAACT ATTATTCACA TAAAAGAGAA ACATCTTTGT 
CATGCTCAGA CGTCTCCTAA GCTGTTTTGG GCACTGGTCG TGGTTGCTGG AGTCCTGCTG 
TGTTATGGCT TGCTAGTGAC AGTGACTCTT TGTATTATCT GGACAAATAG CAGAAGGAAC 
AGGCTCCTTC AAAGTGACTA CATGAACATG ACACCGCGGA GACTCGGGCC CACGCGCAAG 
CATTACCAAC CCTATGCCCC AGCGAGAGAC TTTGCAGCGT ACCGCCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cd28 ( XM_008767079.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008765301.1 Rattus norvegicus Cd28 molecule (Cd28), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa32263
Clone ID Related Accession (Same CDS sequence)	XM_008767078.2 , XM_008767079.2
Accession Version	XM_008767079.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	T-cell-specific surface glycoprotein CD28 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008767079.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCTTCA TTCCAACAGT GACACTGGTT CTTTTACTGA GGAGCTTAGA AAACAAGATT 
TTGGTGAAGC AGTCCCCGCT GCTTGTGGTA GATAACAATG AGGTCAGCCT CAGCTGCAGG 
TATTCCTACA ACCTTCTTGC AAAGGAGTTC CGGGCATCCC TTTACAAGGG CGTGAACAGT 
GACGTGGAAG TCTGTGTCGG GAATGGGAAT TTTACCTATC AGCCCCAGTT CCGCCCAAAC 
GTGGGGTTCA ACTGTGATGG GAATTTCGAC AATGAAACAG TGACGTTCCG TCTCTGGAAT 
CTGCATGTTA ATCACACAGA TATTTACTTC TGCAAAATCG AGGTCATGTA TCCTCCGCCA 
TACCTGGACA ACGAGAAGAG CAACGGAACT ATTATTCACA TAAAAGAGAA ACATCTTTGT 
CATGCTCAGA CGTCTCCTAA GCTGTTTTGG GCACTGGTCG TGGTTGCTGG AGTCCTGCTG 
TGTTATGGCT TGCTAGTGAC AGTGACTCTT TGTATTATCT GGACAAATAG CAGAAGGAAC 
AGGCTCCTTC AAAGTGACTA CATGAACATG ACACCGCGGA GACTCGGGCC CACGCGCAAG 
CATTACCAAC CCTATGCCCC AGCGAGAGAC TTTGCAGCGT ACCGCCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008765301.1
CDS	181..831
Translation	MSFIPTVTLVLLLRSLENKILVKQSPLLVVDNNEVSLSCRYSYNLLAKEFRASLYKGVNSDVEVCVGNGNFTYQPQFRPNVGFNCDGNFDNETVTFRLWNLHVNHTDIYFCKIEVMYPPPYLDNEKSNGTIIHIKEKHLCHAQTSPKLFWALVVVAGVLLCYGLLVTVTLCIIWTNSRRNRLLQSDYMNMTPRRLGPTRKHYQPYAPARDFAAYRP

Target ORF information:

RefSeq Version	XM_008767079.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Cd28 molecule (Cd28), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008767079.2

ORF Insert Sequence:

ATGTCCTTCA TTCCAACAGT GACACTGGTT CTTTTACTGA GGAGCTTAGA AAACAAGATT 
TTGGTGAAGC AGTCCCCGCT GCTTGTGGTA GATAACAATG AGGTCAGCCT CAGCTGCAGG 
TATTCCTACA ACCTTCTTGC AAAGGAGTTC CGGGCATCCC TTTACAAGGG CGTGAACAGT 
GACGTGGAAG TCTGTGTCGG GAATGGGAAT TTTACCTATC AGCCCCAGTT CCGCCCAAAC 
GTGGGGTTCA ACTGTGATGG GAATTTCGAC AATGAAACAG TGACGTTCCG TCTCTGGAAT 
CTGCATGTTA ATCACACAGA TATTTACTTC TGCAAAATCG AGGTCATGTA TCCTCCGCCA 
TACCTGGACA ACGAGAAGAG CAACGGAACT ATTATTCACA TAAAAGAGAA ACATCTTTGT 
CATGCTCAGA CGTCTCCTAA GCTGTTTTGG GCACTGGTCG TGGTTGCTGG AGTCCTGCTG 
TGTTATGGCT TGCTAGTGAC AGTGACTCTT TGTATTATCT GGACAAATAG CAGAAGGAAC 
AGGCTCCTTC AAAGTGACTA CATGAACATG ACACCGCGGA GACTCGGGCC CACGCGCAAG 
CATTACCAAC CCTATGCCCC AGCGAGAGAC TTTGCAGCGT ACCGCCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of novel MicroRNA signatures linked to experimental autoimmune myasthenia gravis pathogenesis: down-regulated miR-145 promotes pathogenetic Th17 cell response.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology8(5)1287-302(2013 Dec)
Wang J,Zheng S,Xin N,Dou C,Fu L,Zhang X,Chen J,Zhang Y,Geng D,Xiao C,Cui G,Shen X,Lu Y,Wang J,Dong R,Qiao Y,Zhang Y

Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation.
European journal of immunology43(10)2741-9(2013 Oct)
Gieseke F,Kruchen A,Tzaribachev N,Bentzien F,Dominici M,M?ller I

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Nature immunology14(8)858-66(2013 Aug)
Liang Y,Cucchetti M,Roncagalli R,Yokosuka T,Malzac A,Bertosio E,Imbert J,Nijman IJ,Suchanek M,Saito T,W?lfing C,Malissen B,Malissen M

Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)190(10)5030-6(2013 May)
Ammann JU,Cooke A,Trowsdale J

CD28 superagonist antibody treatment attenuated obliterative bronchiolitis in rat allo-orthotopic tracheal transplantation by preferentially expanding Foxp3-expressing regulatory T cells.
Transplantation proceedings44(4)1060-6(2012 May)
Shi Q,Niu Y,Cao H,Zhou X,Jiang S,Liu Z,Fan H

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Cd28 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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