Gckr cDNA ORF clone, Rattus norvegicus(Norway rat)

Crystal structure of glucokinase regulatory protein.
Pautsch A, Stadler N, L?hle A, Rist W, Berg A, Glocker L, Nar H, Reinert D, Lenter M, Heckel A, Schnapp G, Kauschke SG
Biochemistry52(20)3523-31(2013 May)

Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis.
Bourbonais FJ, Chen J, Huang C, Zhang Y, Pfefferkorn JA, Landro JA
The Biochemical journal441(3)881-7(2012 Feb)

Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD.
B?ger CA, Gorski M, Li M, Hoffmann MM, Huang C, Yang Q, Teumer A, Krane V, O'Seaghdha CM, Kutalik Z, Wichmann HE, Haak T, Boes E, Coassin S, Coresh J, Kollerits B, Haun M, Paulweber B, K?ttgen A, Li G, Shlipak MG, Powe N, Hwang SJ, Dehghan A, Rivadeneira F, Uitterlinden A, Hofman A, Beckmann JS, Kr?mer BK, Witteman J, Bochud M, Siscovick D, Rettig R, Kronenberg F, Wanner C, Thadhani RI, Heid IM, Fox CS, Kao WH,
PLoS genetics7(9)e1002292(2011 Sep)

Variants of GCKR affect both ?-cell and kidney function in patients with newly diagnosed type 2 diabetes: the Verona newly diagnosed type 2 diabetes study 2.
Bonetti S, Trombetta M, Boselli ML, Turrini F, Malerba G, Trabetti E, Pignatti PF, Bonora E, Bonadonna RC
Diabetes care34(5)1205-10(2011 May)

Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion.
Hu C, Zhang R, Wang C, Yu W, Lu J, Ma X, Wang J, Jiang F, Tang S, Bao Y, Xiang K, Jia W
PloS one5(7)e11761(2010 Jul)

When GK is pre-incubated with glucose and compound A, the inhibition observed by GKRP is time dependent, but independent of GKRP concentration, reflecting the GKA-controlled transition between closed and open GK conformations.
Title: Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis.

Our findings indicate that both glucokinase and glucokinase regulatory proteins may be functionally active before birth and that they can act within a glucose sensor system involved in controlling food intake.
Title: Glucokinase and glucokinase regulatory proteins are functionally coexpressed before birth in the rat brain.

Prototypical activator of Glucokinase (GK) of the amino-heteroaryl-amide type bound to GK in a glucose-dependent manner and impaired the association of GK with GK regulatory protein
Title: Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein: impact of physiological and pharmacological effectors.

mechanisms downstream of AMP-activated protein kinase activation, involving phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and GKRP are involved in the ATP-independent inhibition of glucose-induced glucokinase translocation
Title: Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

Substrates and glucagon induced adaptive changes in the mitochondrial glucokinase/GKRP ratio suggesting a regulatory role for GKRP.
Title: Glucokinase regulatory protein is associated with mitochondria in hepatocytes.