Igfbp6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Igfbp6
Entrez Gene ID	25641
Full Name	insulin-like growth factor binding protein 6
Synonyms	IGF-BP6,RBP6A,RBP6G
General protein information	Preferred Names insulin-like growth factor binding protein 6 Names insulin-like growth factor-binding protein 6 IBP-6 IGF-binding protein 6 IGFBP-6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q36
Summary	high-affinity IGF binding ptotein with substantially greater affinity for insulin-like growth factor-II (IGF-II) than IGF-I [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013104.3	NP_037236.1	insulin-like growth factor-binding protein 6 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IGFBP6	NP_002169.1
Pan troglodytes (chimpanzee)	IGFBP6	XP_509089.2
Rattus norvegicus (Norway rat)	Igfbp6	NP_037236.1
Canis lupus familiaris (dog)	IGFBP6	XP_849343.1
Bos taurus (cattle)	IGFBP6	NP_001035585.1
Mus musculus (house mouse)	Igfbp6	NP_032370.2

Gene Ontology
Bibliography

Related articles in PubMed

Insulin-like Growth Factor Binding Protein6 Associated with?Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats.
Dai Q, Jiang P, Gu Y, Zhu L, Dai H, Yao Z, Liu H, Ma X, Duan C, Qu L
Cellular and molecular neurobiology37(7)1207-1216(2017 Oct)

The Expression of IGFBP6 after Spinal Cord Injury: Implications for Neuronal Apoptosis.
Wang S, Liu Y, Wu C, Zhao W, Zhang J, Bao G, Xu G, Sun Y, Chen J, Cui Z
Neurochemical research42(2)455-467(2017 Feb)

Kininogen 1 and insulin-like growth factor binding protein 6: candidate serum biomarkers of proliferative vitreoretinopathy.
Yu J, Peng R, Chen H, Cui C, Ba J, Wang F
Clinical & experimental optometry97(1)72-9(2014 Jan)

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M
Circulation research113(10)1138-47(2013 Oct)

Differential gene expression and immunolocalization of insulin-like growth factors and insulin-like growth factor binding proteins between experimental nonunions and standard healing fractures.
Koh A, Niikura T, Lee SY, Oe K, Koga T, Dogaki Y, Kurosaka M
Journal of orthopaedic research : official publication of the Orthopaedic Research Society29(12)1820-6(2011 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Following spinal cord injury, IGFBP6 was significantly up-regulated.
Title: The Expression of IGFBP6 after Spinal Cord Injury: Implications for Neuronal Apoptosis.

IGFs/IGFBPs may have important roles not only in fracture healing but also in nonunion formation.
Title: Differential gene expression and immunolocalization of insulin-like growth factors and insulin-like growth factor binding proteins between experimental nonunions and standard healing fractures.

Toxic effect of TCDD on osteogenesis through altering Igfbp6 gene expression in osteoblasts is reported.
Title: Toxic effects of TCDD on osteogenesis through altering IGFBP-6 gene expression in osteoblasts.

IGFBP-6, a new negative effector of oligodendrocyte survival and differentiation, is expressed and localized to the Golgi complex in rat oligodendrocyte precursor (O2A) cells.
Title: Insulin-like growth factor-binding protein 6 inhibits survival and differentiation of rat oligodendrocyte precursor cells.

IGFBP6 has a role in binding to endothelial cells and in transendothelial transportation
Title: Structure-function relationships of insulin-like growth factor binding protein 6 (IGFBP-6) and its chimeras.

The following Igfbp6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Igfbp6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01992	NM_013104.3 Latest version!	Rattus norvegicus insulin-like growth factor binding protein 6 (Igfbp6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Igfbp6 ( NM_013104.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037236.1 Rattus norvegicus insulin-like growth factor binding protein 6 (Igfbp6), mRNA.

Price & Availability↑

CloneID	ORa01992
Clone ID Related Accession (Same CDS sequence)	NM_013104.3
Accession Version	NM_013104.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 681bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Rattus norvegicus(Norway rat)
Product	insulin-like growth factor-binding protein 6 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M69055.1. On Aug 31, 2012 this sequence version replaced NM_013104.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC099742.1, FQ220221.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMEA2689595 [ECO:0000348] ##Evidence-Data-END##

ATGACCTGGG ACGGACTGCC CACACAGCCG CTGTTGATGC TGTTAATGCT GTTGTTCGCT 
GCGGGCTCCG AGTCCGCCTT AGCGGGGTGC CCGGGCTGCG GGCCGGGGGT GCAGGAGGAA 
GACGCGGGGT CGCCTGCAGA CGGCTGTGCA GAGACCGGAG GCTGTTTCAG GAGAGAGGGG 
CAACCGTGCG GGGTCTACAT CCCTAAGTGC GCCCCAGGAC TGCAGTGCCA ACCCCGAGAG 
AACGAAGAGA CACCTTTGCG GGCGCTGCTG ATCGGCCAGG GCCGCTGTCA ACGCGCCAGA 
GGGCCGTCGG AAGAGACTAC CAAGGAGAGC AAACCCCATG GAGGCGCCTC CCGCCCACGT 
GACAGAGACC GGCAAAAGAA TCCACGGACC TCGGCTGCCC CTATAAGGCC CAGTCCTGTT 
CAAGATGGTG AAATGGGCCC CTGCCGCAGA CACTTGGATT CAGTACTGCA GCAGCTCCAG 
ACTGAGGTCT TCAGAGGCGG AGCAAATGGG CTCTATGTGC CAAACTGTGA CCTCAGAGGT 
TTCTACCGCA AGCAGCAGTG TCGTTCCTCG CAGGGGAATC GCCGTGGTCC CTGCTGGTGT 
GTGGATCCGA TGGGCCAGCC TTTGCCAGTG TCTCCAGATG GCCAGGGAAG CTCTCAGTGC 
TCTGCCAGGA GCAGCGGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037236.1
CDS	3..683
Translation	MTWDGLPTQPLLMLLMLLFAAGSESALAGCPGCGPGVQEEDAGSPADGCAETGGCFRREGQPCGVYIPKCAPGLQCQPRENEETPLRALLIGQGRCQRARGPSEETTKESKPHGGASRPRDRDRQKNPRTSAAPIRPSPVQDGEMGPCRRHLDSVLQQLQTEVFRGGANGLYVPNCDLRGFYRKQQCRSSQGNRRGPCWCVDPMGQPLPVSPDGQGSSQCSARSSG

Target ORF information:

RefSeq Version	NM_013104.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin-like growth factor binding protein 6 (Igfbp6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013104.3

ORF Insert Sequence:

ATGACCTGGG ACGGACTGCC CACACAGCCG CTGTTGATGC TGTTAATGCT GTTGTTCGCT 
GCGGGCTCCG AGTCCGCCTT AGCGGGGTGC CCGGGCTGCG GGCCGGGGGT GCAGGAGGAA 
GACGCGGGGT CGCCTGCAGA CGGCTGTGCA GAGACCGGAG GCTGTTTCAG GAGAGAGGGG 
CAACCGTGCG GGGTCTACAT CCCTAAGTGC GCCCCAGGAC TGCAGTGCCA ACCCCGAGAG 
AACGAAGAGA CACCTTTGCG GGCGCTGCTG ATCGGCCAGG GCCGCTGTCA ACGCGCCAGA 
GGGCCGTCGG AAGAGACTAC CAAGGAGAGC AAACCCCATG GAGGCGCCTC CCGCCCACGT 
GACAGAGACC GGCAAAAGAA TCCACGGACC TCGGCTGCCC CTATAAGGCC CAGTCCTGTT 
CAAGATGGTG AAATGGGCCC CTGCCGCAGA CACTTGGATT CAGTACTGCA GCAGCTCCAG 
ACTGAGGTCT TCAGAGGCGG AGCAAATGGG CTCTATGTGC CAAACTGTGA CCTCAGAGGT 
TTCTACCGCA AGCAGCAGTG TCGTTCCTCG CAGGGGAATC GCCGTGGTCC CTGCTGGTGT 
GTGGATCCGA TGGGCCAGCC TTTGCCAGTG TCTCCAGATG GCCAGGGAAG CTCTCAGTGC 
TCTGCCAGGA GCAGCGGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Insulin-like Growth Factor Binding Protein6 Associated with?Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats.
Cellular and molecular neurobiology37(7)1207-1216(2017 Oct)
Dai Q,Jiang P,Gu Y,Zhu L,Dai H,Yao Z,Liu H,Ma X,Duan C,Qu L

The Expression of IGFBP6 after Spinal Cord Injury: Implications for Neuronal Apoptosis.
Neurochemical research42(2)455-467(2017 Feb)
Wang S,Liu Y,Wu C,Zhao W,Zhang J,Bao G,Xu G,Sun Y,Chen J,Cui Z

Kininogen 1 and insulin-like growth factor binding protein 6: candidate serum biomarkers of proliferative vitreoretinopathy.
Clinical & experimental optometry97(1)72-9(2014 Jan)
Yu J,Peng R,Chen H,Cui C,Ba J,Wang F

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Circulation research113(10)1138-47(2013 Oct)
Abonnenc M,Nabeebaccus AA,Mayr U,Barallobre-Barreiro J,Dong X,Cuello F,Sur S,Drozdov I,Langley SR,Lu R,Stathopoulou K,Didangelos A,Yin X,Zimmermann WH,Shah AM,Zampetaki A,Mayr M

Differential gene expression and immunolocalization of insulin-like growth factors and insulin-like growth factor binding proteins between experimental nonunions and standard healing fractures.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society29(12)1820-6(2011 Dec)
Koh A,Niikura T,Lee SY,Oe K,Koga T,Dogaki Y,Kurosaka M

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Igfbp6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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