Vamp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Vamp1
Entrez Gene ID	25624
Full Name	vesicle-associated membrane protein 1
Synonyms	Syb1
General protein information	Preferred Names vesicle-associated membrane protein 1 Names vesicle-associated membrane protein 1 VAMP-1 synaptobrevin-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42
Summary	plays a role in protein transport to the plasma membrane [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013090.2	NP_037222.2	vesicle-associated membrane protein 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Vamp1	NP_037222.2
Caenorhabditis elegans (roundworm)	snb-2	NP_506093.2

Gene Ontology
Bibliography

Related articles in PubMed

Indication for differential sorting of the rat v-SNARE splice isoforms VAMP-1a and -1b.
Rodepeter FR, Wiegand S, L?ers HG, Bonaterra GA, Lowe AW, Bette M, Jacob R, Mandic R
Biochemistry and cell biology = Biochimie et biologie cellulaire95(4)500-509(2017 Aug)

Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion.
Sitarska E, Xu J, Park S, Liu X, Quade B, Stepien K, Sugita K, Brautigam CA, Sugita S, Rizo J
eLife6(2017 May)

Identification of the SNARE complex mediating the exocytosis of NMDA receptors.
Gu Y, Huganir RL
Proceedings of the National Academy of Sciences of the United States of America113(43)12280-12285(2016 Oct)

TNF? induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion.
Meng J, Wang J, Steinhoff M, Dolly JO
Scientific reports621226(2016 Feb)

Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins.
Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, Tepp WH, Zhang SC, Johnson EA, Sawyer SL, Dong M
PLoS pathogens10(7)e1004177(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

differential sorting of the rat v-SNARE splice isoforms VAMP-1a and -1b
Title: Indication for differential sorting of the rat v-SNARE splice isoforms VAMP-1a and -1b.

TNFalpha induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion.
Title: TNF? induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion.

syntaxin 1 and vesicle-associated membrane protein 1 are more suitable targets to abolish functional soluble N-ethylmaleimide-sensitive factor attachment protein receptor complexes
Title: Selective cleavage of SNAREs in sensory neurons unveils protein complexes mediating peptide exocytosis triggered by different stimuli.

residue 48 of VAMP1 varies frequently between M and I across seventeen closely related primate species, suggesting a potential selective pressure from members of BoNTs for resistance in vertebrates.
Title: Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins.

distribution of SNAP25, VAMP1 and VAMP2 in adult deep cerebellar nuclei differs significantly from that found in newborn DCN and administration of E2 in the newborn DCN affected synaptic density and also changed their distribution
Title: Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration.

The following Vamp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vamp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01941	NM_013090.2 Latest version!	Rattus norvegicus vesicle-associated membrane protein 1 (Vamp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Vamp1 ( NM_013090.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037222.2 Rattus norvegicus vesicle-associated membrane protein 1 (Vamp1), mRNA.

Price & Availability↑

CloneID	ORa01941
Clone ID Related Accession (Same CDS sequence)	NM_013090.2
Accession Version	NM_013090.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	vesicle-associated membrane protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB582258.1, CO567426.1, BC092206.1 and AI059682.1. On Sep 28, 2005 this sequence version replaced NM_013090.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FM030153.1, BC092206.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCTGCTC CAGCTCAGCC ACCTGCTGAA GGGACAGAAG GGGCTGCCCC AGGTGGGGGT 
CCTCCTGGTC CTCCTCCCAA TACGACCAGT AACAGACGAT TACAGCAAAC CCAGGCACAA 
GTGGAGGAGG TGGTGGACAT CATGCGCGTG AATGTGGACA AGGTCTTGGA GAGGGACCAG 
AAGTTGTCAG AGTTGGATGA CCGAGCTGAC GCCTTGCAGG CAGGAGCGTC AGTGTTTGAG 
AGCAGTGCTG CCAAGCTAAA AAGGAAGTAT TGGTGGAAAA ACTGCAAGAT GATGATCATG 
CTGGGAGCTA TCTGTGCCAT CATCGTGGTA GTAATTGTAA TCTACATTTT TACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037222.2
CDS	135..491
Translation	MSAPAQPPAEGTEGAAPGGGPPGPPPNTTSNRRLQQTQAQVEEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASVFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVIYIFT

Target ORF information:

RefSeq Version	NM_013090.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus vesicle-associated membrane protein 1 (Vamp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013090.2

ORF Insert Sequence:

ATGTCTGCTC CAGCTCAGCC ACCTGCTGAA GGGACAGAAG GGGCTGCCCC AGGTGGGGGT 
CCTCCTGGTC CTCCTCCCAA TACGACCAGT AACAGACGAT TACAGCAAAC CCAGGCACAA 
GTGGAGGAGG TGGTGGACAT CATGCGCGTG AATGTGGACA AGGTCTTGGA GAGGGACCAG 
AAGTTGTCAG AGTTGGATGA CCGAGCTGAC GCCTTGCAGG CAGGAGCGTC AGTGTTTGAG 
AGCAGTGCTG CCAAGCTAAA AAGGAAGTAT TGGTGGAAAA ACTGCAAGAT GATGATCATG 
CTGGGAGCTA TCTGTGCCAT CATCGTGGTA GTAATTGTAA TCTACATTTT TACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Indication for differential sorting of the rat v-SNARE splice isoforms VAMP-1a and -1b.
Biochemistry and cell biology = Biochimie et biologie cellulaire95(4)500-509(2017 Aug)
Rodepeter FR,Wiegand S,L?ers HG,Bonaterra GA,Lowe AW,Bette M,Jacob R,Mandic R

Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion.
eLife6(2017 May)
Sitarska E,Xu J,Park S,Liu X,Quade B,Stepien K,Sugita K,Brautigam CA,Sugita S,Rizo J

Identification of the SNARE complex mediating the exocytosis of NMDA receptors.
Proceedings of the National Academy of Sciences of the United States of America113(43)12280-12285(2016 Oct)
Gu Y,Huganir RL

TNF? induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion.
Scientific reports621226(2016 Feb)
Meng J,Wang J,Steinhoff M,Dolly JO

Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins.
PLoS pathogens10(7)e1004177(2014 Jul)
Peng L,Adler M,Demogines A,Borrell A,Liu H,Tao L,Tepp WH,Zhang SC,Johnson EA,Sawyer SL,Dong M

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Vamp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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