Ptk2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ptk2
Entrez Gene ID	25614
Full Name	protein tyrosine kinase 2
Synonyms	FAK,FRNK,p125FAK
General protein information	Preferred Names protein tyrosine kinase 2 Names focal adhesion kinase 1 FADK 1 PTK2 protein tyrosine kinase 2 focal adhesion kinase-related nonkinase pp125FAK
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q34
Summary	tyrosine kinase that is enriched in focal adhesions; may regulate mechanical signal transduction in cardiac myocytes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013081.2	NP_037213.1	focal adhesion kinase 1
XM_017594678.1	XP_017450167.1	focal adhesion kinase 1 isoform X1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	PTK2	NP_990766.1
Xenopus tropicalis (tropical clawed frog)	ptk2	XP_002934523.2
Homo sapiens (human)	PTK2	NP_005598.3
	PTK2	XP_001093060.2
Danio rerio (zebrafish)	ptk2ab	NP_571871.1
Pan troglodytes (chimpanzee)	PTK2	XP_519982.2
Mus musculus (house mouse)	Ptk2	NP_032008.2
Canis lupus familiaris (dog)	PTK2	XP_005628050.1
Rattus norvegicus (Norway rat)	Ptk2	NP_037213.1
Drosophila melanogaster (fruit fly)	Fak	NP_001137719.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011118	XP_309528.4
Bos taurus (cattle)	PTK2	NP_001068718.2
Caenorhabditis elegans (roundworm)	kin-32	NP_740841.1

Gene Ontology
Bibliography

Related articles in PubMed

Macrophage migration inhibitory factor (MIF) promotes rat airway muscle cell proliferation and migration mediated by ERK1/2 and FAK signaling.
Lan H, Wang N, Chen Y, Wang X, Gong Y, Qi X, Luo Y, Yao F
Cell biology international42(1)75-83(2018 Jan)

Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration.
Chen YR, Chou HC, Yang CH, Chen HY, Liu YW, Lin TY, Yeh CL, Chao WT, Tsou HH, Chuang HC, Tan TH
Oncogene36(47)6509-6517(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TGF-beta1-induced epithelial-myofibroblast plasticity is FAK- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK signaling is inhibited.
Title: Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-?.

Stimulation of glucose transport in cardiomyocytes requires FAK activity prior to stimulation. The chronic reduction of FAK activity in cardiomyocytes exposed to free fatty acids contributes to the loss of glucose transport responsiveness to insulin or metabolic inhibition.
Title: A Role for Focal Adhesion Kinase in the Stimulation of Glucose Transport in Cardiomyocytes.

Pre-treatment of p38 inhibitor did not alter FAK activation.
Title: FAK contributes to proteinuria in hypercholesterolaemic rats and modulates podocyte F-actin re-organization via activating p38 in response to ox-LDL.

Hydrostatic mechanical force enhances the viability and decreases the apoptosis of condylar chondrocytes through integrin-FAK-ERK/PI3K pathway.
Title: Hydrostatic Compress Force Enhances the Viability and Decreases the Apoptosis of Condylar Chondrocytes through Integrin-FAK-ERK/PI3K Pathway.

In cardiomyocytes exposed to biomechanical stimulation, FAK accumulates in the nucleus, binds to and upregulates the transcriptional activity of MEF2c through an interaction with the FAK focal adhesion targeting (FAT) domain.
Title: FAK Forms a Complex with MEF2 to Couple Biomechanical Signaling to Transcription in Cardiomyocytes.

The following Ptk2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ptk2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13630	NM_013081.2 Latest version!	Rattus norvegicus protein tyrosine kinase 2 (Ptk2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$776.30 $1109.00
ORa43173	XM_017594678.1 Latest version!	Rattus norvegicus protein tyrosine kinase 2 (Ptk2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ptk2 ( NM_013081.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037213.1 Rattus norvegicus protein tyrosine kinase 2 (Ptk2), mRNA.

Price & Availability↑

CloneID	ORa13630
Clone ID Related Accession (Same CDS sequence)	NM_013081.2
Accession Version	NM_013081.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3168bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	focal adhesion kinase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07058403.1, AF020777.1, EV773243.1, U43942.1, CB713440.1, CA511845.1, CA508631.1 and AI717382.1. On Jul 31, 2012 this sequence version replaced NM_013081.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF020777.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END##

ATGGCAGCTG CTTATCTTGA CCCAAACTTG AATCACACAC CAAGTTCGAG TACTAAGACT 
CACCTGGGTA CTGGCACGGA ACGGTCCCCT GGTGCAATGG AACGAGTATT AAAGGTCTTT 
CATTATTTTG AAAGCAGTAA TGAGCCAACC ACCTGGGCCA GTATTATCAG GCATGGAGAC 
GCTACTGACG TCAGGGGAAT CATTCAGAAG ATAGTGGACA GTCACAAAGT AAAGCACGTG 
GCCTGCTATG GATTTCGCCT CAGTCACCTG CGATCGGAGG AGGTGCACTG GCTGCATGTG 
GACATGGGTG TCTCCAGTGT GAGGGAGAAA TACGAACTCG CCCACCCACC AGAGGAGTGG 
AAATATGAGT TGAGAATTCG TTATTTGCCA AAAGGATTTC TAAACCAGTT TACTGAAGAT 
AAGCCAACAT TGAATTTCTT CTATCAACAG GTGAAGAGTG ACTACATGCT AGAAATAGCT 
GATCAAGTAG ACCAAGACAT AGCTTTGAAG TTGGGTTGTT TGGAAATTAG GCGATCCTAC 
TGGGAGATGA GGGGCAACGC CCTAGAGAAG AAGTCCAACT ATGAAGTGTT AGAGAAAGAT 
GTTGGTTTAA AGCGATTTTT TCCCAAGAGT TTACTGGATT CCGTCAAGGC CAAAACACTA 
AGAAAGCTGA TCCAGCAAAC ATTCAGGCAG TTTGCCAACC TTAATAGAGA AGAAAGCATC 
CTGAAATTCT TTGAGATTCT CTCTCCAGTG TACAGATTTG ACAAAGAGTG CTTCAAGTGT 
GCCCTTGGGT CAAGTTGGAT TATTTCTGTG GAACTGGCGA TCGGCCCAGA AGAAGGGATC 
AGTTACCTGA CAGACAAGGG CTGCAATCCC ACACACCTAG CGGACTTCAA CCAAGTGCAG 
ACTATCCAGT ACTCAAACAG TGAAGACAAA GACAGGAAAG GAATGCTACA ACTCAAAATC 
GCTGGTGCTC CTGAGCCTCT GACAGTGACG GCCCCATCCC TAACCATTGC AGAGAACATG 
GCTGACCTGA TCGATGGATA CTGCCGGCTG GTGAACGGAG CCACGCAGTC CTTCATCATC 
AGACCCCAGA AAGAAGGTGA ACGGGCATTG CCATCAATAC CAAAGTTGGC CAACAATGAA 
AAGCAAGGCA TGCGGACACA TGCAGTCTCT GTGTCAGAGA CAGATGACTA TGCCGAGATC 
ATCGATGAGG AAGACACATA CACCATGCCC TCAACCAGGG ATTATGAGAT TCAGAGAGAA 
AGAATAGAAC TTGGACGCTG TATTGGAGAA GGCCAGTTTG GAGATGTACA TCAAGGCGTG 
TACCTGAGCC CAGAGAATCC AGCTTTGGCT GTTGCAATCA AAACATGTAA AAACTGTACT 
TCGGACAGCG TGAGAGAGAA GTTCCTTCAA GAAGCCTTAA CAATGCGCCA GTTTGACCAT 
CCTCACATCG TGAAGCTGAT TGGAGTCATT ACAGAGAACC CAGTTTGGAT AATCATGGAG 
TTGTGCACAC TTGGAGAGCT GAGGTCATTT TTGCAAGTAA GGAAATACAG CTTGGATCTA 
GCATCTTTGA TCTTATATGC CTATCAGCTT AGTACAGCAC TCGCGTATCT GGAGAGCAAA 
AGATTTGTTC ACAGGGACAT TGCTGCACGG AATGTTCTGG TGTCTTCAAA TGATTGTGTA 
AAATTAGGAG ACTTTGGATT ATCTCGATAT ATGGAAGACA GTACTTACTA TAAAGCTTCC 
AAAGGAAAAT TACCTATTAA ATGGATGGCT CCAGAGTCAA TCAATTTTCG ACGTTTTACC 
TCAGCTAGTG ACGTGTGGAT GTTTGGTGTG TGTATGTGGG AGATACTGAT GCATGGCGTG 
AAGCCTTTTC AAGGAGTGAA GAACAATGAT GTGATCGGTC GAATTGAAAA TGGGGAAAGA 
TTACCAATGC CTCCAAATTG TCCTCCCACC CTCTACAGCC TTATGACGAA ATGTTGGGCC 
TATGACCCCA GCAGACGGCC CAGGTTTACT GAACTAAAAG CTCAGCTCAG CACAATCCTG 
GAGGAAGAGA AGGTGCAGCA AGAAGAACGG ATGAGGATGG AATCCAGAAG ACAGGCAACA 
GTGTCCTGGG ACTCTGGAGG GTCTGATGAA GCACCACCCA AGCCCAGCAG ACCTGGTTAT 
CCTAGCCCGA GGTCCAGTGA AGGATTTTAT CCCAGCCCAC AGCACATGGT CCAGACCAAT 
CACTATCAGA TCTCTGGCTA CCCAGGTTCC CATGGAATCC CAGCCATGGC TGGCAGCATT 
TACCCAGGTC AGGCATCTCT TCTGGACCAG ACAGAATTGT GGAATCACAG ACCTCAGGAG 
ATGTCCATGT GGCAGCCCAG TGTGGAGGAC TCAGCAGCTT TAGATCTTCG AGGGATGGGA 
CAGGTGCTTC CTCCTCACCT GATGGAAGAG CGGCTAATCC GACAGCAGCA GGAAATGGAG 
GAAGACCAGC GCTGGCTGGA AAAGGAAGAG CGATTCCTGA AACCTGATGT GAGGCTCTCT 
CGAGGCAGCA TCGACAGGGA GGACGGGAGT TTTCAGGGTC CGACTGGAAA CCAACACATC 
TATCAGCCTG TGGGAAAACC AGATCCTGCA GCTCCACCAA AGAAACCACC TCGCCCTGGA 
GCACCTGGCC ACCTAAGCAA CTTGTCCAGC ATCAGCAGCC CTGCAGAAAG CTACAATGAG 
GGTGTCAAGC CGTGGAGGCT TCAGCCCCAG GAAATCAGCC CCCCTCCCAC TGCCAACCTT 
GACCGATCCA ATGACAAGGT ATATGAAAAT GTGACGGGCC TAGTGAAGGC TGTCATTGAG 
ATGTCCAGCA AAATCCAACC AGCTCCTCCA GAAGAGTACG TCCCTATGGT GAAGGAAGTT 
GGCCTGGCCC TGCGGACCTT ACTGGCCACT GTGGATGAGA CCATTCCCAT CCTTCCAGCC 
AGCACCCATC GAGAGATCGA GATGGCACAG AAGCTGCTGA ACTCCGACTT GGGTGAGCTC 
ATCAGCAAGA TGAAGCTGGC GCAGCAGTAT GTCATGACCA GCCTTCAGCA GGAGTACAAG 
AAGCAGATGC TGACAGCTGC TCACGCCCTG GCTGTGGATG CCAAGAATCT ACTTGATGTT 
ATTGATCAAG CGAGACTGAA AATGCTAGGG CAGACACGGC CACACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037213.1
CDS	433..3600
Translation	MAAAYLDPNLNHTPSSSTKTHLGTGTERSPGAMERVLKVFHYFESSNEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQDIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFIIRPQKEGERALPSIPKLANNEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGVYLSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKVQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQISGYPGSHGIPAMAGSIYPGQASLLDQTELWNHRPQEMSMWQPSVEDSAALDLRGMGQVLPPHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSFQGPTGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLSNLSSISSPAESYNEGVKPWRLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPILPASTHREIEMAQKLLNSDLGELISKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH

Target ORF information:

RefSeq Version	NM_013081.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein tyrosine kinase 2 (Ptk2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013081.2

ORF Insert Sequence:

ATGGCAGCTG CTTATCTTGA CCCAAACTTG AATCACACAC CAAGTTCGAG TACTAAGACT 
CACCTGGGTA CTGGCACGGA ACGGTCCCCT GGTGCAATGG AACGAGTATT AAAGGTCTTT 
CATTATTTTG AAAGCAGTAA TGAGCCAACC ACCTGGGCCA GTATTATCAG GCATGGAGAC 
GCTACTGACG TCAGGGGAAT CATTCAGAAG ATAGTGGACA GTCACAAAGT AAAGCACGTG 
GCCTGCTATG GATTTCGCCT CAGTCACCTG CGATCGGAGG AGGTGCACTG GCTGCATGTG 
GACATGGGTG TCTCCAGTGT GAGGGAGAAA TACGAACTCG CCCACCCACC AGAGGAGTGG 
AAATATGAGT TGAGAATTCG TTATTTGCCA AAAGGATTTC TAAACCAGTT TACTGAAGAT 
AAGCCAACAT TGAATTTCTT CTATCAACAG GTGAAGAGTG ACTACATGCT AGAAATAGCT 
GATCAAGTAG ACCAAGACAT AGCTTTGAAG TTGGGTTGTT TGGAAATTAG GCGATCCTAC 
TGGGAGATGA GGGGCAACGC CCTAGAGAAG AAGTCCAACT ATGAAGTGTT AGAGAAAGAT 
GTTGGTTTAA AGCGATTTTT TCCCAAGAGT TTACTGGATT CCGTCAAGGC CAAAACACTA 
AGAAAGCTGA TCCAGCAAAC ATTCAGGCAG TTTGCCAACC TTAATAGAGA AGAAAGCATC 
CTGAAATTCT TTGAGATTCT CTCTCCAGTG TACAGATTTG ACAAAGAGTG CTTCAAGTGT 
GCCCTTGGGT CAAGTTGGAT TATTTCTGTG GAACTGGCGA TCGGCCCAGA AGAAGGGATC 
AGTTACCTGA CAGACAAGGG CTGCAATCCC ACACACCTAG CGGACTTCAA CCAAGTGCAG 
ACTATCCAGT ACTCAAACAG TGAAGACAAA GACAGGAAAG GAATGCTACA ACTCAAAATC 
GCTGGTGCTC CTGAGCCTCT GACAGTGACG GCCCCATCCC TAACCATTGC AGAGAACATG 
GCTGACCTGA TCGATGGATA CTGCCGGCTG GTGAACGGAG CCACGCAGTC CTTCATCATC 
AGACCCCAGA AAGAAGGTGA ACGGGCATTG CCATCAATAC CAAAGTTGGC CAACAATGAA 
AAGCAAGGCA TGCGGACACA TGCAGTCTCT GTGTCAGAGA CAGATGACTA TGCCGAGATC 
ATCGATGAGG AAGACACATA CACCATGCCC TCAACCAGGG ATTATGAGAT TCAGAGAGAA 
AGAATAGAAC TTGGACGCTG TATTGGAGAA GGCCAGTTTG GAGATGTACA TCAAGGCGTG 
TACCTGAGCC CAGAGAATCC AGCTTTGGCT GTTGCAATCA AAACATGTAA AAACTGTACT 
TCGGACAGCG TGAGAGAGAA GTTCCTTCAA GAAGCCTTAA CAATGCGCCA GTTTGACCAT 
CCTCACATCG TGAAGCTGAT TGGAGTCATT ACAGAGAACC CAGTTTGGAT AATCATGGAG 
TTGTGCACAC TTGGAGAGCT GAGGTCATTT TTGCAAGTAA GGAAATACAG CTTGGATCTA 
GCATCTTTGA TCTTATATGC CTATCAGCTT AGTACAGCAC TCGCGTATCT GGAGAGCAAA 
AGATTTGTTC ACAGGGACAT TGCTGCACGG AATGTTCTGG TGTCTTCAAA TGATTGTGTA 
AAATTAGGAG ACTTTGGATT ATCTCGATAT ATGGAAGACA GTACTTACTA TAAAGCTTCC 
AAAGGAAAAT TACCTATTAA ATGGATGGCT CCAGAGTCAA TCAATTTTCG ACGTTTTACC 
TCAGCTAGTG ACGTGTGGAT GTTTGGTGTG TGTATGTGGG AGATACTGAT GCATGGCGTG 
AAGCCTTTTC AAGGAGTGAA GAACAATGAT GTGATCGGTC GAATTGAAAA TGGGGAAAGA 
TTACCAATGC CTCCAAATTG TCCTCCCACC CTCTACAGCC TTATGACGAA ATGTTGGGCC 
TATGACCCCA GCAGACGGCC CAGGTTTACT GAACTAAAAG CTCAGCTCAG CACAATCCTG 
GAGGAAGAGA AGGTGCAGCA AGAAGAACGG ATGAGGATGG AATCCAGAAG ACAGGCAACA 
GTGTCCTGGG ACTCTGGAGG GTCTGATGAA GCACCACCCA AGCCCAGCAG ACCTGGTTAT 
CCTAGCCCGA GGTCCAGTGA AGGATTTTAT CCCAGCCCAC AGCACATGGT CCAGACCAAT 
CACTATCAGA TCTCTGGCTA CCCAGGTTCC CATGGAATCC CAGCCATGGC TGGCAGCATT 
TACCCAGGTC AGGCATCTCT TCTGGACCAG ACAGAATTGT GGAATCACAG ACCTCAGGAG 
ATGTCCATGT GGCAGCCCAG TGTGGAGGAC TCAGCAGCTT TAGATCTTCG AGGGATGGGA 
CAGGTGCTTC CTCCTCACCT GATGGAAGAG CGGCTAATCC GACAGCAGCA GGAAATGGAG 
GAAGACCAGC GCTGGCTGGA AAAGGAAGAG CGATTCCTGA AACCTGATGT GAGGCTCTCT 
CGAGGCAGCA TCGACAGGGA GGACGGGAGT TTTCAGGGTC CGACTGGAAA CCAACACATC 
TATCAGCCTG TGGGAAAACC AGATCCTGCA GCTCCACCAA AGAAACCACC TCGCCCTGGA 
GCACCTGGCC ACCTAAGCAA CTTGTCCAGC ATCAGCAGCC CTGCAGAAAG CTACAATGAG 
GGTGTCAAGC CGTGGAGGCT TCAGCCCCAG GAAATCAGCC CCCCTCCCAC TGCCAACCTT 
GACCGATCCA ATGACAAGGT ATATGAAAAT GTGACGGGCC TAGTGAAGGC TGTCATTGAG 
ATGTCCAGCA AAATCCAACC AGCTCCTCCA GAAGAGTACG TCCCTATGGT GAAGGAAGTT 
GGCCTGGCCC TGCGGACCTT ACTGGCCACT GTGGATGAGA CCATTCCCAT CCTTCCAGCC 
AGCACCCATC GAGAGATCGA GATGGCACAG AAGCTGCTGA ACTCCGACTT GGGTGAGCTC 
ATCAGCAAGA TGAAGCTGGC GCAGCAGTAT GTCATGACCA GCCTTCAGCA GGAGTACAAG 
AAGCAGATGC TGACAGCTGC TCACGCCCTG GCTGTGGATG CCAAGAATCT ACTTGATGTT 
ATTGATCAAG CGAGACTGAA AATGCTAGGG CAGACACGGC CACACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ptk2 ( XM_017594678.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017450167.1 Rattus norvegicus protein tyrosine kinase 2 (Ptk2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa43173
Clone ID Related Accession (Same CDS sequence)	XM_017594678.1
Accession Version	XM_017594678.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3339bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	focal adhesion kinase 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGTTGG AACGGGCAGG CCAAGAGGCC CTGAGATCTA CAGGTGCCGT CTATATGGAG 
AAAAGCGGCT GTAGTCCATT TCCAGTGTGT TGGGCTAAAG AATATGACAG ATACCTAGCA 
TCTAGCAAAA GAATGGCAGC TGCTTATCTT GACCCAAACT TGAATCACAC ACCAAGTTCG 
AGTACTAAGA CTCACCTGGG TACTGGCACG GAACGGTCCC CTGGTGCAAT GGAACGAGTA 
TTAAAGGTCT TTCATTATTT TGAAAGCAGT AATGAGCCAA CCACCTGGGC CAGTATTATC 
AGGCATGGAG ACGCTACTGA CGTCAGGGGA ATCATTCAGA AGATAGTGGA CAGTCACAAA 
GTAAAGCACG TGGCCTGCTA TGGATTTCGC CTCAGTCACC TGCGATCGGA GGAGGTGCAC 
TGGCTGCATG TGGACATGGG TGTCTCCAGT GTGAGGGAGA AATACGAACT CGCCCACCCA 
CCAGAGGAGT GGAAATATGA GTTGAGAATT CGTTATTTGC CAAAAGGATT TCTAAACCAG 
TTTACTGAAG ATAAGCCAAC ATTGAATTTC TTCTATCAAC AGGTGAAGAG TGACTACATG 
CTAGAAATAG CTGATCAAGT AGACCAAGAC ATAGCTTTGA AGTTGGGTTG TTTGGAAATT 
AGGCGATCCT ACTGGGAGAT GAGGGGCAAC GCCCTAGAGA AGAAGTCCAA CTATGAAGTG 
TTAGAGAAAG ATGTTGGTTT AAAGCGATTT TTTCCCAAGA GTTTACTGGA TTCCGTCAAG 
GCCAAAACAC TAAGAAAGCT GATCCAGCAA ACATTCAGGC AGTTTGCCAA CCTTAATAGA 
GAAGAAAGCA TCCTGAAATT CTTTGAGATT CTCTCTCCAG TGTACAGATT TGACAAAGAG 
TGCTTCAAGT GTGCCCTTGG GTCAAGTTGG ATTATTTCTG TGGAACTGGC GATCGGCCCA 
GAAGAAGGGA TCAGTTACCT GACAGACAAG GGCTGCAATC CCACACACCT AGCGGACTTC 
AACCAAGTGC AGACTATCCA GTACTCAAAC AGTGAAGACA AAGACAGGAA AGGAATGCTA 
CAACTCAAAA TCGCTGGTGC TCCTGAGCCT CTGACAGTGA CGGCCCCATC CCTAACCATT 
GCAGAGAACA TGGCTGACCT GATCGATGGA TACTGCCGGC TGGTGAACGG AGCCACGCAG 
TCCTTCATCA TCAGACCCCA GAAAGAAGGT GAACGGGCAT TGCCATCAAT ACCAAAGTTG 
GCCAACAATG AAAAGCAAGG CATGCGGACA CATGCAGTCT CTGTGTCAGA TGAAATTAGT 
GGGGACGAGA CAGATGACTA TGCCGAGATC ATCGATGAGG AAGACACATA CACCATGCCC 
TCAAAAAGCT ATGGAATAGA TGAAGCCAGG GATTATGAGA TTCAGAGAGA AAGAATAGAA 
CTTGGACGCT GTATTGGAGA AGGCCAGTTT GGAGATGTAC ATCAAGGCGT GTACCTGAGC 
CCAGAGAATC CAGCTTTGGC TGTTGCAATC AAAACATGTA AAAACTGTAC TTCGGACAGC 
GTGAGAGAGA AGTTCCTTCA AGAAGCCTTA ACAATGCGCC AGTTTGACCA TCCTCACATC 
GTGAAGCTGA TTGGAGTCAT TACAGAGAAC CCAGTTTGGA TAATCATGGA GTTGTGCACA 
CTTGGAGAGC TGAGGTCATT TTTGCAAGTA AGGAAATACA GCTTGGATCT AGCATCTTTG 
ATCTTATATG CCTATCAGCT TAGTACAGCA CTCGCGTATC TGGAGAGCAA AAGATTTGTT 
CACAGGGACA TTGCTGCACG GAATGTTCTG GTGTCTTCAA ATGATTGTGT AAAATTAGGA 
GACTTTGGAT TATCTCGATA TATGGAAGAC AGTACTTACT ATAAAGCTTC CAAAGGAAAA 
TTACCTATTA AATGGATGGC TCCAGAGTCA ATCAATTTTC GACGTTTTAC CTCAGCTAGT 
GACGTGTGGA TGTTTGGTGT GTGTATGTGG GAGATACTGA TGCATGGCGT GAAGCCTTTT 
CAAGGAGTGA AGAACAATGA TGTGATCGGT CGAATTGAAA ATGGGGAAAG ATTACCAATG 
CCTCCAAATT GTCCTCCCAC CCTCTACAGC CTTATGACGA AATGTTGGGC CTATGACCCC 
AGCAGACGGC CCAGGTTTAC TGAACTAAAA GCTCAGCTCA GCACAATCCT GGAGGAAGAG 
AAGGTGCAGC AAGAAGAACG GATGAGGATG GAATCCAGAA GACAGGCAAC AGTGTCCTGG 
GACTCTGGAG GGTCTGATGA AGCACCACCC AAGCCCAGCA GACCTGGTTA TCCTAGCCCG 
AGGTCCAGTG AAGGATTTTA TCCCAGCCCA CAGCACATGG TCCAGACCAA TCACTATCAG 
ATCTCTGGCT ACCCAGGTTC CCATGGAATC CCAGCCATGG CTGGCAGCAT TTACCCAGGT 
CAGGCATCTC TTCTGGACCA GACAGAATTG TGGAATCACA GACCTCAGGA GATGTCCATG 
TGGCAGCCCA GTGTGGAGGA CTCAGCAGCT TTAGATCTTC GAGGGATGGG ACAGGTGCTT 
CCTCCTCACC TGATGGAAGA GCGGCTAATC CGACAGCAGC AGGAAATGGA GGAAGACCAG 
CGCTGGCTGG AAAAGGAAGA GCGATTCCTG AAACCTGATG TGAGGCTCTC TCGAGGCAGC 
ATCGACAGGG AGGACGGGAG TTTTCAGGGT CCGACTGGAA ACCAACACAT CTATCAGCCT 
GTGGGAAAAC CAGATCCTGC AGCTCCACCA AAGAAACCAC CTCGCCCTGG AGCACCTGGC 
CACCTAAGCA ACTTGTCCAG CATCAGCAGC CCTGCAGAAA GCTACAATGA GGGTGTCAAG 
CCGTGGAGGC TTCAGCCCCA GGAAATCAGC CCCCCTCCCA CTGCCAACCT TGACCGATCC 
AATGACAAGG TATATGAAAA TGTGACGGGC CTAGTGAAGG CTGTCATTGA GATGTCCAGC 
AAAATCCAAC CAGCTCCTCC AGAAGAGTAC GTCCCTATGG TGAAGGAAGT TGGCCTGGCC 
CTGCGGACCT TACTGGCCAC TGTGGATGAG ACCATTCCCA TCCTTCCAGC CAGCACCCAT 
CGAGAGATCG AGATGGCACA GAAGCTGCTG AACTCCGACT TGGGTGAGCT CATCAGCAAG 
ATGAAGCTGG CGCAGCAGTA TGTCATGACC AGCCTTCAGC AGGAGTACAA GAAGCAGATG 
CTGACAGCTG CTCACGCCCT GGCTGTGGAT GCCAAGAATC TACTTGATGT TATTGATCAA 
GCGAGACTGA AAATGCTAGG GCAGACACGG CCACACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017450167.1
CDS	311..3649
Translation	MLLERAGQEALRSTGAVYMEKSGCSPFPVCWAKEYDRYLASSKRMAAAYLDPNLNHTPSSSTKTHLGTGTERSPGAMERVLKVFHYFESSNEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQDIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFIIRPQKEGERALPSIPKLANNEKQGMRTHAVSVSDEISGDETDDYAEIIDEEDTYTMPSKSYGIDEARDYEIQRERIELGRCIGEGQFGDVHQGVYLSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKVQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQISGYPGSHGIPAMAGSIYPGQASLLDQTELWNHRPQEMSMWQPSVEDSAALDLRGMGQVLPPHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSFQGPTGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLSNLSSISSPAESYNEGVKPWRLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPILPASTHREIEMAQKLLNSDLGELISKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH

Target ORF information:

RefSeq Version	XM_017594678.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein tyrosine kinase 2 (Ptk2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017594678.1

ORF Insert Sequence:

ATGTTGTTGG AACGGGCAGG CCAAGAGGCC CTGAGATCTA CAGGTGCCGT CTATATGGAG 
AAAAGCGGCT GTAGTCCATT TCCAGTGTGT TGGGCTAAAG AATATGACAG ATACCTAGCA 
TCTAGCAAAA GAATGGCAGC TGCTTATCTT GACCCAAACT TGAATCACAC ACCAAGTTCG 
AGTACTAAGA CTCACCTGGG TACTGGCACG GAACGGTCCC CTGGTGCAAT GGAACGAGTA 
TTAAAGGTCT TTCATTATTT TGAAAGCAGT AATGAGCCAA CCACCTGGGC CAGTATTATC 
AGGCATGGAG ACGCTACTGA CGTCAGGGGA ATCATTCAGA AGATAGTGGA CAGTCACAAA 
GTAAAGCACG TGGCCTGCTA TGGATTTCGC CTCAGTCACC TGCGATCGGA GGAGGTGCAC 
TGGCTGCATG TGGACATGGG TGTCTCCAGT GTGAGGGAGA AATACGAACT CGCCCACCCA 
CCAGAGGAGT GGAAATATGA GTTGAGAATT CGTTATTTGC CAAAAGGATT TCTAAACCAG 
TTTACTGAAG ATAAGCCAAC ATTGAATTTC TTCTATCAAC AGGTGAAGAG TGACTACATG 
CTAGAAATAG CTGATCAAGT AGACCAAGAC ATAGCTTTGA AGTTGGGTTG TTTGGAAATT 
AGGCGATCCT ACTGGGAGAT GAGGGGCAAC GCCCTAGAGA AGAAGTCCAA CTATGAAGTG 
TTAGAGAAAG ATGTTGGTTT AAAGCGATTT TTTCCCAAGA GTTTACTGGA TTCCGTCAAG 
GCCAAAACAC TAAGAAAGCT GATCCAGCAA ACATTCAGGC AGTTTGCCAA CCTTAATAGA 
GAAGAAAGCA TCCTGAAATT CTTTGAGATT CTCTCTCCAG TGTACAGATT TGACAAAGAG 
TGCTTCAAGT GTGCCCTTGG GTCAAGTTGG ATTATTTCTG TGGAACTGGC GATCGGCCCA 
GAAGAAGGGA TCAGTTACCT GACAGACAAG GGCTGCAATC CCACACACCT AGCGGACTTC 
AACCAAGTGC AGACTATCCA GTACTCAAAC AGTGAAGACA AAGACAGGAA AGGAATGCTA 
CAACTCAAAA TCGCTGGTGC TCCTGAGCCT CTGACAGTGA CGGCCCCATC CCTAACCATT 
GCAGAGAACA TGGCTGACCT GATCGATGGA TACTGCCGGC TGGTGAACGG AGCCACGCAG 
TCCTTCATCA TCAGACCCCA GAAAGAAGGT GAACGGGCAT TGCCATCAAT ACCAAAGTTG 
GCCAACAATG AAAAGCAAGG CATGCGGACA CATGCAGTCT CTGTGTCAGA TGAAATTAGT 
GGGGACGAGA CAGATGACTA TGCCGAGATC ATCGATGAGG AAGACACATA CACCATGCCC 
TCAAAAAGCT ATGGAATAGA TGAAGCCAGG GATTATGAGA TTCAGAGAGA AAGAATAGAA 
CTTGGACGCT GTATTGGAGA AGGCCAGTTT GGAGATGTAC ATCAAGGCGT GTACCTGAGC 
CCAGAGAATC CAGCTTTGGC TGTTGCAATC AAAACATGTA AAAACTGTAC TTCGGACAGC 
GTGAGAGAGA AGTTCCTTCA AGAAGCCTTA ACAATGCGCC AGTTTGACCA TCCTCACATC 
GTGAAGCTGA TTGGAGTCAT TACAGAGAAC CCAGTTTGGA TAATCATGGA GTTGTGCACA 
CTTGGAGAGC TGAGGTCATT TTTGCAAGTA AGGAAATACA GCTTGGATCT AGCATCTTTG 
ATCTTATATG CCTATCAGCT TAGTACAGCA CTCGCGTATC TGGAGAGCAA AAGATTTGTT 
CACAGGGACA TTGCTGCACG GAATGTTCTG GTGTCTTCAA ATGATTGTGT AAAATTAGGA 
GACTTTGGAT TATCTCGATA TATGGAAGAC AGTACTTACT ATAAAGCTTC CAAAGGAAAA 
TTACCTATTA AATGGATGGC TCCAGAGTCA ATCAATTTTC GACGTTTTAC CTCAGCTAGT 
GACGTGTGGA TGTTTGGTGT GTGTATGTGG GAGATACTGA TGCATGGCGT GAAGCCTTTT 
CAAGGAGTGA AGAACAATGA TGTGATCGGT CGAATTGAAA ATGGGGAAAG ATTACCAATG 
CCTCCAAATT GTCCTCCCAC CCTCTACAGC CTTATGACGA AATGTTGGGC CTATGACCCC 
AGCAGACGGC CCAGGTTTAC TGAACTAAAA GCTCAGCTCA GCACAATCCT GGAGGAAGAG 
AAGGTGCAGC AAGAAGAACG GATGAGGATG GAATCCAGAA GACAGGCAAC AGTGTCCTGG 
GACTCTGGAG GGTCTGATGA AGCACCACCC AAGCCCAGCA GACCTGGTTA TCCTAGCCCG 
AGGTCCAGTG AAGGATTTTA TCCCAGCCCA CAGCACATGG TCCAGACCAA TCACTATCAG 
ATCTCTGGCT ACCCAGGTTC CCATGGAATC CCAGCCATGG CTGGCAGCAT TTACCCAGGT 
CAGGCATCTC TTCTGGACCA GACAGAATTG TGGAATCACA GACCTCAGGA GATGTCCATG 
TGGCAGCCCA GTGTGGAGGA CTCAGCAGCT TTAGATCTTC GAGGGATGGG ACAGGTGCTT 
CCTCCTCACC TGATGGAAGA GCGGCTAATC CGACAGCAGC AGGAAATGGA GGAAGACCAG 
CGCTGGCTGG AAAAGGAAGA GCGATTCCTG AAACCTGATG TGAGGCTCTC TCGAGGCAGC 
ATCGACAGGG AGGACGGGAG TTTTCAGGGT CCGACTGGAA ACCAACACAT CTATCAGCCT 
GTGGGAAAAC CAGATCCTGC AGCTCCACCA AAGAAACCAC CTCGCCCTGG AGCACCTGGC 
CACCTAAGCA ACTTGTCCAG CATCAGCAGC CCTGCAGAAA GCTACAATGA GGGTGTCAAG 
CCGTGGAGGC TTCAGCCCCA GGAAATCAGC CCCCCTCCCA CTGCCAACCT TGACCGATCC 
AATGACAAGG TATATGAAAA TGTGACGGGC CTAGTGAAGG CTGTCATTGA GATGTCCAGC 
AAAATCCAAC CAGCTCCTCC AGAAGAGTAC GTCCCTATGG TGAAGGAAGT TGGCCTGGCC 
CTGCGGACCT TACTGGCCAC TGTGGATGAG ACCATTCCCA TCCTTCCAGC CAGCACCCAT 
CGAGAGATCG AGATGGCACA GAAGCTGCTG AACTCCGACT TGGGTGAGCT CATCAGCAAG 
ATGAAGCTGG CGCAGCAGTA TGTCATGACC AGCCTTCAGC AGGAGTACAA GAAGCAGATG 
CTGACAGCTG CTCACGCCCT GGCTGTGGAT GCCAAGAATC TACTTGATGT TATTGATCAA 
GCGAGACTGA AAATGCTAGG GCAGACACGG CCACACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Macrophage migration inhibitory factor (MIF) promotes rat airway muscle cell proliferation and migration mediated by ERK1/2 and FAK signaling.
Cell biology international42(1)75-83(2018 Jan)
Lan H,Wang N,Chen Y,Wang X,Gong Y,Qi X,Luo Y,Yao F

Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration.
Oncogene36(47)6509-6517(2017 Nov)
Chen YR,Chou HC,Yang CH,Chen HY,Liu YW,Lin TY,Yeh CL,Chao WT,Tsou HH,Chuang HC,Tan TH

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Ptk2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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