Hcrtr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Role of orexin-1 receptors in the dorsal hippocampus (CA1 region) in expression and extinction of the morphine-induced conditioned place preference in the rats.
Farahimanesh S, Karimi S, Haghparast A
Peptides10125-31(2017 Dec)

Suggest that elevated paraventricular nucleus OX1R activation may contribute to salt-sensitive hypertension by enhancing AVP signaling.
Title: Increased activity of the orexin system in the paraventricular nucleus contributes to salt-sensitive hypertension.

orexin-A promoted the GLT-1 expression via OX1R/PKCalpha/ERK1/2 pathway in astrocytes and protected co-cultured cells against anoxia/hypoglycemic injury.
Title: Orexin-A promotes Glu uptake by OX1R/PKC?/ERK1/2/GLT-1 pathway in astrocytes and protects co-cultured astrocytes and neurons against apoptosis in anoxia/hypoglycemic injury in vitro.

Data indicate that ORX signaling at the OX1R receptor specifically regulates high levels of motivation for alcohol, even in the absence of direct alcohol reinforcement. This implicates the ORX system in the pathological motivation underlying alcohol abuse and alcoholism and demonstrates that the OX1R may be an important target for treating alcohol abuse.
Title: Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats.

The results of the present study show upregulation of orexin activity and of the OX1R in the hypothalamus following exposure of rats to footshocks and highlight a specific role of OX1R in contextual fear.
Title: Role of the orexin (hypocretin) system in contextual fear conditioning in rats.

Study suggests that the orexin-1 and orexin-2 receptor mediated projections from the lateral hypothalamus to dentate gyrus are involved in the development, expression and extinction of conditioned place preference induced by lateral hypothalamus stimulation
Title: Involvement of orexin-1 and orexin-2 receptors within the dentate gyrus of the hippocampus in the acquisition, expression and extinction of lateral hypothalamic-induced conditioned place preference in the rats.