Id2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Id2
Entrez Gene ID	25587
Full Name	inhibitor of DNA binding 2
Synonyms	Ac2-300
General protein information	Preferred Names inhibitor of DNA binding 2 Names DNA-binding protein inhibitor ID-2 inhibitor of DNA binding 2, HLH protein inhibitor of DNA binding 2, dominant negative helix-loop-helix protein inhibitor of differentiation 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q16
Summary	a helix-loop-helix protein that lacks a DNA binding domain; involved in transcription regulation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013060.3	NP_037192.1	DNA-binding protein inhibitor ID-2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	id2a	NP_958448.1
Pan troglodytes (chimpanzee)	ID2	XP_003308921.1
Mus musculus (house mouse)	Id2	NP_034626.1
Xenopus tropicalis (tropical clawed frog)	id2	NP_988885.1
Homo sapiens (human)	ID2	NP_002157.2
	ID2	XP_001081982.2
Gallus gallus (chicken)	ID2	NP_990333.1
Bos taurus (cattle)	ID2	NP_001029403.1
Rattus norvegicus (Norway rat)	Id2	NP_037192.1

Gene Ontology
Bibliography

Related articles in PubMed

Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration.
Ko HR, Kwon IS, Hwang I, Jin EJ, Shin JH, Brennan-Minnella AM, Swanson R, Cho SW, Lee KH, Ahn JY
eLife5(2016 12)

Silencing of Id2 Alleviates Chronic Neuropathic Pain Following Chronic Constriction Injury.
Jiang L, Wu Q, Yang T
Journal of molecular neuroscience : MN59(1)99-105(2016 May)

Silencing of Id2 attenuates hypoxia/ischemia-induced neuronal injury via inhibition of neuronal apoptosis.
Guo L, Yang X, Lin X, Lin Y, Shen L, Nie Q, Ren L, Guo Q, Que S, Qiu Y
Behavioural brain research292528-36(2015 Oct)

Hypoxia/ischemia up-regulates Id2 expression in neuronal cells in vivo and in vitro.
Guo L, Lan J, Lin Y, Guo P, Nie Q, Mao Q, Ren L, Qiu Y
Neuroscience letters55488-93(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Here, the authors discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone formation through phosphorylation of serine 14 (S14) on Inhibitor of DNA binding 2 (Id2).
Title: Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration.

Knockdown of Id2 alleviates neuropathic pain by inhibiting the NF-kappaB activation.
Title: Silencing of Id2 Alleviates Chronic Neuropathic Pain Following Chronic Constriction Injury.

The data support the implication of inhibitor of DNA binding/differentiation 2 in the modulation of hypoxia/ischemia-induced neuronal apoptosis.
Title: Silencing of Id2 attenuates hypoxia/ischemia-induced neuronal injury via inhibition of neuronal apoptosis.

Hypoxia/ischemia (H/I) up-regulates Id2 expression in neuronal cells, and Id2 might play an important role in H/I-induced neuronal apoptosis.
Title: Hypoxia/ischemia up-regulates Id2 expression in neuronal cells in vivo and in vitro.

CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 and were hypomethylated in PRMT5-deficient cells, suggesting that PRMT5 plays a role in gene silencing during glial cell
Title: Type II arginine methyltransferase PRMT5 regulates gene expression of inhibitors of differentiation/DNA binding Id2 and Id4 during glial cell differentiation.

The following Id2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Id2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13476	NM_013060.3 Latest version!	Rattus norvegicus inhibitor of DNA binding 2 (Id2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Id2 ( NM_013060.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037192.1 Rattus norvegicus inhibitor of DNA binding 2 (Id2), mRNA.

Price & Availability↑

CloneID	ORa13476
Clone ID Related Accession (Same CDS sequence)	NM_013060.3
Accession Version	NM_013060.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	DNA-binding protein inhibitor ID-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D10863.1. On Jun 3, 2007 this sequence version replaced NM_013060.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D10863.1, FQ212969.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAAGCCT TCAGTCCGGT GAGGTCCGTT AGGAAAAACA GCCTGTCGGA CCACAGCTTG 
GGCATCTCCC GGAGCAAAAC CCCGGTGGAC GACCCGATGA GTCTGCTCTA CAACATGAAC 
GACTGCTACT CCAAGCTCAA GGAACTGGTG CCCAGCATCC CCCAGAACAA GAAGGTGACC 
AAGATGGAAA TCCTGCAGCA CGTCATCGAT TATATCTTGG ACCTGCAGAT CGCCCTGGAC 
TCGCACCCCA CTATCGTCAG CCTGCACCAC CAGAGACCTG GACAGAACCA AACGTCCAGG 
ACGCCGCTGA CCACCCTGAA CACGGACATC AGCATCCTGT CCTTGCAGGC GTCTGAATTC 
CCTTCTGAGC TTATGTCGAA TGACAGCAAA GTACTCTGTG GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037192.1
CDS	64..468
Translation	MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVTKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQTSRTPLTTLNTDISILSLQASEFPSELMSNDSKVLCG

Target ORF information:

RefSeq Version	NM_013060.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus inhibitor of DNA binding 2 (Id2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013060.3

ORF Insert Sequence:

ATGAAAGCCT TCAGTCCGGT GAGGTCCGTT AGGAAAAACA GCCTGTCGGA CCACAGCTTG 
GGCATCTCCC GGAGCAAAAC CCCGGTGGAC GACCCGATGA GTCTGCTCTA CAACATGAAC 
GACTGCTACT CCAAGCTCAA GGAACTGGTG CCCAGCATCC CCCAGAACAA GAAGGTGACC 
AAGATGGAAA TCCTGCAGCA CGTCATCGAT TATATCTTGG ACCTGCAGAT CGCCCTGGAC 
TCGCACCCCA CTATCGTCAG CCTGCACCAC CAGAGACCTG GACAGAACCA AACGTCCAGG 
ACGCCGCTGA CCACCCTGAA CACGGACATC AGCATCCTGT CCTTGCAGGC GTCTGAATTC 
CCTTCTGAGC TTATGTCGAA TGACAGCAAA GTACTCTGTG GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration.
eLife5(2016 12)
Ko HR,Kwon IS,Hwang I,Jin EJ,Shin JH,Brennan-Minnella AM,Swanson R,Cho SW,Lee KH,Ahn JY

Silencing of Id2 Alleviates Chronic Neuropathic Pain Following Chronic Constriction Injury.
Journal of molecular neuroscience : MN59(1)99-105(2016 May)
Jiang L,Wu Q,Yang T

Silencing of Id2 attenuates hypoxia/ischemia-induced neuronal injury via inhibition of neuronal apoptosis.
Behavioural brain research292528-36(2015 Oct)
Guo L,Yang X,Lin X,Lin Y,Shen L,Nie Q,Ren L,Guo Q,Que S,Qiu Y

Hypoxia/ischemia up-regulates Id2 expression in neuronal cells in vivo and in vitro.
Neuroscience letters55488-93(2013 Oct)
Guo L,Lan J,Lin Y,Guo P,Nie Q,Mao Q,Ren L,Qiu Y

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Id2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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