Ywhaz cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ywhaz
Entrez Gene ID	25578
Full Name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Synonyms	14-3-3z
General protein information	Preferred Names tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta Names 14-3-3 protein zeta/delta KCIP-1 mitochondrial import stimulation factor S1 subunit protein kinase C inhibitor protein 1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q22
Summary	30kDa component of the mitochondrial import stimulation factor, a protein complex that facilitates the import of in vitro synthesized precursor proteins into mitochondria [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013011.3	NP_037143.2	14-3-3 protein zeta/delta
XM_006241529.3	XP_006241591.1	14-3-3 protein zeta/delta isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	YWHAZ	NP_001129173.1
Canis lupus familiaris (dog)	YWHAZ	XP_849044.1
Pan troglodytes (chimpanzee)	YWHAZ	XP_003951364.1
	YWHAZ	XP_002805465.1
Mus musculus (house mouse)	Ywhaz	NP_001240734.1
Rattus norvegicus (Norway rat)	Ywhaz	NP_037143.2
Gallus gallus (chicken)	YWHAZ	NP_001026514.1
Danio rerio (zebrafish)	ywhabl	NP_955856.1
Caenorhabditis elegans (roundworm)	par-5	NP_502235.1
Bos taurus (cattle)	YWHAZ	NP_777239.1
Drosophila melanogaster (fruit fly)	14-3-3zeta	NP_995792.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007643	XP_001687869.1
Caenorhabditis elegans (roundworm)	ftt-2	NP_509939.1
Xenopus tropicalis (tropical clawed frog)	ywhaz	NP_989173.1

Gene Ontology
Bibliography

Related articles in PubMed

miR-22 targets YWHAZ to inhibit metastasis of hepatocellular carcinoma and its down-regulation predicts a poor survival.
Chen M, Hu W, Xiong CL, Qu Z, Yin CQ, Wang YH, Luo CL, Guan Q, Yuan CH, Wang FB
Oncotarget7(49)80751-80764(2016 Dec)

Posttranscriptional regulation of 14-3-3? by RNA-binding protein HuR modulating intestinal epithelial restitution after wounding.
Hansraj NZ, Xiao L, Wu J, Chen G, Turner DJ, Wang JY, Rao JN
Physiological reports4(13)(2016 Jul)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

Role of NMDA receptors in the trigeminal pathway, and the modulatory effect of magnesium in a model of rat temporomandibular joint arthritis.
Cavalcante AL, Siqueira RM, Araujo JC, Gondim DV, Ribeiro RA, Quetz JS, Havt A, Lima AA, Vale ML
European journal of oral sciences121(6)573-83(2013 Dec)

Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons.
Qureshi HY, Han D, MacDonald R, Paudel HK
PloS one8(12)e84615(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results indicate that HuR induces 14-3-3zeta translation via interaction with its 3' UTR and that 14-3-3zeta is necessary for stimulation of intestinal epithelial cell migration after wounding.
Title: Posttranscriptional regulation of 14-3-3? by RNA-binding protein HuR modulating intestinal epithelial restitution after wounding.

Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons.
Title: Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons.

the reduced expression of 14-3-3zeta plays a role in the excessive apoptosis that occurs in spina bifida
Title: Altered expression of 14-3-3? protein in spinal cords of rat fetuses with spina bifida aperta.

In the dorsal spinal cord of neuropathic rats, 14-3-3zeta is overexpressed and weakens GABAB inhibition.
Title: Impairment of GABAB receptor dimer by endogenous 14-3-3? in chronic pain conditions.

the function of nuclear RACK1 is mediated through its interaction with 14-3-3zeta
Title: Direct interaction between scaffolding proteins RACK1 and 14-3-3? regulates brain-derived neurotrophic factor (BDNF) transcription.

The following Ywhaz gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ywhaz cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12676	NM_013011.3 Latest version!	Rattus norvegicus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta (Ywhaz), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa12676	XM_006241529.3 Latest version!	Rattus norvegicus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta (Ywhaz), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ywhaz ( NM_013011.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037143.2 Rattus norvegicus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta (Ywhaz), mRNA.

Price & Availability↑

CloneID	ORa12676
Clone ID Related Accession (Same CDS sequence)	NM_013011.3 , XM_006241529.3
Accession Version	NM_013011.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	14-3-3 protein zeta/delta
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC070941.1. On Jun 10, 2007 this sequence version replaced NM_013011.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070941.1, BC094305.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906348, SAMN01906350 [ECO:0000348] ##Evidence-Data-END##

ATGGATAAAA ATGAGCTGGT GCAGAAGGCC AAGCTGGCCG AGCAGGCAGA GCGATACGAT 
GACATGGCAG CCTGCATGAA GTCTGTCACT GAGCAAGGAG CCGAGCTGTC TAACGAGGAG 
AGGAACCTTC TCTCTGTTGC TTATAAAAAC GTTGTAGGAG CCCGTAGGTC ATCTTGGAGG 
GTCGTCTCGA GTATTGAGCA GAAGACGGAA GGTGCTGAGA AAAAGCAGCA GATGGCTCGA 
GAATACAGAG AGAAGATCGA GACGGAGCTG AGGGACATCT GCAACGACGT ACTGTCTCTT 
TTGGAAAAGT TCTTGATCCC CAATGCTTCG CAGCCAGAAA GCAAAGTCTT CTATTTGAAA 
ATGAAGGGTG ACTACTACCG CTACTTGGCT GAGGTTGCTG CTGGTGATGA CAAGAAAGGA 
ATTGTGGACC AGTCACAGCA AGCATACCAA GAAGCATTTG AAATCAGCAA AAAGGAGATG 
CAGCCGACAC ACCCCATCAG ACTGGGTCTG GCCCTCAACT TCTCTGTGTT CTACTATGAG 
ATCCTGAACT CCCCAGAGAA AGCCTGCTCT CTTGCAAAAA CAGCTTTTGA TGAAGCCATT 
GCTGAACTTG ATACATTAAG TGAAGAGTCG TACAAAGACA GCACGCTAAT AATGCAGTTA 
CTGAGAGACA ACTTGACATT GTGGACATCG GATACCCAAG GAGACGAAGC AGAAGCGGGA 
GAAGGAGGGG AAAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037143.2
CDS	62..799
Translation	MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQPESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN

Target ORF information:

RefSeq Version	NM_013011.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta (Ywhaz), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013011.3

ORF Insert Sequence:

ATGGATAAAA ATGAGCTGGT GCAGAAGGCC AAGCTGGCCG AGCAGGCAGA GCGATACGAT 
GACATGGCAG CCTGCATGAA GTCTGTCACT GAGCAAGGAG CCGAGCTGTC TAACGAGGAG 
AGGAACCTTC TCTCTGTTGC TTATAAAAAC GTTGTAGGAG CCCGTAGGTC ATCTTGGAGG 
GTCGTCTCGA GTATTGAGCA GAAGACGGAA GGTGCTGAGA AAAAGCAGCA GATGGCTCGA 
GAATACAGAG AGAAGATCGA GACGGAGCTG AGGGACATCT GCAACGACGT ACTGTCTCTT 
TTGGAAAAGT TCTTGATCCC CAATGCTTCG CAGCCAGAAA GCAAAGTCTT CTATTTGAAA 
ATGAAGGGTG ACTACTACCG CTACTTGGCT GAGGTTGCTG CTGGTGATGA CAAGAAAGGA 
ATTGTGGACC AGTCACAGCA AGCATACCAA GAAGCATTTG AAATCAGCAA AAAGGAGATG 
CAGCCGACAC ACCCCATCAG ACTGGGTCTG GCCCTCAACT TCTCTGTGTT CTACTATGAG 
ATCCTGAACT CCCCAGAGAA AGCCTGCTCT CTTGCAAAAA CAGCTTTTGA TGAAGCCATT 
GCTGAACTTG ATACATTAAG TGAAGAGTCG TACAAAGACA GCACGCTAAT AATGCAGTTA 
CTGAGAGACA ACTTGACATT GTGGACATCG GATACCCAAG GAGACGAAGC AGAAGCGGGA 
GAAGGAGGGG AAAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ywhaz ( XM_006241529.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006241591.1 Rattus norvegicus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta (Ywhaz), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa12676
Clone ID Related Accession (Same CDS sequence)	NM_013011.3 , XM_006241529.3
Accession Version	XM_006241529.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	14-3-3 protein zeta/delta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006241529.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATAAAA ATGAGCTGGT GCAGAAGGCC AAGCTGGCCG AGCAGGCAGA GCGATACGAT 
GACATGGCAG CCTGCATGAA GTCTGTCACT GAGCAAGGAG CCGAGCTGTC TAACGAGGAG 
AGGAACCTTC TCTCTGTTGC TTATAAAAAC GTTGTAGGAG CCCGTAGGTC ATCTTGGAGG 
GTCGTCTCGA GTATTGAGCA GAAGACGGAA GGTGCTGAGA AAAAGCAGCA GATGGCTCGA 
GAATACAGAG AGAAGATCGA GACGGAGCTG AGGGACATCT GCAACGACGT ACTGTCTCTT 
TTGGAAAAGT TCTTGATCCC CAATGCTTCG CAGCCAGAAA GCAAAGTCTT CTATTTGAAA 
ATGAAGGGTG ACTACTACCG CTACTTGGCT GAGGTTGCTG CTGGTGATGA CAAGAAAGGA 
ATTGTGGACC AGTCACAGCA AGCATACCAA GAAGCATTTG AAATCAGCAA AAAGGAGATG 
CAGCCGACAC ACCCCATCAG ACTGGGTCTG GCCCTCAACT TCTCTGTGTT CTACTATGAG 
ATCCTGAACT CCCCAGAGAA AGCCTGCTCT CTTGCAAAAA CAGCTTTTGA TGAAGCCATT 
GCTGAACTTG ATACATTAAG TGAAGAGTCG TACAAAGACA GCACGCTAAT AATGCAGTTA 
CTGAGAGACA ACTTGACATT GTGGACATCG GATACCCAAG GAGACGAAGC AGAAGCGGGA 
GAAGGAGGGG AAAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006241591.1
CDS	615..1352
Translation	MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQPESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN

Target ORF information:

RefSeq Version	XM_006241529.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta (Ywhaz), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006241529.3

ORF Insert Sequence:

ATGGATAAAA ATGAGCTGGT GCAGAAGGCC AAGCTGGCCG AGCAGGCAGA GCGATACGAT 
GACATGGCAG CCTGCATGAA GTCTGTCACT GAGCAAGGAG CCGAGCTGTC TAACGAGGAG 
AGGAACCTTC TCTCTGTTGC TTATAAAAAC GTTGTAGGAG CCCGTAGGTC ATCTTGGAGG 
GTCGTCTCGA GTATTGAGCA GAAGACGGAA GGTGCTGAGA AAAAGCAGCA GATGGCTCGA 
GAATACAGAG AGAAGATCGA GACGGAGCTG AGGGACATCT GCAACGACGT ACTGTCTCTT 
TTGGAAAAGT TCTTGATCCC CAATGCTTCG CAGCCAGAAA GCAAAGTCTT CTATTTGAAA 
ATGAAGGGTG ACTACTACCG CTACTTGGCT GAGGTTGCTG CTGGTGATGA CAAGAAAGGA 
ATTGTGGACC AGTCACAGCA AGCATACCAA GAAGCATTTG AAATCAGCAA AAAGGAGATG 
CAGCCGACAC ACCCCATCAG ACTGGGTCTG GCCCTCAACT TCTCTGTGTT CTACTATGAG 
ATCCTGAACT CCCCAGAGAA AGCCTGCTCT CTTGCAAAAA CAGCTTTTGA TGAAGCCATT 
GCTGAACTTG ATACATTAAG TGAAGAGTCG TACAAAGACA GCACGCTAAT AATGCAGTTA 
CTGAGAGACA ACTTGACATT GTGGACATCG GATACCCAAG GAGACGAAGC AGAAGCGGGA 
GAAGGAGGGG AAAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-22 targets YWHAZ to inhibit metastasis of hepatocellular carcinoma and its down-regulation predicts a poor survival.
Oncotarget7(49)80751-80764(2016 Dec)
Chen M,Hu W,Xiong CL,Qu Z,Yin CQ,Wang YH,Luo CL,Guan Q,Yuan CH,Wang FB

Posttranscriptional regulation of 14-3-3? by RNA-binding protein HuR modulating intestinal epithelial restitution after wounding.
Physiological reports4(13)(2016 Jul)
Hansraj NZ,Xiao L,Wu J,Chen G,Turner DJ,Wang JY,Rao JN

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

Role of NMDA receptors in the trigeminal pathway, and the modulatory effect of magnesium in a model of rat temporomandibular joint arthritis.
European journal of oral sciences121(6)573-83(2013 Dec)
Cavalcante AL,Siqueira RM,Araujo JC,Gondim DV,Ribeiro RA,Quetz JS,Havt A,Lima AA,Vale ML

Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons.
PloS one8(12)e84615(2013)
Qureshi HY,Han D,MacDonald R,Paudel HK

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Ywhaz cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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