Stxbp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Stxbp1
Entrez Gene ID	25558
Full Name	syntaxin binding protein 1
Synonyms	ANC18HA,Munc18-1,NSEC1A,Sec1,Unc18-1,n-sec1,nSec1,rbSec1,rbSec1A,rbSec1B
General protein information	Preferred Names syntaxin binding protein 1 Names syntaxin-binding protein 1 p67 protein unc-18 homolog 1 protein unc-18 homolog A unc-18 homolog unc-18-1 unc-18A
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3p11
Summary	inhibits binding of synaptobrevin and SNAP-25 to syntaxin 1A to modulate SNARE complex formation; acts to regulate neurotransmission [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006233939.3	XP_006234001.1	syntaxin-binding protein 1 isoform X1
NM_013038.3	NP_037170.1	syntaxin-binding protein 1

Pathways from BioSystems

Homologies

	STXBP1	XP_001095617.2
Mus musculus (house mouse)	Stxbp1	NP_033321.2
Drosophila melanogaster (fruit fly)	Rop	NP_001261404.1
Caenorhabditis elegans (roundworm)	unc-18	NP_001024606.1
Canis lupus familiaris (dog)	STXBP1	XP_851554.2
Danio rerio (zebrafish)	stxbp1a	NP_001020353.1
Oryza sativa (rice)	Os04g0252400	NP_001052319.2
Xenopus tropicalis (tropical clawed frog)	stxbp1	NP_001072521.1
Homo sapiens (human)	STXBP1	NP_001027392.1
Bos taurus (cattle)	STXBP1	NP_777044.1
Gallus gallus (chicken)	STXBP1	XP_004945852.1
Arabidopsis thaliana (thale cress)	SEC1A	NP_001184888.1
Arabidopsis thaliana (thale cress)	SEC1B	NP_567388.1
Pan troglodytes (chimpanzee)	STXBP1	XP_003312377.1
Rattus norvegicus (Norway rat)	Stxbp1	NP_037170.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003023	XP_311854.4
Arabidopsis thaliana (thale cress)	KEU	NP_563905.1

Gene Ontology
Bibliography

Related articles in PubMed

Munc18a clusters SNARE-bearing liposomes prior to
Arnold MG, Adhikari P, Kang B, Xu ?? H
The Biochemical journal474(19)3339-3354(2017 09)

An activated Q-SNARE/SM protein complex as a possible intermediate in SNARE assembly.
Jakhanwal S, Lee CT, Urlaub H, Jahn R
The EMBO journal36(12)1788-1802(2017 06)

Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion.
Sitarska E, Xu J, Park S, Liu X, Quade B, Stepien K, Sugita K, Brautigam CA, Sugita S, Rizo J
eLife6(2017 May)

Munc18-1 is a molecular chaperone for ?-synuclein, controlling its self-replicating aggregation.
Chai YJ, Sierecki E, Tomatis VM, Gormal RS, Giles N, Morrow IC, Xia D, G?tz J, Parton RG, Collins BM, Gambin Y, Meunier FA
The Journal of cell biology214(6)705-18(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Munc18a promotes membrane clustering in a step that is independent of trans-SNARE activation.
Title: Munc18a clusters SNARE-bearing liposomes prior to

The ternary complex of syntaxin1:SNAP25:Munc18-1binds synaptobrevin with fast kinetics, resulting in the rapid formation of a fully zippered SNARE complex to which Munc18-1 remains tethered by the N-terminal domain of syntaxin1.
Title: An activated Q-SNARE/SM protein complex as a possible intermediate in SNARE assembly.

Munc18-1 mutations and haploinsufficiency may therefore trigger a pathogenic gain of function through both the corruption of native Munc18-1 and a perturbed chaperone activity for alpha-Syn leading to aggregation-induced neurodegeneration.
Title: Munc18-1 is a molecular chaperone for ?-synuclein, controlling its self-replicating aggregation.

Data demonstrate that the open-closed syntaxin equilibrium is shifted toward the open state when syntaxin and Munc18-1 are associated with SNAP25, and the results indicate that a syntaxin/SNAP25:Munc18-1 complex is a likely starting point for SNARE assembly.
Title: Munc18-1 and the Syntaxin-1 N Terminus Regulate Open-Closed States in a t-SNARE Complex.

TNFalpha induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion.
Title: TNF? induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion.

The following Stxbp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Stxbp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01733	NM_013038.3 Latest version!	Rattus norvegicus syntaxin binding protein 1 (Stxbp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$349.30 $499.00
ORa25716	XM_006233939.3 Latest version!	Rattus norvegicus syntaxin binding protein 1 (Stxbp1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Stxbp1 ( NM_013038.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037170.1 Rattus norvegicus syntaxin binding protein 1 (Stxbp1), mRNA.

Price & Availability↑

CloneID	ORa01733
Clone ID Related Accession (Same CDS sequence)	NM_013038.3
Accession Version	NM_013038.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1785bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	syntaxin-binding protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC088850.1. On Jan 12, 2005 this sequence version replaced NM_013038.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC088850.1, L26264.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCCCA TTGGCCTCAA GGCGGTGGTC GGAGAGAAGA TCATGCATGA TGTTATCAAG 
AAGGTGAAGA AGAAGGGCGA GTGGAAGGTG CTGGTGGTGG ACCAGTTAAG CATGAGGATG 
CTGTCTTCCT GCTGCAAGAT GACAGACATC ATGACCGAGG GGATCACAAT TGTGGAGGAT 
ATCAACAAGC GCCGAGAGCC GCTCCCCAGC CTAGAGGCCG TGTACCTCAT CACCCCGTCT 
GAGAAGTCTG TCCACTCTCT CATCAGTGAT TTTAAGGACC CGCCGACTGC TAAATATCGG 
GCCGCACATG TGTTCTTCAC AGACTCATGT CCAGATGCCC TGTTTAACGA GCTGGTAAAA 
TCTCGAGCAG CCAAAGTCAT CAAGACGCTG ACGGAAATCA ACATTGCGTT TCTCCCCTAT 
GAGTCCCAGG TGTATTCCCT GGACTCCGCT GACTCTTTCC AAAGTTTCTA CAGCCCTCAC 
AAGGCACAGA TGAAGAATCC CATACTGGAA CGCCTGGCAG AGCAAATCGC CACCCTGTGT 
GCCACCCTGA AGGAGTACCC GGCTGTGCGG TATCGGGGGG AGTACAAGGA CAATGCCTTG 
CTGGCTCAGC TGATCCAGGA CAAGCTGGAC GCTTATAAAG CTGATGACCC GACAATGGGG 
GAGGGTCCCG ACAAGGCACG GTCCCAGCTC CTGATCCTGG ATCGTGGCTT TGACCCCAGC 
TCCCCTGTGC TTCATGAACT GACGTTTCAG GCTATGAGTT ACGACCTGCT GCCTATTGAA 
AATGATGTTT ACAAGTATGA GACCAGCGGC ATTGGAGAGG CGAGGGTGAA GGAGGTGCTC 
CTGGATGAGG ACGATGACCT GTGGATTGCA CTGCGACACA AGCACATCGC AGAGGTGTCC 
CAGGAAGTGA CCCGGTCTCT GAAGGACTTT TCCTCTAGCA AGAGGATGAA TACTGGAGAG 
AAGACCACCA TGCGGGACCT GTCCCAGATG CTGAAGAAAA TGCCCCAGTA CCAGAAGGAG 
CTCAGCAAGT ATTCGACTCA CCTGCACCTT GCTGAAGACT GTATGAAGCA TTACCAAGGC 
ACCGTAGACA AACTCTGCCG CGTGGAGCAG GACCTGGCGA TGGGCACAGA TGCTGAGGGG 
GAAAAAATCA AGGACCCCAT GAGAGCCATT GTCCCCATCC TGCTGGATGC AAATGTCAGC 
ACTTATGACA AAATTCGCAT CATCCTTCTC TACATCTTCC TGAAGAACGG TATCACTGAA 
GAAAACCTAA ACAAACTCAT CCAGCACGCC CAGATCCCCC CAGAAGACAG TGAGATCATC 
ACCAACATGG CTCACCTCGG GGTGCCCATC GTCACGGATT CCACACTACG CCGCAGAAGC 
AAGCCGGAGC GGAAGGAGCG CATCAGTGAG CAGACCTACC AGCTCTCACG ATGGACCCCG 
ATCATTAAAG ACATTATGGA GGACACCATT GAAGACAAAC TGGATACAAA GCACTACCCA 
TACATCTCTA CCCGCTCTTC CGCATCCTTC AGCACCACTG CTGTGAGTGC CCGCTATGGA 
CATTGGCACA AGAATAAGGC CCCCGGGGAG TACCGCAGCG GCCCCCGCCT CATTATTTTC 
ATCCTTGGGG GCGTGAGCCT GAATGAGATG CGCTGTGCCT ACGAAGTGAC GCAGGCCAAC 
GGCAAGTGGG AAGTGCTCAT AGGATCCACG CACATTCTCA CCCCACAGAA ACTGCTGGAC 
ACGCTGAAGA AGCTGAATAA AACAGACGAA GAAATAAGCA GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037170.1
CDS	107..1891
Translation	MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPQKLLDTLKKLNKTDEEISS

Target ORF information:

RefSeq Version	NM_013038.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus syntaxin binding protein 1 (Stxbp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013038.3

ORF Insert Sequence:

ATGGCCCCCA TTGGCCTCAA GGCGGTGGTC GGAGAGAAGA TCATGCATGA TGTTATCAAG 
AAGGTGAAGA AGAAGGGCGA GTGGAAGGTG CTGGTGGTGG ACCAGTTAAG CATGAGGATG 
CTGTCTTCCT GCTGCAAGAT GACAGACATC ATGACCGAGG GGATCACAAT TGTGGAGGAT 
ATCAACAAGC GCCGAGAGCC GCTCCCCAGC CTAGAGGCCG TGTACCTCAT CACCCCGTCT 
GAGAAGTCTG TCCACTCTCT CATCAGTGAT TTTAAGGACC CGCCGACTGC TAAATATCGG 
GCCGCACATG TGTTCTTCAC AGACTCATGT CCAGATGCCC TGTTTAACGA GCTGGTAAAA 
TCTCGAGCAG CCAAAGTCAT CAAGACGCTG ACGGAAATCA ACATTGCGTT TCTCCCCTAT 
GAGTCCCAGG TGTATTCCCT GGACTCCGCT GACTCTTTCC AAAGTTTCTA CAGCCCTCAC 
AAGGCACAGA TGAAGAATCC CATACTGGAA CGCCTGGCAG AGCAAATCGC CACCCTGTGT 
GCCACCCTGA AGGAGTACCC GGCTGTGCGG TATCGGGGGG AGTACAAGGA CAATGCCTTG 
CTGGCTCAGC TGATCCAGGA CAAGCTGGAC GCTTATAAAG CTGATGACCC GACAATGGGG 
GAGGGTCCCG ACAAGGCACG GTCCCAGCTC CTGATCCTGG ATCGTGGCTT TGACCCCAGC 
TCCCCTGTGC TTCATGAACT GACGTTTCAG GCTATGAGTT ACGACCTGCT GCCTATTGAA 
AATGATGTTT ACAAGTATGA GACCAGCGGC ATTGGAGAGG CGAGGGTGAA GGAGGTGCTC 
CTGGATGAGG ACGATGACCT GTGGATTGCA CTGCGACACA AGCACATCGC AGAGGTGTCC 
CAGGAAGTGA CCCGGTCTCT GAAGGACTTT TCCTCTAGCA AGAGGATGAA TACTGGAGAG 
AAGACCACCA TGCGGGACCT GTCCCAGATG CTGAAGAAAA TGCCCCAGTA CCAGAAGGAG 
CTCAGCAAGT ATTCGACTCA CCTGCACCTT GCTGAAGACT GTATGAAGCA TTACCAAGGC 
ACCGTAGACA AACTCTGCCG CGTGGAGCAG GACCTGGCGA TGGGCACAGA TGCTGAGGGG 
GAAAAAATCA AGGACCCCAT GAGAGCCATT GTCCCCATCC TGCTGGATGC AAATGTCAGC 
ACTTATGACA AAATTCGCAT CATCCTTCTC TACATCTTCC TGAAGAACGG TATCACTGAA 
GAAAACCTAA ACAAACTCAT CCAGCACGCC CAGATCCCCC CAGAAGACAG TGAGATCATC 
ACCAACATGG CTCACCTCGG GGTGCCCATC GTCACGGATT CCACACTACG CCGCAGAAGC 
AAGCCGGAGC GGAAGGAGCG CATCAGTGAG CAGACCTACC AGCTCTCACG ATGGACCCCG 
ATCATTAAAG ACATTATGGA GGACACCATT GAAGACAAAC TGGATACAAA GCACTACCCA 
TACATCTCTA CCCGCTCTTC CGCATCCTTC AGCACCACTG CTGTGAGTGC CCGCTATGGA 
CATTGGCACA AGAATAAGGC CCCCGGGGAG TACCGCAGCG GCCCCCGCCT CATTATTTTC 
ATCCTTGGGG GCGTGAGCCT GAATGAGATG CGCTGTGCCT ACGAAGTGAC GCAGGCCAAC 
GGCAAGTGGG AAGTGCTCAT AGGATCCACG CACATTCTCA CCCCACAGAA ACTGCTGGAC 
ACGCTGAAGA AGCTGAATAA AACAGACGAA GAAATAAGCA GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Stxbp1 ( XM_006233939.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006234001.1 Rattus norvegicus syntaxin binding protein 1 (Stxbp1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa25716
Clone ID Related Accession (Same CDS sequence)	XM_006233939.3
Accession Version	XM_006233939.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1812bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	syntaxin-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006233939.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCCCCA TTGGCCTCAA GGCGGTGGTC GGAGAGAAGA TCATGCATGA TGTTATCAAG 
AAGGTGAAGA AGAAGGGCGA GTGGAAGGTG CTGGTGGTGG ACCAGTTAAG CATGAGGATG 
CTGTCTTCCT GCTGCAAGAT GACAGACATC ATGACCGAGG GGATCACAAT TGTGGAGGAT 
ATCAACAAGC GCCGAGAGCC GCTCCCCAGC CTAGAGGCCG TGTACCTCAT CACCCCGTCT 
GAGAAGTCTG TCCACTCTCT CATCAGTGAT TTTAAGGACC CGCCGACTGC TAAATATCGG 
GCCGCACATG TGTTCTTCAC AGACTCATGT CCAGATGCCC TGTTTAACGA GCTGGTAAAA 
TCTCGAGCAG CCAAAGTCAT CAAGACGCTG ACGGAAATCA ACATTGCGTT TCTCCCCTAT 
GAGTCCCAGG TGTATTCCCT GGACTCCGCT GACTCTTTCC AAAGTTTCTA CAGCCCTCAC 
AAGGCACAGA TGAAGAATCC CATACTGGAA CGCCTGGCAG AGCAAATCGC CACCCTGTGT 
GCCACCCTGA AGGAGTACCC GGCTGTGCGG TATCGGGGGG AGTACAAGGA CAATGCCTTG 
CTGGCTCAGC TGATCCAGGA CAAGCTGGAC GCTTATAAAG CTGATGACCC GACAATGGGG 
GAGGGTCCCG ACAAGGCACG GTCCCAGCTC CTGATCCTGG ATCGTGGCTT TGACCCCAGC 
TCCCCTGTGC TTCATGAACT GACGTTTCAG GCTATGAGTT ACGACCTGCT GCCTATTGAA 
AATGATGTTT ACAAGTATGA GACCAGCGGC ATTGGAGAGG CGAGGGTGAA GGAGGTGCTC 
CTGGATGAGG ACGATGACCT GTGGATTGCA CTGCGACACA AGCACATCGC AGAGGTGTCC 
CAGGAAGTGA CCCGGTCTCT GAAGGACTTT TCCTCTAGCA AGAGGATGAA TACTGGAGAG 
AAGACCACCA TGCGGGACCT GTCCCAGATG CTGAAGAAAA TGCCCCAGTA CCAGAAGGAG 
CTCAGCAAGT ATTCGACTCA CCTGCACCTT GCTGAAGACT GTATGAAGCA TTACCAAGGC 
ACCGTAGACA AACTCTGCCG CGTGGAGCAG GACCTGGCGA TGGGCACAGA TGCTGAGGGG 
GAAAAAATCA AGGACCCCAT GAGAGCCATT GTCCCCATCC TGCTGGATGC AAATGTCAGC 
ACTTATGACA AAATTCGCAT CATCCTTCTC TACATCTTCC TGAAGAACGG TATCACTGAA 
GAAAACCTAA ACAAACTCAT CCAGCACGCC CAGATCCCCC CAGAAGACAG TGAGATCATC 
ACCAACATGG CTCACCTCGG GGTGCCCATC GTCACGGATT CCACACTACG CCGCAGAAGC 
AAGCCGGAGC GGAAGGAGCG CATCAGTGAG CAGACCTACC AGCTCTCACG ATGGACCCCG 
ATCATTAAAG ACATTATGGA GGACACCATT GAAGACAAAC TGGATACAAA GCACTACCCA 
TACATCTCTA CCCGCTCTTC CGCATCCTTC AGCACCACTG CTGTGAGTGC CCGCTATGGA 
CATTGGCACA AGAATAAGGC CCCCGGGGAG TACCGCAGCG GCCCCCGCCT CATTATTTTC 
ATCCTTGGGG GCGTGAGCCT GAATGAGATG CGCTGTGCCT ACGAAGTGAC GCAGGCCAAC 
GGCAAGTGGG AAGTGCTCAT AGGTTCTACT CACATTCTCA CTCCCACCAA ATTCCTCATG 
GACCTGAGAC ACCCCGACTT CAGGGAGTCC TCTAGGGTAT CTTTTGAGGA TCAGGCTCCA 
ACAATGGAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006234001.1
CDS	169..1980
Translation	MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPTKFLMDLRHPDFRESSRVSFEDQAPTME

Target ORF information:

RefSeq Version	XM_006233939.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus syntaxin binding protein 1 (Stxbp1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233939.3

ORF Insert Sequence:

ATGGCCCCCA TTGGCCTCAA GGCGGTGGTC GGAGAGAAGA TCATGCATGA TGTTATCAAG 
AAGGTGAAGA AGAAGGGCGA GTGGAAGGTG CTGGTGGTGG ACCAGTTAAG CATGAGGATG 
CTGTCTTCCT GCTGCAAGAT GACAGACATC ATGACCGAGG GGATCACAAT TGTGGAGGAT 
ATCAACAAGC GCCGAGAGCC GCTCCCCAGC CTAGAGGCCG TGTACCTCAT CACCCCGTCT 
GAGAAGTCTG TCCACTCTCT CATCAGTGAT TTTAAGGACC CGCCGACTGC TAAATATCGG 
GCCGCACATG TGTTCTTCAC AGACTCATGT CCAGATGCCC TGTTTAACGA GCTGGTAAAA 
TCTCGAGCAG CCAAAGTCAT CAAGACGCTG ACGGAAATCA ACATTGCGTT TCTCCCCTAT 
GAGTCCCAGG TGTATTCCCT GGACTCCGCT GACTCTTTCC AAAGTTTCTA CAGCCCTCAC 
AAGGCACAGA TGAAGAATCC CATACTGGAA CGCCTGGCAG AGCAAATCGC CACCCTGTGT 
GCCACCCTGA AGGAGTACCC GGCTGTGCGG TATCGGGGGG AGTACAAGGA CAATGCCTTG 
CTGGCTCAGC TGATCCAGGA CAAGCTGGAC GCTTATAAAG CTGATGACCC GACAATGGGG 
GAGGGTCCCG ACAAGGCACG GTCCCAGCTC CTGATCCTGG ATCGTGGCTT TGACCCCAGC 
TCCCCTGTGC TTCATGAACT GACGTTTCAG GCTATGAGTT ACGACCTGCT GCCTATTGAA 
AATGATGTTT ACAAGTATGA GACCAGCGGC ATTGGAGAGG CGAGGGTGAA GGAGGTGCTC 
CTGGATGAGG ACGATGACCT GTGGATTGCA CTGCGACACA AGCACATCGC AGAGGTGTCC 
CAGGAAGTGA CCCGGTCTCT GAAGGACTTT TCCTCTAGCA AGAGGATGAA TACTGGAGAG 
AAGACCACCA TGCGGGACCT GTCCCAGATG CTGAAGAAAA TGCCCCAGTA CCAGAAGGAG 
CTCAGCAAGT ATTCGACTCA CCTGCACCTT GCTGAAGACT GTATGAAGCA TTACCAAGGC 
ACCGTAGACA AACTCTGCCG CGTGGAGCAG GACCTGGCGA TGGGCACAGA TGCTGAGGGG 
GAAAAAATCA AGGACCCCAT GAGAGCCATT GTCCCCATCC TGCTGGATGC AAATGTCAGC 
ACTTATGACA AAATTCGCAT CATCCTTCTC TACATCTTCC TGAAGAACGG TATCACTGAA 
GAAAACCTAA ACAAACTCAT CCAGCACGCC CAGATCCCCC CAGAAGACAG TGAGATCATC 
ACCAACATGG CTCACCTCGG GGTGCCCATC GTCACGGATT CCACACTACG CCGCAGAAGC 
AAGCCGGAGC GGAAGGAGCG CATCAGTGAG CAGACCTACC AGCTCTCACG ATGGACCCCG 
ATCATTAAAG ACATTATGGA GGACACCATT GAAGACAAAC TGGATACAAA GCACTACCCA 
TACATCTCTA CCCGCTCTTC CGCATCCTTC AGCACCACTG CTGTGAGTGC CCGCTATGGA 
CATTGGCACA AGAATAAGGC CCCCGGGGAG TACCGCAGCG GCCCCCGCCT CATTATTTTC 
ATCCTTGGGG GCGTGAGCCT GAATGAGATG CGCTGTGCCT ACGAAGTGAC GCAGGCCAAC 
GGCAAGTGGG AAGTGCTCAT AGGTTCTACT CACATTCTCA CTCCCACCAA ATTCCTCATG 
GACCTGAGAC ACCCCGACTT CAGGGAGTCC TCTAGGGTAT CTTTTGAGGA TCAGGCTCCA 
ACAATGGAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Munc18a clusters SNARE-bearing liposomes prior to
The Biochemical journal474(19)3339-3354(2017 09)
Arnold MG,Adhikari P,Kang B,Xu ?? H

An activated Q-SNARE/SM protein complex as a possible intermediate in SNARE assembly.
The EMBO journal36(12)1788-1802(2017 06)
Jakhanwal S,Lee CT,Urlaub H,Jahn R

Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion.
eLife6(2017 May)
Sitarska E,Xu J,Park S,Liu X,Quade B,Stepien K,Sugita K,Brautigam CA,Sugita S,Rizo J

Munc18-1 is a molecular chaperone for ?-synuclein, controlling its self-replicating aggregation.
The Journal of cell biology214(6)705-18(2016 Sep)
Chai YJ,Sierecki E,Tomatis VM,Gormal RS,Giles N,Morrow IC,Xia D,G?tz J,Parton RG,Collins BM,Gambin Y,Meunier FA

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Stxbp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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