Nfkbia cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nfkbia
Entrez Gene ID	25493
Full Name	NFKB inhibitor alpha
Synonyms	RL/IF-1
General protein information	Preferred Names NFKB inhibitor alpha Names NF-kappa-B inhibitor alpha I-kappa-B-alpha Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha ikB-alpha ikappaBalpha nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q23
Summary	inhibitor of NF-kappa-B; binds NF kappa B and retains it in the cytoplasm [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001105720.2	NP_001099190.2	NF-kappa-B inhibitor alpha

Pathways from BioSystems

Homologies

	NFKBIA	XP_001087842.1
Canis lupus familiaris (dog)	NFKBIA	XP_537413.3
Bos taurus (cattle)	NFKBIA	NP_001039333.1
Danio rerio (zebrafish)	nfkbiaa	NP_998349.1
Pan troglodytes (chimpanzee)	NFKBIA	XP_522823.2
Rattus norvegicus (Norway rat)	Nfkbia	NP_001099190.2
Gallus gallus (chicken)	NFKBIA	NP_001001472.2
Danio rerio (zebrafish)	nfkbiab	NP_955923.1
Anopheles gambiae (African malaria mosquito)	CACT	XP_317542.4
Homo sapiens (human)	NFKBIA	NP_065390.1
Mus musculus (house mouse)	Nfkbia	NP_035037.2
Xenopus tropicalis (tropical clawed frog)	nfkbia	NP_001004851.1
Drosophila melanogaster (fruit fly)	cact	NP_001260496.1

Gene Ontology
Bibliography

Related articles in PubMed

Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting I
Liao HH, Zhu JX, Feng H, Ni J, Zhang N, Chen S, Liu HJ, Yang Z, Deng W, Tang QZ
Oxidative medicine and cellular longevity20178370593(2017)

A Constitutive Intrinsic Inflammatory Signaling Circuit Composed of miR-196b, Meis2, PPP3CC, and p65 Drives Prostate Cancer Castration Resistance.
Jeong JH, Park SJ, Dickinson SI, Luo JL
Molecular cell65(1)154-167(2017 Jan)

Downregulation of miR-199b promotes the acute spinal cord injury through IKK?-NF-?B signaling pathway activating microglial cells.
Zhou HJ, Wang LQ, Xu QS, Fan ZX, Zhu Y, Jiang H, Zheng XJ, Ma YH, Zhan RY
Experimental cell research349(1)60-67(2016 Nov)

Increased miR-381a-3p Contributes to Osteoarthritis by Targeting IkB?.
Xia S, Yan K, Wang Y
Annals of clinical and laboratory science46(3)247-53(2016 May)

Polymorphisms in NF-?B pathway genes & their association with risk of lung cancer in the Chinese population.
Zhang JW, Chen QS, Zhai JX, Lv PJ, Sun XY
Pakistan journal of medical sciences31(6)1411-6(2015 Nov-Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that expression and phosphorylation of Nfkbia in adipose tissue can be altered by dietary factors; here, obese rats treated with anti-obesity dietary supplement taurine exhibit increased expression of Nfkbia and decreased ratio of phosphorylated/non-phosphorylated Nfkbia intra-abdominal adipose tissue (and decreased adiposity).
Title: Taurine supplementation regulates I?-B? protein expression in adipose tissue and serum IL-4 and TNF-? concentrations in MSG obesity.

These results indicated that miR-199b attenuated acute spinal cord injury at least partly through IKKbeta-NF-kappaB signaling pathway and affecting the function of microglia.
Title: Downregulation of miR-199b promotes the acute spinal cord injury through IKK?-NF-?B signaling pathway activating microglial cells.

enhanced miR-381a-3p expression contributed to the injury of osteoarthritis mainly by inhibiting the expression of IkappaBalpha.
Title: Increased miR-381a-3p Contributes to Osteoarthritis by Targeting IkB?.

SM22alpha is a phosphorylation-regulated suppressor of IKK-IkappaBalpha-NF-kappaB signaling cascades.
Title: SM22? inhibits vascular inflammation via stabilization of I?B? in vascular smooth muscle cells.

Thus, the inhibition of the IKK complex might be an effective strategy for the prevention of multiple organ failure associated with hemorrhagic shock
Title: Inhibition of I?B Kinase Attenuates the Organ Injury and Dysfunction Associated with Hemorrhagic Shock.

The following Nfkbia gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nfkbia cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12547	NM_001105720.2 Latest version!	Rattus norvegicus NFKB inhibitor alpha (Nfkbia), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nfkbia ( NM_001105720.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099190.2 Rattus norvegicus NFKB inhibitor alpha (Nfkbia), mRNA.

Price & Availability↑

CloneID	ORa12547
Clone ID Related Accession (Same CDS sequence)	NM_001105720.2
Accession Version	NM_001105720.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	NF-kappa-B inhibitor alpha
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB793714.1, CB316505.1, BF417507.1, CB324027.1 and CA509173.1. On Nov 15, 2007 this sequence version replaced NM_001105720.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ234262.1, BC166886.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTTCAGC CAGCTGGGCA CGGCCAGGAC TGGGCCATGG AGGGCCCGCG GGACGGCCTC 
AAGAAGGAGC GGTTGGTGGA CGACCGCCAC GACAGCGGCT TGGACTCCAT GAAGGACGAG 
GATTACGAGC AGATGGTGAA GGAGCTGCGG GAGATCCGCC TGCAGCCGCA GGAGGCGCCT 
CTGGCTGCCG AGCCCTGGAA GCAACAGCTC ACGGAGGACG GAGACTCGTT CCTGCACTTG 
GCAATCATCC ATGAAGAGAA GACACTGACC ATGGAAGTGA TTGGTCAGGT GAAGGGAGAC 
CTGGCCTTCC TCAACTTCCA GAACAACCTG CAGCAGACTC CACTCCACTT GGCTGTGATC 
ACCAACCAGC CAGGAATTGC TGAGGCACTT CTGAAAGCTG GCTGTGATCC TGAGCTCCGA 
GACTTTCGAG GAAATACCCC TCTCCATCTT GCCTGTGAGC AGGGCTGCCT GGCCAGTGTA 
GCAGTCTTGA CTCAGACCTG TACGCCCCAG CATCTCCACT CCGTCCTGCA GGCCACCAAC 
TACAACGGCC ACACGTGTCT ACACTTAGCC TCTATCCATG GCTACCTGGG CATCGTGGAG 
CACTTGGTGA CTTTGGGTGC TGATGTCAAC GCTCAGGAGC CCTGTAATGG CCGGACAGCC 
CTCCACCTTG CAGTGGACCT GCAGAATCCT GACCTGGTCT CGCTCCTGTT GAAGTGTGGG 
GCTGATGTCA ACAGAGTAAC CTACCAGGGC TACTCCCCCT ACCAGCTTAC GTGGGGCCGC 
CCAAGTACCC GGATACAGCA GCAGCTGGGC CAGCTGACCC TGGAAAATCT TCAGACGCTG 
CCCGAGAGTG AGGATGAGGA GAGCTATGAC ACGGAGTCAG AATTCACGGA AGATGAGTTG 
CCCTACGATG ACTGTGTGTT TGGAGGCCAG CGTCTGACGT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099190.2
CDS	120..1064
Translation	MFQPAGHGQDWAMEGPRDGLKKERLVDDRHDSGLDSMKDEDYEQMVKELREIRLQPQEAPLAAEPWKQQLTEDGDSFLHLAIIHEEKTLTMEVIGQVKGDLAFLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPELRDFRGNTPLHLACEQGCLASVAVLTQTCTPQHLHSVLQATNYNGHTCLHLASIHGYLGIVEHLVTLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQTLPESEDEESYDTESEFTEDELPYDDCVFGGQRLTL

Target ORF information:

RefSeq Version	NM_001105720.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NFKB inhibitor alpha (Nfkbia), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105720.2

ORF Insert Sequence:

ATGTTTCAGC CAGCTGGGCA CGGCCAGGAC TGGGCCATGG AGGGCCCGCG GGACGGCCTC 
AAGAAGGAGC GGTTGGTGGA CGACCGCCAC GACAGCGGCT TGGACTCCAT GAAGGACGAG 
GATTACGAGC AGATGGTGAA GGAGCTGCGG GAGATCCGCC TGCAGCCGCA GGAGGCGCCT 
CTGGCTGCCG AGCCCTGGAA GCAACAGCTC ACGGAGGACG GAGACTCGTT CCTGCACTTG 
GCAATCATCC ATGAAGAGAA GACACTGACC ATGGAAGTGA TTGGTCAGGT GAAGGGAGAC 
CTGGCCTTCC TCAACTTCCA GAACAACCTG CAGCAGACTC CACTCCACTT GGCTGTGATC 
ACCAACCAGC CAGGAATTGC TGAGGCACTT CTGAAAGCTG GCTGTGATCC TGAGCTCCGA 
GACTTTCGAG GAAATACCCC TCTCCATCTT GCCTGTGAGC AGGGCTGCCT GGCCAGTGTA 
GCAGTCTTGA CTCAGACCTG TACGCCCCAG CATCTCCACT CCGTCCTGCA GGCCACCAAC 
TACAACGGCC ACACGTGTCT ACACTTAGCC TCTATCCATG GCTACCTGGG CATCGTGGAG 
CACTTGGTGA CTTTGGGTGC TGATGTCAAC GCTCAGGAGC CCTGTAATGG CCGGACAGCC 
CTCCACCTTG CAGTGGACCT GCAGAATCCT GACCTGGTCT CGCTCCTGTT GAAGTGTGGG 
GCTGATGTCA ACAGAGTAAC CTACCAGGGC TACTCCCCCT ACCAGCTTAC GTGGGGCCGC 
CCAAGTACCC GGATACAGCA GCAGCTGGGC CAGCTGACCC TGGAAAATCT TCAGACGCTG 
CCCGAGAGTG AGGATGAGGA GAGCTATGAC ACGGAGTCAG AATTCACGGA AGATGAGTTG 
CCCTACGATG ACTGTGTGTT TGGAGGCCAG CGTCTGACGT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting I
Oxidative medicine and cellular longevity20178370593(2017)
Liao HH,Zhu JX,Feng H,Ni J,Zhang N,Chen S,Liu HJ,Yang Z,Deng W,Tang QZ

A Constitutive Intrinsic Inflammatory Signaling Circuit Composed of miR-196b, Meis2, PPP3CC, and p65 Drives Prostate Cancer Castration Resistance.
Molecular cell65(1)154-167(2017 Jan)
Jeong JH,Park SJ,Dickinson SI,Luo JL

Downregulation of miR-199b promotes the acute spinal cord injury through IKK?-NF-?B signaling pathway activating microglial cells.
Experimental cell research349(1)60-67(2016 Nov)
Zhou HJ,Wang LQ,Xu QS,Fan ZX,Zhu Y,Jiang H,Zheng XJ,Ma YH,Zhan RY

Increased miR-381a-3p Contributes to Osteoarthritis by Targeting IkB?.
Annals of clinical and laboratory science46(3)247-53(2016 May)
Xia S,Yan K,Wang Y

Polymorphisms in NF-?B pathway genes & their association with risk of lung cancer in the Chinese population.
Pakistan journal of medical sciences31(6)1411-6(2015 Nov-Dec)
Zhang JW,Chen QS,Zhai JX,Lv PJ,Sun XY

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Nfkbia cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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