Kcne1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcne1
Entrez Gene ID	25471
Full Name	potassium voltage-gated channel subfamily E regulatory subunit 1
Synonyms	Isk,m
General protein information	Preferred Names potassium voltage-gated channel subfamily E regulatory subunit 1 Names potassium voltage-gated channel subfamily E member 1 IKs producing slow voltage-gated potassium channel subunit beta Mink delayed rectifier potassium channel subunit IsK minimal potassium channel mink potassium (K+) channel protein, slowly activating (Isk) potassium channel, voltage gated subfamily E regulatory beta subunit 1 potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 1 potassium voltage-gated channel Shaw-related subfamily member 1 potassium voltage-gated channel, Isk-related family, member 1 potassium voltage-gated channel, Isk-related subfamily, member 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q11
Summary	beta subunit of the voltage-gated potassium channel complex; involved in modulating channel kinetics [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006248035.2	XP_006248097.1	potassium voltage-gated channel subfamily E member 1 isoform X1
XM_006248034.3	XP_006248096.1	potassium voltage-gated channel subfamily E member 1 isoform X1
XM_008768566.2	XP_008766788.1	potassium voltage-gated channel subfamily E member 1 isoform X1
NM_012973.1	NP_037105.1	potassium voltage-gated channel subfamily E member 1
XM_017597886.1	XP_017453375.1	potassium voltage-gated channel subfamily E member 1 isoform X1
XM_017597887.1	XP_017453376.1	potassium voltage-gated channel subfamily E member 1 isoform X1

Pathways from BioSystems

Homologies

	KCNE1	XP_001089061.1
Canis lupus familiaris (dog)	LOC487743	XP_005638943.1
Homo sapiens (human)	LOC102723475	XP_006724009.1
Bos taurus (cattle)	KCNE1	NP_001071445.1
Mus musculus (house mouse)	Kcne1	NP_032450.1
Xenopus tropicalis (tropical clawed frog)	kcne1	XP_004912192.1
Pan troglodytes (chimpanzee)	KCNE1	XP_001167449.1
Rattus norvegicus (Norway rat)	Kcne1	NP_037105.1

Gene Ontology
Bibliography

Related articles in PubMed

Adult Ventricular Myocytes Segregate KCNQ1 and KCNE1 to Keep the
Jiang M, Wang Y, Tseng GN
Circulation. Arrhythmia and electrophysiology10(6)(2017 Jun)

[Differentially expressed genes in the locus associated with relative kidney weight and resting blood pressure in hypertensive rats of the ISIAH strain].
Redina OE, Smolenskaya SE, Fedoseeva LA, Markel AL
Molekuliarnaia biologiia50(6)944-952(2016 Nov-Dec)

Millimeter wave promotes the synthesis of extracellular matrix and the proliferation of chondrocyte by regulating the voltage-gated K+ channel.
Li X, Liu C, Liang W, Ye H, Chen W, Lin R, Li Z, Liu X, Wu M
Journal of bone and mineral metabolism32(4)367-77(2014 Jul)

A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation.
Bartos DC, Giudicessi JR, Tester DJ, Ackerman MJ, Ohno S, Horie M, Gollob MH, Burgess DE, Delisle BP
Heart rhythm11(3)459-68(2014 Mar)

BACE1 and presenilin/?-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels.
Sachse CC, Kim YH, Agsten M, Huth T, Alzheimer C, Kovacs DM, Kim DY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(6)2458-67(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In adult ventricular myocytes, KCNE1 maintains a stable presence on the cell surface, whereas KCNQ1 is dynamic in its localization. KCNQ1 is largely in an intracellular reservoir under basal conditions but can traffic to the cell surface and boost the IKs amplitude in response to stress.
Title: Adult Ventricular Myocytes Segregate KCNQ1 and KCNE1 to Keep the

Six differentially expressed genes (Kcne1, Rcan1, Mx1, Mx2, Tmprss2, and RGD1559516) were identified in the renal cortex, and three genes (Rcan1, Mx2, and Tmprss2) were identified in the renal medulla.
Title: [Differentially expressed genes in the locus associated with relative kidney weight and resting blood pressure in hypertensive rats of the ISIAH strain].

KCNE1 and KCNE2, auxiliary subunits of voltage-gated potassium channels, undergo sequential cleavage mediated by either alpha-secretase and presenilin(PS)/gamma-secretase or BACE1 and PS/gamma-secretase in cells.
Title: BACE1 and presenilin/?-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels.

KCNE1 and KCNE2 suppress currents generated by homomeric Kv1.4, Kv3.3, and Kv3.4 channels
Title: KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel ?-subunit composition.

currents generated by homomeric Kv1.4, Kv3.3, and Kv3.4 channels are all strongly suppressed by the single transmembrane domain ancillary (beta) subunits KCNE1 and KCNE2
Title: KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels.

The following Kcne1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcne1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa01520	NM_012973.1 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa34132	XM_008768566.2 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa34132	XM_017597887.1 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa34132	XM_006248034.3 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa34132	XM_006248035.2 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa34132	XM_017597886.1 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcne1 ( NM_012973.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037105.1 Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), mRNA.

Price & Availability↑

CloneID	ORa01520
Clone ID Related Accession (Same CDS sequence)	NM_012973.1
Accession Version	NM_012973.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily E member 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M22412.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M22412.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689604, SAMN01906350 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCTGT CCAATTCCAC AACTGTTCTG CCTTTTCTGG CCTCGCTGTG GCAGGAAACA 
GATGAGCCGG GTGGCAATAT GTCGGCGGAC TTGGCTCGTA GGTCCCAGCT CCGAGATGAC 
AGCAAGCTGG AGGCTCTCTA TATCCTCATG GTGCTGGGTT TCTTCGGCTT CTTCACCCTG 
GGCATCATGC TGAGTTACAT CCGATCCAAG AAGCTGGAAC ACTCGCACGA CCCTTTCAAC 
GTGTACATCG AGTCGGACGC CTGGCAGGAG AAAGGCAAGG CCCTCTTCCA GGCCCGCGTT 
CTGGAGAGCT TCAGAGCTTG CTATGTCATT GAAAACCAGG CGGCCGTAGA ACAACCTGCC 
ACACACCTTC CTGAACTGAA GCCACTGTCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037105.1
CDS	64..456
Translation	MALSNSTTVLPFLASLWQETDEPGGNMSADLARRSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKALFQARVLESFRACYVIENQAAVEQPATHLPELKPLS

Target ORF information:

RefSeq Version	NM_012973.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012973.1

ORF Insert Sequence:

ATGGCCCTGT CCAATTCCAC AACTGTTCTG CCTTTTCTGG CCTCGCTGTG GCAGGAAACA 
GATGAGCCGG GTGGCAATAT GTCGGCGGAC TTGGCTCGTA GGTCCCAGCT CCGAGATGAC 
AGCAAGCTGG AGGCTCTCTA TATCCTCATG GTGCTGGGTT TCTTCGGCTT CTTCACCCTG 
GGCATCATGC TGAGTTACAT CCGATCCAAG AAGCTGGAAC ACTCGCACGA CCCTTTCAAC 
GTGTACATCG AGTCGGACGC CTGGCAGGAG AAAGGCAAGG CCCTCTTCCA GGCCCGCGTT 
CTGGAGAGCT TCAGAGCTTG CTATGTCATT GAAAACCAGG CGGCCGTAGA ACAACCTGCC 
ACACACCTTC CTGAACTGAA GCCACTGTCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcne1 ( XM_006248035.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006248097.1 Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa34132
Clone ID Related Accession (Same CDS sequence)	XM_006248035.2 , XM_006248034.3 , XM_008768566.2 , XM_017597886.1 , XM_017597887.1
Accession Version	XM_006248035.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily E member 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005110.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006248035.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCCTGT CCAATTCCAC AACTGTTCTG CCTTTTCTGG CCTCGCTGTG GCAGGAAACA 
GATGAGCCGG GTGGCAATAT GTCGGCGGAC TTGGCTCGTA GGTCCCAGCT CCGAGATGAC 
AGCAAGCTGG AGGCTCTCTA TATCCTCATG GTGCTGGGTT TCTTCGGCTT CTTCACCCTG 
GGCATCATGC TGAGTTACAT CCGATCCAAG AAGCTGGAAC ACTCGCACGA CCCTTTCAAC 
GTGTACATTG AGTCGGACGC CTGGCAGGAG AAAGGCAAGG CCCTCTTCCA GGCCCGCGTT 
CTGGAGAGCT TCAGAGCTTG CTATGTCATT GAAAACCAGG CGGCCGTAGA ACAACCTGCC 
ACACACCTTC CTGAACTGAA GCCACTGTCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006248097.1
CDS	231..623
Translation	MALSNSTTVLPFLASLWQETDEPGGNMSADLARRSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKALFQARVLESFRACYVIENQAAVEQPATHLPELKPLS

Target ORF information:

RefSeq Version	XM_006248035.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006248035.2

ORF Insert Sequence:

ATGGCCCTGT CCAATTCCAC AACTGTTCTG CCTTTTCTGG CCTCGCTGTG GCAGGAAACA 
GATGAGCCGG GTGGCAATAT GTCGGCGGAC TTGGCTCGTA GGTCCCAGCT CCGAGATGAC 
AGCAAGCTGG AGGCTCTCTA TATCCTCATG GTGCTGGGTT TCTTCGGCTT CTTCACCCTG 
GGCATCATGC TGAGTTACAT CCGATCCAAG AAGCTGGAAC ACTCGCACGA CCCTTTCAAC 
GTGTACATTG AGTCGGACGC CTGGCAGGAG AAAGGCAAGG CCCTCTTCCA GGCCCGCGTT 
CTGGAGAGCT TCAGAGCTTG CTATGTCATT GAAAACCAGG CGGCCGTAGA ACAACCTGCC 
ACACACCTTC CTGAACTGAA GCCACTGTCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcne1 ( XM_006248034.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006248096.1 Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), transcript variant X4, mRNA.

Price & Availability↑

CloneID	ORa34132
Clone ID Related Accession (Same CDS sequence)	XM_006248035.2 , XM_006248034.3 , XM_008768566.2 , XM_017597886.1 , XM_017597887.1
Accession Version	XM_006248034.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily E member 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005110.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006248034.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCCTGT CCAATTCCAC AACTGTTCTG CCTTTTCTGG CCTCGCTGTG GCAGGAAACA 
GATGAGCCGG GTGGCAATAT GTCGGCGGAC TTGGCTCGTA GGTCCCAGCT CCGAGATGAC 
AGCAAGCTGG AGGCTCTCTA TATCCTCATG GTGCTGGGTT TCTTCGGCTT CTTCACCCTG 
GGCATCATGC TGAGTTACAT CCGATCCAAG AAGCTGGAAC ACTCGCACGA CCCTTTCAAC 
GTGTACATTG AGTCGGACGC CTGGCAGGAG AAAGGCAAGG CCCTCTTCCA GGCCCGCGTT 
CTGGAGAGCT TCAGAGCTTG CTATGTCATT GAAAACCAGG CGGCCGTAGA ACAACCTGCC 
ACACACCTTC CTGAACTGAA GCCACTGTCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006248096.1
CDS	187..579
Translation	MALSNSTTVLPFLASLWQETDEPGGNMSADLARRSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKALFQARVLESFRACYVIENQAAVEQPATHLPELKPLS

Target ORF information:

RefSeq Version	XM_006248034.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006248034.3

ORF Insert Sequence:

ATGGCCCTGT CCAATTCCAC AACTGTTCTG CCTTTTCTGG CCTCGCTGTG GCAGGAAACA 
GATGAGCCGG GTGGCAATAT GTCGGCGGAC TTGGCTCGTA GGTCCCAGCT CCGAGATGAC 
AGCAAGCTGG AGGCTCTCTA TATCCTCATG GTGCTGGGTT TCTTCGGCTT CTTCACCCTG 
GGCATCATGC TGAGTTACAT CCGATCCAAG AAGCTGGAAC ACTCGCACGA CCCTTTCAAC 
GTGTACATTG AGTCGGACGC CTGGCAGGAG AAAGGCAAGG CCCTCTTCCA GGCCCGCGTT 
CTGGAGAGCT TCAGAGCTTG CTATGTCATT GAAAACCAGG CGGCCGTAGA ACAACCTGCC 
ACACACCTTC CTGAACTGAA GCCACTGTCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcne1 ( XM_008768566.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008766788.1 Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa34132
Clone ID Related Accession (Same CDS sequence)	XM_006248035.2 , XM_006248034.3 , XM_008768566.2 , XM_017597886.1 , XM_017597887.1
Accession Version	XM_008768566.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily E member 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005110.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008768566.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCCTGT CCAATTCCAC AACTGTTCTG CCTTTTCTGG CCTCGCTGTG GCAGGAAACA 
GATGAGCCGG GTGGCAATAT GTCGGCGGAC TTGGCTCGTA GGTCCCAGCT CCGAGATGAC 
AGCAAGCTGG AGGCTCTCTA TATCCTCATG GTGCTGGGTT TCTTCGGCTT CTTCACCCTG 
GGCATCATGC TGAGTTACAT CCGATCCAAG AAGCTGGAAC ACTCGCACGA CCCTTTCAAC 
GTGTACATTG AGTCGGACGC CTGGCAGGAG AAAGGCAAGG CCCTCTTCCA GGCCCGCGTT 
CTGGAGAGCT TCAGAGCTTG CTATGTCATT GAAAACCAGG CGGCCGTAGA ACAACCTGCC 
ACACACCTTC CTGAACTGAA GCCACTGTCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008766788.1
CDS	495..887
Translation	MALSNSTTVLPFLASLWQETDEPGGNMSADLARRSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKALFQARVLESFRACYVIENQAAVEQPATHLPELKPLS

Target ORF information:

RefSeq Version	XM_008768566.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008768566.2

ORF Insert Sequence:

ATGGCCCTGT CCAATTCCAC AACTGTTCTG CCTTTTCTGG CCTCGCTGTG GCAGGAAACA 
GATGAGCCGG GTGGCAATAT GTCGGCGGAC TTGGCTCGTA GGTCCCAGCT CCGAGATGAC 
AGCAAGCTGG AGGCTCTCTA TATCCTCATG GTGCTGGGTT TCTTCGGCTT CTTCACCCTG 
GGCATCATGC TGAGTTACAT CCGATCCAAG AAGCTGGAAC ACTCGCACGA CCCTTTCAAC 
GTGTACATTG AGTCGGACGC CTGGCAGGAG AAAGGCAAGG CCCTCTTCCA GGCCCGCGTT 
CTGGAGAGCT TCAGAGCTTG CTATGTCATT GAAAACCAGG CGGCCGTAGA ACAACCTGCC 
ACACACCTTC CTGAACTGAA GCCACTGTCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcne1 ( XM_017597886.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017453375.1 Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa34132
Clone ID Related Accession (Same CDS sequence)	XM_006248035.2 , XM_006248034.3 , XM_008768566.2 , XM_017597886.1 , XM_017597887.1
Accession Version	XM_017597886.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily E member 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005110.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCCTGT CCAATTCCAC AACTGTTCTG CCTTTTCTGG CCTCGCTGTG GCAGGAAACA 
GATGAGCCGG GTGGCAATAT GTCGGCGGAC TTGGCTCGTA GGTCCCAGCT CCGAGATGAC 
AGCAAGCTGG AGGCTCTCTA TATCCTCATG GTGCTGGGTT TCTTCGGCTT CTTCACCCTG 
GGCATCATGC TGAGTTACAT CCGATCCAAG AAGCTGGAAC ACTCGCACGA CCCTTTCAAC 
GTGTACATTG AGTCGGACGC CTGGCAGGAG AAAGGCAAGG CCCTCTTCCA GGCCCGCGTT 
CTGGAGAGCT TCAGAGCTTG CTATGTCATT GAAAACCAGG CGGCCGTAGA ACAACCTGCC 
ACACACCTTC CTGAACTGAA GCCACTGTCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017453375.1
CDS	489..881
Translation	MALSNSTTVLPFLASLWQETDEPGGNMSADLARRSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKALFQARVLESFRACYVIENQAAVEQPATHLPELKPLS

Target ORF information:

RefSeq Version	XM_017597886.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597886.1

ORF Insert Sequence:

ATGGCCCTGT CCAATTCCAC AACTGTTCTG CCTTTTCTGG CCTCGCTGTG GCAGGAAACA 
GATGAGCCGG GTGGCAATAT GTCGGCGGAC TTGGCTCGTA GGTCCCAGCT CCGAGATGAC 
AGCAAGCTGG AGGCTCTCTA TATCCTCATG GTGCTGGGTT TCTTCGGCTT CTTCACCCTG 
GGCATCATGC TGAGTTACAT CCGATCCAAG AAGCTGGAAC ACTCGCACGA CCCTTTCAAC 
GTGTACATTG AGTCGGACGC CTGGCAGGAG AAAGGCAAGG CCCTCTTCCA GGCCCGCGTT 
CTGGAGAGCT TCAGAGCTTG CTATGTCATT GAAAACCAGG CGGCCGTAGA ACAACCTGCC 
ACACACCTTC CTGAACTGAA GCCACTGTCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcne1 ( XM_017597887.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017453376.1 Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), transcript variant X5, mRNA.

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CloneID	ORa34132
Clone ID Related Accession (Same CDS sequence)	XM_006248035.2 , XM_006248034.3 , XM_008768566.2 , XM_017597886.1 , XM_017597887.1
Accession Version	XM_017597887.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily E member 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005110.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCCTGT CCAATTCCAC AACTGTTCTG CCTTTTCTGG CCTCGCTGTG GCAGGAAACA 
GATGAGCCGG GTGGCAATAT GTCGGCGGAC TTGGCTCGTA GGTCCCAGCT CCGAGATGAC 
AGCAAGCTGG AGGCTCTCTA TATCCTCATG GTGCTGGGTT TCTTCGGCTT CTTCACCCTG 
GGCATCATGC TGAGTTACAT CCGATCCAAG AAGCTGGAAC ACTCGCACGA CCCTTTCAAC 
GTGTACATTG AGTCGGACGC CTGGCAGGAG AAAGGCAAGG CCCTCTTCCA GGCCCGCGTT 
CTGGAGAGCT TCAGAGCTTG CTATGTCATT GAAAACCAGG CGGCCGTAGA ACAACCTGCC 
ACACACCTTC CTGAACTGAA GCCACTGTCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017453376.1
CDS	101..493
Translation	MALSNSTTVLPFLASLWQETDEPGGNMSADLARRSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKALFQARVLESFRACYVIENQAAVEQPATHLPELKPLS

Target ORF information:

RefSeq Version	XM_017597887.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 1 (Kcne1), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597887.1

ORF Insert Sequence:

ATGGCCCTGT CCAATTCCAC AACTGTTCTG CCTTTTCTGG CCTCGCTGTG GCAGGAAACA 
GATGAGCCGG GTGGCAATAT GTCGGCGGAC TTGGCTCGTA GGTCCCAGCT CCGAGATGAC 
AGCAAGCTGG AGGCTCTCTA TATCCTCATG GTGCTGGGTT TCTTCGGCTT CTTCACCCTG 
GGCATCATGC TGAGTTACAT CCGATCCAAG AAGCTGGAAC ACTCGCACGA CCCTTTCAAC 
GTGTACATTG AGTCGGACGC CTGGCAGGAG AAAGGCAAGG CCCTCTTCCA GGCCCGCGTT 
CTGGAGAGCT TCAGAGCTTG CTATGTCATT GAAAACCAGG CGGCCGTAGA ACAACCTGCC 
ACACACCTTC CTGAACTGAA GCCACTGTCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Adult Ventricular Myocytes Segregate KCNQ1 and KCNE1 to Keep the
Circulation. Arrhythmia and electrophysiology10(6)(2017 Jun)
Jiang M,Wang Y,Tseng GN

[Differentially expressed genes in the locus associated with relative kidney weight and resting blood pressure in hypertensive rats of the ISIAH strain].
Molekuliarnaia biologiia50(6)944-952(2016 Nov-Dec)
Redina OE,Smolenskaya SE,Fedoseeva LA,Markel AL

Millimeter wave promotes the synthesis of extracellular matrix and the proliferation of chondrocyte by regulating the voltage-gated K+ channel.
Journal of bone and mineral metabolism32(4)367-77(2014 Jul)
Li X,Liu C,Liang W,Ye H,Chen W,Lin R,Li Z,Liu X,Wu M

A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation.
Heart rhythm11(3)459-68(2014 Mar)
Bartos DC,Giudicessi JR,Tester DJ,Ackerman MJ,Ohno S,Horie M,Gollob MH,Burgess DE,Delisle BP

BACE1 and presenilin/?-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(6)2458-67(2013 Jun)
Sachse CC,Kim YH,Agsten M,Huth T,Alzheimer C,Kovacs DM,Kim DY

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Kcne1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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