Hrh2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hrh2
Entrez Gene ID	25461
Full Name	histamine receptor H 2
Synonyms	H2R
General protein information	Preferred Names histamine receptor H 2 Names histamine H2 receptor HH2R gastric receptor I
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17p14
Summary	G-protein coupled receptor for histamine [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008771486.2	XP_008769708.1	histamine H2 receptor isoform X1
NM_012965.3	NP_037097.3	histamine H2 receptor

Pathways from BioSystems

Homologies

Homo sapiens (human)	HRH2	NP_071640.1
	HRH2	XP_001082927.1
Mus musculus (house mouse)	Hrh2	NP_001010973.1
Gallus gallus (chicken)	HRH2	XP_004944962.1
Anopheles gambiae (African malaria mosquito)	GPRNNA3	XP_003436281.1
Rattus norvegicus (Norway rat)	Hrh2	NP_037097.3
Xenopus tropicalis (tropical clawed frog)	hrh2	XP_002938111.1
Pan troglodytes (chimpanzee)	HRH2	NP_001009124.1
Drosophila melanogaster (fruit fly)	Octbeta3R	NP_001034043.2
Canis lupus familiaris (dog)	HRH2	NP_001182773.1
Bos taurus (cattle)	LOC521257	XP_005211286.1
Danio rerio (zebrafish)	hrh2	NP_001038803.1

Gene Ontology
Bibliography

Related articles in PubMed

Disruption of histamine H2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis.
Zeng Z, Shen L, Li X, Luo T, Wei X, Zhang J, Cao S, Huang X, Fukushima Y, Bin J, Kitakaze M, Xu D, Liao Y
Clinical science (London, England : 1979)127(7)435-48(2014 Oct)

Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.
Kurtz KH, Moor AN, Souza-Smith FM, Breslin JW
Microcirculation (New York, N.Y. : 1994)21(7)593-605(2014 Oct)

CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.
Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT
Proceedings of the National Academy of Sciences of the United States of America110(24)9932-7(2013 Jun)

Identification of a novel family of G protein-coupled receptor associated sorting proteins.
Simonin F, Karcher P, Boeuf JJ, Matifas A, Kieffer BL
Journal of neurochemistry89(3)766-75(2004 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings indicate that histamine H1, H2, and H3 receptors are present in rat olfactory epithelium and may play a physiological role in olfactory transmission.
Title: Expression and localization of histamine H

Isolated rat mesenteric collecting lymphatics were treated with 1- to 100-muM histamine. Pharmacologic blockade of either H1 or H2 histamine receptors significantly inhibited the response to histamine.
Title: Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.

Na+-Ca2+ exchangers coupled to H1 receptors and hyperpolarization-activated cyclic nucleotide-gated channels linked to H2 receptors co-mediate the strong postsynaptic excitatory action of histamine on al vestibular nucleus neurons
Title: Postsynaptic mechanisms underlying the excitatory action of histamine on medial vestibular nucleus neurons in rats.

Histamine H2 receptors, unlike the H1 receptor type, do not mediate emotional memory consolidation impairment.
Title: Emotional memory consolidation impairment induced by histamine is mediated by H1 but not H2 receptors.

Data suggest histamine stimulates proliferation of Leydig tumor cells via activation of HRH2 and a transient increase in intracellular cAMP levels. Normal/immature Leydig cells and progenitor Leydig cells exhibit very low levels of HDC expression.
Title: Proliferative effect of histamine on MA-10 Leydig tumor cells mediated through HRH2 activation, transient elevation in cAMP production, and increased extracellular signal-regulated kinase phosphorylation levels.

The following Hrh2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hrh2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42656	NM_012965.3 Latest version!	Rattus norvegicus histamine receptor H 2 (Hrh2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa37679	XM_008771486.2 Latest version!	Rattus norvegicus histamine receptor H 2 (Hrh2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hrh2 ( NM_012965.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037097.3 Rattus norvegicus histamine receptor H 2 (Hrh2), mRNA.

Price & Availability↑

CloneID	ORa42656
Clone ID Related Accession (Same CDS sequence)	NM_012965.3
Accession Version	NM_012965.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1077bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	histamine H2 receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from S57565.1. On Apr 28, 2006 this sequence version replaced NM_012965.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGAGCCCA ATGGCACAGT TCATTCCTGC TGCTTGGACT CTATGGCATT GAAAGTCACC 
ATCAGTGTGG TCCTTACCAC GCTCATCCTC ATCACCATTG CTGGCAATGT GGTCGTCTGC 
CTGGCTGTCA GCTTGAACCG TCGGCTCCGC AGTCTGACCA ATTGCTTCAT TGTGTCCCTG 
GCAGCCACTG ACCTGCTTCT TGGACTCCTG GTGCTGCCCT TCTCTGCCAT TTACCAGCTG 
TCCTTCACGT GGAGTTTTGG CCACGTCTTC TGCAACATCT ACACCAGCTT GGATGTGATG 
CTCTGCACGG CCTCCATCCT CAACCTCTTC ATGATCAGCT TGGACCGCTA CTGCGCTGTC 
ACGGACCCAC TGCGGTACCC TGTGCTGGTC ACCCCAGTTC GAGTTGCCAT CTCTTTGGTC 
TTTATTTGGG TTATTTCTAT CACCCTATCC TTCCTCTCTA TTCACCTAGG ATGGAACAGC 
AGAAATGGGA CCAGAGGGGG CAATGACACC TTCAAGTGCA AAGTCCAGGT CAATGAGGTG 
TACGGACTGG TGGATGGGCT GGTCACCTTC TACCTGCCTC TTCTCATCAT GTGTGTCACT 
TACTACAGAA TCTTTAAGAT TGCCAGGGAG CAGGCCAAAC GGATCAACCA CATCAGCTCC 
TGGAAGGCAG CCACCATCAG AGAGCACAAA GCCACCGTGA CACTGGCAGC CGTCATGGGA 
GCGTTCATCA TCTGCTGGTT TCCTTACTTC ACTGCATTCG TTTACCGTGG GCTGAGAGGG 
GATGATGCCA TCAATGAGGC GGTCGAGGGC ATTGTCCTAT GGTTGGGCTA TGCCAATTCA 
GCCCTGAACC CCATCCTGTA CGCTGCTCTC AACAGAGACT TCCGCACGGC GTACCAACAG 
CTCTTCCACT GCAAGTTCGC AAGCCACAAC TCTCACAAAA CTTCCCTGAG GTTGAACAAC 
TCTCTGCTGC CCAGGAGCCA GAGCCGAGAA GGTAGATGGC AGGAGGAGAA GCCCTTGAAG 
CTCCAAGTGT GGAGTGGGAC AGAACTCACA CACCCCCAGG GAAACCCAAT CAGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037097.3
CDS	1..1077
Translation	MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFTWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQEEKPLKLQVWSGTELTHPQGNPIR

Target ORF information:

RefSeq Version	NM_012965.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus histamine receptor H 2 (Hrh2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012965.3

ORF Insert Sequence:

ATGGAGCCCA ATGGCACAGT TCATTCCTGC TGCTTGGACT CTATGGCATT GAAAGTCACC 
ATCAGTGTGG TCCTTACCAC GCTCATCCTC ATCACCATTG CTGGCAATGT GGTCGTCTGC 
CTGGCTGTCA GCTTGAACCG TCGGCTCCGC AGTCTGACCA ATTGCTTCAT TGTGTCCCTG 
GCAGCCACTG ACCTGCTTCT TGGACTCCTG GTGCTGCCCT TCTCTGCCAT TTACCAGCTG 
TCCTTCACGT GGAGTTTTGG CCACGTCTTC TGCAACATCT ACACCAGCTT GGATGTGATG 
CTCTGCACGG CCTCCATCCT CAACCTCTTC ATGATCAGCT TGGACCGCTA CTGCGCTGTC 
ACGGACCCAC TGCGGTACCC TGTGCTGGTC ACCCCAGTTC GAGTTGCCAT CTCTTTGGTC 
TTTATTTGGG TTATTTCTAT CACCCTATCC TTCCTCTCTA TTCACCTAGG ATGGAACAGC 
AGAAATGGGA CCAGAGGGGG CAATGACACC TTCAAGTGCA AAGTCCAGGT CAATGAGGTG 
TACGGACTGG TGGATGGGCT GGTCACCTTC TACCTGCCTC TTCTCATCAT GTGTGTCACT 
TACTACAGAA TCTTTAAGAT TGCCAGGGAG CAGGCCAAAC GGATCAACCA CATCAGCTCC 
TGGAAGGCAG CCACCATCAG AGAGCACAAA GCCACCGTGA CACTGGCAGC CGTCATGGGA 
GCGTTCATCA TCTGCTGGTT TCCTTACTTC ACTGCATTCG TTTACCGTGG GCTGAGAGGG 
GATGATGCCA TCAATGAGGC GGTCGAGGGC ATTGTCCTAT GGTTGGGCTA TGCCAATTCA 
GCCCTGAACC CCATCCTGTA CGCTGCTCTC AACAGAGACT TCCGCACGGC GTACCAACAG 
CTCTTCCACT GCAAGTTCGC AAGCCACAAC TCTCACAAAA CTTCCCTGAG GTTGAACAAC 
TCTCTGCTGC CCAGGAGCCA GAGCCGAGAA GGTAGATGGC AGGAGGAGAA GCCCTTGAAG 
CTCCAAGTGT GGAGTGGGAC AGAACTCACA CACCCCCAGG GAAACCCAAT CAGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hrh2 ( XM_008771486.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008769708.1 Rattus norvegicus histamine receptor H 2 (Hrh2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa37679
Clone ID Related Accession (Same CDS sequence)	XM_008771486.2
Accession Version	XM_008771486.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1242bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	histamine H2 receptor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005116.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008771486.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCCA ATGGCACAGT TCATTCCTGC TGCTTGGACT CTATGGCATT GAAAGTCACC 
ATCAGTGTGG TCCTTACCAC GCTCATCCTC ATCACCATTG CTGGCAATGT GGTCGTCTGC 
CTGGCTGTCA GCTTGAACCG TCGGCTCCGC AGTCTGACCA ATTGCTTCAT TGTGTCCCTG 
GCAGCCACTG ACCTGCTTCT TGGACTCCTG GTGCTGCCCT TCTCTGCCAT TTACCAGCTG 
TCCTTCAAGT GGAGTTTTGG CCACGTCTTC TGCAACATCT ACACCAGCTT GGATGTGATG 
CTCTGCACGG CCTCCATCCT CAACCTCTTC ATGATCAGCT TGGACCGCTA CTGCGCTGTC 
ACGGACCCAC TGCGGTACCC TGTGCTGGTC ACCCCAGTTC GAGTTGCCAT CTCTTTGGTC 
TTTATTTGGG TTATTTCTAT CACCCTATCC TTCCTCTCTA TTCACCTAGG ATGGAACAGC 
AGAAATGGGA CCAGAGGGGG CAATGACACC TTCAAGTGCA AAGTCCAGGT CAATGAGGTG 
TACGGACTGG TGGATGGGCT GGTCACCTTC TACCTGCCTC TTCTCATCAT GTGTGTCACT 
TACTACAGAA TCTTTAAGAT TGCCAGGGAG CAGGCCAAAC GGATCAACCA CATCAGCTCC 
TGGAAGGCAG CCACCATCAG AGAGCACAAA GCCACCGTGA CACTGGCGGC CGTCATGGGA 
GCGTTCATCA TCTGCTGGTT TCCTTACTTC ACTGCATTCG TTTACCGTGG GCTGAGAGGG 
GATGATGCCA TCAATGAGGC GGTCGAGGGC ATTGTCCTAT GGTTGGGCTA TGCCAATTCA 
GCCCTGAACC CCATCCTGTA CGCTGCTCTC AACAGAGACT TCCGCACGGC GTACCAACAG 
CTCTTCCACT GCAAGTTCGC AAGCCACAAC TCTCACAAAA CTTCCCTGAG GTTGAACAAC 
TCTCTGCTGC CCAGGAGCCA GAGCCGAGAA GGTAGATGGC AGGAGGAGAA GCCCTTGAAG 
CTCCAAGTGT GGAGTGGGAC AGAACTCACA CACCCCCAGG GAAACCCAAT CAGATTGTGC 
CTCTCCCCTG GCCTCTCTCT AAGACAGGCC AGCAGACACT GCCTTCCCAG GACCTGGGAA 
GAGATGAAAG GGCCGCCAAC TTGTCAACTT TCACCTTTAG GAAAAAAGAC TTCACCCAGG 
GAGCAGACAC ACCATGATGT CACAGATGAA GGAAAACCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008769708.1
CDS	1329..2570
Translation	MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFKWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQEEKPLKLQVWSGTELTHPQGNPIRLCLSPGLSLRQASRHCLPRTWEEMKGPPTCQLSPLGKKTSPREQTHHDVTDEGKP

Target ORF information:

RefSeq Version	XM_008771486.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus histamine receptor H 2 (Hrh2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008771486.2

ORF Insert Sequence:

ATGGAGCCCA ATGGCACAGT TCATTCCTGC TGCTTGGACT CTATGGCATT GAAAGTCACC 
ATCAGTGTGG TCCTTACCAC GCTCATCCTC ATCACCATTG CTGGCAATGT GGTCGTCTGC 
CTGGCTGTCA GCTTGAACCG TCGGCTCCGC AGTCTGACCA ATTGCTTCAT TGTGTCCCTG 
GCAGCCACTG ACCTGCTTCT TGGACTCCTG GTGCTGCCCT TCTCTGCCAT TTACCAGCTG 
TCCTTCAAGT GGAGTTTTGG CCACGTCTTC TGCAACATCT ACACCAGCTT GGATGTGATG 
CTCTGCACGG CCTCCATCCT CAACCTCTTC ATGATCAGCT TGGACCGCTA CTGCGCTGTC 
ACGGACCCAC TGCGGTACCC TGTGCTGGTC ACCCCAGTTC GAGTTGCCAT CTCTTTGGTC 
TTTATTTGGG TTATTTCTAT CACCCTATCC TTCCTCTCTA TTCACCTAGG ATGGAACAGC 
AGAAATGGGA CCAGAGGGGG CAATGACACC TTCAAGTGCA AAGTCCAGGT CAATGAGGTG 
TACGGACTGG TGGATGGGCT GGTCACCTTC TACCTGCCTC TTCTCATCAT GTGTGTCACT 
TACTACAGAA TCTTTAAGAT TGCCAGGGAG CAGGCCAAAC GGATCAACCA CATCAGCTCC 
TGGAAGGCAG CCACCATCAG AGAGCACAAA GCCACCGTGA CACTGGCGGC CGTCATGGGA 
GCGTTCATCA TCTGCTGGTT TCCTTACTTC ACTGCATTCG TTTACCGTGG GCTGAGAGGG 
GATGATGCCA TCAATGAGGC GGTCGAGGGC ATTGTCCTAT GGTTGGGCTA TGCCAATTCA 
GCCCTGAACC CCATCCTGTA CGCTGCTCTC AACAGAGACT TCCGCACGGC GTACCAACAG 
CTCTTCCACT GCAAGTTCGC AAGCCACAAC TCTCACAAAA CTTCCCTGAG GTTGAACAAC 
TCTCTGCTGC CCAGGAGCCA GAGCCGAGAA GGTAGATGGC AGGAGGAGAA GCCCTTGAAG 
CTCCAAGTGT GGAGTGGGAC AGAACTCACA CACCCCCAGG GAAACCCAAT CAGATTGTGC 
CTCTCCCCTG GCCTCTCTCT AAGACAGGCC AGCAGACACT GCCTTCCCAG GACCTGGGAA 
GAGATGAAAG GGCCGCCAAC TTGTCAACTT TCACCTTTAG GAAAAAAGAC TTCACCCAGG 
GAGCAGACAC ACCATGATGT CACAGATGAA GGAAAACCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Disruption of histamine H2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis.
Clinical science (London, England : 1979)127(7)435-48(2014 Oct)
Zeng Z,Shen L,Li X,Luo T,Wei X,Zhang J,Cao S,Huang X,Fukushima Y,Bin J,Kitakaze M,Xu D,Liao Y

Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.
Microcirculation (New York, N.Y. : 1994)21(7)593-605(2014 Oct)
Kurtz KH,Moor AN,Souza-Smith FM,Breslin JW

CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.
Proceedings of the National Academy of Sciences of the United States of America110(24)9932-7(2013 Jun)
Slater LH,Hett EC,Clatworthy AE,Mark KG,Hung DT

Identification of a novel family of G protein-coupled receptor associated sorting proteins.
Journal of neurochemistry89(3)766-75(2004 May)
Simonin F,Karcher P,Boeuf JJ,Matifas A,Kieffer BL

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Hrh2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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