Hmmr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hmmr
Entrez Gene ID	25460
Full Name	hyaluronan-mediated motility receptor
Synonyms	RHAMM
General protein information	Preferred Names hyaluronan-mediated motility receptor Names hyaluronan-mediated motility receptor intracellular hyaluronic acid-binding protein receptor for hyaluronan-mediated motility
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q12
Summary	binds hyaluronan; may play a role in ceell signaling and regulation of the cytoskeleton in the central nervous system [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012964.2	NP_037096.2	hyaluronan-mediated motility receptor

Pathways from BioSystems

Homologies

Homo sapiens (human)	HMMR	NP_001136028.1
	HMMR	XP_001088518.1
Canis lupus familiaris (dog)	HMMR	XP_854651.2
Bos taurus (cattle)	HMMR	NP_001193550.1
Gallus gallus (chicken)	HMMR	XP_414495.4
Pan troglodytes (chimpanzee)	HMMR	XP_001145921.2
Mus musculus (house mouse)	Hmmr	NP_038580.2
Danio rerio (zebrafish)	hmmr	NP_955874.1
Xenopus tropicalis (tropical clawed frog)	hmmr	XP_002935941.1
Rattus norvegicus (Norway rat)	Hmmr	NP_037096.2

Gene Ontology
Bibliography

Related articles in PubMed

Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis.
Bahrami SB, Tolg C, Peart T, Symonette C, Veiseh M, Umoh JU, Holdsworth DW, McCarthy JB, Luyt LG, Bissell MJ, Yazdani A, Turley EA
Integrative biology : quantitative biosciences from nano to macro9(3)223-237(2017 Mar)

Temporal expression of hyaluronic acid and hyaluronic acid receptors in a porcine small intestinal submucosa-augmented rat bladder regeneration model.
Mondalek FG, Fung KM, Yang Q, Wu W, Lu W, Palmer BW, Frimberger DC, Greenwood-Van Meerveld B, Hurst RE, Kropp BP, Lin HK
World journal of urology33(8)1119-28(2015 Aug)

Loss of the hyaluronan receptor RHAMM prevents constrictive artery wall remodeling.
Ma X, Pearce JD, Wilson DB, English WP, Edwards MS, Geary RL
Journal of vascular surgery59(3)804-13(2014 Mar)

Rear polarization of the microtubule-organizing center in neointimal smooth muscle cells depends on PKC?, ARPC5, and RHAMM.
Silverman-Gavrila R, Silverman-Gavrila L, Hou G, Zhang M, Charlton M, Bendeck MP
The American journal of pathology178(2)895-910(2011 Feb)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Blocking RHAMM function by peptide injection or topical application is a novel and minimally invasive method for potentially promoting subcutaneous adipogenesis in lipodystrophic diseases and a complementary tool to subcutaneous fat augmentation techniques.
Title: Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis.

RHAMM mRNA increased over the course of bladder regeneration.
Title: Temporal expression of hyaluronic acid and hyaluronic acid receptors in a porcine small intestinal submucosa-augmented rat bladder regeneration model.

RHAMM and hyaluronic acid mediate smooth muscle cell interactions with collagen and changes in SMC shape, polarity, and movement.
Title: Loss of the hyaluronan receptor RHAMM prevents constrictive artery wall remodeling.

Both ARPC5 and RHAMM, in addition to PKC, were required for migration of neointimal smooth muscle cells.
Title: Rear polarization of the microtubule-organizing center in neointimal smooth muscle cells depends on PKC?, ARPC5, and RHAMM.

The interaction of RHAMM with hyaluronic acid is a critical component of the recruitment of inflammatory cells to the lung after injury.
Title: Expression and role of the hyaluronan receptor RHAMM in inflammation after bleomycin injury.

The following Hmmr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hmmr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13220	NM_012964.2 Latest version!	Rattus norvegicus hyaluronan-mediated motility receptor (Hmmr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$419.30 $599.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hmmr ( NM_012964.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037096.2 Rattus norvegicus hyaluronan-mediated motility receptor (Hmmr), mRNA.

Price & Availability↑

CloneID	ORa13220
Clone ID Related Accession (Same CDS sequence)	NM_012964.2
Accession Version	NM_012964.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2142bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	hyaluronan-mediated motility receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF336825.1. On May 6, 2004 this sequence version replaced NM_012964.1. ##Evidence-Data-START## Transcript exon combination :: AF133037.1, AF336825.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCCTTCC CTAAGGCGCC CCTGAAAAGA TTCAATGACC CTTCGGGTTG TGCTCCATCT 
CCAGGTGCTT ACGATGTTAA AACTTCAGAA TCAACTAAAG GACCAGTGTC TTTTCAGAAA 
TCACAAAGAT TTAAAAACCA AAGAGAGTCT CAACAAAATC TTAACATTGA CAAAGATACG 
ACCTTGCTTG CTTCTGCTAA AAAAGCAAAG ACGTTGGTGT CAAAGAAGGA GTCTCAGAAG 
AATGATAAAG ATGTGAAGAG ATTAGAAAAA GAGATTCATG TTCTTTTGCA AGAACGAGGG 
ACTCAGGACA AACGGATCCA GGACATGGAG TCTGAGTTGG AGAATACAGA AGCCAATCTA 
AATGCACCAG TCACAGAGAA ACCATCTCTG TCTGCCAATA ATGCTTCACT GGAAAAACGG 
CTTACTGAGC TGACCAGAGC CAACGAGCTC CTAAAGTCTA AGTTTTCTGA AGATGCTCAC 
CAAAAGAATA TGAGAACTCT AAGCCTGGAA TTGATGAAAC TGAGAAATAA GAGAGAGACA 
AAGATGAGGA GCATGATGGC TAAACAGGAA GGCATGGAGC TGAAGCTGCA GGCCACTCAG 
AAGGACCTCA TTGAGTCTAA GGGGAAAATA GTACAGCTGG AGGGAAAACT TGTTTCAATA 
GAGAAAGAAA AGATCGATGA AAAATCTGAA ACAGAAAAAC TCTTAGAATA CATAGAAGAA 
ATTAGCTGTG CATCTGATCA AGTGGAAAAA TACAAACTAG ATATTGCCCA GTTAGAAGAA 
GATTTGAAAG AGAAGGATCG TGAGATTTTA TGCCTTAAGC AATCTCTTGA GGAAAAGGTT 
TCCTTTTCTA AGCAAATAGA AGACCTGACT GTTAAATGTC AGCTGCTTGA AGCAGAAAGA 
GATGATCTCG TCAGCAAGGA CAGAGAAAGG GCTGAAAGCC TCAGTGCTGA GATGCAGGTT 
CTAACAGAGA AGCTGCTTCT AGAAAGGCAA GAATATGAAA AGCTGCAACA AAATGAATTG 
CAAAGCCAGT CACTTCTGCA GCAAGAAAAG GAACTGTCTG CTCATCTTCA GCAGCAGCTC 
TGCTCATTTC AAGAGGAAAT GACCTCCGAG AGGAATGTCT TTAAAGAACA GTTGAAGCTT 
GCCCTGGATG AGCTGGATGC CGTCCAGCAG AAAAAGGAGC AGAGTGAAAA GCTGGTTAAA 
CAGCTAGAAG AGGAAACGAA GTCAACTGCG GAACAGCTGA GGCGGCTGGA TGATCTGCTG 
AGAGAGAAAG AAATTGAACT GGAGAAAAGA ACCGCTGCAC ATGCCCAGGC CACTGTGATT 
GCGCAAGAGA AGTACAGTGA CACAGCGCAG ACTCTGAGAG ATGTTACTGC TCAGTTAGAA 
AGCTATAAGT CATCAACACT TAAAGAAATA GAAGATCTTA AACTGGAGAA TTTGACTCTA 
CAAGAAAAAG TAGCCATGGC TGAGAAAAGG GTAGAAGATG TTCAACAACA AATATTAACA 
GCTGAGAGCA CAAATCAGGA ATATGCAAAG GTGGTTCAAG ATTTGCAGAA CAGCTCAACA 
TTGAAAGAAG CAGAAATTAA AGAAATCACA TCTTCATATC TTGAGAAAAT AACTGATTTG 
CAAAATCAAC TCCGACAACA AAATGAAGAC TTTAGGAAGC AGCTGGAAGA GGAAGGGGCA 
AAAATGACAG AGAAAGAAAC TGCAGTGACA GAATTAACCA TGGAAATTAA TAAATGGCGT 
CTCCTATATG AAGAACTGTT TGACAAAACT AAACCTTTTC AGCAACAACT GGATGCCTTC 
GAAGCAGAGA AGCAGGCACT GTTGAATGAA CATGGTGCAA CTCAGGAGCA GCTAAGTAAA 
ATCAGAGACT CCTACGCACA GCTGCTTGGC CACCAGAATC TGAAGCAAAA AATCAAACAT 
GTCGTGAAAT TGAAAGATGA AAATAGCCAG CTCAAATCGG AGGTGTCAAA ACTCCGATCT 
CAGCTTGCTA AAAGGAAACA AAATGAGCTC AGACTTCAGG GAGAATTAGA TAAAGCTCTG 
GGCATCAGGC ACTTTGACCC TTCTAAGGCT TTTTGCCATG AATCTAAGGA GAATGTGACC 
CTCAAGACTC CATTGAAAGA AGGCAACCCG AACTGCTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037096.2
CDS	25..2166
Translation	MSFPKAPLKRFNDPSGCAPSPGAYDVKTSESTKGPVSFQKSQRFKNQRESQQNLNIDKDTTLLASAKKAKTLVSKKESQKNDKDVKRLEKEIHVLLQERGTQDKRIQDMESELENTEANLNAPVTEKPSLSANNASLEKRLTELTRANELLKSKFSEDAHQKNMRTLSLELMKLRNKRETKMRSMMAKQEGMELKLQATQKDLIESKGKIVQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEEDLKEKDREILCLKQSLEEKVSFSKQIEDLTVKCQLLEAERDDLVSKDRERAESLSAEMQVLTEKLLLERQEYEKLQQNELQSQSLLQQEKELSAHLQQQLCSFQEEMTSERNVFKEQLKLALDELDAVQQKKEQSEKLVKQLEEETKSTAEQLRRLDDLLREKEIELEKRTAAHAQATVIAQEKYSDTAQTLRDVTAQLESYKSSTLKEIEDLKLENLTLQEKVAMAEKRVEDVQQQILTAESTNQEYAKVVQDLQNSSTLKEAEIKEITSSYLEKITDLQNQLRQQNEDFRKQLEEEGAKMTEKETAVTELTMEINKWRLLYEELFDKTKPFQQQLDAFEAEKQALLNEHGATQEQLSKIRDSYAQLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRSQLAKRKQNELRLQGELDKALGIRHFDPSKAFCHESKENVTLKTPLKEGNPNCC

Target ORF information:

RefSeq Version	NM_012964.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus hyaluronan-mediated motility receptor (Hmmr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012964.2

ORF Insert Sequence:

ATGTCCTTCC CTAAGGCGCC CCTGAAAAGA TTCAATGACC CTTCGGGTTG TGCTCCATCT 
CCAGGTGCTT ACGATGTTAA AACTTCAGAA TCAACTAAAG GACCAGTGTC TTTTCAGAAA 
TCACAAAGAT TTAAAAACCA AAGAGAGTCT CAACAAAATC TTAACATTGA CAAAGATACG 
ACCTTGCTTG CTTCTGCTAA AAAAGCAAAG ACGTTGGTGT CAAAGAAGGA GTCTCAGAAG 
AATGATAAAG ATGTGAAGAG ATTAGAAAAA GAGATTCATG TTCTTTTGCA AGAACGAGGG 
ACTCAGGACA AACGGATCCA GGACATGGAG TCTGAGTTGG AGAATACAGA AGCCAATCTA 
AATGCACCAG TCACAGAGAA ACCATCTCTG TCTGCCAATA ATGCTTCACT GGAAAAACGG 
CTTACTGAGC TGACCAGAGC CAACGAGCTC CTAAAGTCTA AGTTTTCTGA AGATGCTCAC 
CAAAAGAATA TGAGAACTCT AAGCCTGGAA TTGATGAAAC TGAGAAATAA GAGAGAGACA 
AAGATGAGGA GCATGATGGC TAAACAGGAA GGCATGGAGC TGAAGCTGCA GGCCACTCAG 
AAGGACCTCA TTGAGTCTAA GGGGAAAATA GTACAGCTGG AGGGAAAACT TGTTTCAATA 
GAGAAAGAAA AGATCGATGA AAAATCTGAA ACAGAAAAAC TCTTAGAATA CATAGAAGAA 
ATTAGCTGTG CATCTGATCA AGTGGAAAAA TACAAACTAG ATATTGCCCA GTTAGAAGAA 
GATTTGAAAG AGAAGGATCG TGAGATTTTA TGCCTTAAGC AATCTCTTGA GGAAAAGGTT 
TCCTTTTCTA AGCAAATAGA AGACCTGACT GTTAAATGTC AGCTGCTTGA AGCAGAAAGA 
GATGATCTCG TCAGCAAGGA CAGAGAAAGG GCTGAAAGCC TCAGTGCTGA GATGCAGGTT 
CTAACAGAGA AGCTGCTTCT AGAAAGGCAA GAATATGAAA AGCTGCAACA AAATGAATTG 
CAAAGCCAGT CACTTCTGCA GCAAGAAAAG GAACTGTCTG CTCATCTTCA GCAGCAGCTC 
TGCTCATTTC AAGAGGAAAT GACCTCCGAG AGGAATGTCT TTAAAGAACA GTTGAAGCTT 
GCCCTGGATG AGCTGGATGC CGTCCAGCAG AAAAAGGAGC AGAGTGAAAA GCTGGTTAAA 
CAGCTAGAAG AGGAAACGAA GTCAACTGCG GAACAGCTGA GGCGGCTGGA TGATCTGCTG 
AGAGAGAAAG AAATTGAACT GGAGAAAAGA ACCGCTGCAC ATGCCCAGGC CACTGTGATT 
GCGCAAGAGA AGTACAGTGA CACAGCGCAG ACTCTGAGAG ATGTTACTGC TCAGTTAGAA 
AGCTATAAGT CATCAACACT TAAAGAAATA GAAGATCTTA AACTGGAGAA TTTGACTCTA 
CAAGAAAAAG TAGCCATGGC TGAGAAAAGG GTAGAAGATG TTCAACAACA AATATTAACA 
GCTGAGAGCA CAAATCAGGA ATATGCAAAG GTGGTTCAAG ATTTGCAGAA CAGCTCAACA 
TTGAAAGAAG CAGAAATTAA AGAAATCACA TCTTCATATC TTGAGAAAAT AACTGATTTG 
CAAAATCAAC TCCGACAACA AAATGAAGAC TTTAGGAAGC AGCTGGAAGA GGAAGGGGCA 
AAAATGACAG AGAAAGAAAC TGCAGTGACA GAATTAACCA TGGAAATTAA TAAATGGCGT 
CTCCTATATG AAGAACTGTT TGACAAAACT AAACCTTTTC AGCAACAACT GGATGCCTTC 
GAAGCAGAGA AGCAGGCACT GTTGAATGAA CATGGTGCAA CTCAGGAGCA GCTAAGTAAA 
ATCAGAGACT CCTACGCACA GCTGCTTGGC CACCAGAATC TGAAGCAAAA AATCAAACAT 
GTCGTGAAAT TGAAAGATGA AAATAGCCAG CTCAAATCGG AGGTGTCAAA ACTCCGATCT 
CAGCTTGCTA AAAGGAAACA AAATGAGCTC AGACTTCAGG GAGAATTAGA TAAAGCTCTG 
GGCATCAGGC ACTTTGACCC TTCTAAGGCT TTTTGCCATG AATCTAAGGA GAATGTGACC 
CTCAAGACTC CATTGAAAGA AGGCAACCCG AACTGCTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis.
Integrative biology : quantitative biosciences from nano to macro9(3)223-237(2017 Mar)
Bahrami SB,Tolg C,Peart T,Symonette C,Veiseh M,Umoh JU,Holdsworth DW,McCarthy JB,Luyt LG,Bissell MJ,Yazdani A,Turley EA

Temporal expression of hyaluronic acid and hyaluronic acid receptors in a porcine small intestinal submucosa-augmented rat bladder regeneration model.
World journal of urology33(8)1119-28(2015 Aug)
Mondalek FG,Fung KM,Yang Q,Wu W,Lu W,Palmer BW,Frimberger DC,Greenwood-Van Meerveld B,Hurst RE,Kropp BP,Lin HK

Loss of the hyaluronan receptor RHAMM prevents constrictive artery wall remodeling.
Journal of vascular surgery59(3)804-13(2014 Mar)
Ma X,Pearce JD,Wilson DB,English WP,Edwards MS,Geary RL

Rear polarization of the microtubule-organizing center in neointimal smooth muscle cells depends on PKC?, ARPC5, and RHAMM.
The American journal of pathology178(2)895-910(2011 Feb)
Silverman-Gavrila R,Silverman-Gavrila L,Hou G,Zhang M,Charlton M,Bendeck MP

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

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Hmmr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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