Drd4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Drd4
Entrez Gene ID	25432
Full Name	dopamine receptor D4
Synonyms	D4RA
General protein information	Preferred Names dopamine receptor D4 Names D(4) dopamine receptor d(2C) dopamine receptor dopamine D4 receptor dopamine receptor 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q41
Summary	may play a role in exploratory behavior and motor coordination; may be involved in lesion induced hyperactivity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006230521.2	XP_006230583.1	D(4) dopamine receptor isoform X1
NM_012944.2	NP_037076.2	D(4) dopamine receptor
XM_006230522.2	XP_006230584.1	D(4) dopamine receptor isoform X2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	DRD4	NP_001136321.1
Danio rerio (zebrafish)	drd4a	NP_001012634.1
	DRD4	XP_001087197.1
Rattus norvegicus (Norway rat)	Drd4	NP_037076.1
Danio rerio (zebrafish)	drd4b	NP_001012636.1
Mus musculus (house mouse)	Drd4	NP_031904.1
Anopheles gambiae (African malaria mosquito)	GPRDOP3	XP_003436820.1
Homo sapiens (human)	DRD4	NP_000788.2
Xenopus tropicalis (tropical clawed frog)	drd4	XP_002937535.2

Gene Ontology
Bibliography

Related articles in PubMed

Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder.
Chawla A, Cordner ZA, Boersma G, Moran TH
Physiology & behavior18078-90(2017 Oct)

Activation of type 4 dopaminergic receptors in the prelimbic area of medial prefrontal cortex is necessary for the expression of innate fear behavior.
Vergara MD, Keller VN, Fuentealba JA, Gysling K
Behavioural brain research324130-137(2017 05)

Palmitoylation of the carboxyl-terminal tail of dopamine D
Zhang X, Kim KM
Biochemical and biophysical research communications479(2)398-403(2016 Oct)

Elucidating the role of D4 receptors in mediating attributions of salience to incentive stimuli on Pavlovian conditioned approach and conditioned reinforcement paradigms.
Cocker PJ, Vonder Haar C, Winstanley CA
Behavioural brain research31255-63(2016 10)

Activation of dopamine D4 receptors within the anterior cingulate cortex enhances the erroneous expectation of reward on a rat slot machine task.
Cocker PJ, Hosking JG, Murch WS, Clark L, Winstanley CA
Neuropharmacology105186-195(2016 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Dopamine D4 receptor (D4R) antagonism in the prelimbic area (PL) decreases the expression of innate fear-behavior indicating that the activation of D4R in the PL is necessary for the expression of innate fear-behavior.
Title: Activation of type 4 dopaminergic receptors in the prelimbic area of medial prefrontal cortex is necessary for the expression of innate fear behavior.

Data provide novel evidence that the dopamine D4 receptor does not alter incentive motivation in response to cues on simple behavioural tasks.
Title: Elucidating the role of D4 receptors in mediating attributions of salience to incentive stimuli on Pavlovian conditioned approach and conditioned reinforcement paradigms.

Data indicate that the anterior cingulate cortex is critically involved in parsing the appropriate response when competing stimulus-outcome associations are activated, and that signalling via dopamine D4 receptors may play a particularly important role in gating the temporal and spatial summation of salient events.
Title: Activation of dopamine D4 receptors within the anterior cingulate cortex enhances the erroneous expectation of reward on a rat slot machine task.

Regulatory role of the D(4) receptor on AT(1a) receptor expression and function in VSMCs and suggest that targeting the action of the D(4) receptor may represent an effective therapeutic approach for the treatment of cardiovascular diseases.
Title: Activation of the D4 dopamine receptor attenuates proliferation and migration of vascular smooth muscle cells through downregulation of AT1a receptor expression.

Activation of DRD4 receptors suppresses the proliferation and migration of vascular smooth muscle cells, thereby inhibiting atherosclerosis via reducing the effects of insulin on artery remodeling.
Title: Dopamine D? receptors inhibit proliferation and migration of vascular smooth muscle cells induced by insulin via down-regulation of insulin receptor expression.

The following Drd4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Drd4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa23592	XM_006230522.2 Latest version!	Rattus norvegicus dopamine receptor D4 (Drd4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa43112	NM_012944.2 Latest version!	Rattus norvegicus dopamine receptor D4 (Drd4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
ORa23591	XM_006230521.2 Latest version!	Rattus norvegicus dopamine receptor D4 (Drd4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Drd4 ( XM_006230522.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006230584.1 Rattus norvegicus dopamine receptor D4 (Drd4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa23592
Clone ID Related Accession (Same CDS sequence)	XM_006230522.2
Accession Version	XM_006230522.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1086bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	D(4) dopamine receptor isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006230522.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGAACA GCAGCGCTAC TGGTGACGGT GGGCTGTTGG CCGGGCGTGG GCCAGAGTCC 
TTAGGGAACT CGCTCGTTTG CGTGAGCGTG GCCTCCGAGC GCATCCTGCA GACACCCACC 
AACTACTTCA TCGTGAGCCT GGCGGCTGCC GACCTCCTCC TCGCGGTGCT GGTGTTGCCT 
CTCTTTGTCT ACTCCGAGGT CCAGGGTGGC GTGTGGCTGC TGAGCCCCCG CCTCTGTGAC 
ACCCTCATGG CCATGGACGT CATGCTGTGC ACCGCCTCCA TCTTCAACCT GTGCGCCATC 
AGCGTGGACA GGTTTGTGGC TGTGACCGTG CCACTGCGCT ACAACCAGCA GGGTCAGTGC 
CAGCTGCTGC TCATCGCCGC CACGTGGCTG CTGTCTGCCG CGGTGGCTGC GCCCGTCGTG 
TGCGGCCTCA ATGATGTGCC CGGTCGCGAT CCAACCGTGT GCTGCCTGGA GGACCGCGAC 
TACGTGGTCT ACTCATCCAT TTGTTCCTTC TTCCTGCCCT GTCCGCTCAT GCTACTGCTT 
TACTGGGCCA CTTTCCGTGG CTTGCGGCGC TGGGAGGCAG CCCGGCACAC CAAGCTTCAC 
AGCCGCGCGC CGCGCCGACC CAGCGGCCCG GGCCCGCCGG TGTCGGACCC TACTCAGGGT 
CCCCTCTTCT CAGATTGTCC GCCTCCCTCA CCCAGCCTCC GGACGAGCCC CACCGTCTCC 
AGCAGACCAG AGTCAGACCT CTCTCAGAGC CCCTGCAGCC CCGGGTGTCT GCTCCCTGAT 
GCAGCGCTCG CGCAACCGCC TGCGCCGTCT TCCCGCAGAA AGAGAGGCGC CAAGATCACT 
GGAAGGGAGC GCAAGGCGAT GAGAGTCCTG CCGGTGGTAG TTGGGGCCTT CCTGATGTGT 
TGGACGCCTT TCTTCGTGGT GCACATCACA CGGGCGCTGT GTCCGGCTTG TTTCGTGTCC 
CCACGCCTGG TCAGTGCTGT CACCTGGCTG GGCTATGTCA ACAGTGCCCT CAACCCCATC 
ATCTACACCA TCTTCAATGC CGAGTTTCGA AGTGTCTTCC GCAAGACTCT TCGTCTCCGC 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006230584.1
CDS	24..1109
Translation	MGNSSATGDGGLLAGRGPESLGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC

Target ORF information:

RefSeq Version	XM_006230522.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus dopamine receptor D4 (Drd4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006230522.2

ORF Insert Sequence:

ATGGGGAACA GCAGCGCTAC TGGTGACGGT GGGCTGTTGG CCGGGCGTGG GCCAGAGTCC 
TTAGGGAACT CGCTCGTTTG CGTGAGCGTG GCCTCCGAGC GCATCCTGCA GACACCCACC 
AACTACTTCA TCGTGAGCCT GGCGGCTGCC GACCTCCTCC TCGCGGTGCT GGTGTTGCCT 
CTCTTTGTCT ACTCCGAGGT CCAGGGTGGC GTGTGGCTGC TGAGCCCCCG CCTCTGTGAC 
ACCCTCATGG CCATGGACGT CATGCTGTGC ACCGCCTCCA TCTTCAACCT GTGCGCCATC 
AGCGTGGACA GGTTTGTGGC TGTGACCGTG CCACTGCGCT ACAACCAGCA GGGTCAGTGC 
CAGCTGCTGC TCATCGCCGC CACGTGGCTG CTGTCTGCCG CGGTGGCTGC GCCCGTCGTG 
TGCGGCCTCA ATGATGTGCC CGGTCGCGAT CCAACCGTGT GCTGCCTGGA GGACCGCGAC 
TACGTGGTCT ACTCATCCAT TTGTTCCTTC TTCCTGCCCT GTCCGCTCAT GCTACTGCTT 
TACTGGGCCA CTTTCCGTGG CTTGCGGCGC TGGGAGGCAG CCCGGCACAC CAAGCTTCAC 
AGCCGCGCGC CGCGCCGACC CAGCGGCCCG GGCCCGCCGG TGTCGGACCC TACTCAGGGT 
CCCCTCTTCT CAGATTGTCC GCCTCCCTCA CCCAGCCTCC GGACGAGCCC CACCGTCTCC 
AGCAGACCAG AGTCAGACCT CTCTCAGAGC CCCTGCAGCC CCGGGTGTCT GCTCCCTGAT 
GCAGCGCTCG CGCAACCGCC TGCGCCGTCT TCCCGCAGAA AGAGAGGCGC CAAGATCACT 
GGAAGGGAGC GCAAGGCGAT GAGAGTCCTG CCGGTGGTAG TTGGGGCCTT CCTGATGTGT 
TGGACGCCTT TCTTCGTGGT GCACATCACA CGGGCGCTGT GTCCGGCTTG TTTCGTGTCC 
CCACGCCTGG TCAGTGCTGT CACCTGGCTG GGCTATGTCA ACAGTGCCCT CAACCCCATC 
ATCTACACCA TCTTCAATGC CGAGTTTCGA AGTGTCTTCC GCAAGACTCT TCGTCTCCGC 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Drd4 ( NM_012944.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037076.2 Rattus norvegicus dopamine receptor D4 (Drd4), mRNA.

Price & Availability↑

CloneID	ORa43112
Clone ID Related Accession (Same CDS sequence)	NM_012944.2
Accession Version	NM_012944.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1164bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	D(4) dopamine receptor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC118351.14. On Apr 28, 2015 this sequence version replaced NM_012944.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M84009.1 [ECO:0000332] ##Evidence-Data-END##

ATGGGGAACA GCAGCGCTAC TGGTGACGGT GGGCTGTTGG CCGGGCGTGG GCCAGAGTCC 
TTAGGTACTG GCACCGGACT TGGGGGCGCG GGCGCGGGCG CGGCGGCGCT GGTGGGAGGC 
GTGCTGCTCA TCGGCATGGT GTTGGCAGGG AACTCGCTCG TTTGCGTGAG CGTGGCCTCC 
GAGCGCATCC TGCAGACACC CACCAACTAC TTCATCGTGA GCCTGGCGGC TGCCGACCTC 
CTCCTCGCGG TGCTGGTGTT GCCTCTCTTT GTCTACTCCG AGGGTGGCGT GTGGCTGCTG 
AGCCCCCGCC TCTGTGACAC CCTCATGGCC ATGGACGTCA TGCTGTGCAC CGCCTCCATC 
TTCAACCTGT GCGCCATCAG CGTGGACAGG TTTGTGGCTG TGACCGTGCC ACTGCGCTAC 
AACCAGCAGG GTCAGTGCCA GCTGCTGCTC ATCGCCGCCA CGTGGCTGCT GTCTGCCGCG 
GTGGCTGCGC CCGTCGTGTG CGGCCTCAAT GATGTGCCCG GTCGCGATCC AACCGTGTGC 
TGCCTGGAGG ACCGCGACTA CGTGGTCTAC TCATCCATTT GTTCCTTCTT CCTGCCCTGT 
CCGCTCATGC TACTGCTTTA CTGGGCCACT TTCCGTGGCT TGCGGCGCTG GGAGGCAGCC 
CGGCACACCA AGCTTCACAG CCGCGCGCCG CGCCGACCCA GCGGCCCGGG CCCGCCGGTG 
TCGGACCCTA CTCAGGGTCC CCTCTTCTCA GATTGTCCGC CTCCCTCACC CAGCCTCCGG 
ACGAGCCCCA CCGTCTCCAG CAGACCAGAG TCAGACCTCT CTCAGAGCCC CTGCAGCCCC 
GGGTGTCTGC TCCCTGATGC AGCGCTCGCG CAACCGCCTG CGCCGTCTTC CCGCAGAAAG 
AGAGGCGCCA AGATCACTGG AAGGGAGCGC AAGGCGATGA GAGTCCTGCC GGTGGTAGTT 
GGGGCCTTCC TGATGTGTTG GACGCCTTTC TTCGTGGTGC ACATCACACG GGCGCTGTGT 
CCGGCTTGTT TCGTGTCCCC ACGCCTGGTC AGTGCTGTCA CCTGGCTGGG CTATGTCAAC 
AGTGCCCTCA ACCCCATCAT CTACACCATC TTCAATGCCG AGTTTCGAAG TGTCTTCCGC 
AAGACTCTTC GTCTCCGCTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037076.2
CDS	131..1294
Translation	MGNSSATGDGGLLAGRGPESLGTGTGLGGAGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC

Target ORF information:

RefSeq Version	NM_012944.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus dopamine receptor D4 (Drd4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012944.2

ORF Insert Sequence:

ATGGGGAACA GCAGCGCTAC TGGTGACGGT GGGCTGTTGG CCGGGCGTGG GCCAGAGTCC 
TTAGGTACTG GCACCGGACT TGGGGGCGCG GGCGCGGGCG CGGCGGCGCT GGTGGGAGGC 
GTGCTGCTCA TCGGCATGGT GTTGGCAGGG AACTCGCTCG TTTGCGTGAG CGTGGCCTCC 
GAGCGCATCC TGCAGACACC CACCAACTAC TTCATCGTGA GCCTGGCGGC TGCCGACCTC 
CTCCTCGCGG TGCTGGTGTT GCCTCTCTTT GTCTACTCCG AGGGTGGCGT GTGGCTGCTG 
AGCCCCCGCC TCTGTGACAC CCTCATGGCC ATGGACGTCA TGCTGTGCAC CGCCTCCATC 
TTCAACCTGT GCGCCATCAG CGTGGACAGG TTTGTGGCTG TGACCGTGCC ACTGCGCTAC 
AACCAGCAGG GTCAGTGCCA GCTGCTGCTC ATCGCCGCCA CGTGGCTGCT GTCTGCCGCG 
GTGGCTGCGC CCGTCGTGTG CGGCCTCAAT GATGTGCCCG GTCGCGATCC AACCGTGTGC 
TGCCTGGAGG ACCGCGACTA CGTGGTCTAC TCATCCATTT GTTCCTTCTT CCTGCCCTGT 
CCGCTCATGC TACTGCTTTA CTGGGCCACT TTCCGTGGCT TGCGGCGCTG GGAGGCAGCC 
CGGCACACCA AGCTTCACAG CCGCGCGCCG CGCCGACCCA GCGGCCCGGG CCCGCCGGTG 
TCGGACCCTA CTCAGGGTCC CCTCTTCTCA GATTGTCCGC CTCCCTCACC CAGCCTCCGG 
ACGAGCCCCA CCGTCTCCAG CAGACCAGAG TCAGACCTCT CTCAGAGCCC CTGCAGCCCC 
GGGTGTCTGC TCCCTGATGC AGCGCTCGCG CAACCGCCTG CGCCGTCTTC CCGCAGAAAG 
AGAGGCGCCA AGATCACTGG AAGGGAGCGC AAGGCGATGA GAGTCCTGCC GGTGGTAGTT 
GGGGCCTTCC TGATGTGTTG GACGCCTTTC TTCGTGGTGC ACATCACACG GGCGCTGTGT 
CCGGCTTGTT TCGTGTCCCC ACGCCTGGTC AGTGCTGTCA CCTGGCTGGG CTATGTCAAC 
AGTGCCCTCA ACCCCATCAT CTACACCATC TTCAATGCCG AGTTTCGAAG TGTCTTCCGC 
AAGACTCTTC GTCTCCGCTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Drd4 ( XM_006230521.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006230583.1 Rattus norvegicus dopamine receptor D4 (Drd4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa23591
Clone ID Related Accession (Same CDS sequence)	XM_006230521.2
Accession Version	XM_006230521.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1170bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	D(4) dopamine receptor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006230521.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGAACA GCAGCGCTAC TGGTGACGGT GGGCTGTTGG CCGGGCGTGG GCCAGAGTCC 
TTAGGTACTG GCACCGGACT TGGGGGCGCG GGCGCGGGCG CGGCGGCGCT GGTGGGAGGC 
GTGCTGCTCA TCGGCATGGT GTTGGCAGGG AACTCGCTCG TTTGCGTGAG CGTGGCCTCC 
GAGCGCATCC TGCAGACACC CACCAACTAC TTCATCGTGA GCCTGGCGGC TGCCGACCTC 
CTCCTCGCGG TGCTGGTGTT GCCTCTCTTT GTCTACTCCG AGGTCCAGGG TGGCGTGTGG 
CTGCTGAGCC CCCGCCTCTG TGACACCCTC ATGGCCATGG ACGTCATGCT GTGCACCGCC 
TCCATCTTCA ACCTGTGCGC CATCAGCGTG GACAGGTTTG TGGCTGTGAC CGTGCCACTG 
CGCTACAACC AGCAGGGTCA GTGCCAGCTG CTGCTCATCG CCGCCACGTG GCTGCTGTCT 
GCCGCGGTGG CTGCGCCCGT CGTGTGCGGC CTCAATGATG TGCCCGGTCG CGATCCAACC 
GTGTGCTGCC TGGAGGACCG CGACTACGTG GTCTACTCAT CCATTTGTTC CTTCTTCCTG 
CCCTGTCCGC TCATGCTACT GCTTTACTGG GCCACTTTCC GTGGCTTGCG GCGCTGGGAG 
GCAGCCCGGC ACACCAAGCT TCACAGCCGC GCGCCGCGCC GACCCAGCGG CCCGGGCCCG 
CCGGTGTCGG ACCCTACTCA GGGTCCCCTC TTCTCAGATT GTCCGCCTCC CTCACCCAGC 
CTCCGGACGA GCCCCACCGT CTCCAGCAGA CCAGAGTCAG ACCTCTCTCA GAGCCCCTGC 
AGCCCCGGGT GTCTGCTCCC TGATGCAGCG CTCGCGCAAC CGCCTGCGCC GTCTTCCCGC 
AGAAAGAGAG GCGCCAAGAT CACTGGAAGG GAGCGCAAGG CGATGAGAGT CCTGCCGGTG 
GTAGTTGGGG CCTTCCTGAT GTGTTGGACG CCTTTCTTCG TGGTGCACAT CACACGGGCG 
CTGTGTCCGG CTTGTTTCGT GTCCCCACGC CTGGTCAGTG CTGTCACCTG GCTGGGCTAT 
GTCAACAGTG CCCTCAACCC CATCATCTAC ACCATCTTCA ATGCCGAGTT TCGAAGTGTC 
TTCCGCAAGA CTCTTCGTCT CCGCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006230583.1
CDS	1..1170
Translation	MGNSSATGDGGLLAGRGPESLGTGTGLGGAGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC

Target ORF information:

RefSeq Version	XM_006230521.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus dopamine receptor D4 (Drd4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006230521.2

ORF Insert Sequence:

ATGGGGAACA GCAGCGCTAC TGGTGACGGT GGGCTGTTGG CCGGGCGTGG GCCAGAGTCC 
TTAGGTACTG GCACCGGACT TGGGGGCGCG GGCGCGGGCG CGGCGGCGCT GGTGGGAGGC 
GTGCTGCTCA TCGGCATGGT GTTGGCAGGG AACTCGCTCG TTTGCGTGAG CGTGGCCTCC 
GAGCGCATCC TGCAGACACC CACCAACTAC TTCATCGTGA GCCTGGCGGC TGCCGACCTC 
CTCCTCGCGG TGCTGGTGTT GCCTCTCTTT GTCTACTCCG AGGTCCAGGG TGGCGTGTGG 
CTGCTGAGCC CCCGCCTCTG TGACACCCTC ATGGCCATGG ACGTCATGCT GTGCACCGCC 
TCCATCTTCA ACCTGTGCGC CATCAGCGTG GACAGGTTTG TGGCTGTGAC CGTGCCACTG 
CGCTACAACC AGCAGGGTCA GTGCCAGCTG CTGCTCATCG CCGCCACGTG GCTGCTGTCT 
GCCGCGGTGG CTGCGCCCGT CGTGTGCGGC CTCAATGATG TGCCCGGTCG CGATCCAACC 
GTGTGCTGCC TGGAGGACCG CGACTACGTG GTCTACTCAT CCATTTGTTC CTTCTTCCTG 
CCCTGTCCGC TCATGCTACT GCTTTACTGG GCCACTTTCC GTGGCTTGCG GCGCTGGGAG 
GCAGCCCGGC ACACCAAGCT TCACAGCCGC GCGCCGCGCC GACCCAGCGG CCCGGGCCCG 
CCGGTGTCGG ACCCTACTCA GGGTCCCCTC TTCTCAGATT GTCCGCCTCC CTCACCCAGC 
CTCCGGACGA GCCCCACCGT CTCCAGCAGA CCAGAGTCAG ACCTCTCTCA GAGCCCCTGC 
AGCCCCGGGT GTCTGCTCCC TGATGCAGCG CTCGCGCAAC CGCCTGCGCC GTCTTCCCGC 
AGAAAGAGAG GCGCCAAGAT CACTGGAAGG GAGCGCAAGG CGATGAGAGT CCTGCCGGTG 
GTAGTTGGGG CCTTCCTGAT GTGTTGGACG CCTTTCTTCG TGGTGCACAT CACACGGGCG 
CTGTGTCCGG CTTGTTTCGT GTCCCCACGC CTGGTCAGTG CTGTCACCTG GCTGGGCTAT 
GTCAACAGTG CCCTCAACCC CATCATCTAC ACCATCTTCA ATGCCGAGTT TCGAAGTGTC 
TTCCGCAAGA CTCTTCGTCT CCGCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder.
Physiology & behavior18078-90(2017 Oct)
Chawla A,Cordner ZA,Boersma G,Moran TH

Activation of type 4 dopaminergic receptors in the prelimbic area of medial prefrontal cortex is necessary for the expression of innate fear behavior.
Behavioural brain research324130-137(2017 05)
Vergara MD,Keller VN,Fuentealba JA,Gysling K

Palmitoylation of the carboxyl-terminal tail of dopamine D
Biochemical and biophysical research communications479(2)398-403(2016 Oct)
Zhang X,Kim KM

Elucidating the role of D4 receptors in mediating attributions of salience to incentive stimuli on Pavlovian conditioned approach and conditioned reinforcement paradigms.
Behavioural brain research31255-63(2016 10)
Cocker PJ,Vonder Haar C,Winstanley CA

Activation of dopamine D4 receptors within the anterior cingulate cortex enhances the erroneous expectation of reward on a rat slot machine task.
Neuropharmacology105186-195(2016 06)
Cocker PJ,Hosking JG,Murch WS,Clark L,Winstanley CA

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Drd4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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