Dpysl2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dpysl2
Entrez Gene ID	25416
Full Name	dihydropyrimidinase-like 2
Synonyms	Crmp2,TOAD-64
General protein information	Preferred Names dihydropyrimidinase-like 2 Names dihydropyrimidinase-related protein 2 CRMP-2 DRP-2 collapsin response mediator protein 2 turned on after division, 64 kDa protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p12
Summary	membrane-associated protein, may be important for axonal outgrowth and pathfinding [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006252097.3	XP_006252159.1	dihydropyrimidinase-related protein 2 isoform X1
NM_001105717.2	NP_001099187.1	dihydropyrimidinase-related protein 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	DPYSL2	XP_849125.1
Pan troglodytes (chimpanzee)	DPYSL2	XP_001161598.1
Bos taurus (cattle)	DPYSL2	NP_001069468.1
Gallus gallus (chicken)	DPYSL2	NP_989825.1
Mus musculus (house mouse)	Dpysl2	NP_034085.2
Rattus norvegicus (Norway rat)	Dpysl2	NP_001099187.1
Xenopus tropicalis (tropical clawed frog)	dpysl2	NP_001121465.1
Homo sapiens (human)	DPYSL2	NP_001184222.1
	DPYSL2	XP_001108565.1

Gene Ontology
Bibliography

Related articles in PubMed

CRMP2 is necessary for Neurofibromatosis type 1 related pain.
Moutal A, Cai S, Luo S, Voisin R, Khanna R
Channels (Austin, Tex.)12(1)47-50(2018 Jan)

CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide.
Moutal A, Yang X, Li W, Gilbraith KB, Luo S, Cai S, Fran?ois-Moutal L, Chew LA, Yeon SK, Bellampalli SS, Qu C, Xie JY, Ibrahim MM, Khanna M, Park KD, Porreca F, Khanna R
Pain158(12)2301-2319(2017 Dec)

Active exercise promotes Achilles tendon healing and is accompanied by the upregulation of collapsin response mediator protein?2 in rats.
Qianman B, Jialihasi A, Asilehan B, Kubai A, Aibek R, Wupuer A, Tangkejie W, Maimaitiaili A, Shawutali N, Badelhan A, Aizezi A, Aisaiding A, Wuerliebieke J, Bakyt Y, Makemutibieke E, Jielile J
Molecular medicine reports16(3)2355-2360(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results of this study suggested that the neuroplasticity effect of BMSCs on cerebral ischemia may be associated with the phosphorylated modulation of CRMP2.
Title: Bone marrow stromal cells promote neuroplasticity of cerebral ischemic rats via a phosphorylated CRMP2-mediated mechanism.

The present findings demonstrated that the downregulation of genes such as Dpysl2 and Dypsl3 in a rat model of prenatal stress may affect subsequent behavioral changes
Title: Changes in Dpysl2 expression are associated with prenatally stressed rat offspring and susceptibility to schizophrenia in humans.

Data suggest collapsin response mediator proteins (CRMP) CRMP2 and CRMP4 form complexes to bridge microtubules and actin and work cooperatively to regulate growth cone development and axonal elongation.
Title: CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation.

CRMP2 interacts with NCX and NMDAR and TAT-CBD3 protects against glutamate-induced Ca(2+) dysregulation most likely via suppression of both NMDAR and NCX activities
Title: Collapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+/Ca2+ exchanger and regulates their functional activity.

CRMP-2-dependent regulation of ROCK II activity is mediated through interaction of the CRMP-2L N terminus with the ROCK II catalytic domain as well as by GSK3-dependent phosphorylation of CRMP-2.
Title: Phosphorylation and mRNA splicing of collapsin response mediator protein-2 determine inhibition of rho-associated protein kinase (ROCK) II function in carcinoma cell migration and invasion.

The following Dpysl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dpysl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13622	NM_001105717.2 Latest version!	Rattus norvegicus dihydropyrimidinase-like 2 (Dpysl2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$335.30 $479.00
ORa36753	XM_006252097.3 Latest version!	Rattus norvegicus dihydropyrimidinase-like 2 (Dpysl2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dpysl2 ( NM_001105717.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099187.1 Rattus norvegicus dihydropyrimidinase-like 2 (Dpysl2), mRNA.

Price & Availability↑

CloneID	ORa13622
Clone ID Related Accession (Same CDS sequence)	NM_001105717.2
Accession Version	NM_001105717.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1719bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Rattus norvegicus(Norway rat)
Product	dihydropyrimidinase-related protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB749736.1, AABR07018155.1, CB729753.1, CA510768.1 and CB577285.1. On Oct 24, 2007 this sequence version replaced NM_001105717.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTTATC AGGGGAAGAA AAATATTCCA CGCATCACGA GCGATCGTCT TCTGATCAAA 
GGTGGCAAGA TTGTGAATGA TGACCAGTCC TTCTATGCAG ACATATACAT GGAAGATGGG 
TTGATCAAGC AAATAGGAGA AAACCTGATT GTGCCAGGAG GGGTGAAGAC CATCGAAGCC 
CACTCCAGAA TGGTGATCCC TGGAGGAATT GACGTGCACA CTCGCTTCCA GATGCCAGAC 
CAGGGAATGA CATCAGCTGA TGACTTCTTC CAGGGAACCA AGGCAGCCCT GGCCGGAGGA 
ACCACCATGA TCATCGACCA TGTTGTTCCT GAGCCCGGGA CAAGCCTATT GGCAGCCTTT 
GATCAGTGGA GGGAGTGGGC GGACAGCAAG TCCTGCTGTG ACTATTCGCT GCACGTGGAC 
ATCACGGAGT GGCACAAGGG CATCCAGGAG GAGATGGAAG CTCTGGTGAA GGACCACGGG 
GTAAACTCCT TCCTCGTGTA CATGGCTTTC AAAGATCGGT TCCAGCTGAC GGATTCCCAG 
ATCTATGAAG TACTGAGCGT GATCCGGGAT ATTGGTGCCA TAGCTCAAGT CCATGCAGAG 
AATGGTGACA TCATTGCAGA GGAACAGCAG AGGATCCTGG ATCTGGGCAT CACAGGCCCC 
GAGGGACACG TGCTGAGCCG GCCAGAGGAG GTCGAGGCTG AAGCTGTGAA CCGGTCCATC 
ACCATTGCCA ATCAGACCAA CTGCCCGCTG TATGTCACCA AGGTGATGAG CAAGAGTGCT 
GCTGAAGTCA TCGCCCAGGC ACGGAAGAAG GGAACTGTGG TGTATGGTGA GCCCATCACT 
GCCAGCCTGG GGACTGATGG CTCTCATTAT TGGAGCAAGA ACTGGGCCAA GGCCGCTGCC 
TTTGTCACCT CTCCACCCTT GAGCCCCGAC CCAACCACTC CAGACTTTCT CAACTCGTTG 
CTGTCCTGTG GAGACCTCCA GGTCACTGGC AGTGCCCACT GTACCTTCAA CACTGCCCAG 
AAGGCTGTGG GGAAGGATAA CTTCACCTTG ATTCCAGAGG GCACCAATGG CACTGAGGAG 
CGGATGTCTG TCATTTGGGA TAAAGCTGTG GTCACTGGGA AGATGGACGA GAACCAGTTT 
GTGGCTGTGA CTAGCACCAA CGCAGCCAAA GTCTTCAATC TTTACCCACG GAAAGGTCGT 
ATCTCCGTGG GATCTGACGC AGACTTGGTC ATCTGGGACC CTGACAGTGT GAAGACCATC 
TCTGCCAAGA CGCACAACAG TGCTCTTGAG TACAACATCT TTGAAGGCAT GGAGTGTCGG 
GGCTCCCCAC TGGTGGTCAT CAGCCAGGGC AAGATTGTCC TGGAGGACGG CACGTTGCAT 
GTCACGGAAG GCTCAGGACG CTACATTCCC CGGAAGCCCT TCCCTGACTT TGTGTACAAA 
CGCATCAAGG CAAGGAGCAG GCTGGCTGAG CTGAGGGGGG TCCCTCGTGG CCTGTATGAT 
GGACCCGTAT GCGAGGTGTC TGTGACGCCC AAGACGGTCA CTCCGGCCTC ATCAGCTAAG 
ACATCCCCTG CCAAGCAGCA GGCGCCACCT GTTCGGAACC TGCACCAGTC TGGTTTCAGC 
TTGTCTGGTG CTCAGATTGA CGACAACATT CCCCGCCGCA CCACCCAGCG CATTGTGGCA 
CCCCCTGGTG GCCGCGCCAA CATCACCAGC CTGGGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099187.1
CDS	225..1943
Translation	MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLHVDITEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDSQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRSITIANQTNCPLYVTKVMSKSAAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRISVGSDADLVIWDPDSVKTISAKTHNSALEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFSLSGAQIDDNIPRRTTQRIVAPPGGRANITSLG

Target ORF information:

RefSeq Version	NM_001105717.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus dihydropyrimidinase-like 2 (Dpysl2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105717.2

ORF Insert Sequence:

ATGTCTTATC AGGGGAAGAA AAATATTCCA CGCATCACGA GCGATCGTCT TCTGATCAAA 
GGTGGCAAGA TTGTGAATGA TGACCAGTCC TTCTATGCAG ACATATACAT GGAAGATGGG 
TTGATCAAGC AAATAGGAGA AAACCTGATT GTGCCAGGAG GGGTGAAGAC CATCGAAGCC 
CACTCCAGAA TGGTGATCCC TGGAGGAATT GACGTGCACA CTCGCTTCCA GATGCCAGAC 
CAGGGAATGA CATCAGCTGA TGACTTCTTC CAGGGAACCA AGGCAGCCCT GGCCGGAGGA 
ACCACCATGA TCATCGACCA TGTTGTTCCT GAGCCCGGGA CAAGCCTATT GGCAGCCTTT 
GATCAGTGGA GGGAGTGGGC GGACAGCAAG TCCTGCTGTG ACTATTCGCT GCACGTGGAC 
ATCACGGAGT GGCACAAGGG CATCCAGGAG GAGATGGAAG CTCTGGTGAA GGACCACGGG 
GTAAACTCCT TCCTCGTGTA CATGGCTTTC AAAGATCGGT TCCAGCTGAC GGATTCCCAG 
ATCTATGAAG TACTGAGCGT GATCCGGGAT ATTGGTGCCA TAGCTCAAGT CCATGCAGAG 
AATGGTGACA TCATTGCAGA GGAACAGCAG AGGATCCTGG ATCTGGGCAT CACAGGCCCC 
GAGGGACACG TGCTGAGCCG GCCAGAGGAG GTCGAGGCTG AAGCTGTGAA CCGGTCCATC 
ACCATTGCCA ATCAGACCAA CTGCCCGCTG TATGTCACCA AGGTGATGAG CAAGAGTGCT 
GCTGAAGTCA TCGCCCAGGC ACGGAAGAAG GGAACTGTGG TGTATGGTGA GCCCATCACT 
GCCAGCCTGG GGACTGATGG CTCTCATTAT TGGAGCAAGA ACTGGGCCAA GGCCGCTGCC 
TTTGTCACCT CTCCACCCTT GAGCCCCGAC CCAACCACTC CAGACTTTCT CAACTCGTTG 
CTGTCCTGTG GAGACCTCCA GGTCACTGGC AGTGCCCACT GTACCTTCAA CACTGCCCAG 
AAGGCTGTGG GGAAGGATAA CTTCACCTTG ATTCCAGAGG GCACCAATGG CACTGAGGAG 
CGGATGTCTG TCATTTGGGA TAAAGCTGTG GTCACTGGGA AGATGGACGA GAACCAGTTT 
GTGGCTGTGA CTAGCACCAA CGCAGCCAAA GTCTTCAATC TTTACCCACG GAAAGGTCGT 
ATCTCCGTGG GATCTGACGC AGACTTGGTC ATCTGGGACC CTGACAGTGT GAAGACCATC 
TCTGCCAAGA CGCACAACAG TGCTCTTGAG TACAACATCT TTGAAGGCAT GGAGTGTCGG 
GGCTCCCCAC TGGTGGTCAT CAGCCAGGGC AAGATTGTCC TGGAGGACGG CACGTTGCAT 
GTCACGGAAG GCTCAGGACG CTACATTCCC CGGAAGCCCT TCCCTGACTT TGTGTACAAA 
CGCATCAAGG CAAGGAGCAG GCTGGCTGAG CTGAGGGGGG TCCCTCGTGG CCTGTATGAT 
GGACCCGTAT GCGAGGTGTC TGTGACGCCC AAGACGGTCA CTCCGGCCTC ATCAGCTAAG 
ACATCCCCTG CCAAGCAGCA GGCGCCACCT GTTCGGAACC TGCACCAGTC TGGTTTCAGC 
TTGTCTGGTG CTCAGATTGA CGACAACATT CCCCGCCGCA CCACCCAGCG CATTGTGGCA 
CCCCCTGGTG GCCGCGCCAA CATCACCAGC CTGGGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dpysl2 ( XM_006252097.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006252159.1 Rattus norvegicus dihydropyrimidinase-like 2 (Dpysl2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa36753
Clone ID Related Accession (Same CDS sequence)	XM_006252097.3
Accession Version	XM_006252097.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2022bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	dihydropyrimidinase-related protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006252097.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCGAGA GAAAGCAATC TGGGAAGGCA GCAGAGGACG AAGAGGTCCC TGCCTTTTTT 
AAAAACCTGG GTTCGGGCAG TCCGAAGCCG CGGCAGAAAT TCTGCGGCAT GTTCTGCCCC 
GTGGAAGGAT CCTCGGAGAA CAAGACCATC GATTTCGACT CGCTTTCAGT GGGCCGGGGC 
TCGGGGCAGG TGGTGGCTCA GCAGCGGGAT GTCGCCCACT TGGGCCCGGA CCCGCACCGG 
CAGAGCCGGC GTGCCAGCGG GGAGCCATCT GTTGAATCGG GCCGGAAGGT GGAGATCCGG 
CGGGCCTCGG GCAAGGAAGC TCTGCAGAAC ATCTACGATC AGAGCGATCG TCTTCTGATC 
AAAGGTGGCA AGATTGTGAA TGATGACCAG TCCTTCTATG CAGACATATA CATGGAAGAT 
GGGTTGATCA AGCAAATAGG AGAAAACCTG ATTGTGCCAG GAGGGGTGAA GACCATCGAA 
GCCCACTCCA GAATGGTGAT CCCTGGAGGA ATTGACGTGC ACACTCGCTT CCAGATGCCA 
GACCAGGGAA TGACATCAGC TGATGACTTC TTCCAGGGAA CCAAGGCAGC CCTGGCCGGA 
GGAACCACCA TGATCATCGA CCATGTTGTT CCTGAGCCCG GGACAAGCCT ATTGGCAGCC 
TTTGATCAGT GGAGGGAGTG GGCGGACAGC AAGTCCTGCT GTGACTATTC GCTGCACGTG 
GACATCACGG AGTGGCACAA GGGCATCCAG GAGGAGATGG AAGCTCTGGT GAAGGACCAC 
GGGGTAAACT CCTTCCTCGT GTACATGGCT TTCAAAGATC GGTTCCAGCT GACGGATTCC 
CAGATCTATG AAGTACTGAG CGTGATCCGG GATATTGGTG CCATAGCTCA AGTCCATGCA 
GAGAATGGTG ACATCATTGC AGAGGAACAG CAGAGGATCC TGGATCTGGG CATCACAGGC 
CCCGAGGGAC ACGTGCTGAG CCGGCCAGAG GAGGTCGAGG CTGAAGCTGT GAACCGGTCC 
ATCACCATTG CCAATCAGAC CAACTGCCCG CTGTATGTCA CCAAGGTGAT GAGCAAGAGT 
GCTGCTGAAG TCATCGCCCA GGCACGGAAG AAGGGAACTG TGGTGTATGG TGAGCCCATC 
ACTGCCAGCC TGGGGACTGA TGGCTCTCAT TATTGGAGCA AGAACTGGGC CAAGGCCGCT 
GCCTTTGTCA CCTCTCCACC CTTGAGCCCC GACCCAACCA CTCCAGACTT TCTCAACTCG 
TTGCTGTCCT GTGGAGACCT CCAGGTCACT GGCAGTGCCC ACTGTACCTT CAACACTGCC 
CAGAAGGCTG TGGGGAAGGA TAACTTCACC TTGATTCCAG AGGGCACCAA TGGCACTGAG 
GAGCGGATGT CTGTCATTTG GGATAAAGCT GTGGTCACTG GGAAGATGGA CGAGAACCAG 
TTTGTGGCTG TGACTAGCAC CAACGCAGCC AAAGTCTTCA ATCTTTACCC ACGGAAAGGT 
CGTATCTCCG TGGGATCTGA CGCAGACTTG GTCATCTGGG ACCCTGACAG TGTGAAGACC 
ATCTCTGCCA AGACGCACAA CAGTGCTCTT GAGTACAACA TCTTTGAAGG CATGGAGTGT 
CGGGGCTCCC CACTGGTGGT CATCAGCCAG GGCAAGATTG TCCTGGAGGA CGGCACGTTG 
CATGTCACGG AAGGCTCAGG ACGCTACATT CCCCGGAAGC CCTTCCCTGA CTTTGTGTAC 
AAACGCATCA AGGCAAGGAG CAGGCTGGCT GAGCTGAGGG GGGTCCCTCG TGGCCTGTAT 
GATGGACCCG TATGCGAGGT GTCTGTGACG CCCAAGACGG TCACTCCGGC CTCATCAGCT 
AAGACATCCC CTGCCAAGCA GCAGGCGCCA CCTGTTCGGA ACCTGCACCA GTCTGGTTTC 
AGCTTGTCTG GTGCTCAGAT TGACGACAAC ATTCCCCGCC GCACCACCCA GCGCATTGTG 
GCACCCCCTG GTGGCCGCGC CAACATCACC AGCCTGGGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006252159.1
CDS	121..2142
Translation	MAERKQSGKAAEDEEVPAFFKNLGSGSPKPRQKFCGMFCPVEGSSENKTIDFDSLSVGRGSGQVVAQQRDVAHLGPDPHRQSRRASGEPSVESGRKVEIRRASGKEALQNIYDQSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLHVDITEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDSQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRSITIANQTNCPLYVTKVMSKSAAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRISVGSDADLVIWDPDSVKTISAKTHNSALEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFSLSGAQIDDNIPRRTTQRIVAPPGGRANITSLG

Target ORF information:

RefSeq Version	XM_006252097.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus dihydropyrimidinase-like 2 (Dpysl2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006252097.3

ORF Insert Sequence:

ATGGCCGAGA GAAAGCAATC TGGGAAGGCA GCAGAGGACG AAGAGGTCCC TGCCTTTTTT 
AAAAACCTGG GTTCGGGCAG TCCGAAGCCG CGGCAGAAAT TCTGCGGCAT GTTCTGCCCC 
GTGGAAGGAT CCTCGGAGAA CAAGACCATC GATTTCGACT CGCTTTCAGT GGGCCGGGGC 
TCGGGGCAGG TGGTGGCTCA GCAGCGGGAT GTCGCCCACT TGGGCCCGGA CCCGCACCGG 
CAGAGCCGGC GTGCCAGCGG GGAGCCATCT GTTGAATCGG GCCGGAAGGT GGAGATCCGG 
CGGGCCTCGG GCAAGGAAGC TCTGCAGAAC ATCTACGATC AGAGCGATCG TCTTCTGATC 
AAAGGTGGCA AGATTGTGAA TGATGACCAG TCCTTCTATG CAGACATATA CATGGAAGAT 
GGGTTGATCA AGCAAATAGG AGAAAACCTG ATTGTGCCAG GAGGGGTGAA GACCATCGAA 
GCCCACTCCA GAATGGTGAT CCCTGGAGGA ATTGACGTGC ACACTCGCTT CCAGATGCCA 
GACCAGGGAA TGACATCAGC TGATGACTTC TTCCAGGGAA CCAAGGCAGC CCTGGCCGGA 
GGAACCACCA TGATCATCGA CCATGTTGTT CCTGAGCCCG GGACAAGCCT ATTGGCAGCC 
TTTGATCAGT GGAGGGAGTG GGCGGACAGC AAGTCCTGCT GTGACTATTC GCTGCACGTG 
GACATCACGG AGTGGCACAA GGGCATCCAG GAGGAGATGG AAGCTCTGGT GAAGGACCAC 
GGGGTAAACT CCTTCCTCGT GTACATGGCT TTCAAAGATC GGTTCCAGCT GACGGATTCC 
CAGATCTATG AAGTACTGAG CGTGATCCGG GATATTGGTG CCATAGCTCA AGTCCATGCA 
GAGAATGGTG ACATCATTGC AGAGGAACAG CAGAGGATCC TGGATCTGGG CATCACAGGC 
CCCGAGGGAC ACGTGCTGAG CCGGCCAGAG GAGGTCGAGG CTGAAGCTGT GAACCGGTCC 
ATCACCATTG CCAATCAGAC CAACTGCCCG CTGTATGTCA CCAAGGTGAT GAGCAAGAGT 
GCTGCTGAAG TCATCGCCCA GGCACGGAAG AAGGGAACTG TGGTGTATGG TGAGCCCATC 
ACTGCCAGCC TGGGGACTGA TGGCTCTCAT TATTGGAGCA AGAACTGGGC CAAGGCCGCT 
GCCTTTGTCA CCTCTCCACC CTTGAGCCCC GACCCAACCA CTCCAGACTT TCTCAACTCG 
TTGCTGTCCT GTGGAGACCT CCAGGTCACT GGCAGTGCCC ACTGTACCTT CAACACTGCC 
CAGAAGGCTG TGGGGAAGGA TAACTTCACC TTGATTCCAG AGGGCACCAA TGGCACTGAG 
GAGCGGATGT CTGTCATTTG GGATAAAGCT GTGGTCACTG GGAAGATGGA CGAGAACCAG 
TTTGTGGCTG TGACTAGCAC CAACGCAGCC AAAGTCTTCA ATCTTTACCC ACGGAAAGGT 
CGTATCTCCG TGGGATCTGA CGCAGACTTG GTCATCTGGG ACCCTGACAG TGTGAAGACC 
ATCTCTGCCA AGACGCACAA CAGTGCTCTT GAGTACAACA TCTTTGAAGG CATGGAGTGT 
CGGGGCTCCC CACTGGTGGT CATCAGCCAG GGCAAGATTG TCCTGGAGGA CGGCACGTTG 
CATGTCACGG AAGGCTCAGG ACGCTACATT CCCCGGAAGC CCTTCCCTGA CTTTGTGTAC 
AAACGCATCA AGGCAAGGAG CAGGCTGGCT GAGCTGAGGG GGGTCCCTCG TGGCCTGTAT 
GATGGACCCG TATGCGAGGT GTCTGTGACG CCCAAGACGG TCACTCCGGC CTCATCAGCT 
AAGACATCCC CTGCCAAGCA GCAGGCGCCA CCTGTTCGGA ACCTGCACCA GTCTGGTTTC 
AGCTTGTCTG GTGCTCAGAT TGACGACAAC ATTCCCCGCC GCACCACCCA GCGCATTGTG 
GCACCCCCTG GTGGCCGCGC CAACATCACC AGCCTGGGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CRMP2 is necessary for Neurofibromatosis type 1 related pain.
Channels (Austin, Tex.)12(1)47-50(2018 Jan)
Moutal A,Cai S,Luo S,Voisin R,Khanna R

CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide.
Pain158(12)2301-2319(2017 Dec)
Moutal A,Yang X,Li W,Gilbraith KB,Luo S,Cai S,Fran?ois-Moutal L,Chew LA,Yeon SK,Bellampalli SS,Qu C,Xie JY,Ibrahim MM,Khanna M,Park KD,Porreca F,Khanna R

Active exercise promotes Achilles tendon healing and is accompanied by the upregulation of collapsin response mediator protein?2 in rats.
Molecular medicine reports16(3)2355-2360(2017 Sep)
Qianman B,Jialihasi A,Asilehan B,Kubai A,Aibek R,Wupuer A,Tangkejie W,Maimaitiaili A,Shawutali N,Badelhan A,Aizezi A,Aisaiding A,Wuerliebieke J,Bakyt Y,Makemutibieke E,Jielile J

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Dpysl2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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