Atf3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atf3
Entrez Gene ID	25389
Full Name	activating transcription factor 3
Synonyms	LRF-1,LRFI
General protein information	Preferred Names activating transcription factor 3 Names cyclic AMP-dependent transcription factor ATF-3 cAMP-dependent transcription factor ATF-3 liver regeneration factor 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q27
Summary	expression is associated with neuronal injury [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012912.2	NP_037044.1	cyclic AMP-dependent transcription factor ATF-3

Pathways from BioSystems

Homologies

	ATF3	XP_001107925.1
Pan troglodytes (chimpanzee)	ATF3	XP_524528.3
Rattus norvegicus (Norway rat)	Atf3	NP_037044.1
Danio rerio (zebrafish)	atf3	NP_957258.1
Canis lupus familiaris (dog)	ATF3	XP_852475.1
Bos taurus (cattle)	ATF3	NP_001039658.1
Mus musculus (house mouse)	Atf3	NP_031524.2
Gallus gallus (chicken)	ATF3	XP_004935391.1
Xenopus tropicalis (tropical clawed frog)	atf3	XP_002934744.1
Homo sapiens (human)	ATF3	NP_001665.1

Gene Ontology
Bibliography

Related articles in PubMed

Activating transcription factor 3 is a target molecule linking hepatic steatosis to impaired glucose homeostasis.
Kim JY, Park KJ, Hwang JY, Kim GH, Lee D, Lee YJ, Song EH, Yoo MG, Kim BJ, Suh YH, Roh GS, Gao B, Kim W, Kim WH
Journal of hepatology67(2)349-359(2017 Aug)

Temporal regulation of extracellular signal-regulated kinase 1/2 phosphorylation, heat shock protein 70 and activating transcription factor 3 during prostaglandin F-induced luteal regression in pseudopregnant rats following heat stress.
Bai WJ, Jin PJ, Kuang MQ, Wei QW, Shi FX, Davis JS, Mao DG
Reproduction, fertility, and development29(6)1184-1193(2017 Jun)

Sublytic C5b-9 triggers glomerular mesangial cell apoptosis in rat Thy-1 nephritis via Gadd45 activation mediated by Egr-1 and p300-dependent ATF3 acetylation.
He F, Zhou M, Yu T, Zhao D, Zhang J, Qiu W, Lu Y, Liu Y, Wang L, Wang Y
Journal of molecular cell biology8(6)477-491(2016 Dec)

Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling.
Liu Z, Shi Q, Song X, Wang Y, Wang Y, Song E, Song Y
Chemical research in toxicology29(9)1510-8(2016 Sep)

Cutaneous tissue damage induces long-lasting nociceptive sensitization and regulation of cellular stress- and nerve injury-associated genes in sensory neurons.
Rau KK, Hill CE, Harrison BJ, Venkat G, Koenig HM, Cook SB, Rabchevsky AG, Taylor BK, Hai T, Petruska JC
Experimental neurology283(Pt A)413-27(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

sublytic C5b-9-induced activation of Egr-1/p300-ATF3/Gadd45 axis plays a critical role in glomerular mesangial cells apoptosis in Thy-1N rats.
Title: Sublytic C5b-9 triggers glomerular mesangial cell apoptosis in rat Thy-1 nephritis via Gadd45 activation mediated by Egr-1 and p300-dependent ATF3 acetylation.

The cellular injury/stress response induced in sensory neurons by tissue damage and indicated by ATF3 expression is positioned to contribute to pain which can occur after tissue damage.
Title: Cutaneous tissue damage induces long-lasting nociceptive sensitization and regulation of cellular stress- and nerve injury-associated genes in sensory neurons.

our data demonstrate that a cell-autonomous program consisting of a stress-induced Atf3-gelsolin cascade affects the change in dendritic spine morphology in models of tuberous sclerosis complex
Title: The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex.

Heroin activates ATF3 and CytC via c-Jun N-terminal kinase pathways to mediate neuronal apoptosis.
Title: Heroin activates ATF3 and CytC via c-Jun N-terminal kinase pathways to mediate neuronal apoptosis.

this is the first study to provide evidence for temporal relationships between MAPK activation and ATF3 expression during PGF-induced luteal regression in the rat.
Title: Prostaglandin F2? induces expression of activating transcription factor 3 (ATF3) and activates MAPK signaling in the rat corpus luteum.

The following Atf3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atf3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12955	NM_012912.2 Latest version!	Rattus norvegicus activating transcription factor 3 (Atf3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atf3 ( NM_012912.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037044.1 Rattus norvegicus activating transcription factor 3 (Atf3), mRNA.

Price & Availability↑

CloneID	ORa12955
Clone ID Related Accession (Same CDS sequence)	NM_012912.2
Accession Version	NM_012912.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Rattus norvegicus(Norway rat)
Product	cyclic AMP-dependent transcription factor ATF-3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078903.1. On Aug 18, 2012 this sequence version replaced NM_012912.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078903.1, M63282.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGATGCTTC AACATCCAGG CCAGGTCTCT GCCTCAGAAG TCAGCGCGAC CGCCATCGTC 
CCCTGCCTCT CACCTCCTGG GTCACTGGTG TTTGAGGATT TTGCTAACCT GACACCTTTT 
GTCAAGGAAG AGCTGAGATT CGCCATCCAG AACAAGCACC TTTGCCATCG GATGTCCTCT 
GCGCTGGAGT CAGTCACCAT CAACAACAGA CCTCTGGAGA TGTCAGTCAC CAAGTCTGAG 
GTGGCCCCTG AAGAAGATGA GAGAAAAAGG AGGCGGCGGG AAAGAAACAA AATTGCTGCT 
GCCAAGTGTC GAAACAAGAA AAAAGAGAAG ACAGAGTGCC TGCAGAAGGA GTCAGAGAAA 
CTGGAGAGTG TGAATGCCGA ACTGAAGGCC CAGATCGAGG AGCTGAAGAA TGAGAAGCAG 
CATCTGATTT ACATGCTCAA CCTGCACCGG CCCACGTGTA TCGTCCGGGC TCAGAACGGG 
CGGACGCCGG AAGACGAGAG GAACCTTTTT ATCCAACAGA TAAAAGAAGG AACATTGCAG 
AGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037044.1
CDS	158..703
Translation	MMLQHPGQVSASEVSATAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTINNRPLEMSVTKSEVAPEEDERKRRRRERNKIAAAKCRNKKKEKTECLQKESEKLESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQS

Target ORF information:

RefSeq Version	NM_012912.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus activating transcription factor 3 (Atf3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012912.2

ORF Insert Sequence:

ATGATGCTTC AACATCCAGG CCAGGTCTCT GCCTCAGAAG TCAGCGCGAC CGCCATCGTC 
CCCTGCCTCT CACCTCCTGG GTCACTGGTG TTTGAGGATT TTGCTAACCT GACACCTTTT 
GTCAAGGAAG AGCTGAGATT CGCCATCCAG AACAAGCACC TTTGCCATCG GATGTCCTCT 
GCGCTGGAGT CAGTCACCAT CAACAACAGA CCTCTGGAGA TGTCAGTCAC CAAGTCTGAG 
GTGGCCCCTG AAGAAGATGA GAGAAAAAGG AGGCGGCGGG AAAGAAACAA AATTGCTGCT 
GCCAAGTGTC GAAACAAGAA AAAAGAGAAG ACAGAGTGCC TGCAGAAGGA GTCAGAGAAA 
CTGGAGAGTG TGAATGCCGA ACTGAAGGCC CAGATCGAGG AGCTGAAGAA TGAGAAGCAG 
CATCTGATTT ACATGCTCAA CCTGCACCGG CCCACGTGTA TCGTCCGGGC TCAGAACGGG 
CGGACGCCGG AAGACGAGAG GAACCTTTTT ATCCAACAGA TAAAAGAAGG AACATTGCAG 
AGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Activating transcription factor 3 is a target molecule linking hepatic steatosis to impaired glucose homeostasis.
Journal of hepatology67(2)349-359(2017 Aug)
Kim JY,Park KJ,Hwang JY,Kim GH,Lee D,Lee YJ,Song EH,Yoo MG,Kim BJ,Suh YH,Roh GS,Gao B,Kim W,Kim WH

Temporal regulation of extracellular signal-regulated kinase 1/2 phosphorylation, heat shock protein 70 and activating transcription factor 3 during prostaglandin F-induced luteal regression in pseudopregnant rats following heat stress.
Reproduction, fertility, and development29(6)1184-1193(2017 Jun)
Bai WJ,Jin PJ,Kuang MQ,Wei QW,Shi FX,Davis JS,Mao DG

Sublytic C5b-9 triggers glomerular mesangial cell apoptosis in rat Thy-1 nephritis via Gadd45 activation mediated by Egr-1 and p300-dependent ATF3 acetylation.
Journal of molecular cell biology8(6)477-491(2016 Dec)
He F,Zhou M,Yu T,Zhao D,Zhang J,Qiu W,Lu Y,Liu Y,Wang L,Wang Y

Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling.
Chemical research in toxicology29(9)1510-8(2016 Sep)
Liu Z,Shi Q,Song X,Wang Y,Wang Y,Song E,Song Y

Cutaneous tissue damage induces long-lasting nociceptive sensitization and regulation of cellular stress- and nerve injury-associated genes in sensory neurons.
Experimental neurology283(Pt A)413-27(2016 Sep)
Rau KK,Hill CE,Harrison BJ,Venkat G,Koenig HM,Cook SB,Rabchevsky AG,Taylor BK,Hai T,Petruska JC

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Atf3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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