Sstr5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sstr5
Entrez Gene ID	25354
Full Name	somatostatin receptor 5
Synonyms	Smstr5,Somato
General protein information	Preferred Names somatostatin receptor 5 Names somatostatin receptor type 5 SS-5-R SS5-R SS5R Somatostatin receptor subtype 5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q12
Summary	transmembrane receptor for somatostatin 28; coupled to a G-protein which inhibits adenylyl cyclase; may also activate the mitogen-activated protein (MAP) kinase cascade [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012882.2	NP_037014.2	somatostatin receptor type 5

Pathways from BioSystems

Homologies

Homo sapiens (human)	SSTR5	NP_001166031.1
Mus musculus (house mouse)	Sstr5	NP_035555.1
Danio rerio (zebrafish)	zgc:85682	NP_998462.1
Xenopus tropicalis (tropical clawed frog)	sstr5	XP_002932329.2
Canis lupus familiaris (dog)	SSTR5	XP_003434920.1
Rattus norvegicus (Norway rat)	Sstr5	NP_037014.2
Pan troglodytes (chimpanzee)	SSTR5	XP_003314946.1
Bos taurus (cattle)	SSTR5	XP_005224651.1
Gallus gallus (chicken)	SSTR5	NP_001020005.1

Gene Ontology
Bibliography

Related articles in PubMed

Somatostatin receptor 5 is a prominent regulator of signaling pathways in cells with coexpression of Cannabinoid receptors 1.
Zou S, Somvanshi RK, Kumar U
Neuroscience340218-231(2017 Jan)

Somatostatin receptor 1-5; expression profiles during rat development.
Ludvigsen E, Carlsson C, Tiensuu Janson E, Sandler S, Stridsberg M
Upsala journal of medical sciences120(3)157-68(2015)

Somatostatin receptor-mediated suppression of gabaergic synaptic transmission in cultured rat retinal amacrine cells.
Chen W, Ke JB, Wu HJ, Miao Y, Li F, Yang XL, Wang Z
Neuroscience273118-27(2014 Jul)

Genetic signatures for enhanced olfaction in the African mole-rats.
Stathopoulos S, Bishop JM, O'Ryan C
PloS one9(4)e93336(2014)

Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release.
Park S, Jiang H, Zhang H, Smith RG
Proceedings of the National Academy of Sciences of the United States of America109(46)19003-8(2012 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results showed that CB1R and SSTR5 colocalized in rat brain cortex, striatum, and hippocampus. CB1R was expressed in SSTR5 immunoprecipitate prepared from the brain tissue lysate, indicating their association in a system where these receptors are endogenously expressed.
Title: Somatostatin receptor 5 is a prominent regulator of signaling pathways in cells with coexpression of Cannabinoid receptors 1.

All SSTR1-5 proteins were observed at embryonal day 10 and increased with time in major structures, but the localization varied between the different subtypes. SSTR5 co-localized with glucagon and pancreatic polypeptide.
Title: Somatostatin receptor 1-5; expression profiles during rat development.

Results suggest that somatostatin suppresses GABA release from the amacrine cells by inhibiting presynaptic Ca2+ channels, in part through activating sst5/sst2 receptors, a process that is mediated by the intracellular cAMP-PKA signaling pathway
Title: Somatostatin receptor-mediated suppression of gabaergic synaptic transmission in cultured rat retinal amacrine cells.

Somatostatin inhibited GIP and glucagon-like peptide-1 (GLP-1) secretion from primary small intestinal cultures, in part through SSTR5.
Title: Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents.

Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release.
Title: Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release.

The following Sstr5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sstr5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13466	NM_012882.2 Latest version!	Rattus norvegicus somatostatin receptor 5 (Sstr5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sstr5 ( NM_012882.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037014.2 Rattus norvegicus somatostatin receptor 5 (Sstr5), mRNA.

Price & Availability↑

CloneID	ORa13466
Clone ID Related Accession (Same CDS sequence)	NM_012882.2
Accession Version	NM_012882.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Rattus norvegicus(Norway rat)
Product	somatostatin receptor type 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC098959.8. On Oct 24, 2007 this sequence version replaced NM_012882.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L04535.1 [ECO:0000332] ##Evidence-Data-END##

ATGGAGCCCC TCTCTCTGGC CTCCACACCA AGCTGGAATG CCTCGGCTGC TTCCAGTGGT 
AACCATAACT GGTCACTGGT GGGCTCAGCA TCGCCAATGG GAGCCCGGGC AGTATTAGTG 
CCTGTGCTCT ACCTGTTGGT GTGCACCGTG GGACTGAGTG GAAATACACT GGTCATTTAT 
GTGGTGCTGC GGCACGCCAA GATGAAGACA GTTACTAACG TGTACATCCT GAACCTGGCC 
GTGGCTGACG TATTATTTAT GTTGGGACTT CCTTTCCTGG CCACGCAGAA CGCCGTCTCC 
TACTGGCCCT TCGGCTCCTT CTTGTGCCGC CTGGTCATGA CACTGGATGG CATCAACCAG 
TTCACCAGTA TCTTCTGCCT GATGGTCATG AGTGTTGACC GCTACCTGGC CGTGGTCCAC 
CCTCTCCGCT CAGCCCGGTG GCGTCGCCCA CGGGTAGCCA AGATGGCCAG CGCGGCCGTC 
TGGGTCTTTT CGCTGCTCAT GTCTCTGCCG CTCTTGGTCT TCGCGGATGT CCAGGAGGGC 
TGGGGCACCT GCAACCTGAG CTGGCCAGAG CCTGTGGGGC TGTGGGGTGC AGCCTTCATC 
ACCTACACGT CTGTGTTGGG CTTCTTTGGG CCCCTGCTGG TCATCTGCTT GTGCTACCTG 
CTCATTGTGG TCAAGGTGAA GGCTGCAGGC ATGCGCGTAG GCTCCTCAAG GCGGAGGCGC 
TCGGAGCGCA AGGTGACTCG CATGGTGGTG GTCGTGGTGC TGGTGTTTGT GGGCTGCTGG 
CTGCCTTTCT TCATTGTCAA CATCGTCAAC CTGGCCTTCA CACTGCCCGA GGAACCCACA 
TCTGCCGGCC TCTATTTCTT TGTGGTGGTC CTATCTTATG CCAATAGCTG TGCCAACCCC 
CTGCTCTACG GCTTTCTCTC GGACAACTTC CGCCAGAGCT TCCGGAAGGT TCTGTGCCTA 
CGTAGAGGAT ACGGTATGGA GGATGCGGAC GCCATAGAGC CACGGCCAGA CAAGAGTGGG 
CGGCCTCAGG CCACACTGCC CACACGCAGC TGCGAGGCCA ATGGGCTCAT GCAGACCAGC 
AGGATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037014.2
CDS	154..1242
Translation	MEPLSLASTPSWNASAASSGNHNWSLVGSASPMGARAVLVPVLYLLVCTVGLSGNTLVIYVVLRHAKMKTVTNVYILNLAVADVLFMLGLPFLATQNAVSYWPFGSFLCRLVMTLDGINQFTSIFCLMVMSVDRYLAVVHPLRSARWRRPRVAKMASAAVWVFSLLMSLPLLVFADVQEGWGTCNLSWPEPVGLWGAAFITYTSVLGFFGPLLVICLCYLLIVVKVKAAGMRVGSSRRRRSERKVTRMVVVVVLVFVGCWLPFFIVNIVNLAFTLPEEPTSAGLYFFVVVLSYANSCANPLLYGFLSDNFRQSFRKVLCLRRGYGMEDADAIEPRPDKSGRPQATLPTRSCEANGLMQTSRI

Target ORF information:

RefSeq Version	NM_012882.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus somatostatin receptor 5 (Sstr5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012882.2

ORF Insert Sequence:

ATGGAGCCCC TCTCTCTGGC CTCCACACCA AGCTGGAATG CCTCGGCTGC TTCCAGTGGT 
AACCATAACT GGTCACTGGT GGGCTCAGCA TCGCCAATGG GAGCCCGGGC AGTATTAGTG 
CCTGTGCTCT ACCTGTTGGT GTGCACCGTG GGACTGAGTG GAAATACACT GGTCATTTAT 
GTGGTGCTGC GGCACGCCAA GATGAAGACA GTTACTAACG TGTACATCCT GAACCTGGCC 
GTGGCTGACG TATTATTTAT GTTGGGACTT CCTTTCCTGG CCACGCAGAA CGCCGTCTCC 
TACTGGCCCT TCGGCTCCTT CTTGTGCCGC CTGGTCATGA CACTGGATGG CATCAACCAG 
TTCACCAGTA TCTTCTGCCT GATGGTCATG AGTGTTGACC GCTACCTGGC CGTGGTCCAC 
CCTCTCCGCT CAGCCCGGTG GCGTCGCCCA CGGGTAGCCA AGATGGCCAG CGCGGCCGTC 
TGGGTCTTTT CGCTGCTCAT GTCTCTGCCG CTCTTGGTCT TCGCGGATGT CCAGGAGGGC 
TGGGGCACCT GCAACCTGAG CTGGCCAGAG CCTGTGGGGC TGTGGGGTGC AGCCTTCATC 
ACCTACACGT CTGTGTTGGG CTTCTTTGGG CCCCTGCTGG TCATCTGCTT GTGCTACCTG 
CTCATTGTGG TCAAGGTGAA GGCTGCAGGC ATGCGCGTAG GCTCCTCAAG GCGGAGGCGC 
TCGGAGCGCA AGGTGACTCG CATGGTGGTG GTCGTGGTGC TGGTGTTTGT GGGCTGCTGG 
CTGCCTTTCT TCATTGTCAA CATCGTCAAC CTGGCCTTCA CACTGCCCGA GGAACCCACA 
TCTGCCGGCC TCTATTTCTT TGTGGTGGTC CTATCTTATG CCAATAGCTG TGCCAACCCC 
CTGCTCTACG GCTTTCTCTC GGACAACTTC CGCCAGAGCT TCCGGAAGGT TCTGTGCCTA 
CGTAGAGGAT ACGGTATGGA GGATGCGGAC GCCATAGAGC CACGGCCAGA CAAGAGTGGG 
CGGCCTCAGG CCACACTGCC CACACGCAGC TGCGAGGCCA ATGGGCTCAT GCAGACCAGC 
AGGATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Somatostatin receptor 5 is a prominent regulator of signaling pathways in cells with coexpression of Cannabinoid receptors 1.
Neuroscience340218-231(2017 Jan)
Zou S,Somvanshi RK,Kumar U

Somatostatin receptor 1-5; expression profiles during rat development.
Upsala journal of medical sciences120(3)157-68(2015)
Ludvigsen E,Carlsson C,Tiensuu Janson E,Sandler S,Stridsberg M

Somatostatin receptor-mediated suppression of gabaergic synaptic transmission in cultured rat retinal amacrine cells.
Neuroscience273118-27(2014 Jul)
Chen W,Ke JB,Wu HJ,Miao Y,Li F,Yang XL,Wang Z

Genetic signatures for enhanced olfaction in the African mole-rats.
PloS one9(4)e93336(2014)
Stathopoulos S,Bishop JM,O'Ryan C

Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release.
Proceedings of the National Academy of Sciences of the United States of America109(46)19003-8(2012 Nov)
Park S,Jiang H,Zhang H,Smith RG

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Sstr5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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