Mgp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mgp
Entrez Gene ID	25333
Full Name	matrix Gla protein
Synonyms	Mglap
General protein information	Preferred Names matrix Gla protein Names matrix Gla protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q43
Summary	a vitamin K-dependent protein; part of the bone matrix [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012862.1	NP_036994.1	matrix Gla protein precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	MGP	NP_000891.2
	MGP	XP_001090877.1
Canis lupus familiaris (dog)	MGP	XP_003640024.1
Bos taurus (cattle)	MGP	NP_777132.1
Mus musculus (house mouse)	Mgp	NP_032623.1
Pan troglodytes (chimpanzee)	MGP	XP_003952171.1
Rattus norvegicus (Norway rat)	Mgp	NP_036994.1

Gene Ontology
Bibliography

Related articles in PubMed

Functional Role of Matrix gla Protein in Glioma Cell Migration.
Fu MH, Wang CY, Hsieh YT, Fang KM, Tzeng SF
Molecular neurobiology(2017 Jul)

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M
Circulation134(11)817-32(2016 Sep)

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins MT, Misra S, Stoughton J, Mayr M
Cardiovascular research110(3)419-30(2016 06)

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Zanivan S, Maione F, Hein MY, Hern?ndez-Fernaud JR, Ostasiewicz P, Giraudo E, Mann M
Molecular & cellular proteomics : MCP12(12)3599-611(2013 Dec)

Matrix Gla protein is involved in crystal formation in kidney of hyperoxaluric rats.
Lu X, Gao B, Yasui T, Li Y, Liu T, Mao X, Hirose M, Wu Y, Yu D, Zhu Q, Kohri K, Xiao C
Kidney & blood pressure research37(1)15-23(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

reduced gamma-Carboxylated MGP (cMGP), through an impaired expression of gamma-carboxylase, is involved in the early development of Medial artery calcification (MAC)in diabetes.
Title: Decreased expression of ?-carboxylase in diabetes-associated arterial stiffness: impact on matrix Gla protein.

Quercetin attenuates warfarin-induced vascular calcification in vitro independently from matrix Gla protein
Title: Quercetin attenuates warfarin-induced vascular calcification in vitro independently from matrix Gla protein.

Contiuous expression of Matrix Gla protein contributes to crystal formation in kidney of hyperoxaluric animals.
Title: Matrix Gla protein is involved in crystal formation in kidney of hyperoxaluric rats.

Synthesis of MGP is increased in renal failure and deficiency of GlaMGP is not a primary cause of medial calcification in this condition.
Title: Matrix Gla protein metabolism in vascular smooth muscle and role in uremic vascular calcification.

Selective CaSR activation, either by extracellular calcium or AMG 641, increased MGP expression in vivo in the arterial wall and in vitro in bovine vascular smooth muscle cells.
Title: Effect of calcium and the calcimimetic AMG 641 on matrix-Gla protein in vascular smooth muscle cells.

The following Mgp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mgp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01149	NM_012862.1 Latest version!	Rattus norvegicus matrix Gla protein (Mgp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mgp ( NM_012862.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036994.1 Rattus norvegicus matrix Gla protein (Mgp), mRNA.

Price & Availability↑

CloneID	ORa01149
Clone ID Related Accession (Same CDS sequence)	NM_012862.1
Accession Version	NM_012862.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	matrix Gla protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from J03026.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J03026.1, BC086394.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAAGAGCC TGCTCCCTCT GGCCATCCTG GCTGCGCTGG CCGTGGCAGC CCTGTGCTAT 
GAATCTCACG AAAGCATGGA ATCCTATGAA GTCAGTCCCT TCACCACCCG GAGAAATGCC 
AACACCTTTA TATCCCCTCA GCAGAGATGG CACGCTAAAG CCCAGGAAAG AGTCCGGGAA 
CTCAACAAGC CTGCCCAGGA GATCAACAGG GAGGCCTGTG ATGACTACAA GCTGTGTGAG 
CGCTACGCCC TGATCTACGG GTACAACGCC GCCTACAACC GCTACTTCAG GCAGCGCCGA 
GGAGCCAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036994.1
CDS	13..324
Translation	MKSLLPLAILAALAVAALCYESHESMESYEVSPFTTRRNANTFISPQQRWHAKAQERVRELNKPAQEINREACDDYKLCERYALIYGYNAAYNRYFRQRRGAK

Target ORF information:

RefSeq Version	NM_012862.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus matrix Gla protein (Mgp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012862.1

ORF Insert Sequence:

ATGAAGAGCC TGCTCCCTCT GGCCATCCTG GCTGCGCTGG CCGTGGCAGC CCTGTGCTAT 
GAATCTCACG AAAGCATGGA ATCCTATGAA GTCAGTCCCT TCACCACCCG GAGAAATGCC 
AACACCTTTA TATCCCCTCA GCAGAGATGG CACGCTAAAG CCCAGGAAAG AGTCCGGGAA 
CTCAACAAGC CTGCCCAGGA GATCAACAGG GAGGCCTGTG ATGACTACAA GCTGTGTGAG 
CGCTACGCCC TGATCTACGG GTACAACGCC GCCTACAACC GCTACTTCAG GCAGCGCCGA 
GGAGCCAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional Role of Matrix gla Protein in Glioma Cell Migration.
Molecular neurobiology(2017 Jul)
Fu MH,Wang CY,Hsieh YT,Fang KM,Tzeng SF

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Circulation134(11)817-32(2016 Sep)
Barallobre-Barreiro J,Gupta SK,Zoccarato A,Kitazume-Taneike R,Fava M,Yin X,Werner T,Hirt MN,Zampetaki A,Viviano A,Chong M,Bern M,Kourliouros A,Domenech N,Willeit P,Shah AM,Jahangiri M,Schaefer L,Fischer JW,Iozzo RV,Viner R,Thum T,Heineke J,Kichler A,Otsu K,Mayr M

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Cardiovascular research110(3)419-30(2016 06)
Barallobre-Barreiro J,Oklu R,Lynch M,Fava M,Baig F,Yin X,Barwari T,Potier DN,Albadawi H,Jahangiri M,Porter KE,Watkins MT,Misra S,Stoughton J,Mayr M

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
Molecular & cellular proteomics : MCP12(12)3599-611(2013 Dec)
Zanivan S,Maione F,Hein MY,Hern?ndez-Fernaud JR,Ostasiewicz P,Giraudo E,Mann M

Matrix Gla protein is involved in crystal formation in kidney of hyperoxaluric rats.
Kidney & blood pressure research37(1)15-23(2013)
Lu X,Gao B,Yasui T,Li Y,Liu T,Mao X,Hirose M,Wu Y,Yu D,Zhu Q,Kohri K,Xiao C

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Mgp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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