Fth1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fth1
Entrez Gene ID	25319
Full Name	ferritin heavy chain 1
Synonyms	Fth
General protein information	Preferred Names ferritin heavy chain 1 Names ferritin heavy chain Ferritin subunit H ferritin H subunit ferritin, heavy polypeptide 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q43
Summary	overexpressed during hepatic tumor development; used as an early marker for hepatocellular carcinoma [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012848.2	NP_036980.1	ferritin heavy chain

Pathways from BioSystems

Homologies

	FTH1	XP_002799572.1
Bos taurus (cattle)	FTH1	NP_776487.1
Canis lupus familiaris (dog)	FTH1	XP_005631692.1
Rattus norvegicus (Norway rat)	LOC689130	XP_002729272.1
Xenopus tropicalis (tropical clawed frog)	ftmt	NP_001005135.1
	LOC699053	XP_002806433.1
Mus musculus (house mouse)	Fth1	NP_034369.1
Danio rerio (zebrafish)	fth1b	NP_001004562.1
Pan troglodytes (chimpanzee)	FTH1	XP_001140124.2
Homo sapiens (human)	FTH1	NP_002023.2
Rattus norvegicus (Norway rat)	Fth1	NP_036980.1
Gallus gallus (chicken)	FTH1	NP_990417.1

Gene Ontology
Bibliography

Related articles in PubMed

Induction of Interleukin-1? by Human Immunodeficiency Virus-1 Viral Proteins Leads to Increased Levels of Neuronal Ferritin Heavy Chain, Synaptic Injury, and Deficits in Flexible Attention.
Festa L, Gutoskey CJ, Graziano A, Waterhouse BD, Meucci O
The Journal of neuroscience : the official journal of the Society for Neuroscience35(29)10550-61(2015 Jul)

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.
Lane DJ, Merlot AM, Huang ML, Bae DH, Jansson PJ, Sahni S, Kalinowski DS, Richardson DR
Biochimica et biophysica acta1853(5)1130-44(2015 May)

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella-Taracido I, Harrington E, Fekkes P, Lei H, Fang Q, Digan ME, Burdick D, Powers AF, Helliwell SB, D'Aquin S, Bastien J, Wang H, Wiederschain D, Kuerth J, Bergman P, Schwalb D, Thomas J, Ugwonali S, Harbinski F, Tallarico J, Wilson CJ, Myer VE, Porter JA, Bussiere DE, Finan PM, Labow MA, Mao X, Hamann LG, Manning BD, Valdez RA, Nicholson T, Schirle M, Knapp MS, Keaney EP, Murphy LO
Nature cell biology16(11)1069-79(2014 Nov)

Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration.
Finazzi D, Arosio P
Archives of toxicology88(10)1787-802(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This work demonstrates the key role of the cytokine IL-1beta in the regulation of a novel intracellular mediator [i.e., the protein ferritin heavy chain (FHC)] of HIV-induced dendritic damage and the resulting neurocognitive impairment.
Title: Induction of Interleukin-1? by Human Immunodeficiency Virus-1 Viral Proteins Leads to Increased Levels of Neuronal Ferritin Heavy Chain, Synaptic Injury, and Deficits in Flexible Attention.

Data suggest that soluble transferrin receptor (sTfR) indices and the ratio of sTfR/ferritin could be useful indicators for monitoring iron deficiency during endurance training.
Title: The ratio of sTfR/ferritin is associated with the expression level of TfR in rat bone marrow cells after endurance exercise.

The expression of HO1, FTH, and IRP1 mRNAs is higher in the female hippocampus than that observed in male rats.
Title: Regulation of iron-related molecules in the rat hippocampus: sex- and age-associated differences.

These results indicate that iron-based nanoparticles can cause ROS and decreased glutamate uptake, potentially leading to neurodegeneration.
Title: Ferritin, a protein containing iron nanoparticles, induces reactive oxygen species formation and inhibits glutamate uptake in rat brain synaptosomes.

ubiquitin-conjugating enzyme E2D 3 (UBE2D3), cAMP-dependent protein kinase C beta subunit (PKCbeta), excitatory amino acid carrier 1 (EAAC1), and ferritin heavy polypeptide 1 (Fth1), that were upregulated after a 48-h fast
Title: Identification of fasting-induced genes in the rat hypothalamus: relationship with neuroprotection.

The following Fth1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fth1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01115	NM_012848.2 Latest version!	Rattus norvegicus ferritin heavy chain 1 (Fth1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fth1 ( NM_012848.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036980.1 Rattus norvegicus ferritin heavy chain 1 (Fth1), mRNA.

Price & Availability↑

CloneID	ORa01115
Clone ID Related Accession (Same CDS sequence)	NM_012848.2
Accession Version	NM_012848.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	ferritin heavy chain
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U58829.1. On Aug 30, 2012 this sequence version replaced NM_012848.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U58829.1, FQ229789.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACCACCG CGTCTCCCTC GCAAGTGCGC CAGAACTACC ACCAGGACTC GGAGGCTGCC 
ATCAACCGCC AGATCAACCT GGAGTTGTAT GCCTCCTACG TCTATCTGTC CATGTCTTGT 
TATTTTGACC GGGATGATGT GGCCCTGAAG AACTTTGCCA AATACTTTCT CCATCAATCT 
CATGAAGAGA GGGAACATGC TGAGAAACTG ATGAAGCTGC AGAACCAGCG AGGTGGACGA 
ATCTTCCTGC AGGATATAAA GAAACCTGAC CGTGATGACT GGGAGAGCGG GCTGAATGCA 
ATGGAGTGTG CACTGCACTT GGAAAAGAGT GTGAATCAGT CACTACTGGA ACTTCACAAA 
CTGGCTACTG ACAAGAATGA TCCCCACTTA TGTGACTTCA TTGAGACGCA TTACCTGAAT 
GAGCAGGTGA AATCCATTAA AGAACTGGGT GACCACGTGA CCAACTTACG CAAGATGGGA 
GCCCCTGAAT CTGGCATGGC AGAATATCTC TTTGACAAGC ACACCCTGGG ACACGGTGAT 
GAGAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036980.1
CDS	128..676
Translation	MTTASPSQVRQNYHQDSEAAINRQINLELYASYVYLSMSCYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDRDDWESGLNAMECALHLEKSVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKSIKELGDHVTNLRKMGAPESGMAEYLFDKHTLGHGDES

Target ORF information:

RefSeq Version	NM_012848.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ferritin heavy chain 1 (Fth1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012848.2

ORF Insert Sequence:

ATGACCACCG CGTCTCCCTC GCAAGTGCGC CAGAACTACC ACCAGGACTC GGAGGCTGCC 
ATCAACCGCC AGATCAACCT GGAGTTGTAT GCCTCCTACG TCTATCTGTC CATGTCTTGT 
TATTTTGACC GGGATGATGT GGCCCTGAAG AACTTTGCCA AATACTTTCT CCATCAATCT 
CATGAAGAGA GGGAACATGC TGAGAAACTG ATGAAGCTGC AGAACCAGCG AGGTGGACGA 
ATCTTCCTGC AGGATATAAA GAAACCTGAC CGTGATGACT GGGAGAGCGG GCTGAATGCA 
ATGGAGTGTG CACTGCACTT GGAAAAGAGT GTGAATCAGT CACTACTGGA ACTTCACAAA 
CTGGCTACTG ACAAGAATGA TCCCCACTTA TGTGACTTCA TTGAGACGCA TTACCTGAAT 
GAGCAGGTGA AATCCATTAA AGAACTGGGT GACCACGTGA CCAACTTACG CAAGATGGGA 
GCCCCTGAAT CTGGCATGGC AGAATATCTC TTTGACAAGC ACACCCTGGG ACACGGTGAT 
GAGAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Induction of Interleukin-1? by Human Immunodeficiency Virus-1 Viral Proteins Leads to Increased Levels of Neuronal Ferritin Heavy Chain, Synaptic Injury, and Deficits in Flexible Attention.
The Journal of neuroscience : the official journal of the Society for Neuroscience35(29)10550-61(2015 Jul)
Festa L,Gutoskey CJ,Graziano A,Waterhouse BD,Meucci O

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.
Biochimica et biophysica acta1853(5)1130-44(2015 May)
Lane DJ,Merlot AM,Huang ML,Bae DH,Jansson PJ,Sahni S,Kalinowski DS,Richardson DR

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Nature cell biology16(11)1069-79(2014 Nov)
Dowdle WE,Nyfeler B,Nagel J,Elling RA,Liu S,Triantafellow E,Menon S,Wang Z,Honda A,Pardee G,Cantwell J,Luu C,Cornella-Taracido I,Harrington E,Fekkes P,Lei H,Fang Q,Digan ME,Burdick D,Powers AF,Helliwell SB,D'Aquin S,Bastien J,Wang H,Wiederschain D,Kuerth J,Bergman P,Schwalb D,Thomas J,Ugwonali S,Harbinski F,Tallarico J,Wilson CJ,Myer VE,Porter JA,Bussiere DE,Finan PM,Labow MA,Mao X,Hamann LG,Manning BD,Valdez RA,Nicholson T,Schirle M,Knapp MS,Keaney EP,Murphy LO

Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration.
Archives of toxicology88(10)1787-802(2014 Oct)
Finazzi D,Arosio P

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Fth1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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