Fnta cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fnta
Entrez Gene ID	25318
Full Name	farnesyltransferase, CAAX box, alpha
Synonyms	PFAS
General protein information	Preferred Names farnesyltransferase, CAAX box, alpha Names protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha CAAX farnesyltransferase subunit alpha FTase-alpha Farnesyltransferase, subunit alpha GGTase-I-alpha ras proteins prenyltransferase subunit alpha type I protein geranyl-geranyltransferase subunit alpha
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q12.4
Summary	subunit of the heterodimeric p21ras protein farnesyltransferase that attaches farnesyl residues to a cysteine at the fourth position from the C-terminus; may function as farnesyl pyrophosphate carrier [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012847.1	NP_036979.1	protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Pathways from BioSystems

Homologies

Bos taurus (cattle)	FNTA	NP_803464.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011767	XP_320743.4
Kluyveromyces lactis	KLLA0E17975g	XP_454761.1
Eremothecium gossypii	AGOS_ACR094C	NP_983496.1
Neurospora crassa	NCU03632	XP_961359.2
Oryza sativa (rice)	Os09g0514400	NP_001063659.1
Pan troglodytes (chimpanzee)	FNTA	XP_001145933.2
Rattus norvegicus (Norway rat)	Fnta	NP_036979.1
Drosophila melanogaster (fruit fly)	CG2976	NP_001260048.1
Caenorhabditis elegans (roundworm)	fnta-1	NP_499882.1
Canis lupus familiaris (dog)	FNTA	XP_532786.2
Gallus gallus (chicken)	FNTA	XP_424881.4
Danio rerio (zebrafish)	fnta	NP_001074029.1
Magnaporthe oryzae (rice blast fungus)	MGG_16220	XP_003709689.1
Arabidopsis thaliana (thale cress)	FTA	NP_567084.1
Xenopus tropicalis (tropical clawed frog)	fnta	NP_001116893.1
Homo sapiens (human)	FNTA	NP_002018.1
Mus musculus (house mouse)	Fnta	NP_032059.1
Saccharomyces cerevisiae (baker's yeast)	RAM2	NP_012906.3
Schizosaccharomyces pombe (fission yeast)	cwp1	NP_593518.1

Gene Ontology
Bibliography

Related articles in PubMed

Efficient farnesylation of an extended C-terminal C(x)
Blanden MJ, Suazo KF, Hildebrandt ER, Hardgrove DS, Patel M, Saunders WP, Distefano MD, Schmidt WK, Hougland JL
The Journal of biological chemistry(2017 Dec)

Geranylgeranyltransferase I mediates BDNF-induced synaptogenesis.
Li Z, Sun C, Zhang T, Mo J, Shi Q, Zhang X, Yuan M, Chen L, Mao X, Yu R, Zhou X
Journal of neurochemistry125(5)698-712(2013 Jun)

The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner.
Zhou J, Vos CC, Gjyrezi A, Yoshida M, Khuri FR, Tamanoi F, Giannakakou P
The Journal of biological chemistry284(15)9648-55(2009 Apr)

TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis.
Zhou XP, Wu KY, Liang B, Fu XQ, Luo ZG
Proceedings of the National Academy of Sciences of the United States of America105(44)17181-6(2008 Nov)

Dominant-negative alpha-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells.
Veluthakal R, Kaur H, Goalstone M, Kowluru A
Diabetes56(1)204-10(2007 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GGTase-1 mediates brain derived neurotrophic factor (BDNF)-induced neuronal synaptogenesis in the hippocampus.
Title: Geranylgeranyltransferase I mediates BDNF-induced synaptogenesis.

The following Fnta gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fnta cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01109	NM_012847.1 Latest version!	Rattus norvegicus farnesyltransferase, CAAX box, alpha (Fnta), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fnta ( NM_012847.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036979.1 Rattus norvegicus farnesyltransferase, CAAX box, alpha (Fnta), mRNA.

Price & Availability↑

CloneID	ORa01109
Clone ID Related Accession (Same CDS sequence)	NM_012847.1
Accession Version	NM_012847.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M81225.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M81225.1, BC085758.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCCA CTGAGGGGGT CGGGGAATCT GCGCCAGGCG GTGAGCCGGG ACAGCCAGAG 
CAGCCGCCGC CCCCGCCTCC TCCGCCGCCA GCACAGCAGC CGCAGGAAGA AGAGATGGCG 
GCCGAGGCCG GGGAAGCAGC GGCGTCCCCT ATGGACGACG GGTTTCTGAG CCTGGACTCG 
CCCACCTATG TCTTGTACAG GGACAGGGCA GAGTGGGCTG ACATAGACCC AGTGCCCCAG 
AATGATGGCC CCAGTCCAGT GGTCCAGATC ATCTACAGTG AAAAGTTTAG AGACGTCTAT 
GATTACTTCC GAGCTGTTCT GCAGCGCGAT GAAAGAAGCG AACGAGCCTT TAAGCTCACT 
CGAGATGCTA TTGAGTTAAA CGCAGCCAAC TATACGGTGT GGCATTTTCG GAGAGTTCTC 
TTGAGGTCGC TTCAGAAGGA TCTGCAAGAA GAAATGAACT ACATCATCGC AATAATTGAG 
GAACAGCCCA AAAACTATCA AGTTTGGCAC CATAGGAGAG TATTAGTGGA GTGGCTGAAA 
GATCCTTCTC AAGAGCTCGA GTTCATCGCC GATATCCTTA ATCAGGATGC AAAGAATTAC 
CATGCCTGGC AGCATCGACA GTGGGTCATT CAGGAGTTTC GACTTTGGGA TAATGAGCTG 
CAGTATGTGG ACCAGCTTCT CAAAGAGGAT GTGAGAAATA ACTCTGTGTG GAACCAAAGA 
CACTTCGTCA TTTCTAATAC CACTGGCTAC AGTGATCGCG CTGTGTTGGA GAGAGAAGTC 
CAATATACTC TGGAAATGAT CAAATTAGTG CCACACAATG AGAGTGCGTG GAACTACTTG 
AAAGGGATTT TGCAGGACCG TGGTCTTTCC AGATACCCTA ATCTATTAAA CCAGTTGCTT 
GATTTACAAC CAAGTCACAG CTCCCCCTAC CTAATTGCCT TTCTTGTGGA TATCTATGAA 
GACATGCTGG AAAACCAGTG TGACAACAAG GAGGACATTC TTAATAAAGC ACTAGAGTTA 
TGTGAGATTC TAGCTAAAGA AAAGGACACT ATAAGAAAGG AATATTGGAG ATATATTGGA 
CGGTCCCTCC AGAGTAAACA CAGCAGAGAA AGTGACATAC CGGCGAGTGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036979.1
CDS	57..1190
Translation	MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV

Target ORF information:

RefSeq Version	NM_012847.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus farnesyltransferase, CAAX box, alpha (Fnta), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012847.1

ORF Insert Sequence:

ATGGCGGCCA CTGAGGGGGT CGGGGAATCT GCGCCAGGCG GTGAGCCGGG ACAGCCAGAG 
CAGCCGCCGC CCCCGCCTCC TCCGCCGCCA GCACAGCAGC CGCAGGAAGA AGAGATGGCG 
GCCGAGGCCG GGGAAGCAGC GGCGTCCCCT ATGGACGACG GGTTTCTGAG CCTGGACTCG 
CCCACCTATG TCTTGTACAG GGACAGGGCA GAGTGGGCTG ACATAGACCC AGTGCCCCAG 
AATGATGGCC CCAGTCCAGT GGTCCAGATC ATCTACAGTG AAAAGTTTAG AGACGTCTAT 
GATTACTTCC GAGCTGTTCT GCAGCGCGAT GAAAGAAGCG AACGAGCCTT TAAGCTCACT 
CGAGATGCTA TTGAGTTAAA CGCAGCCAAC TATACGGTGT GGCATTTTCG GAGAGTTCTC 
TTGAGGTCGC TTCAGAAGGA TCTGCAAGAA GAAATGAACT ACATCATCGC AATAATTGAG 
GAACAGCCCA AAAACTATCA AGTTTGGCAC CATAGGAGAG TATTAGTGGA GTGGCTGAAA 
GATCCTTCTC AAGAGCTCGA GTTCATCGCC GATATCCTTA ATCAGGATGC AAAGAATTAC 
CATGCCTGGC AGCATCGACA GTGGGTCATT CAGGAGTTTC GACTTTGGGA TAATGAGCTG 
CAGTATGTGG ACCAGCTTCT CAAAGAGGAT GTGAGAAATA ACTCTGTGTG GAACCAAAGA 
CACTTCGTCA TTTCTAATAC CACTGGCTAC AGTGATCGCG CTGTGTTGGA GAGAGAAGTC 
CAATATACTC TGGAAATGAT CAAATTAGTG CCACACAATG AGAGTGCGTG GAACTACTTG 
AAAGGGATTT TGCAGGACCG TGGTCTTTCC AGATACCCTA ATCTATTAAA CCAGTTGCTT 
GATTTACAAC CAAGTCACAG CTCCCCCTAC CTAATTGCCT TTCTTGTGGA TATCTATGAA 
GACATGCTGG AAAACCAGTG TGACAACAAG GAGGACATTC TTAATAAAGC ACTAGAGTTA 
TGTGAGATTC TAGCTAAAGA AAAGGACACT ATAAGAAAGG AATATTGGAG ATATATTGGA 
CGGTCCCTCC AGAGTAAACA CAGCAGAGAA AGTGACATAC CGGCGAGTGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Efficient farnesylation of an extended C-terminal C(x)
The Journal of biological chemistry(2017 Dec)
Blanden MJ,Suazo KF,Hildebrandt ER,Hardgrove DS,Patel M,Saunders WP,Distefano MD,Schmidt WK,Hougland JL

Geranylgeranyltransferase I mediates BDNF-induced synaptogenesis.
Journal of neurochemistry125(5)698-712(2013 Jun)
Li Z,Sun C,Zhang T,Mo J,Shi Q,Zhang X,Yuan M,Chen L,Mao X,Yu R,Zhou X

The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner.
The Journal of biological chemistry284(15)9648-55(2009 Apr)
Zhou J,Vos CC,Gjyrezi A,Yoshida M,Khuri FR,Tamanoi F,Giannakakou P

TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America105(44)17181-6(2008 Nov)
Zhou XP,Wu KY,Liang B,Fu XQ,Luo ZG

Dominant-negative alpha-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells.
Diabetes56(1)204-10(2007 Jan)
Veluthakal R,Kaur H,Goalstone M,Kowluru A

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Fnta cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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