Comp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Comp
Entrez Gene ID	25304
Full Name	cartilage oligomeric matrix protein
General protein information	Preferred Names cartilage oligomeric matrix protein Names cartilage oligomeric matrix protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p14
Summary	extracellular matrix protein that interacts with fibronectin and may play a role in extracellular matrix assembly and molecular interactions [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006252822.3	XP_006252884.1	cartilage oligomeric matrix protein isoform X1
NM_012834.1	NP_036966.1	cartilage oligomeric matrix protein precursor

Pathways from BioSystems

Homologies

	COMP	XP_001115565.1
Canis lupus familiaris (dog)	COMP	XP_533869.2
Gallus gallus (chicken)	COMP	XP_418238.2
Homo sapiens (human)	COMP	NP_000086.2
Danio rerio (zebrafish)	im:7154332	XP_002663752.3
Rattus norvegicus (Norway rat)	Comp	NP_036966.1
Drosophila melanogaster (fruit fly)	Tsp	NP_523495.2
Xenopus tropicalis (tropical clawed frog)	comp	XP_002940251.2
Pan troglodytes (chimpanzee)	COMP	NP_001092035.1
Bos taurus (cattle)	COMP	NP_001159989.1
Mus musculus (house mouse)	Comp	NP_057894.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002157	XP_308033.5

Gene Ontology
Bibliography

Related articles in PubMed

Lubricin binds cartilage proteins, cartilage oligomeric matrix protein, fibronectin and collagen II at the cartilage surface.
Flowers SA, Zieba A, ?rnros J, Jin C, Rolfson O, Bj?rkman LI, Eisler T, Kalamajski S, Kamali-Moghaddam M, Karlsson NG
Scientific reports7(1)13149(2017 Oct)

Hypoxia decrease expression of cartilage oligomeric matrix protein to promote phenotype switching of pulmonary arterial smooth muscle cells.
Yu H, Jia Q, Feng X, Chen H, Wang L, Ni X, Kong W
The international journal of biochemistry & cell biology91(Pt A)37-44(2017 Oct)

Cartilage oligomeric matrix protein prevents vascular aging and vascular smooth muscle cells senescence.
Wang M, Fu Y, Gao C, Jia Y, Huang Y, Liu L, Wang X, Wang W, Kong W
Biochemical and biophysical research communications478(2)1006-13(2016 09)

Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification.
Fu Y, Gao C, Liang Y, Wang M, Huang Y, Ma W, Li T, Jia Y, Yu F, Zhu W, Cui Q, Li Y, Xu Q, Wang X, Kong W
Circulation research119(2)261-76(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

COMP could normally have a protective role against PASMC phenotype switching
Title: Hypoxia decrease expression of cartilage oligomeric matrix protein to promote phenotype switching of pulmonary arterial smooth muscle cells.

these findings revealed the essential role of COMP in retarding the development of vascular aging and vascular smooth muscle cell senescence.
Title: Cartilage oligomeric matrix protein prevents vascular aging and vascular smooth muscle cells senescence.

COMP-Ang1-stimulated proliferation, differentiation, and migration of progenitor cells may involve the Tie-2-mediated activation of p38 MAPK and PI3K/Akt pathways
Title: COMP-angiopoietin 1 increases proliferation, differentiation, and migration of stem-like cells through Tie-2-mediated activation of p38 MAPK and PI3K/Akt signal transduction pathways.

results suggest the potential importance of COMP-Ang1 as a new therapy for impaired bone formation that is associated with diabetes and advanced age
Title: COMP-Ang1 inhibits apoptosis as well as improves the attenuated osteogenic differentiation of mesenchymal stem cells induced by advanced glycation end products.

The presence of cleaved apoptosis inducing factor (tAIF) and the absence of activated caspases indicated that retention of D469del-COMP triggers cell death in chondrocytes by necroptosis, a caspase-independent programmed necrosis.
Title: D469del-COMP retention in chondrocytes stimulates caspase-independent necroptosis.

The following Comp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Comp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa37182	XM_006252822.3 Latest version!	Rattus norvegicus cartilage oligomeric matrix protein (Comp), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa01079	NM_012834.1 Latest version!	Rattus norvegicus cartilage oligomeric matrix protein (Comp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$447.30 $639.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Comp ( XM_006252822.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006252884.1 Rattus norvegicus cartilage oligomeric matrix protein (Comp), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa37182
Clone ID Related Accession (Same CDS sequence)	XM_006252822.3
Accession Version	XM_006252822.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1956bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cartilage oligomeric matrix protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005115.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006252822.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCTTA AGCGCCCTGA AATGCAGAGG CTTGCCAATC CCTTTGAGTT CGAGGCCAGC 
CTGGTATACA TGTGCAACGC TCACCCCTGT TTCCCGCGCG TGCGGTGCAT CAATACCAGC 
CCTGGCTTTC ACTGCGAAGC CTGTCCCCCT GGGTTCAGCG GGCCCACCCA CGAGGGTGTG 
GGGCTGACCT TCGCCAAGAC CAACAAACAA GTTTGCACAG ATATTAATGA GTGTGAGACC 
GGGCAGCACA ATTGCGTTCC CAACTCCGTG TGCGTCAACA CCCGGGGCTC CTTCCAGTGC 
GGTCCCTGCC AGCCCGGCTT CGTGGGCGAC CAGAGGTCAG GCTGCCAGCG GCGTGGGCAA 
CACTTCTGCC CCGACGGGTC ACCCAGCCCG TGCCATGAGA AAGCAGACTG TATTTTGGAG 
CGCGACGGCT CAAGGTCCTG CGTGTGTGCG GTCGGCTGGG CCGGCAACGG GCTCCTGTGC 
GGACGCGACA CAGACCTGGA CGGTTTCCCG GACGAGAAGC TTCGCTGCTC AGAGCGCCAG 
TGCCGCAAGG ACAACTGCGT GACGGTGCCC AATTCAGGGC AGGAGGATGT GGACCGGGAC 
GGCATTGGAG ATGCTTGTGA CCCGGATGCG GACGGGGATG GAGTCCCTAA TGAGCAAGAC 
AATTGCCCGC TGGTTCGAAA CCCAGACCAG CGCAACTCGG ATAAAGACAA GTGGGGAGAT 
GCCTGCGACA ACTGCCGGTC CCAGAAGAAT GATGACCAGA AAGATACAGA CCGGGATGGC 
CAGGGCGATG CCTGCGACGA CGACATAGAT GGCGATCGAA TCCGAAATGT AGCTGACAAC 
TGTCCCCGGG TGCCCAACTT TGACCAGAGT GACAGCGATG GTGATGGTGT TGGGGATGCC 
TGTGACAATT GTCCCCAGAA AGACAACCCG GACCAGAGGG ACGTGGACCA CGACTTTGTG 
GGTGATGCCT GTGACAGTGA CCAAGACCAG GACGGGGATG GACACCAAGA CTCCCGGGAC 
AACTGCCCCA CAGTACCCAA CAGTGCCCAG CAGGACTCAG ACCATGATGG CAAGGGTGAT 
GCCTGTGATG ATGACGACGA CAATGACGGA GTCCCTGACA GCCGGGACAA TTGCCGCTTG 
GTGCCCAACC CGGGCCAAGA GGACAATGAC CGGGATGGCG TGGGTGACGC TTGTCAGGGT 
GACTTCGATG CTGACAAGGT TATAGACAAG ATCGATGTGT GCCCCGAGAA CGCCGAGGTC 
ACTCTCACCG ACTTCAGGGC CTTCCAAACA GTTGTGCTGG ACCCCGAGGG TGATGCGCAG 
ATCGACCCCA ACTGGGTGGT GCTCAATCAG GGAATGGAGA TCGTTCAGAC CATGAACAGT 
GACCCTGGCC TGGCTGTGGG TTACACGGCA TTCAACGGTG TAGATTTTGA GGGAACGTTC 
CATGTAAACA CCGCCACCGA TGATGACTAC GCTGGCTTCA TCTTCGGCTA TCAAGACAGC 
TCAAGTTTCT ATGTGGTCAT GTGGAAACAG ATGGAGCAGA CGTACTGGCA GGCCAATCCT 
TTCCGGGCAG TGGCTGAACC AGGGATTCAG CTCAAGGCTG TCAAGTCCTC TACAGGTCCC 
GGGGAACAGC TCCGAAATGC GTTGTGGCAC ACGGGGGACA CAGCATCCCA GGTGCGGCTG 
CTGTGGAAGG ATCCTCGAAA TGTGGGCTGG AAGGATAAGA CATCCTACCG CTGGTTCCTG 
CAGCACCGGC CTCAAGTCGG CTACATCAGG GTGCGGTTCT ATGAGGGTCC TGAGCTAGTA 
GCTGACAGCA ACGTGGTGCT GGACACAGCT ATGCGTGGTG GCCGCCTGGG TGTCTTCTGC 
TTCTCCCAAG AGAATATCAT CTGGGCTAAC CTGCGCTACC GTTGCAATGA TACAATCCCT 
GAGGACTATG AGCGTCACCG GCTGCGGAGG GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006252884.1
CDS	525..2480
Translation	MALKRPEMQRLANPFEFEASLVYMCNAHPCFPRVRCINTSPGFHCEACPPGFSGPTHEGVGLTFAKTNKQVCTDINECETGQHNCVPNSVCVNTRGSFQCGPCQPGFVGDQRSGCQRRGQHFCPDGSPSPCHEKADCILERDGSRSCVCAVGWAGNGLLCGRDTDLDGFPDEKLRCSERQCRKDNCVTVPNSGQEDVDRDGIGDACDPDADGDGVPNEQDNCPLVRNPDQRNSDKDKWGDACDNCRSQKNDDQKDTDRDGQGDACDDDIDGDRIRNVADNCPRVPNFDQSDSDGDGVGDACDNCPQKDNPDQRDVDHDFVGDACDSDQDQDGDGHQDSRDNCPTVPNSAQQDSDHDGKGDACDDDDDNDGVPDSRDNCRLVPNPGQEDNDRDGVGDACQGDFDADKVIDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTATDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTASQVRLLWKDPRNVGWKDKTSYRWFLQHRPQVGYIRVRFYEGPELVADSNVVLDTAMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYERHRLRRA

Target ORF information:

RefSeq Version	XM_006252822.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cartilage oligomeric matrix protein (Comp), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006252822.3

ORF Insert Sequence:

ATGGCTCTTA AGCGCCCTGA AATGCAGAGG CTTGCCAATC CCTTTGAGTT CGAGGCCAGC 
CTGGTATACA TGTGCAACGC TCACCCCTGT TTCCCGCGCG TGCGGTGCAT CAATACCAGC 
CCTGGCTTTC ACTGCGAAGC CTGTCCCCCT GGGTTCAGCG GGCCCACCCA CGAGGGTGTG 
GGGCTGACCT TCGCCAAGAC CAACAAACAA GTTTGCACAG ATATTAATGA GTGTGAGACC 
GGGCAGCACA ATTGCGTTCC CAACTCCGTG TGCGTCAACA CCCGGGGCTC CTTCCAGTGC 
GGTCCCTGCC AGCCCGGCTT CGTGGGCGAC CAGAGGTCAG GCTGCCAGCG GCGTGGGCAA 
CACTTCTGCC CCGACGGGTC ACCCAGCCCG TGCCATGAGA AAGCAGACTG TATTTTGGAG 
CGCGACGGCT CAAGGTCCTG CGTGTGTGCG GTCGGCTGGG CCGGCAACGG GCTCCTGTGC 
GGACGCGACA CAGACCTGGA CGGTTTCCCG GACGAGAAGC TTCGCTGCTC AGAGCGCCAG 
TGCCGCAAGG ACAACTGCGT GACGGTGCCC AATTCAGGGC AGGAGGATGT GGACCGGGAC 
GGCATTGGAG ATGCTTGTGA CCCGGATGCG GACGGGGATG GAGTCCCTAA TGAGCAAGAC 
AATTGCCCGC TGGTTCGAAA CCCAGACCAG CGCAACTCGG ATAAAGACAA GTGGGGAGAT 
GCCTGCGACA ACTGCCGGTC CCAGAAGAAT GATGACCAGA AAGATACAGA CCGGGATGGC 
CAGGGCGATG CCTGCGACGA CGACATAGAT GGCGATCGAA TCCGAAATGT AGCTGACAAC 
TGTCCCCGGG TGCCCAACTT TGACCAGAGT GACAGCGATG GTGATGGTGT TGGGGATGCC 
TGTGACAATT GTCCCCAGAA AGACAACCCG GACCAGAGGG ACGTGGACCA CGACTTTGTG 
GGTGATGCCT GTGACAGTGA CCAAGACCAG GACGGGGATG GACACCAAGA CTCCCGGGAC 
AACTGCCCCA CAGTACCCAA CAGTGCCCAG CAGGACTCAG ACCATGATGG CAAGGGTGAT 
GCCTGTGATG ATGACGACGA CAATGACGGA GTCCCTGACA GCCGGGACAA TTGCCGCTTG 
GTGCCCAACC CGGGCCAAGA GGACAATGAC CGGGATGGCG TGGGTGACGC TTGTCAGGGT 
GACTTCGATG CTGACAAGGT TATAGACAAG ATCGATGTGT GCCCCGAGAA CGCCGAGGTC 
ACTCTCACCG ACTTCAGGGC CTTCCAAACA GTTGTGCTGG ACCCCGAGGG TGATGCGCAG 
ATCGACCCCA ACTGGGTGGT GCTCAATCAG GGAATGGAGA TCGTTCAGAC CATGAACAGT 
GACCCTGGCC TGGCTGTGGG TTACACGGCA TTCAACGGTG TAGATTTTGA GGGAACGTTC 
CATGTAAACA CCGCCACCGA TGATGACTAC GCTGGCTTCA TCTTCGGCTA TCAAGACAGC 
TCAAGTTTCT ATGTGGTCAT GTGGAAACAG ATGGAGCAGA CGTACTGGCA GGCCAATCCT 
TTCCGGGCAG TGGCTGAACC AGGGATTCAG CTCAAGGCTG TCAAGTCCTC TACAGGTCCC 
GGGGAACAGC TCCGAAATGC GTTGTGGCAC ACGGGGGACA CAGCATCCCA GGTGCGGCTG 
CTGTGGAAGG ATCCTCGAAA TGTGGGCTGG AAGGATAAGA CATCCTACCG CTGGTTCCTG 
CAGCACCGGC CTCAAGTCGG CTACATCAGG GTGCGGTTCT ATGAGGGTCC TGAGCTAGTA 
GCTGACAGCA ACGTGGTGCT GGACACAGCT ATGCGTGGTG GCCGCCTGGG TGTCTTCTGC 
TTCTCCCAAG AGAATATCAT CTGGGCTAAC CTGCGCTACC GTTGCAATGA TACAATCCCT 
GAGGACTATG AGCGTCACCG GCTGCGGAGG GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Comp ( NM_012834.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036966.1 Rattus norvegicus cartilage oligomeric matrix protein (Comp), mRNA.

Price & Availability↑

CloneID	ORa01079
Clone ID Related Accession (Same CDS sequence)	NM_012834.1
Accession Version	NM_012834.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2268bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	cartilage oligomeric matrix protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X72914.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X72914.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689600 [ECO:0000348] ##Evidence-Data-END##

ATGAGCCCCA CTGCCTGCGT TCTAGTGCTC GCCCTGGCTG CCTTGCGGGC TACCGGCCAG 
GGCCAGATCC CGCTGGGTGG AGACCTAGCC CCACAGATGC TTCGAGAACT CCAGGAGACT 
AATGCGGCGC TGCAAGACGT GAGAGAGCTC TTGCGACACA GGGTCAAGGA GATCACCTTC 
CTGAAGAATA CGGTGATGGA ATGTGACGCT TGCGGAATGC AGCCCGCACG CACCCCCGGT 
CTGAGCGTGC GGCCAGTCGC GCTCTGCGCA CCCGGCTCCT GCTTCCCTGG CGTAGTCTGC 
ACGGAGACAG CTACCGGCGC GCGCTGCGGC CCCTGCCCTC CGGGCTACAC CGGCAACGGC 
TCGCACTGCA CCGACGTTAA TGAGTGCAAC GCTCACCCCT GTTTCCCGCG CGTGCGGTGC 
ATCAATACCA GCCCTGGCTT TCACTGCGAA GCCTGTCCCC CTGGGTTCAG CGGGCCCACC 
CACGAGGGTG TGGGGCTGAC CTTCGCCAAG ACCAACAAAC AAGTTTGCAC AGATATTAAT 
GAGTGTGAGA CCGGGCAGCA CAATTGCGTT CCCAACTCCG TGTGCGTCAA CACCCGGGGC 
TCCTTCCAGT GCGGTCCCTG CCAGCCCGGC TTCGTGGGCG ACCAGAGGTC AGGCTGCCAG 
CGGCGTGGGC AACACTTCTG CCCCGACGGG TCACCCAGCC CGTGCCATGA GAAAGCAGAC 
TGTATTTTGG AGCGCGACGG CTCAAGGTCC TGCGTGTGTG CGGTCGGCTG GGCCGGCAAC 
GGGCTCCTGT GCGGACGCGA CACAGACCTG GACGGTTTCC CGGACGAGAA GCTTCGCTGC 
TCAGAGCGCC AGTGCCGCAA GGACAACTGC GTGACGGTGC CCAATTCAGG GCAGGAGGAT 
GTGGACCGGG ACCGCATTGG AGATGCTTGT GACCCGGATG CGGACGGGGA TGGAGTCCCT 
AATGAGCAAG ACAATTGCCC GCTGGTTCGA AACCCAGACC AGCGCAACTC CGATAAAGAC 
AAGTGGGGAG ATGCCTGCGA CAACTGCCGG TCCCAGAAGA ATGATGACCA GAAAGATACA 
GACCGGGATG GCCAGGGCGA TGCCTGCGAC GACGACATAG ATGGCGATCG AATCCGAAAT 
GTAGCTGACA ACTGTCCCCG GGTGCCCAAC TTTGACCAGA GTGACAGCGA TGGTGATGGT 
GTTGGGGATG CCTGTGACAA TTGTCCCCAG AAAGACAACC CGGACCAGAG GGACGTGGAC 
CACGACTTTG TGGGTGATGC CTGTGACAGT GACCAAGACC AGGACGGGGA TGGACACCAA 
GACTCCCGGG ACAACTGCCC CACAGTGCCC AACAGTGCCC AGCAGGACTC AGACCATGAT 
GGCAAGGGTG ATGCCTGTGA TGATGACGAC GACAATGACG GAGTCCCTGA CAGCCGGGAC 
AATTGCCGCT TGGTGCCCAA CCCGGGCCAA GAGGACAATG ACCGGGATGG CGTGGGTGAC 
GCTTGTCAGG GTGACTTCGA TGCTGACAAG GTTATAGACA AGATCGATGT GTGCCCCGAG 
AACGCCGAGG TCACTCTCAC CGACTTCAGG GCCTTCCAAA CAGTTGTGCT GGACCCCGAG 
GGTGATGCGC AGATCGACCC CAACTGGGTG GTGCTCAATC AGGGAATGGA GATCGTTCAG 
ACCATGAACA GTGACCCTGG CCTGGCTGTG GGTTACACGG CATTCAACGG TGTAGATTTT 
GAGGGAACGT TCCATGTAAA CACCGCCACC GATGATGACT ACGCTGGCTT CATCTTCGGC 
TATCAAGACA GCTCAAGTTT CTATGTGGTC ATGTGGAAAC AGATGGAGCA GACGTACTGG 
CAGGCCAATC CTTTCCGGGC AGTGGCTGAA CCAGGGATTC AGCTCAAGGC TGTCAAGTCC 
TCTACAGGTC CCGGGGAACA GCTCCGAAAT GCGTTGTGGC ACACGGGGGA CACAGCATCC 
CAGGTGCGGC TGCTGTGGAA GGATCCTCGA AATGTGGGCT GGAAGGATAA GACATCCTAC 
CGCTGGTTCC TGCAGCACCG GCCTCAAGTC GGCTACATCA GGGTGCGGTT CTATGAGGGT 
CCTGAGCTAG TAGCTGACAG CAACGTGGTG CTGGACACAG CTATGCGTGG TGGCCGCCTG 
GGTGTCTTCT GCTTCTCCCA AGAGAATATC ATCTGGGCTA ACCTGCGCTA CCGTTGCAAT 
GATACAATCC CTGAGGACTA TGAGCGTCAC CGGCTGCGGA GGGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036966.1
CDS	7..2274
Translation	MSPTACVLVLALAALRATGQGQIPLGGDLAPQMLRELQETNAALQDVRELLRHRVKEITFLKNTVMECDACGMQPARTPGLSVRPVALCAPGSCFPGVVCTETATGARCGPCPPGYTGNGSHCTDVNECNAHPCFPRVRCINTSPGFHCEACPPGFSGPTHEGVGLTFAKTNKQVCTDINECETGQHNCVPNSVCVNTRGSFQCGPCQPGFVGDQRSGCQRRGQHFCPDGSPSPCHEKADCILERDGSRSCVCAVGWAGNGLLCGRDTDLDGFPDEKLRCSERQCRKDNCVTVPNSGQEDVDRDRIGDACDPDADGDGVPNEQDNCPLVRNPDQRNSDKDKWGDACDNCRSQKNDDQKDTDRDGQGDACDDDIDGDRIRNVADNCPRVPNFDQSDSDGDGVGDACDNCPQKDNPDQRDVDHDFVGDACDSDQDQDGDGHQDSRDNCPTVPNSAQQDSDHDGKGDACDDDDDNDGVPDSRDNCRLVPNPGQEDNDRDGVGDACQGDFDADKVIDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTATDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTASQVRLLWKDPRNVGWKDKTSYRWFLQHRPQVGYIRVRFYEGPELVADSNVVLDTAMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYERHRLRRA

Target ORF information:

RefSeq Version	NM_012834.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cartilage oligomeric matrix protein (Comp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012834.1

ORF Insert Sequence:

ATGAGCCCCA CTGCCTGCGT TCTAGTGCTC GCCCTGGCTG CCTTGCGGGC TACCGGCCAG 
GGCCAGATCC CGCTGGGTGG AGACCTAGCC CCACAGATGC TTCGAGAACT CCAGGAGACT 
AATGCGGCGC TGCAAGACGT GAGAGAGCTC TTGCGACACA GGGTCAAGGA GATCACCTTC 
CTGAAGAATA CGGTGATGGA ATGTGACGCT TGCGGAATGC AGCCCGCACG CACCCCCGGT 
CTGAGCGTGC GGCCAGTCGC GCTCTGCGCA CCCGGCTCCT GCTTCCCTGG CGTAGTCTGC 
ACGGAGACAG CTACCGGCGC GCGCTGCGGC CCCTGCCCTC CGGGCTACAC CGGCAACGGC 
TCGCACTGCA CCGACGTTAA TGAGTGCAAC GCTCACCCCT GTTTCCCGCG CGTGCGGTGC 
ATCAATACCA GCCCTGGCTT TCACTGCGAA GCCTGTCCCC CTGGGTTCAG CGGGCCCACC 
CACGAGGGTG TGGGGCTGAC CTTCGCCAAG ACCAACAAAC AAGTTTGCAC AGATATTAAT 
GAGTGTGAGA CCGGGCAGCA CAATTGCGTT CCCAACTCCG TGTGCGTCAA CACCCGGGGC 
TCCTTCCAGT GCGGTCCCTG CCAGCCCGGC TTCGTGGGCG ACCAGAGGTC AGGCTGCCAG 
CGGCGTGGGC AACACTTCTG CCCCGACGGG TCACCCAGCC CGTGCCATGA GAAAGCAGAC 
TGTATTTTGG AGCGCGACGG CTCAAGGTCC TGCGTGTGTG CGGTCGGCTG GGCCGGCAAC 
GGGCTCCTGT GCGGACGCGA CACAGACCTG GACGGTTTCC CGGACGAGAA GCTTCGCTGC 
TCAGAGCGCC AGTGCCGCAA GGACAACTGC GTGACGGTGC CCAATTCAGG GCAGGAGGAT 
GTGGACCGGG ACCGCATTGG AGATGCTTGT GACCCGGATG CGGACGGGGA TGGAGTCCCT 
AATGAGCAAG ACAATTGCCC GCTGGTTCGA AACCCAGACC AGCGCAACTC CGATAAAGAC 
AAGTGGGGAG ATGCCTGCGA CAACTGCCGG TCCCAGAAGA ATGATGACCA GAAAGATACA 
GACCGGGATG GCCAGGGCGA TGCCTGCGAC GACGACATAG ATGGCGATCG AATCCGAAAT 
GTAGCTGACA ACTGTCCCCG GGTGCCCAAC TTTGACCAGA GTGACAGCGA TGGTGATGGT 
GTTGGGGATG CCTGTGACAA TTGTCCCCAG AAAGACAACC CGGACCAGAG GGACGTGGAC 
CACGACTTTG TGGGTGATGC CTGTGACAGT GACCAAGACC AGGACGGGGA TGGACACCAA 
GACTCCCGGG ACAACTGCCC CACAGTGCCC AACAGTGCCC AGCAGGACTC AGACCATGAT 
GGCAAGGGTG ATGCCTGTGA TGATGACGAC GACAATGACG GAGTCCCTGA CAGCCGGGAC 
AATTGCCGCT TGGTGCCCAA CCCGGGCCAA GAGGACAATG ACCGGGATGG CGTGGGTGAC 
GCTTGTCAGG GTGACTTCGA TGCTGACAAG GTTATAGACA AGATCGATGT GTGCCCCGAG 
AACGCCGAGG TCACTCTCAC CGACTTCAGG GCCTTCCAAA CAGTTGTGCT GGACCCCGAG 
GGTGATGCGC AGATCGACCC CAACTGGGTG GTGCTCAATC AGGGAATGGA GATCGTTCAG 
ACCATGAACA GTGACCCTGG CCTGGCTGTG GGTTACACGG CATTCAACGG TGTAGATTTT 
GAGGGAACGT TCCATGTAAA CACCGCCACC GATGATGACT ACGCTGGCTT CATCTTCGGC 
TATCAAGACA GCTCAAGTTT CTATGTGGTC ATGTGGAAAC AGATGGAGCA GACGTACTGG 
CAGGCCAATC CTTTCCGGGC AGTGGCTGAA CCAGGGATTC AGCTCAAGGC TGTCAAGTCC 
TCTACAGGTC CCGGGGAACA GCTCCGAAAT GCGTTGTGGC ACACGGGGGA CACAGCATCC 
CAGGTGCGGC TGCTGTGGAA GGATCCTCGA AATGTGGGCT GGAAGGATAA GACATCCTAC 
CGCTGGTTCC TGCAGCACCG GCCTCAAGTC GGCTACATCA GGGTGCGGTT CTATGAGGGT 
CCTGAGCTAG TAGCTGACAG CAACGTGGTG CTGGACACAG CTATGCGTGG TGGCCGCCTG 
GGTGTCTTCT GCTTCTCCCA AGAGAATATC ATCTGGGCTA ACCTGCGCTA CCGTTGCAAT 
GATACAATCC CTGAGGACTA TGAGCGTCAC CGGCTGCGGA GGGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lubricin binds cartilage proteins, cartilage oligomeric matrix protein, fibronectin and collagen II at the cartilage surface.
Scientific reports7(1)13149(2017 Oct)
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Hypoxia decrease expression of cartilage oligomeric matrix protein to promote phenotype switching of pulmonary arterial smooth muscle cells.
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Comp cDNA ORF clone, Rattus norvegicus(Norway rat)

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