Mrgprx3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mrgprx3
Entrez Gene ID	252960
Full Name	MAS related GPR family member X3
Synonyms	Mgrg1,MrgA,Mrga10,Mrgpra
General protein information	Preferred Names MAS related GPR family member X3 Names mas-related G-protein coupled receptor member A G-protein coupled receptor G-protein coupled receptor; rc 56.1.3 MAS-related G-protein coupled receptor, member A MAS-related GPR, member X3 Mas-related G protein-coupled receptor g1 Mas-related gene A adenine receptor nuclear receptor MrgA10 RF-amide G protein-coupled receptor rc 56.1.3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q22
Summary	seven transmembrane domain G-protein coupled receptor; most often found in sensory neurons [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_145787.2	NP_665730.2	mas-related G-protein coupled receptor member A

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Mrgpra1	NP_694735.2
Mus musculus (house mouse)	Mrgpra2a	NP_001166059.1
Mus musculus (house mouse)	Mrgpra9	NP_001171037.1
Rattus norvegicus (Norway rat)	Mrgprx3	NP_665730.2
Pan troglodytes (chimpanzee)	MRGPRX3	XP_001172934.1
Homo sapiens (human)	MRGPRX3	NP_473372.3
	MRGPRX3	NP_001035511.1
Mus musculus (house mouse)	Mrgpra2b	NP_694741.2

Gene Ontology
Bibliography

Related articles in PubMed

Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes.
Premzl M
Gene540(1)16-9(2014 Apr)

Prediction of the 3-D structure of rat MrgA G protein-coupled receptor and identification of its binding site.
Heo J, Vaidehi N, Wendel J, Goddard WA 3rd
Journal of molecular graphics & modelling26(4)800-12(2007 Nov)

Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.
Gorzalka S, Vittori S, Volpini R, Cristalli G, von K?gelgen I, M?ller CE
Molecular pharmacology67(3)955-64(2005 Mar)

Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.
Zylka MJ, Dong X, Southwell AL, Anderson DJ
Proceedings of the National Academy of Sciences of the United States of America100(17)10043-8(2003 Aug)

Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule.
Bender E, Buist A, Jurzak M, Langlois X, Baggerman G, Verhasselt P, Ercken M, Guo HQ, Wintmolders C, Van den Wyngaert I, Van Oers I, Schoofs L, Luyten W
Proceedings of the National Academy of Sciences of the United States of America99(13)8573-8(2002 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results validate the predicted structure for MrgA and should be useful for seeking other small molecule agonists and antagonists.
Title: Prediction of the 3-D structure of rat MrgA G protein-coupled receptor and identification of its binding site.

Kinetics of adenine binding to the adenine receptor of the rat brain cortex.
Title: Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.

The following Mrgprx3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mrgprx3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12588	NM_145787.2 Latest version!	Rattus norvegicus MAS related GPR family member X3 (Mrgprx3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mrgprx3 ( NM_145787.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_665730.2 Rattus norvegicus MAS related GPR family member X3 (Mrgprx3), mRNA.

Price & Availability↑

CloneID	ORa12588
Clone ID Related Accession (Same CDS sequence)	NM_145787.2
Accession Version	NM_145787.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 996bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-09
Organism	Rattus norvegicus(Norway rat)
Product	mas-related G-protein coupled receptor member A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC089774.1. On or before Nov 4, 2005 this sequence version replaced NM_001002282.1, NM_145787.1. ##Evidence-Data-START## Transcript exon combination :: BC089774.1, CO565764.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMN00632258 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGAAA GCTTCACCGG TACAGGGTTT ATAAACCTAA ACACCTCAGC CTCGACAATA 
GCAGTCACAA CAACAAATCC AATGGACAAA ACCATACCTG GAAGTTTCAA CAGCAGGACC 
CTGATCCCAA ATTTGTTGAT CATCATCTCG GGACTGGTCG GGCTGATAGG AAACGCCATG 
GTGTTCTGGC TCCTGGGCTT CCGCTTAGCC AGGAATGCCT TCTCAGTCTA CATCCTAAAC 
TTGGCCCTGG CTGACTTCCT CTTCCTCCTC TGTCACATCA TAGATTCCAC GCTGCTCCTT 
CTCAAGTTTT CCTACCCCAA CATTATCTTT CTCCCATGCT TTAACACCGT CATGATGGTC 
CCCTACATCG CAGGCCTGAG CATGCTCAGT GCCATCAGCA CCGAGCGCTG CCTGTCTGTT 
GTGTGCCCCA TCTGGTATCG CTGCCGCCGC CCAAAACACA CTTCAACTGT CATGTGCTCT 
GCGATCTGGG TCCTGTCACT GTTGATCTGC ATTCTGAATA GGTATTTCTG TGGCTTCTTA 
GATACCAAAT ACGAAAAGGA CAACCGGTGT CTGGCATCGA ACTTCTTTAC TGCCGCGTGC 
CTGATATTTT TGTTTGTAGT CCTCTGTCTG TCCAGTCTGG CTCTGCTGGT CAGATTGTTC 
TGTGGCGCTG GGCGGATGAA GCTCACCAGA TTGTACGCGA CCATCATGCT GACCGTTTTG 
GTTTTTCTCC TCTGCGGGTT GCCCTTTGGC ATCCACTGGT TCCTGTTAAT CTGGATTAAG 
ATTGATTATG GTAAATTTGC TTACGGTCTT TACCTGGCGG CACTCGTCCT GACTGCTGTT 
AACAGCTGTG CCAACCCCAT CATTTACTTC TTCGTGGGCT CCTTCAGGCA TCAGAAGCAC 
CAGACCCTCA AAATGGTTCT CCAGAGGGCG CTGCAGGACA CCCCTGAGAC AGCGGAAAAC 
ACGGTGGAGA TGTCAAGCAG CAAGGTGGAG CCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_665730.2
CDS	55..1050
Translation	MGESFTGTGFINLNTSASTIAVTTTNPMDKTIPGSFNSRTLIPNLLIIISGLVGLIGNAMVFWLLGFRLARNAFSVYILNLALADFLFLLCHIIDSTLLLLKFSYPNIIFLPCFNTVMMVPYIAGLSMLSAISTERCLSVVCPIWYRCRRPKHTSTVMCSAIWVLSLLICILNRYFCGFLDTKYEKDNRCLASNFFTAACLIFLFVVLCLSSLALLVRLFCGAGRMKLTRLYATIMLTVLVFLLCGLPFGIHWFLLIWIKIDYGKFAYGLYLAALVLTAVNSCANPIIYFFVGSFRHQKHQTLKMVLQRALQDTPETAENTVEMSSSKVEP

Target ORF information:

RefSeq Version	NM_145787.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MAS related GPR family member X3 (Mrgprx3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145787.2

ORF Insert Sequence:

ATGGGGGAAA GCTTCACCGG TACAGGGTTT ATAAACCTAA ACACCTCAGC CTCGACAATA 
GCAGTCACAA CAACAAATCC AATGGACAAA ACCATACCTG GAAGTTTCAA CAGCAGGACC 
CTGATCCCAA ATTTGTTGAT CATCATCTCG GGACTGGTCG GGCTGATAGG AAACGCCATG 
GTGTTCTGGC TCCTGGGCTT CCGCTTAGCC AGGAATGCCT TCTCAGTCTA CATCCTAAAC 
TTGGCCCTGG CTGACTTCCT CTTCCTCCTC TGTCACATCA TAGATTCCAC GCTGCTCCTT 
CTCAAGTTTT CCTACCCCAA CATTATCTTT CTCCCATGCT TTAACACCGT CATGATGGTC 
CCCTACATCG CAGGCCTGAG CATGCTCAGT GCCATCAGCA CCGAGCGCTG CCTGTCTGTT 
GTGTGCCCCA TCTGGTATCG CTGCCGCCGC CCAAAACACA CTTCAACTGT CATGTGCTCT 
GCGATCTGGG TCCTGTCACT GTTGATCTGC ATTCTGAATA GGTATTTCTG TGGCTTCTTA 
GATACCAAAT ACGAAAAGGA CAACCGGTGT CTGGCATCGA ACTTCTTTAC TGCCGCGTGC 
CTGATATTTT TGTTTGTAGT CCTCTGTCTG TCCAGTCTGG CTCTGCTGGT CAGATTGTTC 
TGTGGCGCTG GGCGGATGAA GCTCACCAGA TTGTACGCGA CCATCATGCT GACCGTTTTG 
GTTTTTCTCC TCTGCGGGTT GCCCTTTGGC ATCCACTGGT TCCTGTTAAT CTGGATTAAG 
ATTGATTATG GTAAATTTGC TTACGGTCTT TACCTGGCGG CACTCGTCCT GACTGCTGTT 
AACAGCTGTG CCAACCCCAT CATTTACTTC TTCGTGGGCT CCTTCAGGCA TCAGAAGCAC 
CAGACCCTCA AAATGGTTCT CCAGAGGGCG CTGCAGGACA CCCCTGAGAC AGCGGAAAAC 
ACGGTGGAGA TGTCAAGCAG CAAGGTGGAG CCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes.
Gene540(1)16-9(2014 Apr)
Premzl M

Prediction of the 3-D structure of rat MrgA G protein-coupled receptor and identification of its binding site.
Journal of molecular graphics & modelling26(4)800-12(2007 Nov)
Heo J,Vaidehi N,Wendel J,Goddard WA 3rd

Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.
Molecular pharmacology67(3)955-64(2005 Mar)
Gorzalka S,Vittori S,Volpini R,Cristalli G,von K?gelgen I,M?ller CE

Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.
Proceedings of the National Academy of Sciences of the United States of America100(17)10043-8(2003 Aug)
Zylka MJ,Dong X,Southwell AL,Anderson DJ

Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule.
Proceedings of the National Academy of Sciences of the United States of America99(13)8573-8(2002 Jun)
Bender E,Buist A,Jurzak M,Langlois X,Baggerman G,Verhasselt P,Ercken M,Guo HQ,Wintmolders C,Van den Wyngaert I,Van Oers I,Schoofs L,Luyten W

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Mrgprx3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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