Aqp4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Aqp4
Entrez Gene ID	25293
Full Name	aquaporin 4
Synonyms	AQP-4,Miwc,WCH4
General protein information	Preferred Names aquaporin 4 Names aquaporin-4 mercurial-insensitive water channel
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18p13
Summary	This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001270559.2	NP_001257488.1	aquaporin-4 isoform 4
NM_001270558.2	NP_001257487.1	aquaporin-4 isoform 3
NM_001317749.1	NP_001304678.1	aquaporin-4 isoform M1x
XM_017600857.1	XP_017456346.1	aquaporin-4 isoform X1
NM_001142366.2	NP_001135838.1	aquaporin-4 isoform M23
NM_012825.4	NP_036957.1	aquaporin-4 isoform M1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Aqp4	NP_033830.2
Anopheles gambiae (African malaria mosquito)	AQP_ANOGA	XP_319584.4
Arabidopsis thaliana (thale cress)	PIP1C	NP_171668.1
Oryza sativa (rice)	Os02g0666200	NP_001047672.1
Homo sapiens (human)	AQP4	NP_001641.1
Bos taurus (cattle)	AQP4	NP_851346.1
Gallus gallus (chicken)	AQP4	NP_001004765.1
Arabidopsis thaliana (thale cress)	PIP1A	NP_001078323.1
Oryza sativa (rice)	Os02g0823100	NP_001048566.1
	AQP4	XP_001097418.1
Canis lupus familiaris (dog)	AQP4	XP_855456.2
Arabidopsis thaliana (thale cress)	PIP1B	NP_182120.1
Xenopus tropicalis (tropical clawed frog)	aqp4	XP_002940974.2
Pan troglodytes (chimpanzee)	AQP4	XP_512074.2
Rattus norvegicus (Norway rat)	Aqp4	NP_036957.1
Danio rerio (zebrafish)	aqp4	NP_001003749.1
Drosophila melanogaster (fruit fly)	Drip	NP_001260893.1
Arabidopsis thaliana (thale cress)	PIP1;4	NP_567178.1
Arabidopsis thaliana (thale cress)	PIP1;5	NP_194071.1

Gene Ontology
Bibliography

Related articles in PubMed

Evidence of efficient stop codon readthrough in four mammalian genes.
Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM, Baranov PV, Atkins JF
Nucleic acids research42(14)8928-38(2014 Aug)

Translational regulation mechanisms of aquaporin-4 supramolecular organization in astrocytes.
Pisani F, Rossi A, Nicchia GP, Svelto M, Frigeri A
Glia59(12)1923-32(2011 Dec)

All functional aquaporin-4 isoforms are expressed in the rat cochlea and contribute to the formation of orthogonal arrays of particles.
Hirt B, Gleiser C, Eckhard A, Mack AF, M?ller M, Wolburg H, L?wenheim H
Neuroscience18979-92(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Aquaporin 4 affects the dynamics of cell swelling and regulatory volume decrease in astrocytes exposed to hypo-osmotic conditions.
Title: AQP4e-Based Orthogonal Arrays Regulate Rapid Cell Volume Changes in Astrocytes.

Results provide a novel, complement-dependent mechanism in neuromyelitis optica spectrum disorder by which AQP4-IgG binding to astrocytes injures surrounding oligodendrocytes, resulting in early and marked demyelination.
Title: Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica.

The expressions of AQP4 were colocalized with GFAP. Protein levels of VEGF in the hyperglycemic rat retina were significantly higher than controls. FACS analyses showed that exposure to VEGF enlarged Muller cells, while exposure to TGN-020 suppressed the enlargement.
Title: Implication of VEGF and aquaporin 4 mediating M?ller cell swelling to diabetic retinal edema.

AQP4 interference reduces CBT edema formation, and ADC value may predict TBI severity.
Title: Effects of Aquaporin 4 Knockdown on Brain Edema of the Uninjured Side After Traumatic Brain Injury in Rats.

Age-related modulations of AQP4 and Caveolin-1 in the hippocampus predispose the toxic effect of Phoneutria nigriventer spider venom.
Title: Age-Related Modulations of AQP4 and Caveolin-1 in the Hippocampus Predispose the Toxic Effect of Phoneutria nigriventer Spider Venom.

The following Aqp4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aqp4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa09275	NM_001270559.2 Latest version!	Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa13560	NM_001142366.2 Latest version!	Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa13568	NM_012825.4 Latest version!	Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa13640	NM_001270558.2 Latest version!	Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa13560	XM_017600857.1 Latest version!	Rattus norvegicus aquaporin 4 (Aqp4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa63268	NM_001317749.1 Latest version!	Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Aqp4 ( NM_001270559.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001257488.1 Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 4, mRNA.

Price & Availability↑

CloneID	ORa09275
Clone ID Related Accession (Same CDS sequence)	NM_001270559.2
Accession Version	NM_001270559.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 741bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-23
Organism	Rattus norvegicus(Norway rat)
Product	aquaporin-4 isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AABR07031271.1. On Aug 28, 2014 this sequence version replaced NM_001270559.1. Transcript Variant: This variant (4, also known as AQP4d) contains an alternate 5' terminal exon and lacks an in-frame coding exon compared to variant 1. These changes result in translation initiation from an in-frame, downstream start codon, and an isoform (4) with a shorter N-terminus and missing an internal protein segment compared to isoform M1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGCTT TCAAAGGCGT CTGGACTCAA GCCTTCTGGA AGGCGGTCAC AGCAGAGTTC 
CTGGCCATGC TCATCTTTGT TCTGCTCAGC GTGGGATCCA CCATTAACTG GGGTGGCTCA 
GAGAACCCCC TACCTGTGGA CATGGTCCTC ATCTCCCTCT GCTTTGGACT CAGCATTGCC 
ACCATGGTTC AGTGCTTCGG CCACATCAGC GGTGGCCACA TCAACCCAGC GGTGACAGTG 
GCCATGGTGT GCACACGAAA GATCAGCATC GCCAAGTCCG TCTTCTACAT CACTGCGCAG 
TGCCTGGGGG CCATCATCGG AGCTGGGATC CTCTACCTGG TCACACCCCC CAGCGTGGTG 
GGAGGATTGG GAGTCACCAC GATCAATTAT ACCGGAGCCA GCATGAATCC AGCTCGATCC 
TTTGGCCCTG CAGTTATCAT GGGAAACTGG GAAAACCACT GGATATATTG GGTTGGACCA 
ATCATAGGCG CTGTGCTGGC AGGTGCACTT TACGAGTATG TCTTCTGTCC TGACGTGGAG 
CTCAAACGTC GCCTAAAGGA AGCCTTCAGC AAAGCTGCAC AGCAGACGAA AGGGAGCTAC 
ATGGAGGTGG AGGACAACCG GAGCCAAGTG GAGACAGAAG ACTTGATCCT GAAGCCCGGG 
GTGGTGCATG TGATCGACAT TGACCGTGGA GACGAGAAGA AGGGGAAGGA CTCGTCTGGA 
GAGGTATTAT CTTCTGTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001257488.1
CDS	141..881
Translation	MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYITAQCLGAIIGAGILYLVTPPSVVGGLGVTTINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGSYMEVEDNRSQVETEDLILKPGVVHVIDIDRGDEKKGKDSSGEVLSSV

Target ORF information:

RefSeq Version	NM_001270559.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001270559.2

ORF Insert Sequence:

ATGGTGGCTT TCAAAGGCGT CTGGACTCAA GCCTTCTGGA AGGCGGTCAC AGCAGAGTTC 
CTGGCCATGC TCATCTTTGT TCTGCTCAGC GTGGGATCCA CCATTAACTG GGGTGGCTCA 
GAGAACCCCC TACCTGTGGA CATGGTCCTC ATCTCCCTCT GCTTTGGACT CAGCATTGCC 
ACCATGGTTC AGTGCTTCGG CCACATCAGC GGTGGCCACA TCAACCCAGC GGTGACAGTG 
GCCATGGTGT GCACACGAAA GATCAGCATC GCCAAGTCCG TCTTCTACAT CACTGCGCAG 
TGCCTGGGGG CCATCATCGG AGCTGGGATC CTCTACCTGG TCACACCCCC CAGCGTGGTG 
GGAGGATTGG GAGTCACCAC GATCAATTAT ACCGGAGCCA GCATGAATCC AGCTCGATCC 
TTTGGCCCTG CAGTTATCAT GGGAAACTGG GAAAACCACT GGATATATTG GGTTGGACCA 
ATCATAGGCG CTGTGCTGGC AGGTGCACTT TACGAGTATG TCTTCTGTCC TGACGTGGAG 
CTCAAACGTC GCCTAAAGGA AGCCTTCAGC AAAGCTGCAC AGCAGACGAA AGGGAGCTAC 
ATGGAGGTGG AGGACAACCG GAGCCAAGTG GAGACAGAAG ACTTGATCCT GAAGCCCGGG 
GTGGTGCATG TGATCGACAT TGACCGTGGA GACGAGAAGA AGGGGAAGGA CTCGTCTGGA 
GAGGTATTAT CTTCTGTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Aqp4 ( NM_001142366.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001135838.1 Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa13560
Clone ID Related Accession (Same CDS sequence)	XM_017600857.1 , NM_001142366.2
Accession Version	NM_001142366.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 906bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-23
Organism	Rattus norvegicus(Norway rat)
Product	aquaporin-4 isoform M23
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AABR07031271.1. On Aug 28, 2014 this sequence version replaced NM_001142366.1. Transcript Variant: This variant (2, also known as AQP4c) contains an alternate 5' terminal exon, which causes translation initiation from an in-frame, downstream start codon, compared to variant 1. The resulting isoform (M23) has a shorter N-terminus compared to isoform M1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: L27588.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMD00052296 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGCTT TCAAAGGCGT CTGGACTCAA GCCTTCTGGA AGGCGGTCAC AGCAGAGTTC 
CTGGCCATGC TCATCTTTGT TCTGCTCAGC GTGGGATCCA CCATTAACTG GGGTGGCTCA 
GAGAACCCCC TACCTGTGGA CATGGTCCTC ATCTCCCTCT GCTTTGGACT CAGCATTGCC 
ACCATGGTTC AGTGCTTCGG CCACATCAGC GGTGGCCACA TCAACCCAGC GGTGACAGTG 
GCCATGGTGT GCACACGAAA GATCAGCATC GCCAAGTCCG TCTTCTACAT CACTGCGCAG 
TGCCTGGGGG CCATCATCGG AGCTGGGATC CTCTACCTGG TCACACCCCC CAGCGTGGTG 
GGAGGATTGG GAGTCACCAC GGTTCATGGA AACCTCACTG CTGGCCATGG GCTCCTGGTG 
GAGCTAATAA TCACTTTCCA GCTGGTATTC ACCATTTTTG CCAGCTGTGA TTCCAAACGG 
ACTGATGTTA CTGGTTCCGT TGCTTTAGCA ATTGGGTTTT CCGTTGCAAT TGGACATTTG 
TTTGCAATCA ATTATACCGG AGCCAGCATG AATCCAGCTC GATCCTTTGG CCCTGCAGTT 
ATCATGGGAA ACTGGGAAAA CCACTGGATA TATTGGGTTG GACCAATCAT AGGCGCTGTG 
CTGGCAGGTG CACTTTACGA GTATGTCTTC TGTCCTGACG TGGAGCTCAA ACGTCGCCTA 
AAGGAAGCCT TCAGCAAAGC TGCACAGCAG ACGAAAGGGA GCTACATGGA GGTGGAGGAC 
AACCGGAGCC AAGTGGAGAC AGAAGACTTG ATCCTGAAGC CCGGGGTGGT GCATGTGATC 
GACATTGACC GTGGAGACGA GAAGAAGGGG AAGGACTCGT CTGGAGAGGT ATTATCTTCT 
GTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135838.1
CDS	141..1046
Translation	MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYITAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSVALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGSYMEVEDNRSQVETEDLILKPGVVHVIDIDRGDEKKGKDSSGEVLSSV

Target ORF information:

RefSeq Version	NM_001142366.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142366.2

ORF Insert Sequence:

ATGGTGGCTT TCAAAGGCGT CTGGACTCAA GCCTTCTGGA AGGCGGTCAC AGCAGAGTTC 
CTGGCCATGC TCATCTTTGT TCTGCTCAGC GTGGGATCCA CCATTAACTG GGGTGGCTCA 
GAGAACCCCC TACCTGTGGA CATGGTCCTC ATCTCCCTCT GCTTTGGACT CAGCATTGCC 
ACCATGGTTC AGTGCTTCGG CCACATCAGC GGTGGCCACA TCAACCCAGC GGTGACAGTG 
GCCATGGTGT GCACACGAAA GATCAGCATC GCCAAGTCCG TCTTCTACAT CACTGCGCAG 
TGCCTGGGGG CCATCATCGG AGCTGGGATC CTCTACCTGG TCACACCCCC CAGCGTGGTG 
GGAGGATTGG GAGTCACCAC GGTTCATGGA AACCTCACTG CTGGCCATGG GCTCCTGGTG 
GAGCTAATAA TCACTTTCCA GCTGGTATTC ACCATTTTTG CCAGCTGTGA TTCCAAACGG 
ACTGATGTTA CTGGTTCCGT TGCTTTAGCA ATTGGGTTTT CCGTTGCAAT TGGACATTTG 
TTTGCAATCA ATTATACCGG AGCCAGCATG AATCCAGCTC GATCCTTTGG CCCTGCAGTT 
ATCATGGGAA ACTGGGAAAA CCACTGGATA TATTGGGTTG GACCAATCAT AGGCGCTGTG 
CTGGCAGGTG CACTTTACGA GTATGTCTTC TGTCCTGACG TGGAGCTCAA ACGTCGCCTA 
AAGGAAGCCT TCAGCAAAGC TGCACAGCAG ACGAAAGGGA GCTACATGGA GGTGGAGGAC 
AACCGGAGCC AAGTGGAGAC AGAAGACTTG ATCCTGAAGC CCGGGGTGGT GCATGTGATC 
GACATTGACC GTGGAGACGA GAAGAAGGGG AAGGACTCGT CTGGAGAGGT ATTATCTTCT 
GTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Aqp4 ( NM_012825.4 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036957.1 Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa13568
Clone ID Related Accession (Same CDS sequence)	NM_012825.4
Accession Version	NM_012825.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-23
Organism	Rattus norvegicus(Norway rat)
Product	aquaporin-4 isoform M1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AABR07031271.1. On Aug 28, 2014 this sequence version replaced NM_012825.3. Transcript Variant: This variant (1, also known as AQP4a) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (M1) results from translation termination at the upstream UGA stop codon, while the longer isoform (M1x) results from UGA stop codon readthrough to the downstream UAA termination codon. This RefSeq represents the shorter isoform (M1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U14007.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 21850708 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTGACG GAGCTGCAGC GAGGCGGTGG GGTAAGTGTG GACCTCCCTG CAGCAGAGAG 
AGCATCATGG TGGCTTTCAA AGGCGTCTGG ACTCAAGCCT TCTGGAAGGC GGTCACAGCA 
GAGTTCCTGG CCATGCTCAT CTTTGTTCTG CTCAGCGTGG GATCCACCAT TAACTGGGGT 
GGCTCAGAGA ACCCCCTACC TGTGGACATG GTCCTCATCT CCCTCTGCTT TGGACTCAGC 
ATTGCCACCA TGGTTCAGTG CTTCGGCCAC ATCAGCGGTG GCCACATCAA CCCAGCGGTG 
ACAGTGGCCA TGGTGTGCAC ACGAAAGATC AGCATCGCCA AGTCCGTCTT CTACATCACT 
GCGCAGTGCC TGGGGGCCAT CATCGGAGCT GGGATCCTCT ACCTGGTCAC ACCCCCCAGC 
GTGGTGGGAG GATTGGGAGT CACCACGGTT CATGGAAACC TCACTGCTGG CCATGGGCTC 
CTGGTGGAGC TAATAATCAC TTTCCAGCTG GTATTCACCA TTTTTGCCAG CTGTGATTCC 
AAACGGACTG ATGTTACTGG TTCCGTTGCT TTAGCAATTG GGTTTTCCGT TGCAATTGGA 
CATTTGTTTG CAATCAATTA TACCGGAGCC AGCATGAATC CAGCTCGATC CTTTGGCCCT 
GCAGTTATCA TGGGAAACTG GGAAAACCAC TGGATATATT GGGTTGGACC AATCATAGGC 
GCTGTGCTGG CAGGTGCACT TTACGAGTAT GTCTTCTGTC CTGACGTGGA GCTCAAACGT 
CGCCTAAAGG AAGCCTTCAG CAAAGCTGCA CAGCAGACGA AAGGGAGCTA CATGGAGGTG 
GAGGACAACC GGAGCCAAGT GGAGACAGAA GACTTGATCC TGAAGCCCGG GGTGGTGCAT 
GTGATCGACA TTGACCGTGG AGACGAGAAG AAGGGGAAGG ACTCGTCTGG AGAGGTATTA 
TCTTCTGTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036957.1
CDS	67..1038
Translation	MSDGAAARRWGKCGPPCSRESIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYITAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSVALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGSYMEVEDNRSQVETEDLILKPGVVHVIDIDRGDEKKGKDSSGEVLSSV

Target ORF information:

RefSeq Version	NM_012825.4
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012825.4

ORF Insert Sequence:

ATGAGTGACG GAGCTGCAGC GAGGCGGTGG GGTAAGTGTG GACCTCCCTG CAGCAGAGAG 
AGCATCATGG TGGCTTTCAA AGGCGTCTGG ACTCAAGCCT TCTGGAAGGC GGTCACAGCA 
GAGTTCCTGG CCATGCTCAT CTTTGTTCTG CTCAGCGTGG GATCCACCAT TAACTGGGGT 
GGCTCAGAGA ACCCCCTACC TGTGGACATG GTCCTCATCT CCCTCTGCTT TGGACTCAGC 
ATTGCCACCA TGGTTCAGTG CTTCGGCCAC ATCAGCGGTG GCCACATCAA CCCAGCGGTG 
ACAGTGGCCA TGGTGTGCAC ACGAAAGATC AGCATCGCCA AGTCCGTCTT CTACATCACT 
GCGCAGTGCC TGGGGGCCAT CATCGGAGCT GGGATCCTCT ACCTGGTCAC ACCCCCCAGC 
GTGGTGGGAG GATTGGGAGT CACCACGGTT CATGGAAACC TCACTGCTGG CCATGGGCTC 
CTGGTGGAGC TAATAATCAC TTTCCAGCTG GTATTCACCA TTTTTGCCAG CTGTGATTCC 
AAACGGACTG ATGTTACTGG TTCCGTTGCT TTAGCAATTG GGTTTTCCGT TGCAATTGGA 
CATTTGTTTG CAATCAATTA TACCGGAGCC AGCATGAATC CAGCTCGATC CTTTGGCCCT 
GCAGTTATCA TGGGAAACTG GGAAAACCAC TGGATATATT GGGTTGGACC AATCATAGGC 
GCTGTGCTGG CAGGTGCACT TTACGAGTAT GTCTTCTGTC CTGACGTGGA GCTCAAACGT 
CGCCTAAAGG AAGCCTTCAG CAAAGCTGCA CAGCAGACGA AAGGGAGCTA CATGGAGGTG 
GAGGACAACC GGAGCCAAGT GGAGACAGAA GACTTGATCC TGAAGCCCGG GGTGGTGCAT 
GTGATCGACA TTGACCGTGG AGACGAGAAG AAGGGGAAGG ACTCGTCTGG AGAGGTATTA 
TCTTCTGTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Aqp4 ( NM_001270558.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001257487.1 Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 3, mRNA.

Price & Availability↑

CloneID	ORa13640
Clone ID Related Accession (Same CDS sequence)	NM_001270558.2
Accession Version	NM_001270558.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 807bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-23
Organism	Rattus norvegicus(Norway rat)
Product	aquaporin-4 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AABR07031271.1. On Aug 28, 2014 this sequence version replaced NM_001270558.1. Transcript Variant: This variant (3, also known as AQP4b) lacks an in-frame coding exon compared to variant 1. The resulting isoform (3) is shorter, missing an internal protein segment compared to isoform M1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 21850708 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTGACG GAGCTGCAGC GAGGCGGTGG GGTAAGTGTG GACCTCCCTG CAGCAGAGAG 
AGCATCATGG TGGCTTTCAA AGGCGTCTGG ACTCAAGCCT TCTGGAAGGC GGTCACAGCA 
GAGTTCCTGG CCATGCTCAT CTTTGTTCTG CTCAGCGTGG GATCCACCAT TAACTGGGGT 
GGCTCAGAGA ACCCCCTACC TGTGGACATG GTCCTCATCT CCCTCTGCTT TGGACTCAGC 
ATTGCCACCA TGGTTCAGTG CTTCGGCCAC ATCAGCGGTG GCCACATCAA CCCAGCGGTG 
ACAGTGGCCA TGGTGTGCAC ACGAAAGATC AGCATCGCCA AGTCCGTCTT CTACATCACT 
GCGCAGTGCC TGGGGGCCAT CATCGGAGCT GGGATCCTCT ACCTGGTCAC ACCCCCCAGC 
GTGGTGGGAG GATTGGGAGT CACCACGATC AATTATACCG GAGCCAGCAT GAATCCAGCT 
CGATCCTTTG GCCCTGCAGT TATCATGGGA AACTGGGAAA ACCACTGGAT ATATTGGGTT 
GGACCAATCA TAGGCGCTGT GCTGGCAGGT GCACTTTACG AGTATGTCTT CTGTCCTGAC 
GTGGAGCTCA AACGTCGCCT AAAGGAAGCC TTCAGCAAAG CTGCACAGCA GACGAAAGGG 
AGCTACATGG AGGTGGAGGA CAACCGGAGC CAAGTGGAGA CAGAAGACTT GATCCTGAAG 
CCCGGGGTGG TGCATGTGAT CGACATTGAC CGTGGAGACG AGAAGAAGGG GAAGGACTCG 
TCTGGAGAGG TATTATCTTC TGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001257487.1
CDS	67..873
Translation	MSDGAAARRWGKCGPPCSRESIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYITAQCLGAIIGAGILYLVTPPSVVGGLGVTTINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGSYMEVEDNRSQVETEDLILKPGVVHVIDIDRGDEKKGKDSSGEVLSSV

Target ORF information:

RefSeq Version	NM_001270558.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001270558.2

ORF Insert Sequence:

ATGAGTGACG GAGCTGCAGC GAGGCGGTGG GGTAAGTGTG GACCTCCCTG CAGCAGAGAG 
AGCATCATGG TGGCTTTCAA AGGCGTCTGG ACTCAAGCCT TCTGGAAGGC GGTCACAGCA 
GAGTTCCTGG CCATGCTCAT CTTTGTTCTG CTCAGCGTGG GATCCACCAT TAACTGGGGT 
GGCTCAGAGA ACCCCCTACC TGTGGACATG GTCCTCATCT CCCTCTGCTT TGGACTCAGC 
ATTGCCACCA TGGTTCAGTG CTTCGGCCAC ATCAGCGGTG GCCACATCAA CCCAGCGGTG 
ACAGTGGCCA TGGTGTGCAC ACGAAAGATC AGCATCGCCA AGTCCGTCTT CTACATCACT 
GCGCAGTGCC TGGGGGCCAT CATCGGAGCT GGGATCCTCT ACCTGGTCAC ACCCCCCAGC 
GTGGTGGGAG GATTGGGAGT CACCACGATC AATTATACCG GAGCCAGCAT GAATCCAGCT 
CGATCCTTTG GCCCTGCAGT TATCATGGGA AACTGGGAAA ACCACTGGAT ATATTGGGTT 
GGACCAATCA TAGGCGCTGT GCTGGCAGGT GCACTTTACG AGTATGTCTT CTGTCCTGAC 
GTGGAGCTCA AACGTCGCCT AAAGGAAGCC TTCAGCAAAG CTGCACAGCA GACGAAAGGG 
AGCTACATGG AGGTGGAGGA CAACCGGAGC CAAGTGGAGA CAGAAGACTT GATCCTGAAG 
CCCGGGGTGG TGCATGTGAT CGACATTGAC CGTGGAGACG AGAAGAAGGG GAAGGACTCG 
TCTGGAGAGG TATTATCTTC TGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Aqp4 ( XM_017600857.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017456346.1 Rattus norvegicus aquaporin 4 (Aqp4), transcript variant X1, mRNA.

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CloneID	ORa13560
Clone ID Related Accession (Same CDS sequence)	XM_017600857.1 , NM_001142366.2
Accession Version	XM_017600857.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 906bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	aquaporin-4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGGCTT TCAAAGGCGT CTGGACTCAA GCCTTCTGGA AGGCGGTCAC AGCAGAGTTC 
CTGGCCATGC TCATCTTTGT TCTGCTCAGC GTGGGATCCA CCATTAACTG GGGTGGCTCA 
GAGAACCCCC TACCTGTGGA CATGGTCCTC ATCTCCCTCT GCTTTGGACT CAGCATTGCC 
ACCATGGTTC AGTGCTTCGG CCACATCAGC GGTGGCCACA TCAACCCAGC GGTGACAGTG 
GCCATGGTGT GCACACGAAA GATCAGCATC GCCAAGTCCG TCTTCTACAT CACTGCGCAG 
TGCCTGGGGG CCATCATCGG AGCTGGGATC CTCTACCTGG TCACACCCCC CAGCGTGGTG 
GGAGGATTGG GAGTCACCAC GGTTCATGGA AACCTCACTG CTGGCCATGG GCTCCTGGTG 
GAGCTAATAA TCACTTTCCA GCTGGTATTC ACCATTTTTG CCAGCTGTGA TTCCAAACGG 
ACTGATGTTA CTGGTTCCGT TGCTTTAGCA ATTGGGTTTT CCGTTGCAAT TGGACATTTG 
TTTGCAATCA ATTATACCGG AGCCAGCATG AATCCAGCTC GATCCTTTGG CCCTGCAGTT 
ATCATGGGAA ACTGGGAAAA CCACTGGATA TATTGGGTTG GACCAATCAT AGGCGCTGTG 
CTGGCAGGTG CACTTTACGA GTATGTCTTC TGTCCTGACG TGGAGCTCAA ACGTCGCCTA 
AAGGAAGCCT TCAGCAAAGC TGCACAGCAG ACGAAAGGGA GCTACATGGA GGTGGAGGAC 
AACCGGAGCC AAGTGGAGAC AGAAGACTTG ATCCTGAAGC CCGGGGTGGT GCATGTGATC 
GACATTGACC GTGGAGACGA GAAGAAGGGG AAGGACTCGT CTGGAGAGGT ATTATCTTCT 
GTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017456346.1
CDS	57..962
Translation	MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYITAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSVALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGSYMEVEDNRSQVETEDLILKPGVVHVIDIDRGDEKKGKDSSGEVLSSV

Target ORF information:

RefSeq Version	XM_017600857.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aquaporin 4 (Aqp4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017600857.1

ORF Insert Sequence:

ATGGTGGCTT TCAAAGGCGT CTGGACTCAA GCCTTCTGGA AGGCGGTCAC AGCAGAGTTC 
CTGGCCATGC TCATCTTTGT TCTGCTCAGC GTGGGATCCA CCATTAACTG GGGTGGCTCA 
GAGAACCCCC TACCTGTGGA CATGGTCCTC ATCTCCCTCT GCTTTGGACT CAGCATTGCC 
ACCATGGTTC AGTGCTTCGG CCACATCAGC GGTGGCCACA TCAACCCAGC GGTGACAGTG 
GCCATGGTGT GCACACGAAA GATCAGCATC GCCAAGTCCG TCTTCTACAT CACTGCGCAG 
TGCCTGGGGG CCATCATCGG AGCTGGGATC CTCTACCTGG TCACACCCCC CAGCGTGGTG 
GGAGGATTGG GAGTCACCAC GGTTCATGGA AACCTCACTG CTGGCCATGG GCTCCTGGTG 
GAGCTAATAA TCACTTTCCA GCTGGTATTC ACCATTTTTG CCAGCTGTGA TTCCAAACGG 
ACTGATGTTA CTGGTTCCGT TGCTTTAGCA ATTGGGTTTT CCGTTGCAAT TGGACATTTG 
TTTGCAATCA ATTATACCGG AGCCAGCATG AATCCAGCTC GATCCTTTGG CCCTGCAGTT 
ATCATGGGAA ACTGGGAAAA CCACTGGATA TATTGGGTTG GACCAATCAT AGGCGCTGTG 
CTGGCAGGTG CACTTTACGA GTATGTCTTC TGTCCTGACG TGGAGCTCAA ACGTCGCCTA 
AAGGAAGCCT TCAGCAAAGC TGCACAGCAG ACGAAAGGGA GCTACATGGA GGTGGAGGAC 
AACCGGAGCC AAGTGGAGAC AGAAGACTTG ATCCTGAAGC CCGGGGTGGT GCATGTGATC 
GACATTGACC GTGGAGACGA GAAGAAGGGG AAGGACTCGT CTGGAGAGGT ATTATCTTCT 
GTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Aqp4 ( NM_001317749.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001304678.1 Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 1, mRNA.

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CloneID	ORa63268
Clone ID Related Accession (Same CDS sequence)	NM_001317749.1
Accession Version	NM_001317749.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-23
Organism	Rattus norvegicus(Norway rat)
Product	aquaporin-4 isoform M1x
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AABR07031271.1. Transcript Variant: This variant (1, also known as AQP4a) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (M1) results from translation termination at the upstream UGA stop codon, while the longer isoform (M1x) results from UGA stop codon readthrough to the downstream UAA termination codon. This RefSeq represents the longer, C-terminally extended isoform (M1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U14007.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 21850708 stop codon readthrough :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTGACG GAGCTGCAGC GAGGCGGTGG GGTAAGTGTG GACCTCCCTG CAGCAGAGAG 
AGCATCATGG TGGCTTTCAA AGGCGTCTGG ACTCAAGCCT TCTGGAAGGC GGTCACAGCA 
GAGTTCCTGG CCATGCTCAT CTTTGTTCTG CTCAGCGTGG GATCCACCAT TAACTGGGGT 
GGCTCAGAGA ACCCCCTACC TGTGGACATG GTCCTCATCT CCCTCTGCTT TGGACTCAGC 
ATTGCCACCA TGGTTCAGTG CTTCGGCCAC ATCAGCGGTG GCCACATCAA CCCAGCGGTG 
ACAGTGGCCA TGGTGTGCAC ACGAAAGATC AGCATCGCCA AGTCCGTCTT CTACATCACT 
GCGCAGTGCC TGGGGGCCAT CATCGGAGCT GGGATCCTCT ACCTGGTCAC ACCCCCCAGC 
GTGGTGGGAG GATTGGGAGT CACCACGGTT CATGGAAACC TCACTGCTGG CCATGGGCTC 
CTGGTGGAGC TAATAATCAC TTTCCAGCTG GTATTCACCA TTTTTGCCAG CTGTGATTCC 
AAACGGACTG ATGTTACTGG TTCCGTTGCT TTAGCAATTG GGTTTTCCGT TGCAATTGGA 
CATTTGTTTG CAATCAATTA TACCGGAGCC AGCATGAATC CAGCTCGATC CTTTGGCCCT 
GCAGTTATCA TGGGAAACTG GGAAAACCAC TGGATATATT GGGTTGGACC AATCATAGGC 
GCTGTGCTGG CAGGTGCACT TTACGAGTAT GTCTTCTGTC CTGACGTGGA GCTCAAACGT 
CGCCTAAAGG AAGCCTTCAG CAAAGCTGCA CAGCAGACGA AAGGGAGCTA CATGGAGGTG 
GAGGACAACC GGAGCCAAGT GGAGACAGAA GACTTGATCC TGAAGCCCGG GGTGGTGCAT 
GTGATCGACA TTGACCGTGG AGACGAGAAG AAGGGGAAGG ACTCGTCTGG AGAGGTATTA 
TCTTCTGTAT GACTAGAGGA CAGCACTGAA AACAGAAGAG ACTCCCTAGA ACTGGCCTCA 
GATTTCCTGC CACCCATTAA GGAAACAGAT TTGTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304678.1
CDS	67..1125
Translation	MSDGAAARRWGKCGPPCSRESIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYITAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSVALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGSYMEVEDNRSQVETEDLILKPGVVHVIDIDRGDEKKGKDSSGEVLSSV*LEDSTENRRDSLELASDFLPPIKETDLL

Target ORF information:

RefSeq Version	NM_001317749.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aquaporin 4 (Aqp4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317749.1

ORF Insert Sequence:

ATGAGTGACG GAGCTGCAGC GAGGCGGTGG GGTAAGTGTG GACCTCCCTG CAGCAGAGAG 
AGCATCATGG TGGCTTTCAA AGGCGTCTGG ACTCAAGCCT TCTGGAAGGC GGTCACAGCA 
GAGTTCCTGG CCATGCTCAT CTTTGTTCTG CTCAGCGTGG GATCCACCAT TAACTGGGGT 
GGCTCAGAGA ACCCCCTACC TGTGGACATG GTCCTCATCT CCCTCTGCTT TGGACTCAGC 
ATTGCCACCA TGGTTCAGTG CTTCGGCCAC ATCAGCGGTG GCCACATCAA CCCAGCGGTG 
ACAGTGGCCA TGGTGTGCAC ACGAAAGATC AGCATCGCCA AGTCCGTCTT CTACATCACT 
GCGCAGTGCC TGGGGGCCAT CATCGGAGCT GGGATCCTCT ACCTGGTCAC ACCCCCCAGC 
GTGGTGGGAG GATTGGGAGT CACCACGGTT CATGGAAACC TCACTGCTGG CCATGGGCTC 
CTGGTGGAGC TAATAATCAC TTTCCAGCTG GTATTCACCA TTTTTGCCAG CTGTGATTCC 
AAACGGACTG ATGTTACTGG TTCCGTTGCT TTAGCAATTG GGTTTTCCGT TGCAATTGGA 
CATTTGTTTG CAATCAATTA TACCGGAGCC AGCATGAATC CAGCTCGATC CTTTGGCCCT 
GCAGTTATCA TGGGAAACTG GGAAAACCAC TGGATATATT GGGTTGGACC AATCATAGGC 
GCTGTGCTGG CAGGTGCACT TTACGAGTAT GTCTTCTGTC CTGACGTGGA GCTCAAACGT 
CGCCTAAAGG AAGCCTTCAG CAAAGCTGCA CAGCAGACGA AAGGGAGCTA CATGGAGGTG 
GAGGACAACC GGAGCCAAGT GGAGACAGAA GACTTGATCC TGAAGCCCGG GGTGGTGCAT 
GTGATCGACA TTGACCGTGG AGACGAGAAG AAGGGGAAGG ACTCGTCTGG AGAGGTATTA 
TCTTCTGTAT GACTAGAGGA CAGCACTGAA AACAGAAGAG ACTCCCTAGA ACTGGCCTCA 
GATTTCCTGC CACCCATTAA GGAAACAGAT TTGTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Evidence of efficient stop codon readthrough in four mammalian genes.
Nucleic acids research42(14)8928-38(2014 Aug)
Loughran G,Chou MY,Ivanov IP,Jungreis I,Kellis M,Kiran AM,Baranov PV,Atkins JF

Translational regulation mechanisms of aquaporin-4 supramolecular organization in astrocytes.
Glia59(12)1923-32(2011 Dec)
Pisani F,Rossi A,Nicchia GP,Svelto M,Frigeri A

All functional aquaporin-4 isoforms are expressed in the rat cochlea and contribute to the formation of orthogonal arrays of particles.
Neuroscience18979-92(2011 Aug)
Hirt B,Gleiser C,Eckhard A,Mack AF,M?ller M,Wolburg H,L?wenheim H

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Aqp4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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