Igfbp5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Igfbp5
Entrez Gene ID	25285
Full Name	insulin-like growth factor binding protein 5
Synonyms	IGF-BP5
General protein information	Preferred Names insulin-like growth factor binding protein 5 Names insulin-like growth factor-binding protein 5 IBP-5 IGF-binding protein 5 IGFBP-5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q33
Summary	may be involved in ovarian folliculogenesis and may play a modulatory role in type I fiber-dominated muscles [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012817.1	NP_036949.1	insulin-like growth factor-binding protein 5 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	IGFBP5	NP_001098797.1
Mus musculus (house mouse)	Igfbp5	NP_034648.2
Xenopus tropicalis (tropical clawed frog)	igfbp5	NP_001016042.1
Canis lupus familiaris (dog)	IGFBP5	XP_852885.1
Gallus gallus (chicken)	IGFBP5	XP_422069.3
	IGFBP5	XP_001087664.1
Danio rerio (zebrafish)	igfbp5b	NP_001092224.1
Homo sapiens (human)	IGFBP5	NP_000590.1
Pan troglodytes (chimpanzee)	IGFBP5	XP_003309513.1
Rattus norvegicus (Norway rat)	Igfbp5	NP_036949.1
Danio rerio (zebrafish)	igfbp5a	NP_001119935.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of insulin like growth factor axis in the bleomycin induced lung injury in rats.
Kotarkonda LK, Kulshrestha R, Ravi K
Experimental and molecular pathology102(1)86-96(2017 Feb)

MiR-137 inhibited cell proliferation and migration of vascular smooth muscle cells via targeting IGFBP-5 and modulating the mTOR/STAT3 signaling.
Pan J, Li K, Huang W, Zhang X
PloS one12(10)e0186245(2017)

Critical role of insulin?like growth factor binding protein?5 in methamphetamine?induced apoptosis in cardiomyocytes.
Leung KP, Qu YH, Qiao DF, Xie WB, Li DR, Xu JT, Wang HJ, Yue X
Molecular medicine reports10(5)2306-12(2014 Nov)

Insulin-like growth factor binding protein 5 (IGFBP5) mediates methamphetamine-induced dopaminergic neuron apoptosis.
Qiao D, Xu J, Le C, Huang E, Liu C, Qiu P, Lin Z, Xie WB, Wang H
Toxicology letters230(3)444-53(2014 Nov)

IGFBP5 mediates high glucose-induced cardiac fibroblast activation.
Song SE, Kim YW, Kim JY, Lee DH, Kim JR, Park SY
Journal of molecular endocrinology50(3)291-303(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Insulin growth factor binding protein 5 (IGFBP-5), insulin growth factor (IGF-1) and transforming growth factor (TGF-beta1) in the type II alveolar epithelial cells (AECs) play a key role in lung injury caused by bleomycin and pioglitazone attenuates the lung injury/fibrosis by restoring IGFBP-5 and IGF-1 and decreasing TGF-beta1 expressions in the type II AECs.
Title: Role of insulin like growth factor axis in the bleomycin induced lung injury in rats.

Silencing IGFBP5 with small interfering RNA significantly reduced apoptosis and suppressed the expression of caspase3 in neonatal rat ventricular myocytes following treatment with methamphetamine.
Title: Critical role of insulin?like growth factor binding protein?5 in methamphetamine?induced apoptosis in cardiomyocytes.

IGFBP5 expression was up-regulated in the striatum of methamphetamine exposed male Sprague-Dawley rats.
Title: Insulin-like growth factor binding protein 5 (IGFBP5) mediates methamphetamine-induced dopaminergic neuron apoptosis.

IGFBP5 mediates high glucose-induced cardiac fibroblast activation
Title: IGFBP5 mediates high glucose-induced cardiac fibroblast activation.

IGFs/IGFBPs may have important roles not only in fracture healing but also in nonunion formation.
Title: Differential gene expression and immunolocalization of insulin-like growth factors and insulin-like growth factor binding proteins between experimental nonunions and standard healing fractures.

The following Igfbp5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Igfbp5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01023	NM_012817.1 Latest version!	Rattus norvegicus insulin-like growth factor binding protein 5 (Igfbp5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Igfbp5 ( NM_012817.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036949.1 Rattus norvegicus insulin-like growth factor binding protein 5 (Igfbp5), mRNA.

Price & Availability↑

CloneID	ORa01023
Clone ID Related Accession (Same CDS sequence)	NM_012817.1
Accession Version	NM_012817.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	insulin-like growth factor-binding protein 5 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M62781.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M62781.1, BC087030.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGGTGATCA GCGTGGTCCT CCTGCTGCTG GCCGCCTGTG CCGTGCCGGC TCAAGGCCTG 
GGCTCTTTCG TGCATTGTGA ACCCTGCGAC GAGAAAGCTC TGTCCATGTG TCCCCCCAGC 
CCTCTGGGCT GTGAGCTGGT CAAAGAGCCC GGCTGTGGCT GCTGCATGAC TTGCGCCCTG 
GCGGAGGGAC AGTCGTGTGG CGTCTACACT GAGCGCTGCG CCCAGGGTTT GCGCTGTCTC 
CCCCGGCAGG ATGAGGAGAA GCCGCTGCAC GCCCTGCTGC ACGGCCGCGG GGTTTGCCTC 
AACGAAAAGA GCTACGGCGA GCAAACCAAG ATAGAGAGAG ACTCTCGGGA GCATGAGGAA 
CCCACCACCT CCGAGATGGC TGAGGAGACC TACTCCCCGA AGGTCTTCCG GCCCAAGCAC 
ACTCGCATTT CCGAGCTGAA GGCCGAGGCT GTGAAGAAGG ATCGCAGAAA GAAGCTGACC 
CAGTCTAAGT TTGTGGGGGG CGCGGAGAAC ACTGCCCACC CCCGAGTCAT CCCTGCACCT 
GAGATGAGAC AGGAATCTGA CCAAGGCCCC TGCCGCAGAC ACATGGAAGC TTCCCTCCAG 
GAGTTCAAAG CCAGCCCACG CATGGTGCCC CGTGCCGTGT ACCTGCCCAA CTGTGACCGC 
AAAGGATTCT ACAAGAGAAA GCAGTGCAAG CCTTCTCGTG GCCGCAAACG TGGCATCTGC 
TGGTGTGTGG ACAAGTATGG GATGAAGCTG CCGGGCATGG AGTACGTCGA TGGGGACTTT 
CAGTGCCACG CCTTCGACAG CAGTAACGTT GAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036949.1
CDS	551..1366
Translation	MVISVVLLLLAACAVPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYGEQTKIERDSREHEEPTTSEMAEETYSPKVFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVIPAPEMRQESDQGPCRRHMEASLQEFKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHAFDSSNVE

Target ORF information:

RefSeq Version	NM_012817.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin-like growth factor binding protein 5 (Igfbp5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012817.1

ORF Insert Sequence:

ATGGTGATCA GCGTGGTCCT CCTGCTGCTG GCCGCCTGTG CCGTGCCGGC TCAAGGCCTG 
GGCTCTTTCG TGCATTGTGA ACCCTGCGAC GAGAAAGCTC TGTCCATGTG TCCCCCCAGC 
CCTCTGGGCT GTGAGCTGGT CAAAGAGCCC GGCTGTGGCT GCTGCATGAC TTGCGCCCTG 
GCGGAGGGAC AGTCGTGTGG CGTCTACACT GAGCGCTGCG CCCAGGGTTT GCGCTGTCTC 
CCCCGGCAGG ATGAGGAGAA GCCGCTGCAC GCCCTGCTGC ACGGCCGCGG GGTTTGCCTC 
AACGAAAAGA GCTACGGCGA GCAAACCAAG ATAGAGAGAG ACTCTCGGGA GCATGAGGAA 
CCCACCACCT CCGAGATGGC TGAGGAGACC TACTCCCCGA AGGTCTTCCG GCCCAAGCAC 
ACTCGCATTT CCGAGCTGAA GGCCGAGGCT GTGAAGAAGG ATCGCAGAAA GAAGCTGACC 
CAGTCTAAGT TTGTGGGGGG CGCGGAGAAC ACTGCCCACC CCCGAGTCAT CCCTGCACCT 
GAGATGAGAC AGGAATCTGA CCAAGGCCCC TGCCGCAGAC ACATGGAAGC TTCCCTCCAG 
GAGTTCAAAG CCAGCCCACG CATGGTGCCC CGTGCCGTGT ACCTGCCCAA CTGTGACCGC 
AAAGGATTCT ACAAGAGAAA GCAGTGCAAG CCTTCTCGTG GCCGCAAACG TGGCATCTGC 
TGGTGTGTGG ACAAGTATGG GATGAAGCTG CCGGGCATGG AGTACGTCGA TGGGGACTTT 
CAGTGCCACG CCTTCGACAG CAGTAACGTT GAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of insulin like growth factor axis in the bleomycin induced lung injury in rats.
Experimental and molecular pathology102(1)86-96(2017 Feb)
Kotarkonda LK,Kulshrestha R,Ravi K

MiR-137 inhibited cell proliferation and migration of vascular smooth muscle cells via targeting IGFBP-5 and modulating the mTOR/STAT3 signaling.
PloS one12(10)e0186245(2017)
Pan J,Li K,Huang W,Zhang X

Critical role of insulin?like growth factor binding protein?5 in methamphetamine?induced apoptosis in cardiomyocytes.
Molecular medicine reports10(5)2306-12(2014 Nov)
Leung KP,Qu YH,Qiao DF,Xie WB,Li DR,Xu JT,Wang HJ,Yue X

Insulin-like growth factor binding protein 5 (IGFBP5) mediates methamphetamine-induced dopaminergic neuron apoptosis.
Toxicology letters230(3)444-53(2014 Nov)
Qiao D,Xu J,Le C,Huang E,Liu C,Qiu P,Lin Z,Xie WB,Wang H

IGFBP5 mediates high glucose-induced cardiac fibroblast activation.
Journal of molecular endocrinology50(3)291-303(2013 Jun)
Song SE,Kim YW,Kim JY,Lee DH,Kim JR,Park SY

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Igfbp5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報