Id1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Id1
Entrez Gene ID	25261
Full Name	inhibitor of DNA binding 1, HLH protein
Synonyms	ID125A,Idb1
General protein information	Preferred Names inhibitor of DNA binding 1, HLH protein Names DNA-binding protein inhibitor ID-1 Inhibitor of DNA binding 1 helix-loop-helix protein (splice varaiation) Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation) inhibitor of DNA binding 1, dominant negative helix-loop-helix protein inhibitor of differentiation 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q41
Summary	a negative regulator of gene transcription [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006235267.3	XP_006235329.1	DNA-binding protein inhibitor ID-1 isoform X1
NM_012797.2	NP_036929.2	DNA-binding protein inhibitor ID-1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	ID1	NP_989921.1
Canis lupus familiaris (dog)	ID1	XP_852210.2
Pan troglodytes (chimpanzee)	ID1	XP_001152873.1
	ID1	XP_001110458.1
Homo sapiens (human)	ID1	NP_002156.2
Bos taurus (cattle)	ID1	NP_001091037.1
Mus musculus (house mouse)	Id1	NP_034625.1
Rattus norvegicus (Norway rat)	Id1	NP_036929.2
Danio rerio (zebrafish)	id1	NP_571320.1

Gene Ontology
Bibliography

Related articles in PubMed

Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning.
Patil M, Sharma BK, Elattar S, Chang J, Kapil S, Yuan J, Satyanarayana A
Diabetes66(6)1611-1625(2017 06)

Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons.
Hung YH, Chang SH, Huang CT, Yin JH, Hwang CS, Yang LY, Yang DI
Molecular neurobiology53(2)793-809(2016 Mar)

Inhibitor of DNA Binding 1 Is Induced during Kidney Ischemia-Reperfusion and Is Critical for the Induction of Hypoxia-Inducible Factor-1?.
Wen D, Zou YF, Gao YH, Zhao Q, Xie YY, Shen PY, Xu YW, Xu J, Chen YX, Feng XB, Shi H, Zhang W
BioMed research international20164634386(2016)

Oncogenic herpesvirus KSHV Hijacks BMP-Smad1-Id signaling to promote tumorigenesis.
Liang D, Hu H, Li S, Dong J, Wang X, Wang Y, He L, He Z, Gao Y, Gao SJ, Lan K
PLoS pathogens10(7)e1004253(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results thus established a signaling cascade of "Abeta --> Id1 --> HIF-1 --> SHH" in primary rat cortical cultures; furthermore, SHH may in part contribute to amyloid beta neurotoxicity.
Title: Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons.

Via RNAi, it was found that ID1 induction was inhibited with silencing of HIF-1alpha. Moreover, the suppression of ID1 mRNA expression could lead to decreased expression and transcription of HIF-1alpha during hypoxia and reoxygenation. In addition, it was demonstrated that both ID1 and HIF-1alpha can regulate the transcription of twist
Title: Inhibitor of DNA Binding 1 Is Induced during Kidney Ischemia-Reperfusion and Is Critical for the Induction of Hypoxia-Inducible Factor-1?.

Smad1 as a novel binding protein of KSHV latency-associated nuclear antigen (LANA). LANA interacted with and sustained BMP-activated p-Smad1 in the nucleus and enhanced its loading on the Id promoters.
Title: Oncogenic herpesvirus KSHV Hijacks BMP-Smad1-Id signaling to promote tumorigenesis.

These data suggest that BMP4 may regulate survival through the Id1/EGFR pathway during development of the rat inner ear.
Title: Bone morphogenetic protein 4, inhibitor of differentiation 1, and epidermal growth factor receptor regulate the survival of cochlear sensory epithelial cells.

Results suggest that the Id1/PI3K/Akt/NFkappaB/survivin signalling pathway plays a critical role in endothelial progenitor cell proliferation.
Title: An essential role for the Id1/PI3K/Akt/NFkB/survivin signalling pathway in promoting the proliferation of endothelial progenitor cells in vitro.

The following Id1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Id1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00961	NM_012797.2 Latest version!	Rattus norvegicus inhibitor of DNA binding 1, HLH protein (Id1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa26514	XM_006235267.3 Latest version!	Rattus norvegicus inhibitor of DNA binding 1, HLH protein (Id1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Id1 ( NM_012797.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036929.2 Rattus norvegicus inhibitor of DNA binding 1, HLH protein (Id1), mRNA.

Price & Availability↑

CloneID	ORa00961
Clone ID Related Accession (Same CDS sequence)	NM_012797.2
Accession Version	NM_012797.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	DNA-binding protein inhibitor ID-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M86708.1 and AI073271.1. On Nov 23, 2005 this sequence version replaced NM_012797.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M86708.1, BC127448.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAGGTCG CCAGTAGCAG TGCCGCGGCC ACCGCAGGCC CCAGCTGTTC GCTGAAGGCA 
GGCAGGACGG CGGGCGAAGT GGTGCTTGGT CTGTCGGAGC AAAGCGTTGC CATCTCGCGC 
TGCGCTGGGA CGCGCCTGCC CGCCTTGCTG GACGAACAGC AGGTGAACGT TCTGCTCTAC 
GACATGAACG GCTGCTACTC ACGCCTCAAG GAGCTGGTGC CTACCCTGCC TCAGAACCGC 
AAAGTGAGCA AGGTGGAGAT ACTGCAGCAT GTTATCGACT ACATCAGGGA CCTGCAGCTG 
GAGCTGAACT CTGAGTCTGA AGTCGCGACC GCCGGAGGCC GGGGGCTGCC CGTCCGGGCC 
CCGCTCAGCA CCCTGAACGG CGAGATCAGT GCCTTGGCGG CCGAGGCGGC ATGTGTTCCA 
GCCGACGACC GCATCTTGTG TCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036929.2
CDS	61..507
Translation	MKVASSSAAATAGPSCSLKAGRTAGEVVLGLSEQSVAISRCAGTRLPALLDEQQVNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEVATAGGRGLPVRAPLSTLNGEISALAAEAACVPADDRILCR

Target ORF information:

RefSeq Version	NM_012797.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus inhibitor of DNA binding 1, HLH protein (Id1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012797.2

ORF Insert Sequence:

ATGAAGGTCG CCAGTAGCAG TGCCGCGGCC ACCGCAGGCC CCAGCTGTTC GCTGAAGGCA 
GGCAGGACGG CGGGCGAAGT GGTGCTTGGT CTGTCGGAGC AAAGCGTTGC CATCTCGCGC 
TGCGCTGGGA CGCGCCTGCC CGCCTTGCTG GACGAACAGC AGGTGAACGT TCTGCTCTAC 
GACATGAACG GCTGCTACTC ACGCCTCAAG GAGCTGGTGC CTACCCTGCC TCAGAACCGC 
AAAGTGAGCA AGGTGGAGAT ACTGCAGCAT GTTATCGACT ACATCAGGGA CCTGCAGCTG 
GAGCTGAACT CTGAGTCTGA AGTCGCGACC GCCGGAGGCC GGGGGCTGCC CGTCCGGGCC 
CCGCTCAGCA CCCTGAACGG CGAGATCAGT GCCTTGGCGG CCGAGGCGGC ATGTGTTCCA 
GCCGACGACC GCATCTTGTG TCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Id1 ( XM_006235267.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006235329.1 Rattus norvegicus inhibitor of DNA binding 1, HLH protein (Id1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa26514
Clone ID Related Accession (Same CDS sequence)	XM_006235267.3
Accession Version	XM_006235267.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	DNA-binding protein inhibitor ID-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006235267.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGTCG CCAGTAGCAG TGCCGCGGCC ACCGCAGGCC CCAGCTGTTC GCTGAAGGCA 
GGCAGGACGG CGGGCGAAGT GGTGCTTGGT CTGTCGGAGC AAAGCGTTGC CATCTCGCGC 
TGCGCTGGGA CGCGCCTGCC CGCCTTGCTG GACGAACAGC AGGTGAACGT TCTGCTCTAC 
GACATGAACG GCTGCTACTC ACGCCTCAAG GAGCTGGTGC CTACCCTGCC TCAGAACCGC 
AAAGTGAGCA AGGTGGAGAT ACTGCAGCAT GTTATCGACT ACATCAGGGA CCTGCAGCTG 
GAGCTGAACT CTGAGTCTGA AGTCGCGACC GCCGGAGGCC GGGGGCTGCC CGTCCGGGCC 
CCGCTCAGCA CCCTGAACGG CGAGATCAGT GCCTTGGCGG CCGAGGTGAG GCGGCATGTG 
TTCCAGCCGA CGACCGCATC TTGTGTCGCT GAGGCGGCGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006235329.1
CDS	1026..1490
Translation	MKVASSSAAATAGPSCSLKAGRTAGEVVLGLSEQSVAISRCAGTRLPALLDEQQVNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEVATAGGRGLPVRAPLSTLNGEISALAAEVRRHVFQPTTASCVAEAAH

Target ORF information:

RefSeq Version	XM_006235267.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus inhibitor of DNA binding 1, HLH protein (Id1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006235267.3

ORF Insert Sequence:

ATGAAGGTCG CCAGTAGCAG TGCCGCGGCC ACCGCAGGCC CCAGCTGTTC GCTGAAGGCA 
GGCAGGACGG CGGGCGAAGT GGTGCTTGGT CTGTCGGAGC AAAGCGTTGC CATCTCGCGC 
TGCGCTGGGA CGCGCCTGCC CGCCTTGCTG GACGAACAGC AGGTGAACGT TCTGCTCTAC 
GACATGAACG GCTGCTACTC ACGCCTCAAG GAGCTGGTGC CTACCCTGCC TCAGAACCGC 
AAAGTGAGCA AGGTGGAGAT ACTGCAGCAT GTTATCGACT ACATCAGGGA CCTGCAGCTG 
GAGCTGAACT CTGAGTCTGA AGTCGCGACC GCCGGAGGCC GGGGGCTGCC CGTCCGGGCC 
CCGCTCAGCA CCCTGAACGG CGAGATCAGT GCCTTGGCGG CCGAGGTGAG GCGGCATGTG 
TTCCAGCCGA CGACCGCATC TTGTGTCGCT GAGGCGGCGC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning.
Diabetes66(6)1611-1625(2017 06)
Patil M,Sharma BK,Elattar S,Chang J,Kapil S,Yuan J,Satyanarayana A

Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons.
Molecular neurobiology53(2)793-809(2016 Mar)
Hung YH,Chang SH,Huang CT,Yin JH,Hwang CS,Yang LY,Yang DI

Inhibitor of DNA Binding 1 Is Induced during Kidney Ischemia-Reperfusion and Is Critical for the Induction of Hypoxia-Inducible Factor-1?.
BioMed research international20164634386(2016)
Wen D,Zou YF,Gao YH,Zhao Q,Xie YY,Shen PY,Xu YW,Xu J,Chen YX,Feng XB,Shi H,Zhang W

Oncogenic herpesvirus KSHV Hijacks BMP-Smad1-Id signaling to promote tumorigenesis.
PLoS pathogens10(7)e1004253(2014 Jul)
Liang D,Hu H,Li S,Dong J,Wang X,Wang Y,He L,He Z,Gao Y,Gao SJ,Lan K

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Id1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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