Apod cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Apod
Entrez Gene ID	25239
Full Name	apolipoprotein D
Synonyms	AOPDGN
General protein information	Preferred Names apolipoprotein D Names apolipoprotein D apo-D
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q22
Summary	may play a role in nerve repair in response to injury [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012777.1	NP_036909.1	apolipoprotein D precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	zgc:123339	NP_001032784.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009281	XP_320076.4
Canis lupus familiaris (dog)	APOD	XP_535780.1
Bos taurus (cattle)	APOD	NP_001069769.1
Pan troglodytes (chimpanzee)	APOD	XP_516965.1
	LOC709223	XP_001098104.2
Mus musculus (house mouse)	Apod	NP_031496.2
Homo sapiens (human)	APOD	NP_001638.1
Rattus norvegicus (Norway rat)	Apod	NP_036909.1
Gallus gallus (chicken)	APOD	NP_001011692.1
Danio rerio (zebrafish)	apod	NP_001070050.1
Drosophila melanogaster (fruit fly)	NLaz	NP_001259867.1

Gene Ontology
Bibliography

Related articles in PubMed

Differential expression of apolipoprotein D in male reproductive system of rats by high-fat diet.
Lim W, Bae H, Song G
Andrology4(6)1115-1122(2016 Nov)

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins MT, Misra S, Stoughton J, Mayr M
Cardiovascular research110(3)419-30(2016 06)

Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease.
Tsukamoto K, Mani DR, Shi J, Zhang S, Haagensen DE, Otsuka F, Guan J, Smith JD, Weng W, Liao R, Kolodgie FD, Virmani R, Krieger M
Proceedings of the National Academy of Sciences of the United States of America110(42)17023-8(2013 Oct)

Endothelial cells downregulate apolipoprotein D expression in mural cells through paracrine secretion and Notch signaling.
Pajaniappan M, Glober NK, Kennard S, Liu H, Zhao N, Lilly B
American journal of physiology. Heart and circulatory physiology301(3)H784-93(2011 Sep)

Proteomics characterization of extracellular space components in the human aorta.
Didangelos A, Yin X, Mandal K, Baumert M, Jahangiri M, Mayr M
Molecular & cellular proteomics : MCP9(9)2048-62(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Collectively, results of this study suggest that Apod is a novel regulatory gene in the male reproductive system, especially in penises of rats fed a high-cholesterol diet, and that expression of Apod is regulated at the posttranscriptional level by target microRNAs.
Title: Differential expression of apolipoprotein D in male reproductive system of rats by high-fat diet.

apoD may be part of an intrinsic cardioprotective system, possibly as a consequence of its antioxidation activity.
Title: Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease.

Apolipoprotein D exerts neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures.
Title: Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures.

We propose that apoD promotes its neuroprotective effects by binding to arachidonic acid and cholesterol thus preventing their oxidation to neurotoxic products such as 4-hydroxynonenal (4-HNE) and 7-ketocholesterol.
Title: Apolipoprotein D modulates F2-isoprostane and 7-ketocholesterol formation and has a neuroprotective effect on organotypic hippocampal cultures after kainate-induced excitotoxic injury.

apoD is involved in regenerative processes and scar formation in the peri-infarct area presumably by enhancing lipid trafficking.
Title: Apolipoprotein D is elevated in oligodendrocytes in the peri-infarct region after experimental stroke: influence of enriched environment.

The following Apod gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Apod cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12798	NM_012777.1 Latest version!	Rattus norvegicus apolipoprotein D (Apod), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Apod ( NM_012777.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036909.1 Rattus norvegicus apolipoprotein D (Apod), mRNA.

Price & Availability↑

CloneID	ORa12798
Clone ID Related Accession (Same CDS sequence)	NM_012777.1
Accession Version	NM_012777.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	apolipoprotein D precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X55572.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X55572.1, FQ212999.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGACCA TGCTGTTGCT CCTGGCCACA CTGGCAGGTC TCTTCACCAC AACCGAAGGA 
CAAAGCTTCC ATCTTGGGAA ATGCCCATCT CCTCCGGTGC AAGAGAATTT CGATGTGAAA 
AAGTATCTTG GAAGATGGTA CGAAATCGAG AAGATCCCGG TGAGCTTTGA GAAAGGAAAC 
TGCATTCAAG CCAACTACTC GCTGATGGAG AACGGAAACA TCAAAGTGCT AAACAAGGAG 
CTGCGTCCTG ACGGAACCCT GAACCAAGTT GAGGGTGAAG CCAAACAGAG CAACATGTCA 
GAGCCAGCCA AGCTGGAAGT CCAGTTCTTC TCGTTGATGC CACCGGCACC CTACTGGATC 
CTGGCCACGG ATTACGAGAG CTATGCCCTC GTGTATTCCT GCACCACCTT CTTCTGGTTC 
TTCCACGTGG ACTATGTTTG GATCCTGGGA AGAAATCCTT ACCTCCCTCC AGAAACAATA 
ACCTACCTAA AATATATCCT TACTTCTAAT GACATCGACA TCGCCAAAAT AACAACAAAA 
GACCAAGCAA ACTGCCCGGA CTTCCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036909.1
CDS	73..642
Translation	MATMLLLLATLAGLFTTTEGQSFHLGKCPSPPVQENFDVKKYLGRWYEIEKIPVSFEKGNCIQANYSLMENGNIKVLNKELRPDGTLNQVEGEAKQSNMSEPAKLEVQFFSLMPPAPYWILATDYESYALVYSCTTFFWFFHVDYVWILGRNPYLPPETITYLKYILTSNDIDIAKITTKDQANCPDFL

Target ORF information:

RefSeq Version	NM_012777.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus apolipoprotein D (Apod), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012777.1

ORF Insert Sequence:

ATGGCGACCA TGCTGTTGCT CCTGGCCACA CTGGCAGGTC TCTTCACCAC AACCGAAGGA 
CAAAGCTTCC ATCTTGGGAA ATGCCCATCT CCTCCGGTGC AAGAGAATTT CGATGTGAAA 
AAGTATCTTG GAAGATGGTA CGAAATCGAG AAGATCCCGG TGAGCTTTGA GAAAGGAAAC 
TGCATTCAAG CCAACTACTC GCTGATGGAG AACGGAAACA TCAAAGTGCT AAACAAGGAG 
CTGCGTCCTG ACGGAACCCT GAACCAAGTT GAGGGTGAAG CCAAACAGAG CAACATGTCA 
GAGCCAGCCA AGCTGGAAGT CCAGTTCTTC TCGTTGATGC CACCGGCACC CTACTGGATC 
CTGGCCACGG ATTACGAGAG CTATGCCCTC GTGTATTCCT GCACCACCTT CTTCTGGTTC 
TTCCACGTGG ACTATGTTTG GATCCTGGGA AGAAATCCTT ACCTCCCTCC AGAAACAATA 
ACCTACCTAA AATATATCCT TACTTCTAAT GACATCGACA TCGCCAAAAT AACAACAAAA 
GACCAAGCAA ACTGCCCGGA CTTCCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential expression of apolipoprotein D in male reproductive system of rats by high-fat diet.
Andrology4(6)1115-1122(2016 Nov)
Lim W,Bae H,Song G

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Cardiovascular research110(3)419-30(2016 06)
Barallobre-Barreiro J,Oklu R,Lynch M,Fava M,Baig F,Yin X,Barwari T,Potier DN,Albadawi H,Jahangiri M,Porter KE,Watkins MT,Misra S,Stoughton J,Mayr M

Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease.
Proceedings of the National Academy of Sciences of the United States of America110(42)17023-8(2013 Oct)
Tsukamoto K,Mani DR,Shi J,Zhang S,Haagensen DE,Otsuka F,Guan J,Smith JD,Weng W,Liao R,Kolodgie FD,Virmani R,Krieger M

Endothelial cells downregulate apolipoprotein D expression in mural cells through paracrine secretion and Notch signaling.
American journal of physiology. Heart and circulatory physiology301(3)H784-93(2011 Sep)
Pajaniappan M,Glober NK,Kennard S,Liu H,Zhao N,Lilly B

Proteomics characterization of extracellular space components in the human aorta.
Molecular & cellular proteomics : MCP9(9)2048-62(2010 Sep)
Didangelos A,Yin X,Mandal K,Baumert M,Jahangiri M,Mayr M

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Apod cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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