Tyro3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tyro3
Entrez Gene ID	25232
Full Name	TYRO3 protein tyrosine kinase
Synonyms	Brt
General protein information	Preferred Names TYRO3 protein tyrosine kinase Names tyrosine-protein kinase receptor TYRO3 Bruton agammaglobulinemia tyrosine kinase TYRO3 protein tyrosine kinase 3 tyrosine-protein kinase SKY
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q35
Summary	receptor tyrosine kinase; may have a role in development or function of specific neuronal populations [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017092.1	NP_058788.1	tyrosine-protein kinase receptor TYRO3 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	TYRO3	NP_001178157.1
Mus musculus (house mouse)	Tyro3	NP_062265.2
Xenopus tropicalis (tropical clawed frog)	tyro3	NP_001072731.1
	TYRO3	XP_001099590.1
Homo sapiens (human)	TYRO3	NP_006284.2
Pan troglodytes (chimpanzee)	TYRO3	XP_003314681.2
Rattus norvegicus (Norway rat)	Tyro3	NP_058788.1
Gallus gallus (chicken)	TYRO3	NP_989958.1
Danio rerio (zebrafish)	tyro3	NP_571507.1
Canis lupus familiaris (dog)	TYRO3	XP_544633.2

Gene Ontology
Bibliography

Related articles in PubMed

Novel and selective spiroindoline-based inhibitors of Sky kinase.
Powell NA, Kohrt JT, Filipski KJ, Kaufman M, Sheehan D, Edmunds JE, Delaney A, Wang Y, Bourbonais F, Lee DY, Schwende F, Sun F, McConnell P, Catana C, Chen H, Ohren J, Perrin LA
Bioorganic & medicinal chemistry letters22(1)190-3(2012 Jan)

Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.
Brown JE, Krodel M, Pazos M, Lai C, Prieto AL
PloS one7(5)e36800(2012)

Expressions of Axl and Tyro-3 receptors are under regulation of nerve growth factor and are involved in differentiation of PC12 cells.
Wang Q, Lu QJ, Xiao B, Zheng Y, Wang XM
Neuroscience bulletin27(1)15-22(2011 Feb)

Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.
Zhong Z, Wang Y, Guo H, Sagare A, Fern?ndez JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV
The Journal of neuroscience : the official journal of the Society for Neuroscience30(46)15521-34(2010 Nov)

Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization.
Cosemans JM, Van Kruchten R, Olieslagers S, Schurgers LJ, Verheyen FK, Munnix IC, Waltenberger J, Angelillo-Scherrer A, Hoylaerts MF, Carmeliet P, Heemskerk JW
Journal of thrombosis and haemostasis : JTH8(8)1797-808(2010 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

analysis of novel and selective spiroindoline-based inhibitors of Sky kinase
Title: Novel and selective spiroindoline-based inhibitors of Sky kinase.

Overexpression of Tyro3 in the Rat2 cell line that expresses Axl, but not Mer or Tyro3, resulted in a 5 fold increase in cell proliferation.
Title: Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.

nerve growth factor affected intracellular localization of full-length Axl-eGFP and Tyro-3-eCFP in PC12 cells
Title: Expressions of Axl and Tyro-3 receptors are under regulation of nerve growth factor and are involved in differentiation of PC12 cells.

Tyro3 and Axl receptors are upregulated by nerve growth factor on the differentiating PC12, where they collaborate with TrkA to support neuronal differentiation and survival.
Title: NGF-induced Tyro3 and Axl function as survival factors for differentiating PC12 cells.

Tyro3 signaling may influence synaptic plasticity in the dendritic compartment of hippocampal and cortical neurons.
Title: Localization and signaling of the receptor protein tyrosine kinase Tyro3 in cortical and hippocampal neurons.

The following Tyro3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tyro3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02793	NM_017092.1 Latest version!	Rattus norvegicus TYRO3 protein tyrosine kinase (Tyro3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tyro3 ( NM_017092.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058788.1 Rattus norvegicus TYRO3 protein tyrosine kinase (Tyro3), mRNA.

Price & Availability↑

CloneID	ORa02793
Clone ID Related Accession (Same CDS sequence)	NM_017092.1
Accession Version	NM_017092.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2643bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase receptor TYRO3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D37880.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D37880.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCTGA GGCGGAGCAT GGGGCGGCCG GGGCTCCGGC CGCTGCTGCT GGCGGGGCTG 
GCCTCTCTGC TGCTCCCAGG GTCCGCGGCC GCAGGCCTGA AGCTCATGGG AGCCCCAGTG 
AAGATGACAG TGTCTCAGGG GCAGCCAGTG AAGCTTAACT GCAGTGTGGA AGGGATGGAT 
GACCCTGACA TACACTGGAT GAAGGATGGC GCTGTGGTCC AGAATGCAAG CCAGGTGTCC 
ATCTCAATAA GCGAACAGAA CTGGATTGGC TTACTCAGCC TAAAGTCAGC GGAGCGGTCT 
GATGCCGGCC TGTACTGGTG CCAGGTGAAG GATGGGGAGG AAACCAAGAT CTCTCAGTCA 
GTATGGCTCA CTGTTGAAGG TGTGCCATTC TTCACGGTGG AACCAAAAGA TCTGGCGGTG 
CCACCCAATG TCCCTTTTCA ACTGTCTTGT GAGGCTGTGG GTCCACCAGA ACCCGTAACC 
ATTTTCTGGT GGAGAGGACC CACTAAGGTT GGGGGACCTG CTTCCTCTCC CTCTGTTTTA 
AATGTAACAG GAGTGACCCA GCGCACAGAG TTTTCTTGTG AAGCTCATAA CATAAAAGGC 
CTGGCCACTT CCCGACCAGC CATTATTCGC CTTCAAGCAC CGCCTGCAGC TCCTTTCAAC 
ATCACAGTAA CAACGATCTC CAGCAGCAAC GCTAGTGTGG CCTGGGTGCC GGGTGCTGAT 
GGCTTAGCTC TGCTGCACTC CTGTACTGTA CAGGTGGCAC ATGCCCCAGG AGAATGGGAG 
GCCCTTGCTG TCGTGGTTCC CGTGCCACCC TTTACTTGCT TGCTTCGGAA CTTGGCCCCT 
GCCACCAACT ACAGCCTTAG GGTTCGCTGT GCCAACGCCT TGGGCCCTTC TCCCTATGGC 
GACTGGGTGC CCTTTCAGAC AAAGGGCCTA GCGCCAGCCA GAGCCCCTCA GAATTTCCAC 
GCCATTCGTA CTGACTCAGG CCTTATCCTG GAATGGGAAG AAGTGATTCC TGAGGACCCT 
GGGGAAGGCC CCCTGGGACC TTATAAGCTG TCCTGGGTCC AAGAAAATGG AACCCAGGAT 
GAGCTGATGG TGGAAGGAAC TACGGCCAAT CTGACTGACT GGGATCCCCA GAAGGACCTG 
GTTTTGCGTG TGTGTGCCTC CAATGCAATT GGTGATGGGC CCTGGAGTCA ACCACTGGTG 
GTGTCTTCTC ATGACCATGC AGGGAGGCAG GGCCCTCCTC ACAGCCGTAC ATCCTGGGTG 
CCTGTGGTCC TGGGTGTGCT CACCGCCCTG ATCACAGCTG CTGCCTTGGC CCTCATCCTG 
CTTCGGAAGA GACGCAAGGA GACGCGGTTC GGGCAAGCCT TTGACAGTGT CATGGCCCGA 
GGGGAGCCAG CTGTACACTT CCGGGCAGCC CGGTCTTTCA ATCGAGAAAG GCCTGAACGC 
ATTGAAGCTA CATTGGATAG CCTGGGCATC AGCGATGAAT TGAAGGAGAA GCTGGAGGAC 
GTCCTCATCC CAGAGCAGCA GTTCACCCTC GGCCGGATGT TGGGCAAAGG AGAGTTTGGA 
TCAGTGCGGG AAGCCCAGCT GAAGCAGGAA GATGGCTCCT TTGTGAAAGT GGCAGTGAAG 
ATGCTGAAAG CTGACATCAT TGCCTCAAGC GACATAGAAG AGTTCCTGAG AGAAGCAGCT 
TGCATGAAGG AGTTTGACCA TCCACACGTG GCCAAGCTTG TTGGAGTGAG CCTCCGGAGC 
AGGGCTAAAG GTCGTCTCCC CATTCCCATG GTCATCCTGC CCTTCATGAA GCACGGAGAC 
TTGCATGCCT TTCTGCTCGC CTCCCGAATT GGGGAGAACC CTTTTAACCT GCCCCTCCAG 
ACCCTCGTCC GGTTCATGGT GGACATTGCC TGTGGCATGG AGTACCTGAG CTCCCGGAAC 
TTCATCCACC GAGACCTAGC AGCTCGGAAT TGCATGCTGG CAGAGGACAT GACAGTGTGT 
GTGGCTGACT TTGGACTCTC CCGGAAAATT TATAGCGGGG ACTATTATCG TCAGGGCTGT 
GCCTCCAAAC TGCCTGTCAA GTGGCTGGCC CTGGAGAGCT TGGCTGACAA CTTGTATACT 
GTACACAGCG ATGTGTGGGC CTTCGGGGTG ACCATGTGGG AGATCATGAC TCGTGGGCAG 
ACGCCATATG CTGGCATCGA AAATGCTGAG ATTTACAACT ACCTCATCAG CGGGAACCGC 
CTGAAGCAGC CTCCGGAGTG CATGGAGGAA GTGTATGATC TCATGTACCA GTGCTGGAGT 
GCCGACCCAA AGCAGCGCCC AAGCTTCACA TGCCTGCGAA TGGAACTGGA GAACATTCTG 
GGCCACCTAT CTGTTCTGTC CACCAGCCAG GACCCCTTGT ACATCAACAT TGAGAGAGCT 
GGGCAGCCTG CTGAGAATGG CAGTCCCGAG CTGCCCTGTG GAGAGCAGTC TAGCAGCGAG 
GCGGGGGATG GCAGTGGCAT GGGGGCAATA GGTGGCATCC CCAGTGACTG TCGGTACATC 
TTCAGCCCTG GAGGGTTGGC CGAGTCACCA GGGCAGCTGG AGCAGCAGCC AGAAAGCCCC 
CTCAACGAGA ACCAGAGGCT TTTGTTGTTG CAGCAAGGGC TACTGCCTCA CAGTAGCTGT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058788.1
CDS	26..2668
Translation	MALRRSMGRPGLRPLLLAGLASLLLPGSAAAGLKLMGAPVKMTVSQGQPVKLNCSVEGMDDPDIHWMKDGAVVQNASQVSISISEQNWIGLLSLKSAERSDAGLYWCQVKDGEETKISQSVWLTVEGVPFFTVEPKDLAVPPNVPFQLSCEAVGPPEPVTIFWWRGPTKVGGPASSPSVLNVTGVTQRTEFSCEAHNIKGLATSRPAIIRLQAPPAAPFNITVTTISSSNASVAWVPGADGLALLHSCTVQVAHAPGEWEALAVVVPVPPFTCLLRNLAPATNYSLRVRCANALGPSPYGDWVPFQTKGLAPARAPQNFHAIRTDSGLILEWEEVIPEDPGEGPLGPYKLSWVQENGTQDELMVEGTTANLTDWDPQKDLVLRVCASNAIGDGPWSQPLVVSSHDHAGRQGPPHSRTSWVPVVLGVLTALITAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLISGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLSVLSTSQDPLYINIERAGQPAENGSPELPCGEQSSSEAGDGSGMGAIGGIPSDCRYIFSPGGLAESPGQLEQQPESPLNENQRLLLLQQGLLPHSSC

Target ORF information:

RefSeq Version	NM_017092.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus TYRO3 protein tyrosine kinase (Tyro3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017092.1

ORF Insert Sequence:

ATGGCGCTGA GGCGGAGCAT GGGGCGGCCG GGGCTCCGGC CGCTGCTGCT GGCGGGGCTG 
GCCTCTCTGC TGCTCCCAGG GTCCGCGGCC GCAGGCCTGA AGCTCATGGG AGCCCCAGTG 
AAGATGACAG TGTCTCAGGG GCAGCCAGTG AAGCTTAACT GCAGTGTGGA AGGGATGGAT 
GACCCTGACA TACACTGGAT GAAGGATGGC GCTGTGGTCC AGAATGCAAG CCAGGTGTCC 
ATCTCAATAA GCGAACAGAA CTGGATTGGC TTACTCAGCC TAAAGTCAGC GGAGCGGTCT 
GATGCCGGCC TGTACTGGTG CCAGGTGAAG GATGGGGAGG AAACCAAGAT CTCTCAGTCA 
GTATGGCTCA CTGTTGAAGG TGTGCCATTC TTCACGGTGG AACCAAAAGA TCTGGCGGTG 
CCACCCAATG TCCCTTTTCA ACTGTCTTGT GAGGCTGTGG GTCCACCAGA ACCCGTAACC 
ATTTTCTGGT GGAGAGGACC CACTAAGGTT GGGGGACCTG CTTCCTCTCC CTCTGTTTTA 
AATGTAACAG GAGTGACCCA GCGCACAGAG TTTTCTTGTG AAGCTCATAA CATAAAAGGC 
CTGGCCACTT CCCGACCAGC CATTATTCGC CTTCAAGCAC CGCCTGCAGC TCCTTTCAAC 
ATCACAGTAA CAACGATCTC CAGCAGCAAC GCTAGTGTGG CCTGGGTGCC GGGTGCTGAT 
GGCTTAGCTC TGCTGCACTC CTGTACTGTA CAGGTGGCAC ATGCCCCAGG AGAATGGGAG 
GCCCTTGCTG TCGTGGTTCC CGTGCCACCC TTTACTTGCT TGCTTCGGAA CTTGGCCCCT 
GCCACCAACT ACAGCCTTAG GGTTCGCTGT GCCAACGCCT TGGGCCCTTC TCCCTATGGC 
GACTGGGTGC CCTTTCAGAC AAAGGGCCTA GCGCCAGCCA GAGCCCCTCA GAATTTCCAC 
GCCATTCGTA CTGACTCAGG CCTTATCCTG GAATGGGAAG AAGTGATTCC TGAGGACCCT 
GGGGAAGGCC CCCTGGGACC TTATAAGCTG TCCTGGGTCC AAGAAAATGG AACCCAGGAT 
GAGCTGATGG TGGAAGGAAC TACGGCCAAT CTGACTGACT GGGATCCCCA GAAGGACCTG 
GTTTTGCGTG TGTGTGCCTC CAATGCAATT GGTGATGGGC CCTGGAGTCA ACCACTGGTG 
GTGTCTTCTC ATGACCATGC AGGGAGGCAG GGCCCTCCTC ACAGCCGTAC ATCCTGGGTG 
CCTGTGGTCC TGGGTGTGCT CACCGCCCTG ATCACAGCTG CTGCCTTGGC CCTCATCCTG 
CTTCGGAAGA GACGCAAGGA GACGCGGTTC GGGCAAGCCT TTGACAGTGT CATGGCCCGA 
GGGGAGCCAG CTGTACACTT CCGGGCAGCC CGGTCTTTCA ATCGAGAAAG GCCTGAACGC 
ATTGAAGCTA CATTGGATAG CCTGGGCATC AGCGATGAAT TGAAGGAGAA GCTGGAGGAC 
GTCCTCATCC CAGAGCAGCA GTTCACCCTC GGCCGGATGT TGGGCAAAGG AGAGTTTGGA 
TCAGTGCGGG AAGCCCAGCT GAAGCAGGAA GATGGCTCCT TTGTGAAAGT GGCAGTGAAG 
ATGCTGAAAG CTGACATCAT TGCCTCAAGC GACATAGAAG AGTTCCTGAG AGAAGCAGCT 
TGCATGAAGG AGTTTGACCA TCCACACGTG GCCAAGCTTG TTGGAGTGAG CCTCCGGAGC 
AGGGCTAAAG GTCGTCTCCC CATTCCCATG GTCATCCTGC CCTTCATGAA GCACGGAGAC 
TTGCATGCCT TTCTGCTCGC CTCCCGAATT GGGGAGAACC CTTTTAACCT GCCCCTCCAG 
ACCCTCGTCC GGTTCATGGT GGACATTGCC TGTGGCATGG AGTACCTGAG CTCCCGGAAC 
TTCATCCACC GAGACCTAGC AGCTCGGAAT TGCATGCTGG CAGAGGACAT GACAGTGTGT 
GTGGCTGACT TTGGACTCTC CCGGAAAATT TATAGCGGGG ACTATTATCG TCAGGGCTGT 
GCCTCCAAAC TGCCTGTCAA GTGGCTGGCC CTGGAGAGCT TGGCTGACAA CTTGTATACT 
GTACACAGCG ATGTGTGGGC CTTCGGGGTG ACCATGTGGG AGATCATGAC TCGTGGGCAG 
ACGCCATATG CTGGCATCGA AAATGCTGAG ATTTACAACT ACCTCATCAG CGGGAACCGC 
CTGAAGCAGC CTCCGGAGTG CATGGAGGAA GTGTATGATC TCATGTACCA GTGCTGGAGT 
GCCGACCCAA AGCAGCGCCC AAGCTTCACA TGCCTGCGAA TGGAACTGGA GAACATTCTG 
GGCCACCTAT CTGTTCTGTC CACCAGCCAG GACCCCTTGT ACATCAACAT TGAGAGAGCT 
GGGCAGCCTG CTGAGAATGG CAGTCCCGAG CTGCCCTGTG GAGAGCAGTC TAGCAGCGAG 
GCGGGGGATG GCAGTGGCAT GGGGGCAATA GGTGGCATCC CCAGTGACTG TCGGTACATC 
TTCAGCCCTG GAGGGTTGGC CGAGTCACCA GGGCAGCTGG AGCAGCAGCC AGAAAGCCCC 
CTCAACGAGA ACCAGAGGCT TTTGTTGTTG CAGCAAGGGC TACTGCCTCA CAGTAGCTGT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel and selective spiroindoline-based inhibitors of Sky kinase.
Bioorganic & medicinal chemistry letters22(1)190-3(2012 Jan)
Powell NA,Kohrt JT,Filipski KJ,Kaufman M,Sheehan D,Edmunds JE,Delaney A,Wang Y,Bourbonais F,Lee DY,Schwende F,Sun F,McConnell P,Catana C,Chen H,Ohren J,Perrin LA

Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.
PloS one7(5)e36800(2012)
Brown JE,Krodel M,Pazos M,Lai C,Prieto AL

Expressions of Axl and Tyro-3 receptors are under regulation of nerve growth factor and are involved in differentiation of PC12 cells.
Neuroscience bulletin27(1)15-22(2011 Feb)
Wang Q,Lu QJ,Xiao B,Zheng Y,Wang XM

Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.
The Journal of neuroscience : the official journal of the Society for Neuroscience30(46)15521-34(2010 Nov)
Zhong Z,Wang Y,Guo H,Sagare A,Fern?ndez JA,Bell RD,Barrett TM,Griffin JH,Freeman RS,Zlokovic BV

Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization.
Journal of thrombosis and haemostasis : JTH8(8)1797-808(2010 Aug)
Cosemans JM,Van Kruchten R,Olieslagers S,Schurgers LJ,Verheyen FK,Munnix IC,Waltenberger J,Angelillo-Scherrer A,Hoylaerts MF,Carmeliet P,Heemskerk JW

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Tyro3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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