Gata2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gata2
Entrez Gene ID	25159
Full Name	GATA binding protein 2
General protein information	Preferred Names GATA binding protein 2 Names endothelial transcription factor GATA-2 GATA-bindning protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q34
Summary	mediates phagocytosis function of alveolar macrophages [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017592479.1	XP_017447968.1	endothelial transcription factor GATA-2 isoform X1
NM_033442.1	NP_254277.1	endothelial transcription factor GATA-2
XM_017592480.1	XP_017447969.1	endothelial transcription factor GATA-2 isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gata2	NP_254277.1
Xenopus tropicalis (tropical clawed frog)	LOC100487142	XP_002933110.2
Bos taurus (cattle)	GATA2	NP_001179043.1
Danio rerio (zebrafish)	gata2a	NP_571308.1
Pan troglodytes (chimpanzee)	GATA2	XP_516728.2
Canis lupus familiaris (dog)	GATA2	XP_541740.3
Mus musculus (house mouse)	Gata2	NP_032116.4
Gallus gallus (chicken)	GATA2	NP_001003797.1
Homo sapiens (human)	GATA2	NP_116027.2

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease.
Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K, Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L, Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J, Bauersachs J, Batkai S, Thum T
Circulation134(24)1973-1990(2016 Dec)

GATA2 mutations in patients with acute myeloid leukemia-paired samples analyses show that the mutation is unstable during disease evolution.
Hou HA, Lin YC, Kuo YY, Chou WC, Lin CC, Liu CY, Chen CY, Lin LI, Tseng MH, Huang CF, Chiang YC, Liu MC, Liu CW, Tang JL, Yao M, Huang SY, Ko BS, Hsu SC, Wu SJ, Tsay W, Chen YC, Tien HF
Annals of hematology94(2)211-21(2015 Feb)

Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia.
Celton M, Forest A, Gosse G, Lemieux S, Hebert J, Sauvageau G, Wilhelm BT
Leukemia28(8)1617-26(2014 Aug)

Overexpression of human GATA-1 and GATA-2 interferes with spine formation and produces depressive behavior in rats.
Choi M, Wang SE, Ko SY, Kang HJ, Chae SY, Lee SH, Kim YS, Duman RS, Son H
PloS one9(10)e109253(2014)

GATA2-induced silencing and LIM-homeodomain protein-induced activation are mediated by a bi-functional response element in the rat GnRH receptor gene.
Schang AL, Granger A, Qu?rat B, Bleux C, Cohen-Tannoudji J, Laverri?re JN
Molecular endocrinology (Baltimore, Md.)27(1)74-91(2013 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The trans-repressive action of GATA2 on Gnrhr promoter activity is likely balanced or even hindered by trans-activating effects of LIM homeodomain proteins.
Title: GATA2-induced silencing and LIM-homeodomain protein-induced activation are mediated by a bi-functional response element in the rat GnRH receptor gene.

GATA2 stimulates transcriptional activity of the luteinizing hormone beta gene promoter
Title: GATA transcription factors regulate LH? gene expression.

hese findings indicate that Gata2 plays a required role in the transition of postmitotic neuronal precursor cells of the retinorecipient layers of the superior colliculus into mature neurons
Title: Gata2 is required for migration and differentiation of retinorecipient neurons in the superior colliculus.

There may be a regulatory role played by the Gata-3,-2 transcription factors in prestin expression.
Title: Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti during the postnatal period and in culture.

These results demonstrate that GATA-2 is involved in multiple promoter regions to activate the specific expression of the rPL-I gene in placental tissue.
Title: Identification of trophoblast-specific binding sites for GATA-2 that are essential for rat placental lactogen-I gene expression.

The following Gata2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gata2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa09125	NM_033442.1 Latest version!	Rattus norvegicus GATA binding protein 2 (Gata2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$279.30 $399.00
ORa09125	XM_017592480.1 Latest version!	Rattus norvegicus GATA binding protein 2 (Gata2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$279.30 $399.00
ORa09125	XM_017592479.1 Latest version!	Rattus norvegicus GATA binding protein 2 (Gata2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$279.30 $399.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gata2 ( NM_033442.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_254277.1 Rattus norvegicus GATA binding protein 2 (Gata2), mRNA.

Price & Availability↑

CloneID	ORa09125
Clone ID Related Accession (Same CDS sequence)	XM_017592479.1 , NM_033442.1 , XM_017592480.1
Accession Version	NM_033442.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	endothelial transcription factor GATA-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY032734.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY032734.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02642799 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGTGG CGCCTGAGCA GCCTCGCTGG ATGGCGCACC CCGCCGTATT GAATGCGCAG 
CACCCCGACT CGCACCATCC GGGCCTGGCA CACAACTACA TGGAGCCGGC ACAGCTGCTG 
CCTCCGGACG AGGTGGATGT CTTCTTCAAC CACCTCGACT CGCAGGGCAA CCCCTACTAC 
GCCAACCCAG CCCACGCGCG CGCGCGCGTT TCCTACAGTC CAGCGCATGC CCGTCTCACA 
GGAGGCCAGA TGTGCCGACC ACACTTGTTG CACAGCCCAG GCTTGCCATG GCTGGACGGG 
GGCAAAGCAG CTCTCTCTGC CGCTGCTGCC CATCACCACA GCCCCTGGAC CGTCAGCCCG 
TTCTCCAAGA CCCCGCTGCA CCCCTCAGCT GCTGGAGCAC CTGGAGGGCC TCTGTCTGTG 
TACCCAGGGG CTGCGGGTGG GAGCGGTGGA GGCAGCGGGA GCTCCGTAGC CTCCCTCACC 
CCCACTGCAG CCCACTCAGG CTCCCATCTC TTCGGCTTCC CACCCACGCC ACCCAAAGAA 
GTGTCTCCAG ACCCCAGCAC CACAGGAGCT GCTTCCCCAG CCTCACCTTC AGCAGGGGGT 
AGTGTAGCCC GGGGTGAGGA CAAGGATGGC GTCAAGTATC AAGTGTCACT GTCTGAGAGC 
ATGAAGATGG AAGGTGGCAG TCCCCTGCGC CCGGGCCTAG CTCCCATGGG CACCCAGCCT 
GCAACACACC ACCCAATACC CACCTATCCC TCCTATGTGC CTGCCTCAGC TCATGAATAT 
GGCAGCGGGC TCTTCCATCC CGGAGGCTTC CTGGGTGGCC CAGCCTCCAG CTTCACCCCT 
AAGCAGCGAA GCAAGGCTCG CTCCTGCTCA GAAGGCCGGG AGTGTGTCAA CTGCGGGGCC 
ACAGCCACCC CTCTCTGGCG ACGGGATGGC ACGGGCCACT ACCTGTGCAA TGCCTGTGGG 
CTCTACCACA AGATGAATGG ACAGAATCGG CCGCTCATCA AGCCCAAGAG GAGACTGTCT 
GCTGCCAGGA GAGCGGGCAC CTGTTGTGCA AATTGTCAGA CGACAACCAC CACCTTATGG 
CGCCGGAACG CCAACGGGGA CCCTGTGTGC AACGCCTGTG GCCTCTACTA CAAGCTGCAC 
AATGTTAACA GGCCACTGAC CATGAAGAAG GAAGGGATCC AGACCCGGAA TCGGAAGATG 
TCCAGCAAAT CCAAGAAGAG CAAGAAAGGA GCCGAATGCT TTGAGGAGCT ATCCAAGTGC 
ATGCAGGAGA AGTCATCCCC CTTCAGTGCG GCTGCCCTGG CTGGACACAT GGCACCTGTG 
GGACACCTCC CACCTTTTAG TCACTCTGGA CACATCCTAC CTACGCCAAC GCCTATCCAC 
CCCTCCTCCA GTCTCTCCTT TGGTCACCCC CACCCGTCCA GCATGGTGAC TGCCATGGGC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_254277.1
CDS	444..1886
Translation	MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHSPWTVSPFSKTPLHPSAAGAPGGPLSVYPGAAGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASPSAGGSVARGEDKDGVKYQVSLSESMKMEGGSPLRPGLAPMGTQPATHHPIPTYPSYVPASAHEYGSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSSKSKKSKKGAECFEELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG

Target ORF information:

RefSeq Version	NM_033442.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GATA binding protein 2 (Gata2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033442.1

ORF Insert Sequence:

ATGGAGGTGG CGCCTGAGCA GCCTCGCTGG ATGGCGCACC CCGCCGTATT GAATGCGCAG 
CACCCCGACT CGCACCATCC GGGCCTGGCA CACAACTACA TGGAGCCGGC ACAGCTGCTG 
CCTCCGGACG AGGTGGATGT CTTCTTCAAC CACCTCGACT CGCAGGGCAA CCCCTACTAC 
GCCAACCCAG CCCACGCGCG CGCGCGCGTT TCCTACAGTC CAGCGCATGC CCGTCTCACA 
GGAGGCCAGA TGTGCCGACC ACACTTGTTG CACAGCCCAG GCTTGCCATG GCTGGACGGG 
GGCAAAGCAG CTCTCTCTGC CGCTGCTGCC CATCACCACA GCCCCTGGAC CGTCAGCCCG 
TTCTCCAAGA CCCCGCTGCA CCCCTCAGCT GCTGGAGCAC CTGGAGGGCC TCTGTCTGTG 
TACCCAGGGG CTGCGGGTGG GAGCGGTGGA GGCAGCGGGA GCTCCGTAGC CTCCCTCACC 
CCCACTGCAG CCCACTCAGG CTCCCATCTC TTCGGCTTCC CACCCACGCC ACCCAAAGAA 
GTGTCTCCAG ACCCCAGCAC CACAGGAGCT GCTTCCCCAG CCTCACCTTC AGCAGGGGGT 
AGTGTAGCCC GGGGTGAGGA CAAGGATGGC GTCAAGTATC AAGTGTCACT GTCTGAGAGC 
ATGAAGATGG AAGGTGGCAG TCCCCTGCGC CCGGGCCTAG CTCCCATGGG CACCCAGCCT 
GCAACACACC ACCCAATACC CACCTATCCC TCCTATGTGC CTGCCTCAGC TCATGAATAT 
GGCAGCGGGC TCTTCCATCC CGGAGGCTTC CTGGGTGGCC CAGCCTCCAG CTTCACCCCT 
AAGCAGCGAA GCAAGGCTCG CTCCTGCTCA GAAGGCCGGG AGTGTGTCAA CTGCGGGGCC 
ACAGCCACCC CTCTCTGGCG ACGGGATGGC ACGGGCCACT ACCTGTGCAA TGCCTGTGGG 
CTCTACCACA AGATGAATGG ACAGAATCGG CCGCTCATCA AGCCCAAGAG GAGACTGTCT 
GCTGCCAGGA GAGCGGGCAC CTGTTGTGCA AATTGTCAGA CGACAACCAC CACCTTATGG 
CGCCGGAACG CCAACGGGGA CCCTGTGTGC AACGCCTGTG GCCTCTACTA CAAGCTGCAC 
AATGTTAACA GGCCACTGAC CATGAAGAAG GAAGGGATCC AGACCCGGAA TCGGAAGATG 
TCCAGCAAAT CCAAGAAGAG CAAGAAAGGA GCCGAATGCT TTGAGGAGCT ATCCAAGTGC 
ATGCAGGAGA AGTCATCCCC CTTCAGTGCG GCTGCCCTGG CTGGACACAT GGCACCTGTG 
GGACACCTCC CACCTTTTAG TCACTCTGGA CACATCCTAC CTACGCCAAC GCCTATCCAC 
CCCTCCTCCA GTCTCTCCTT TGGTCACCCC CACCCGTCCA GCATGGTGAC TGCCATGGGC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gata2 ( XM_017592479.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017447968.1 Rattus norvegicus GATA binding protein 2 (Gata2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa09125
Clone ID Related Accession (Same CDS sequence)	XM_017592479.1 , NM_033442.1 , XM_017592480.1
Accession Version	XM_017592479.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	endothelial transcription factor GATA-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGTGG CGCCTGAGCA GCCTCGCTGG ATGGCGCACC CCGCCGTATT GAATGCGCAG 
CACCCCGACT CGCACCATCC GGGCCTGGCA CACAACTACA TGGAGCCGGC ACAGCTGCTG 
CCTCCGGACG AGGTGGATGT CTTCTTCAAC CACCTCGACT CGCAGGGCAA CCCCTACTAC 
GCCAACCCAG CCCACGCGCG CGCGCGCGTT TCCTACAGTC CAGCGCATGC CCGTCTCACA 
GGAGGCCAGA TGTGCCGACC ACACTTGTTG CACAGCCCAG GCTTGCCATG GCTGGACGGG 
GGCAAAGCAG CTCTCTCTGC CGCTGCTGCC CATCACCACA GCCCCTGGAC CGTCAGCCCG 
TTCTCCAAGA CCCCGCTGCA CCCCTCAGCT GCTGGAGCAC CTGGAGGGCC TCTGTCTGTG 
TACCCAGGGG CTGCGGGTGG GAGCGGTGGA GGCAGCGGGA GCTCCGTAGC CTCCCTCACC 
CCCACTGCAG CCCACTCAGG CTCCCATCTC TTCGGCTTCC CACCCACGCC ACCCAAAGAA 
GTGTCTCCAG ACCCCAGCAC CACAGGAGCT GCTTCCCCAG CCTCACCTTC AGCAGGGGGT 
AGTGTAGCCC GGGGTGAGGA CAAGGATGGC GTCAAGTATC AAGTGTCACT GTCTGAGAGC 
ATGAAGATGG AAGGTGGCAG TCCCCTGCGC CCGGGCCTAG CTCCCATGGG CACCCAGCCT 
GCAACACACC ACCCAATACC CACCTATCCC TCCTATGTGC CTGCCTCAGC TCATGAATAT 
GGCAGCGGGC TCTTCCATCC CGGAGGCTTC CTGGGTGGCC CAGCCTCCAG CTTCACCCCT 
AAGCAGCGAA GCAAGGCTCG CTCCTGCTCA GAAGGCCGGG AGTGTGTCAA CTGCGGGGCC 
ACAGCCACCC CTCTCTGGCG ACGGGATGGC ACGGGCCACT ACCTGTGCAA TGCCTGTGGG 
CTCTACCACA AGATGAATGG ACAGAATCGG CCGCTCATCA AGCCCAAGAG GAGACTGTCT 
GCTGCCAGGA GAGCGGGCAC CTGTTGTGCA AATTGTCAGA CGACAACCAC CACCTTATGG 
CGCCGGAACG CCAACGGGGA CCCTGTGTGC AACGCCTGTG GCCTCTACTA CAAGCTGCAC 
AATGTTAACA GGCCACTGAC CATGAAGAAG GAAGGGATCC AGACCCGGAA TCGGAAGATG 
TCCAGCAAAT CCAAGAAGAG CAAGAAAGGA GCCGAATGCT TTGAGGAGCT ATCCAAGTGC 
ATGCAGGAGA AGTCATCCCC CTTCAGTGCG GCTGCCCTGG CTGGACACAT GGCACCTGTG 
GGACACCTCC CACCTTTTAG TCACTCTGGA CACATCCTAC CTACGCCAAC GCCTATCCAC 
CCCTCCTCCA GTCTCTCCTT TGGTCACCCC CACCCGTCCA GCATGGTGAC TGCCATGGGC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017447968.1
CDS	257..1699
Translation	MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHSPWTVSPFSKTPLHPSAAGAPGGPLSVYPGAAGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASPSAGGSVARGEDKDGVKYQVSLSESMKMEGGSPLRPGLAPMGTQPATHHPIPTYPSYVPASAHEYGSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSSKSKKSKKGAECFEELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG

Target ORF information:

RefSeq Version	XM_017592479.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GATA binding protein 2 (Gata2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017592479.1

ORF Insert Sequence:

ATGGAGGTGG CGCCTGAGCA GCCTCGCTGG ATGGCGCACC CCGCCGTATT GAATGCGCAG 
CACCCCGACT CGCACCATCC GGGCCTGGCA CACAACTACA TGGAGCCGGC ACAGCTGCTG 
CCTCCGGACG AGGTGGATGT CTTCTTCAAC CACCTCGACT CGCAGGGCAA CCCCTACTAC 
GCCAACCCAG CCCACGCGCG CGCGCGCGTT TCCTACAGTC CAGCGCATGC CCGTCTCACA 
GGAGGCCAGA TGTGCCGACC ACACTTGTTG CACAGCCCAG GCTTGCCATG GCTGGACGGG 
GGCAAAGCAG CTCTCTCTGC CGCTGCTGCC CATCACCACA GCCCCTGGAC CGTCAGCCCG 
TTCTCCAAGA CCCCGCTGCA CCCCTCAGCT GCTGGAGCAC CTGGAGGGCC TCTGTCTGTG 
TACCCAGGGG CTGCGGGTGG GAGCGGTGGA GGCAGCGGGA GCTCCGTAGC CTCCCTCACC 
CCCACTGCAG CCCACTCAGG CTCCCATCTC TTCGGCTTCC CACCCACGCC ACCCAAAGAA 
GTGTCTCCAG ACCCCAGCAC CACAGGAGCT GCTTCCCCAG CCTCACCTTC AGCAGGGGGT 
AGTGTAGCCC GGGGTGAGGA CAAGGATGGC GTCAAGTATC AAGTGTCACT GTCTGAGAGC 
ATGAAGATGG AAGGTGGCAG TCCCCTGCGC CCGGGCCTAG CTCCCATGGG CACCCAGCCT 
GCAACACACC ACCCAATACC CACCTATCCC TCCTATGTGC CTGCCTCAGC TCATGAATAT 
GGCAGCGGGC TCTTCCATCC CGGAGGCTTC CTGGGTGGCC CAGCCTCCAG CTTCACCCCT 
AAGCAGCGAA GCAAGGCTCG CTCCTGCTCA GAAGGCCGGG AGTGTGTCAA CTGCGGGGCC 
ACAGCCACCC CTCTCTGGCG ACGGGATGGC ACGGGCCACT ACCTGTGCAA TGCCTGTGGG 
CTCTACCACA AGATGAATGG ACAGAATCGG CCGCTCATCA AGCCCAAGAG GAGACTGTCT 
GCTGCCAGGA GAGCGGGCAC CTGTTGTGCA AATTGTCAGA CGACAACCAC CACCTTATGG 
CGCCGGAACG CCAACGGGGA CCCTGTGTGC AACGCCTGTG GCCTCTACTA CAAGCTGCAC 
AATGTTAACA GGCCACTGAC CATGAAGAAG GAAGGGATCC AGACCCGGAA TCGGAAGATG 
TCCAGCAAAT CCAAGAAGAG CAAGAAAGGA GCCGAATGCT TTGAGGAGCT ATCCAAGTGC 
ATGCAGGAGA AGTCATCCCC CTTCAGTGCG GCTGCCCTGG CTGGACACAT GGCACCTGTG 
GGACACCTCC CACCTTTTAG TCACTCTGGA CACATCCTAC CTACGCCAAC GCCTATCCAC 
CCCTCCTCCA GTCTCTCCTT TGGTCACCCC CACCCGTCCA GCATGGTGAC TGCCATGGGC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gata2 ( XM_017592480.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017447969.1 Rattus norvegicus GATA binding protein 2 (Gata2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa09125
Clone ID Related Accession (Same CDS sequence)	XM_017592479.1 , NM_033442.1 , XM_017592480.1
Accession Version	XM_017592480.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	endothelial transcription factor GATA-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGTGG CGCCTGAGCA GCCTCGCTGG ATGGCGCACC CCGCCGTATT GAATGCGCAG 
CACCCCGACT CGCACCATCC GGGCCTGGCA CACAACTACA TGGAGCCGGC ACAGCTGCTG 
CCTCCGGACG AGGTGGATGT CTTCTTCAAC CACCTCGACT CGCAGGGCAA CCCCTACTAC 
GCCAACCCAG CCCACGCGCG CGCGCGCGTT TCCTACAGTC CAGCGCATGC CCGTCTCACA 
GGAGGCCAGA TGTGCCGACC ACACTTGTTG CACAGCCCAG GCTTGCCATG GCTGGACGGG 
GGCAAAGCAG CTCTCTCTGC CGCTGCTGCC CATCACCACA GCCCCTGGAC CGTCAGCCCG 
TTCTCCAAGA CCCCGCTGCA CCCCTCAGCT GCTGGAGCAC CTGGAGGGCC TCTGTCTGTG 
TACCCAGGGG CTGCGGGTGG GAGCGGTGGA GGCAGCGGGA GCTCCGTAGC CTCCCTCACC 
CCCACTGCAG CCCACTCAGG CTCCCATCTC TTCGGCTTCC CACCCACGCC ACCCAAAGAA 
GTGTCTCCAG ACCCCAGCAC CACAGGAGCT GCTTCCCCAG CCTCACCTTC AGCAGGGGGT 
AGTGTAGCCC GGGGTGAGGA CAAGGATGGC GTCAAGTATC AAGTGTCACT GTCTGAGAGC 
ATGAAGATGG AAGGTGGCAG TCCCCTGCGC CCGGGCCTAG CTCCCATGGG CACCCAGCCT 
GCAACACACC ACCCAATACC CACCTATCCC TCCTATGTGC CTGCCTCAGC TCATGAATAT 
GGCAGCGGGC TCTTCCATCC CGGAGGCTTC CTGGGTGGCC CAGCCTCCAG CTTCACCCCT 
AAGCAGCGAA GCAAGGCTCG CTCCTGCTCA GAAGGCCGGG AGTGTGTCAA CTGCGGGGCC 
ACAGCCACCC CTCTCTGGCG ACGGGATGGC ACGGGCCACT ACCTGTGCAA TGCCTGTGGG 
CTCTACCACA AGATGAATGG ACAGAATCGG CCGCTCATCA AGCCCAAGAG GAGACTGTCT 
GCTGCCAGGA GAGCGGGCAC CTGTTGTGCA AATTGTCAGA CGACAACCAC CACCTTATGG 
CGCCGGAACG CCAACGGGGA CCCTGTGTGC AACGCCTGTG GCCTCTACTA CAAGCTGCAC 
AATGTTAACA GGCCACTGAC CATGAAGAAG GAAGGGATCC AGACCCGGAA TCGGAAGATG 
TCCAGCAAAT CCAAGAAGAG CAAGAAAGGA GCCGAATGCT TTGAGGAGCT ATCCAAGTGC 
ATGCAGGAGA AGTCATCCCC CTTCAGTGCG GCTGCCCTGG CTGGACACAT GGCACCTGTG 
GGACACCTCC CACCTTTTAG TCACTCTGGA CACATCCTAC CTACGCCAAC GCCTATCCAC 
CCCTCCTCCA GTCTCTCCTT TGGTCACCCC CACCCGTCCA GCATGGTGAC TGCCATGGGC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017447969.1
CDS	561..2003
Translation	MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHSPWTVSPFSKTPLHPSAAGAPGGPLSVYPGAAGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASPSAGGSVARGEDKDGVKYQVSLSESMKMEGGSPLRPGLAPMGTQPATHHPIPTYPSYVPASAHEYGSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSSKSKKSKKGAECFEELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG

Target ORF information:

RefSeq Version	XM_017592480.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GATA binding protein 2 (Gata2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017592480.1

ORF Insert Sequence:

ATGGAGGTGG CGCCTGAGCA GCCTCGCTGG ATGGCGCACC CCGCCGTATT GAATGCGCAG 
CACCCCGACT CGCACCATCC GGGCCTGGCA CACAACTACA TGGAGCCGGC ACAGCTGCTG 
CCTCCGGACG AGGTGGATGT CTTCTTCAAC CACCTCGACT CGCAGGGCAA CCCCTACTAC 
GCCAACCCAG CCCACGCGCG CGCGCGCGTT TCCTACAGTC CAGCGCATGC CCGTCTCACA 
GGAGGCCAGA TGTGCCGACC ACACTTGTTG CACAGCCCAG GCTTGCCATG GCTGGACGGG 
GGCAAAGCAG CTCTCTCTGC CGCTGCTGCC CATCACCACA GCCCCTGGAC CGTCAGCCCG 
TTCTCCAAGA CCCCGCTGCA CCCCTCAGCT GCTGGAGCAC CTGGAGGGCC TCTGTCTGTG 
TACCCAGGGG CTGCGGGTGG GAGCGGTGGA GGCAGCGGGA GCTCCGTAGC CTCCCTCACC 
CCCACTGCAG CCCACTCAGG CTCCCATCTC TTCGGCTTCC CACCCACGCC ACCCAAAGAA 
GTGTCTCCAG ACCCCAGCAC CACAGGAGCT GCTTCCCCAG CCTCACCTTC AGCAGGGGGT 
AGTGTAGCCC GGGGTGAGGA CAAGGATGGC GTCAAGTATC AAGTGTCACT GTCTGAGAGC 
ATGAAGATGG AAGGTGGCAG TCCCCTGCGC CCGGGCCTAG CTCCCATGGG CACCCAGCCT 
GCAACACACC ACCCAATACC CACCTATCCC TCCTATGTGC CTGCCTCAGC TCATGAATAT 
GGCAGCGGGC TCTTCCATCC CGGAGGCTTC CTGGGTGGCC CAGCCTCCAG CTTCACCCCT 
AAGCAGCGAA GCAAGGCTCG CTCCTGCTCA GAAGGCCGGG AGTGTGTCAA CTGCGGGGCC 
ACAGCCACCC CTCTCTGGCG ACGGGATGGC ACGGGCCACT ACCTGTGCAA TGCCTGTGGG 
CTCTACCACA AGATGAATGG ACAGAATCGG CCGCTCATCA AGCCCAAGAG GAGACTGTCT 
GCTGCCAGGA GAGCGGGCAC CTGTTGTGCA AATTGTCAGA CGACAACCAC CACCTTATGG 
CGCCGGAACG CCAACGGGGA CCCTGTGTGC AACGCCTGTG GCCTCTACTA CAAGCTGCAC 
AATGTTAACA GGCCACTGAC CATGAAGAAG GAAGGGATCC AGACCCGGAA TCGGAAGATG 
TCCAGCAAAT CCAAGAAGAG CAAGAAAGGA GCCGAATGCT TTGAGGAGCT ATCCAAGTGC 
ATGCAGGAGA AGTCATCCCC CTTCAGTGCG GCTGCCCTGG CTGGACACAT GGCACCTGTG 
GGACACCTCC CACCTTTTAG TCACTCTGGA CACATCCTAC CTACGCCAAC GCCTATCCAC 
CCCTCCTCCA GTCTCTCCTT TGGTCACCCC CACCCGTCCA GCATGGTGAC TGCCATGGGC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease.
Circulation134(24)1973-1990(2016 Dec)
Hartmann D,Fiedler J,Sonnenschein K,Just A,Pfanne A,Zimmer K,Remke J,Foinquinos A,Butzlaff M,Schimmel K,Maegdefessel L,Hilfiker-Kleiner D,Lachmann N,Schober A,Froese N,Heineke J,Bauersachs J,Batkai S,Thum T

GATA2 mutations in patients with acute myeloid leukemia-paired samples analyses show that the mutation is unstable during disease evolution.
Annals of hematology94(2)211-21(2015 Feb)
Hou HA,Lin YC,Kuo YY,Chou WC,Lin CC,Liu CY,Chen CY,Lin LI,Tseng MH,Huang CF,Chiang YC,Liu MC,Liu CW,Tang JL,Yao M,Huang SY,Ko BS,Hsu SC,Wu SJ,Tsay W,Chen YC,Tien HF

Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia.
Leukemia28(8)1617-26(2014 Aug)
Celton M,Forest A,Gosse G,Lemieux S,Hebert J,Sauvageau G,Wilhelm BT

Overexpression of human GATA-1 and GATA-2 interferes with spine formation and produces depressive behavior in rats.
PloS one9(10)e109253(2014)
Choi M,Wang SE,Ko SY,Kang HJ,Chae SY,Lee SH,Kim YS,Duman RS,Son H

GATA2-induced silencing and LIM-homeodomain protein-induced activation are mediated by a bi-functional response element in the rat GnRH receptor gene.
Molecular endocrinology (Baltimore, Md.)27(1)74-91(2013 Jan)
Schang AL,Granger A,Qu?rat B,Bleux C,Cohen-Tannoudji J,Laverri?re JN